Pieler, Tomas

[["dc.bibliographiccitation.artnumber","PII S0925-4773(02)00005-9"],["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.lastpage","98"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Burke, L. J."],["dc.contributor.author","Holleman, T."],["dc.contributor.author","Pieler, T."],["dc.contributor.author","Renkawitz, R."],["dc.date.accessioned","2018-11-07T10:30:58Z"],["dc.date.available","2018-11-07T10:30:58Z"],["dc.date.issued","2002"],["dc.description.abstract","The zinc finger protein CTCF has been shown to mediate multiple functions connected to gene repression. Transcriptional inhibition as well as enhancer blocking and chromatin insulation are documented for CTCF in men, mice and chickens. Additionally, hCTCF has been linked to epigenetics and disease. In line with these basic cellular functions, CTCF has been found to be expressed in every cell type and adult tissue tested and has thus been deemed an ubiquitous protein. Here, we report the identification of the CTCF homologue from Xenopus and the analysis of the spatio-temporal expression of xCTCF during embryogenesis. Within the DNA binding domain, xCTCF is virtually identical to other identified vertebrate CTCF proteins. Homology also extends to other conserved regions that are important for CTCF function. Although xCTCF mRNA is present during all stages of early Xenopus development, a remarkable increase in expression is observed in neuronal tissues. Early in development. xCTCF is highly expressed in the neural plate and later in the neural tube and developing brain. By tailbud stage, elevated expression is also seen in the developing sensory organs of the head. This is the first detailed description of the expression pattern of a vertebrate insulator protein during embryogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0925-4773(02)00005-9"],["dc.identifier.isi","000175082300012"],["dc.identifier.pmid","11900981"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43987"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0925-4773"],["dc.title","Molecular cloning and expression of the chromatin insulator protein CTCF in Xenopus laevis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1441"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Genes & Development"],["dc.bibliographiccitation.lastpage","1446"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Afelik, S."],["dc.contributor.author","Chen, Y. L."],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T09:44:57Z"],["dc.date.available","2018-11-07T09:44:57Z"],["dc.date.issued","2006"],["dc.description.abstract","Patterning of the embryonic endoderm into distinct sets of precursor cells involves the precisely regulated activities of key transcription regulators. Ectopic, pan-endodermal activation of Xftf1a/p48 during pancreas precursor cell stages of Xenopus embryogenesis results in an expansion of the pancreatic territory, precisely within the borders of X1Hbox-8 expression. A combination of both activities is sufficient to expand the pancreatic precursor cell population also into more posterior portions of the endoderm. Both treatments result in the formation of a giant pancreas that persists up to late tadpole stages of development and carries both supernumerary endocrine and exocrine cells. A combination of XPtf1a/p48 and X1Hbox8 is thus sufficient to convert nonpancreatic endodermal cells into pancreatic precursor cells."],["dc.identifier.doi","10.1101/gad.378706"],["dc.identifier.isi","000238273700007"],["dc.identifier.pmid","16751182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34513"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cold Spring Harbor Lab Press, Publications Dept"],["dc.relation.issn","0890-9369"],["dc.title","Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","339"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The International Journal of Developmental Biology"],["dc.bibliographiccitation.lastpage","343"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Souopgui, Jacob"],["dc.contributor.author","Klisch, Tiemo J."],["dc.contributor.author","Pieler, Tomas"],["dc.contributor.author","Henningfeld, Kristine A."],["dc.date.accessioned","2018-11-07T11:06:42Z"],["dc.date.available","2018-11-07T11:06:42Z"],["dc.date.issued","2007"],["dc.description.abstract","The collaspin response mediator proteins (CRMPs) are a family of cytosolic phosphoproteins which play a critical role in the establishment of neuronal polarity and growth cone guidance. Here, we describe the temporal and spatial expression of CRMP-4 during early Xenopus embryogenesis. CRMP-4 transcripts were first detected by whole mount in situ hybridization at the end of gastrulation in the prospective neuroectoderm. During open neural plate stages, CRMP4 was expressed broadly throughout the anterior neural plate and in the three bilateral stripes of the posterior neural plate where primary neurons arise. The expression in theterritories of primary neurogenesis prefigures that of the post-mitotic neuronal marker N-tubulin. At tadpole stages, expression was maintained throughout the central nervous system and in the retina of the eye. Consistent with the observed expression, CRMP-4 transcripts are positively regulated by X-ngnr-1 and negatively by Notch signaling. The observed expression and regulation of CRMP-4 differ from that of the CRMP-2, which is induced by the events of neural induction."],["dc.identifier.doi","10.1387/ijdb.062235js"],["dc.identifier.isi","000247391900010"],["dc.identifier.pmid","17554687"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52377"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","U B C Press"],["dc.relation.issn","0214-6282"],["dc.title","Expression and regulation of Xenopus CRMP-4 in the developing nervous system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2961"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Development"],["dc.bibliographiccitation.lastpage","2971"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Taelman, Vincent"],["dc.contributor.author","van Campenhout, Claude"],["dc.contributor.author","Soelter, Marion"],["dc.contributor.author","Pieler, Tomas"],["dc.contributor.author","Bellefroid, Eric J."],["dc.date.accessioned","2018-11-07T09:27:34Z"],["dc.date.available","2018-11-07T09:27:34Z"],["dc.date.issued","2006"],["dc.description.abstract","Notch signaling has been shown to play a role in cell fate decisions in the Xenopus pronephros anlagen. Here, we show that the Xenopus Hairy-related transcription factor (HRT) gene XHRT1, and the Hairy/Enhancer of split (HES) genes Xhairy1, Xhairy2b, esr9 and esr10, have distinct restricted dynamic expression patterns during pronephros development, and that their expression is regulated by Notch. XHRT1, which is the earliest and strongest gene expressed in the pronephric region, is initially transcribed predominantly in the forming glomus, where it is downregulated by antisense morpholino oligonucleotide inhibition of xWT1. Later, it is activated in the most dorsoanterior part of the pronephros anlagen that gives rise to the proximal tubules. In agreement with this dynamic expression pro. le, we found that early activation of Notch favors glomus, whereas only later activation promotes proximal tubule formation. We show that, among the bHLH-O factors tested, only XHRT1 efficiently inhibits distal tubule and duct formation, and that only its translational inhibition causes a reduction of the expression of proximal tubule and glomus markers. Using domain swap experiments, we found that the XHRT1 C-terminal region is crucial for its activity. Together, our results provide evidence that XHRT1 plays an important role in glomerular development and early proximodistal patterning that is distinct from those of the other pronephric bHLH repressors."],["dc.identifier.doi","10.1242/dev.02458"],["dc.identifier.isi","000239758500018"],["dc.identifier.pmid","16818449"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30568"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Company Of Biologists Ltd"],["dc.relation.issn","0950-1991"],["dc.title","The Notch-effector HRT1 gene plays a role in glomerular development and patterning of the Xenopus pronephros anlagen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","79"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biology of the Cell"],["dc.bibliographiccitation.lastpage","88"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Pieler, T."],["dc.contributor.author","Chen, Y. L."],["dc.date.accessioned","2018-11-07T10:20:45Z"],["dc.date.available","2018-11-07T10:20:45Z"],["dc.date.issued","2006"],["dc.description.abstract","Diseases related to the pancreas are of highest importance in public health. It is anticipated that a detailed understanding of the molecular events that govern the embryonic development of this organ will have an immediate impact on clinical research relating to this issue. One major aim is the reconstruction of embryonic development in vitro with appropriate precursor cells, a second strategy is aimed at understanding the transdifferentiation of non-pancreatic into pancreatic tissue, and a third avenue is defined by the stimulation of the intrinsic ability of the pancreas to regenerate. Recent progress in developmental biology with respect to these different topics is reviewed in the present article. In addition, we also address evolutionary aspects of pancreas development, emphasizing the role of the South African clawed frog, Xenopus laevis, as an additional useful model system to study the molecular control of pancreas development."],["dc.identifier.doi","10.1042/BC20050069"],["dc.identifier.isi","000235478000001"],["dc.identifier.pmid","16417468"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41947"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Portland Press Ltd"],["dc.relation.issn","0248-4900"],["dc.title","Forgotten and novel aspects in pancreas development"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","FEBS Letters"],["dc.bibliographiccitation.lastpage","18"],["dc.bibliographiccitation.volume","583"],["dc.contributor.author","El Bounkari, Omar"],["dc.contributor.author","Guria, Anuja"],["dc.contributor.author","Klebba-Faerber, Sabine"],["dc.contributor.author","Claussen, Maike"],["dc.contributor.author","Pieler, Tomas"],["dc.contributor.author","Griffiths, John R."],["dc.contributor.author","Whetton, Anthony D."],["dc.contributor.author","Koch, Alexandra"],["dc.contributor.author","Tamura, Teruko"],["dc.date.accessioned","2018-11-07T08:33:34Z"],["dc.date.available","2018-11-07T08:33:34Z"],["dc.date.issued","2009"],["dc.description.abstract","THOC7 and Fms-interacting protein (FMIP) are members of the THO complex that associate with the mRNA export apparatus. FMIP is a nucleocytoplasmic shuttling protein with a nuclear localization signal (NLS), whereas THOC7 does not contain a typical NLS motif. We show here that THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly. FMIP is detected mainly in the nucleus. In the absence of exogenous FMIP, THOC7 resides mainly in the cytoplasm, while in the presence of FMIP, THOC7 is transported into the nucleus with FMIP. Furthermore, THOC7 lacking the FMIP binding site does not co-localize with FMIP, indicating that THOC7/FMIP interaction is required for nuclear localization of THOC7."],["dc.identifier.doi","10.1016/j.febslet.2008.11.024"],["dc.identifier.isi","000261949200003"],["dc.identifier.pmid","19059247"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17610"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0014-5793"],["dc.title","Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP)"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9105"],["dc.bibliographiccitation.issue","42"],["dc.bibliographiccitation.journal","The Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","9121"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Desmaris, Elodie"],["dc.contributor.author","Keruzore, Marc"],["dc.contributor.author","Saulnier, Amandine"],["dc.contributor.author","Ratié, Leslie"],["dc.contributor.author","Assimacopoulos, Stavroula"],["dc.contributor.author","De Clercq, Sarah"],["dc.contributor.author","Nan, Xinsheng"],["dc.contributor.author","Roychoudhury, Kaushik"],["dc.contributor.author","Qin, Shenyue"],["dc.contributor.author","Kricha, Sadia"],["dc.contributor.author","Chevalier, Clément"],["dc.contributor.author","Lingner, Thomas"],["dc.contributor.author","Henningfeld, Kristine A."],["dc.contributor.author","Zarkower, David"],["dc.contributor.author","Mallamaci, Antonello"],["dc.contributor.author","Theil, Thomas"],["dc.contributor.author","Campbell, Kenneth"],["dc.contributor.author","Pieler, Tomas"],["dc.contributor.author","Li, Meng"],["dc.contributor.author","Grove, Elizabeth A."],["dc.contributor.author","Bellefroid, Eric J."],["dc.date.accessioned","2020-12-10T18:42:34Z"],["dc.date.available","2020-12-10T18:42:34Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1523/JNEUROSCI.0375-18.2018"],["dc.identifier.eissn","1529-2401"],["dc.identifier.issn","0270-6474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78009"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium–Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","341"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","EMBO Reports"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Loop, S."],["dc.contributor.author","Katzer, M."],["dc.contributor.author","Pieler, T."],["dc.date.accessioned","2018-11-07T11:10:35Z"],["dc.date.available","2018-11-07T11:10:35Z"],["dc.date.issued","2005"],["dc.description.abstract","Receptor-mediated nucleocytoplasmic transport of clock proteins is an important, conserved element of the core mechanism for circadian rhythmicity. A systematic analysis of the nuclear export characteristics for the different murine period (mPER) and cryptochrome (mCRY) proteins using Xenopus oocytes as an experimental system demonstrates that all three mPER proteins, but neither mCRY1 nor mCRY2, are exported if injected individually. However, nuclear injection of heterodimeric complexes that contain combinations of mPER and mCRY proteins shows that mPER1 serves as an export adaptor for mCRY1 and mCRY2. Functional analysis of dominant-negative mPER1 variants designed either to sequester mPER3 to the cytoplasm or to inhibit nuclear export of mCRY1/2 in synchronized, stably transfected fibroblasts suggests that mPER1-mediated export of mCRY1/2 defines an important new element of the core clock machinery in vertebrates."],["dc.identifier.doi","10.1038/sj.embor.7400372"],["dc.identifier.isi","000228327200012"],["dc.identifier.pmid","15791269"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53237"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1469-221X"],["dc.title","mPER1-mediated nuclear export of mCRY1/2 is an important element in establishing circadian rhythm"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","352"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Genomics"],["dc.bibliographiccitation.lastpage","364"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Cimica, Velasco"],["dc.contributor.author","Batusic, D."],["dc.contributor.author","Chen, Y. L."],["dc.contributor.author","Hollemann, T."],["dc.contributor.author","Pieler, T."],["dc.contributor.author","Ramadori, Giuliano"],["dc.date.accessioned","2018-11-07T10:56:09Z"],["dc.date.available","2018-11-07T10:56:09Z"],["dc.date.issued","2005"],["dc.description.abstract","We have performed serial analysis of gene expression of the regenerating liver. In the rat model of partial hepatectomy and 2-acetamidofluorene treatment liver regeneration recruits hepatic stem cells referred to as oval cells. We analyzed a total of 153,057 tags in livers from normal control (52,343 tags), from sham 2-acetamidofluorene-treated control (50,502 tags), and from the early stage of oval cell proliferation (50,212 tags). Comparative analysis of the three transcriptomes identified 27 up-regulated and 18 down-regulated genes. Real-time PCR analysis confirmed I I temporally regulated genes that correlate with oval cell development. Interestingly, we found by Western blot protein analysis of regenerating livers that the cell cycle gene Cdc42 was induced concomitant with the proliferation marker cyclin D I and the oval cell marker alpha-fetoprotein. Our studies provide new insights into the molecular mechanism of liver regeneration through oval cells. (c) 2005 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ygeno.2005.05.001"],["dc.identifier.isi","000231350300011"],["dc.identifier.pmid","15993033"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49946"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0888-7543"],["dc.title","Transcriptome analysis of rat liver regeneration in a model of oval hepatic stem cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","296"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","315"],["dc.bibliographiccitation.volume","277"],["dc.contributor.author","Cornesse, Y."],["dc.contributor.author","Pieler, T."],["dc.contributor.author","Hollemann, T."],["dc.date.accessioned","2018-11-07T08:32:22Z"],["dc.date.available","2018-11-07T08:32:22Z"],["dc.date.issued","2005"],["dc.description.abstract","The integration of multiple signaling pathways is a key issue in several aspects of embryonic development. In this context, extracellular inhibitors of secreted growth factors play an important role, which is to antagonize specifically the activity of the corresponding signaling previously described as a Hedgehog-specific molecule. We provide evidence that the Hedgehog interacting protein (Hip) from Xenopus. antagonist in the mouse, interferes with Wnt-8 and eFgf/Faf-8 signaling pathways as well. To address the function of Hip during early embryonic development, we performed gain- and loss-of-function studies in the frog. Overexpression of Xhip or mHip1 resulted in a dramatic increase of retinal structures and larger olfactory placodes primarily at the expense of other brain tissues. Furthermore, loss of Xhip function resulted in a suppression of olfactory and lens placode formation. Therefore. the localized expression of Xhip may counteract certain overlapping signaling activities, which inhibit the induction of distinct sensory placodes. (C) 2004 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2004.09.016"],["dc.identifier.isi","000226225700003"],["dc.identifier.pmid","15617676"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17325"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Olfactory and lens placode formation is controlled by the hedgehog-interacting protein (Xhip) in Xenopus"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]