Flügel, Alexander

[["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Luehder, Fred"],["dc.contributor.author","Winchenbach, Jan"],["dc.contributor.author","Fluegel, Alexander"],["dc.date.accessioned","2018-11-07T09:11:32Z"],["dc.date.available","2018-11-07T09:11:32Z"],["dc.date.issued","2012"],["dc.identifier.isi","000303204801256"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26744"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","64th Annual Meeting of the American-Academy-of-Neurology (AAN)"],["dc.relation.eventlocation","New Orleans, LA"],["dc.relation.issn","0028-3878"],["dc.title","Analysis of Laquinimod Efficiency during Experimental Autoimmune Encephalomyelitis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.volume","228"],["dc.contributor.author","Francesca, Odoardi"],["dc.contributor.author","Chiara, Cordiglieri"],["dc.contributor.author","Zhang, Bo"],["dc.contributor.author","Merle, Nebel"],["dc.contributor.author","Naoto, Kawakami"],["dc.contributor.author","Wolfgang, Klinkert E. F."],["dc.contributor.author","Dimtri, Lodygin"],["dc.contributor.author","Fred, Luehder"],["dc.contributor.author","Barry, Potter V. L."],["dc.contributor.author","Andreas, Guse H."],["dc.contributor.author","Alexander, Fluegel"],["dc.date.accessioned","2018-11-07T08:36:54Z"],["dc.date.available","2018-11-07T08:36:54Z"],["dc.date.issued","2010"],["dc.identifier.isi","000283694400401"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18415"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.eventlocation","Sitges, SPAIN"],["dc.title","NAADP-mediated calcium signaling in effector T cells regulates autoimmunity of the nervous system"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Engele, J."],["dc.contributor.author","Pelkner, F."],["dc.contributor.author","Fluegel, Alexander"],["dc.contributor.author","Puchert, M."],["dc.date.accessioned","2018-11-07T09:54:17Z"],["dc.date.available","2018-11-07T09:54:17Z"],["dc.date.issued","2015"],["dc.format.extent","E322"],["dc.identifier.isi","000356386700548"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36505"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","12th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","Bilbao, SPAIN"],["dc.relation.issn","1098-1136"],["dc.relation.issn","0894-1491"],["dc.title","Profiling glial CXCL12 receptor expression during experimental autoimmune encephalomyelitis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1977"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Clinical Investigation"],["dc.bibliographiccitation.lastpage","1990"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Li, Zhilin"],["dc.contributor.author","Korhonen, Emilia A."],["dc.contributor.author","Merlini, Arianna"],["dc.contributor.author","Strauss, Judith"],["dc.contributor.author","Wihuri, Eleonoora"],["dc.contributor.author","Nurmi, Harri"],["dc.contributor.author","Antila, Salli"],["dc.contributor.author","Paech, Jennifer"],["dc.contributor.author","Deutsch, Urban"],["dc.contributor.author","Engelhardt, Britta"],["dc.contributor.author","Chintharlapalli, Sudhakar"],["dc.contributor.author","Koh, Gou Young"],["dc.contributor.author","Flügel, Alexander"],["dc.contributor.author","Alitalo, Kari"],["dc.date.accessioned","2020-12-10T18:38:18Z"],["dc.date.available","2020-12-10T18:38:18Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1172/JCI130308"],["dc.identifier.eissn","1558-8238"],["dc.identifier.issn","0021-9738"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77266"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","979"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Immunobiology"],["dc.bibliographiccitation.lastpage","987"],["dc.bibliographiccitation.volume","216"],["dc.contributor.author","Miljkovic, Djordje"],["dc.contributor.author","Stanojevic, Zeljka"],["dc.contributor.author","Momcilovic, Miljana"],["dc.contributor.author","Odoardi, Francesca"],["dc.contributor.author","Fluegel, Alexander"],["dc.contributor.author","Mostarica-Stojkovic, Marija"],["dc.date.accessioned","2018-11-07T08:52:09Z"],["dc.date.available","2018-11-07T08:52:09Z"],["dc.date.issued","2011"],["dc.description.abstract","Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis, a chronic inflammatory and demyelinating disease of the CNS. Albino Oxford (AO) rats are resistant to the induction of EAE, while the disease can be readily induced in Dark Agouti (DA) rats. Here we investigated a potential contribution of the CNS milieu in the limitation of the encephalitogenic autoimmune response. EAE was induced by immunization of the respective rat strains with spinal cord homogenate emulsified in complete Freund's adjuvant. AO rats did not exhibit clinical signs after immunization while DA rats developed severe neurologic deficits. Infiltration of immune cells into spinal cords (SC) was evident in both strains 12-14 days after the immunization. EAE lesions of AO rats contained substantially lower numbers of CD4+ T cells and CD11b+ cells compared to those in DA rats. This went together with lower levels of interferon (IFN)-gamma and interleukin (IL)-17 in the cells isolated from SC. We found a dramatic increase of CXCL12 expression in SC tissue and microvessels of AO rats, whereas DA rats markedly decreased the expression of this chemokine within their CNS. Administration of the CXCL12 antagonist AMD3100 to a substrain of AO rats that developed a weak EAE led to earlier onset and exacerbation of the disease. These results suggest a role of CXCL12 in down-regulating autoimmune processes in AO rats during EAE. Therapeutic modulation of CXCL12 could be a promising strategy for the treatment of CNS autoimmunity. (C) 2011 Elsevier GmbH. All rights reserved."],["dc.identifier.doi","10.1016/j.imbio.2011.03.013"],["dc.identifier.isi","000295606600002"],["dc.identifier.pmid","21601937"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22101"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","0171-2985"],["dc.title","CXCL12 expression within the CNS contributes to the resistance against experimental autoimmune encephalomyelitis in Albino Oxford rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","eabd5647"],["dc.bibliographiccitation.issue","675"],["dc.bibliographiccitation.journal","Science Signaling"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Roggenkamp, Hannes G."],["dc.contributor.author","Khansahib, Imrankhan"],["dc.contributor.author","Hernandez C., Lola C."],["dc.contributor.author","Zhang, Yunpeng"],["dc.contributor.author","Lodygin, Dmitri"],["dc.contributor.author","Krüger, Aileen"],["dc.contributor.author","Gu, Feng"],["dc.contributor.author","Möckl, Franziska"],["dc.contributor.author","Löhndorf, Anke"],["dc.contributor.author","Wolters, Valerie"],["dc.contributor.author","Woike, Daniel"],["dc.contributor.author","Rosche, Anette"],["dc.contributor.author","Bauche, Andreas"],["dc.contributor.author","Schetelig, Daniel"],["dc.contributor.author","Werner, René"],["dc.contributor.author","Schlüter, Hartmut"],["dc.contributor.author","Failla, Antonio V."],["dc.contributor.author","Meier, Chris"],["dc.contributor.author","Fliegert, Ralf"],["dc.contributor.author","Walseth, Timothy F."],["dc.contributor.author","Flügel, Alexander"],["dc.contributor.author","Diercks, Björn-Philipp"],["dc.contributor.author","Guse, Andreas H."],["dc.date.accessioned","2021-04-14T08:28:14Z"],["dc.date.available","2021-04-14T08:28:14Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1126/scisignal.abd5647"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82545"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1937-9145"],["dc.relation.issn","1945-0877"],["dc.title","HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.volume","253"],["dc.contributor.author","Lodygin, Dmitri"],["dc.contributor.author","Odoardi, Francesca"],["dc.contributor.author","Schlaeger, Christian"],["dc.contributor.author","Koerner, Henrike"],["dc.contributor.author","van den Brandt, Jens"],["dc.contributor.author","Reichardt, Holger"],["dc.contributor.author","Kitz, Alexandra"],["dc.contributor.author","Nosov, Michail"],["dc.contributor.author","Haberl, Michael"],["dc.contributor.author","Fluegel, Alexander"],["dc.date.accessioned","2018-11-07T09:02:16Z"],["dc.date.available","2018-11-07T09:02:16Z"],["dc.date.issued","2012"],["dc.identifier.isi","000312764800352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24643"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.eventlocation","Boston, MA"],["dc.title","Direct imaging of T cell activation during experimental autoimmune encephalomyelitis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S340"],["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.lastpage","S341"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Luehder, Fred"],["dc.contributor.author","Winchenbach, Jan"],["dc.contributor.author","Fluegel, Alexander"],["dc.date.accessioned","2018-11-07T08:51:28Z"],["dc.date.available","2018-11-07T08:51:28Z"],["dc.date.issued","2011"],["dc.identifier.isi","000209137301134"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21940"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","Analysis of laquinimod efficiency during experimental autoimmune encephalomyelitis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","667"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Trends in Neurosciences"],["dc.bibliographiccitation.lastpage","679"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Mundt, Sarah"],["dc.contributor.author","Greter, Melanie"],["dc.contributor.author","Flügel, Alexander"],["dc.contributor.author","Becher, Burkhard"],["dc.date.accessioned","2020-12-10T15:21:36Z"],["dc.date.available","2020-12-10T15:21:36Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.tins.2019.07.008"],["dc.identifier.issn","0166-2236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73084"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The CNS Immune Landscape from the Viewpoint of a T Cell"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1405"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Clinical Investigation"],["dc.bibliographiccitation.lastpage","1416"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Mueller, Nora"],["dc.contributor.author","van den Brandt, Jens"],["dc.contributor.author","Odoardi, Francesca"],["dc.contributor.author","Tischner, Denise"],["dc.contributor.author","Herath, Judith"],["dc.contributor.author","Fluegel, Alexander"],["dc.contributor.author","Reichardt, Holger Michael"],["dc.date.accessioned","2018-11-07T11:16:37Z"],["dc.date.available","2018-11-07T11:16:37Z"],["dc.date.issued","2008"],["dc.description.abstract","Administration of the CD28 superagonistic antibody JJ316 is an efficient means to treat autoimmune diseases in rats, but the humanized antibody TGN1412 caused devastating side effects in healthy volunteers during a clinical trial. Here we show that JJ316 treatment of rats induced a dramatic redistribution of T lymphocytes from the periphery to the secondary lymphoid organs, resulting in severe T lymphopenia. Live imaging of secondary lymphoid organs revealed that JJ316 administration almost instantaneously (<2 minutes) arrested T cells in situ. This reduction in T cell motility was accompanied by profound cytoskeletal rearrangements and increased cell size. In addition, surface expression of lymphocyte function-associated antigen-1 was enhanced, endothelial differentiation sphingolipid G protein-coupled receptor 1 and L selectin levels were downregulated, and the cells lost their responsiveness to sphingosine 1-phosphate-directed migration. These proadhesive alterations were accompanied by signs of strong activation, including upregulation of CD25, CD69, CD134, and proinflammatory mediators. However, this did not lead to a cytokine storm similar to the clinical trial. While most of the early changes disappeared within 48 hours, we observed that CD4(+)CD25(+)FoxP3(+) regulatory T cells experienced a second phase of activation, which resulted in massive cell enlargement, extensive polarization, and increased motility. These data suggest that CD28 superagonists elicit 2 qualitatively distinct waves of activation."],["dc.identifier.doi","10.1172/JCI32698"],["dc.identifier.isi","000254588600034"],["dc.identifier.pmid","18357346"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6254"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54633"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Clinical Investigation Inc"],["dc.relation.issn","0021-9738"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]