Karedla, Narain

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.volume","108"],["dc.contributor.author","Valley, Christopher C."],["dc.contributor.author","Arndt-Jovin, Donna J."],["dc.contributor.author","Jovin, Thomas M."],["dc.contributor.author","Steinkamp, Mara P."],["dc.contributor.author","Chizhik, Alexey I."],["dc.contributor.author","Karedla, Narain V. R."],["dc.contributor.author","Hlavacek, William S."],["dc.contributor.author","Wilson, Bridget S."],["dc.contributor.author","Lidke, Keith A."],["dc.contributor.author","Lidke, Diane S."],["dc.date.accessioned","2018-11-07T10:01:57Z"],["dc.date.available","2018-11-07T10:01:57Z"],["dc.date.issued","2015"],["dc.format.extent","351A"],["dc.identifier.isi","000362849400177"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38135"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.publisher.place","Cambridge"],["dc.relation.conference","59th Annual Meeting of the Biophysical-Society"],["dc.relation.eventlocation","Baltimore, MD"],["dc.relation.issn","1542-0086"],["dc.relation.issn","0006-3495"],["dc.title","Inside-Out Signaling of Oncogenic EGFR Mutants Promotes Ligand-Independent Dimerization"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","860"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Nature Photonics"],["dc.bibliographiccitation.lastpage","865"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Ghosh, Arindam"],["dc.contributor.author","Sharma, Akshita"],["dc.contributor.author","Chizhik, Alexey I."],["dc.contributor.author","Isbaner, Sebastian"],["dc.contributor.author","Ruhlandt, Daja"],["dc.contributor.author","Tsukanov, Roman"],["dc.contributor.author","Gregor, Ingo"],["dc.contributor.author","Karedla, Narain"],["dc.contributor.author","Enderlein, Jörg"],["dc.date.accessioned","2020-12-10T18:09:58Z"],["dc.date.available","2020-12-10T18:09:58Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1038/s41566-019-0510-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73814"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/21"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.workinggroup","RG Enderlein"],["dc.title","Graphene-based metal-induced energy transfer for sub-nanometre optical localization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","letter_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11839"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","ACS Nano"],["dc.bibliographiccitation.lastpage","11846"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Chizhik, Anna M."],["dc.contributor.author","Ruhlandt, Daja"],["dc.contributor.author","Pfaff, Janine"],["dc.contributor.author","Karedla, Narain"],["dc.contributor.author","Chizhik, Alexey I."],["dc.contributor.author","Gregor, Ingo"],["dc.contributor.author","Kehlenbach, Ralph H."],["dc.contributor.author","Enderlein, Jörg"],["dc.date.accessioned","2018-04-23T11:48:40Z"],["dc.date.available","2018-04-23T11:48:40Z"],["dc.date.issued","2017"],["dc.description.abstract","The nuclear envelope, comprising the inner and the outer nuclear membrane, separates the nucleus from the cytoplasm and plays a key role in cellular functions. Nuclear pore complexes (NPCs), which are embedded in the nuclear envelope, control transport of macromolecules between the two compartments. Here, using dual-color metal-induced energy transfer (MIET), we determine the axial distance between Lap2β and Nup358 as markers for the inner nuclear membrane and the cytoplasmic side of the NPC, respectively. Using MIET imaging, we reconstruct the 3D profile of the nuclear envelope over the whole basal area, with an axial resolution of a few nanometers. This result demonstrates that optical microscopy can achieve nanometer axial resolution in biological samples and without recourse to complex interferometric approaches."],["dc.identifier.doi","10.1021/acsnano.7b04671"],["dc.identifier.gro","3142097"],["dc.identifier.pmid","28921961"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13555"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/13"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P07: Dynamik von Proteinen der inneren Kernmembran"],["dc.relation.issn","1936-0851"],["dc.relation.workinggroup","RG Kehlenbach (Nuclear Transport)"],["dc.title","Three-Dimensional Reconstruction of Nuclear Envelope Architecture Using Dual-Color Metal-Induced Energy Transfer Imaging"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4087"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Molecular Biology of the Cell"],["dc.bibliographiccitation.lastpage","4099"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Valley, Christopher C."],["dc.contributor.author","Arndt-Jovin, Donna J."],["dc.contributor.author","Karedla, Narain V. R."],["dc.contributor.author","Steinkamp, Mara P."],["dc.contributor.author","Chizhik, Alexey I."],["dc.contributor.author","Hlavacek, William S."],["dc.contributor.author","Wilson, Bridget S."],["dc.contributor.author","Lidke, Keith A."],["dc.contributor.author","Lidke, Diane S."],["dc.date.accessioned","2018-11-07T09:49:02Z"],["dc.date.available","2018-11-07T09:49:02Z"],["dc.date.issued","2015"],["dc.description.abstract","Mutations within the epidermal growth factor receptor (EGFR/erbB1/Her1) are often associated with tumorigenesis. In particular, a number of EGFR mutants that demonstrate ligand-independent signaling are common in non-small cell lung cancer (NSCLC), including kinase domain mutations L858R (also called L834R) and exon 19 deletions (e.g., Delta L747-P753insS), which collectively make up nearly 90% of mutations in NSCLC. The molecular mechanisms by which these mutations confer constitutive activity remain unresolved. Using multiple subdiffraction-limit imaging modalities, we reveal the altered receptor structure and interaction kinetics of NSCLC-associated EGFR mutants. We applied two-color single quantum dot tracking to quantify receptor dimerization kinetics on living cells and show that, in contrast to wild-type EGFR, mutants are capable of forming stable, ligand-independent dimers. Two-color superresolution localization microscopy confirmed ligand-independent aggregation of EGFR mutants. Live-cell Forster resonance energy transfer measurements revealed that the L858R kinase mutation alters ectodomain structure such that unliganded mutant EGFR adopts an extended, dimerization-competent conformation. Finally, mutation of the putative dimerization arm confirmed a critical role for ectodomain engagement in ligand-independent signaling. These data support a model in which dysregulated activity of NSCLC-associated kinase mutants is driven by coordinated interactions involving both the kinase and extracellular domains that lead to enhanced dimerization."],["dc.identifier.doi","10.1091/mbc.E15-05-0269"],["dc.identifier.isi","000366324900022"],["dc.identifier.pmid","26337388"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35430"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Cell Biology"],["dc.relation.issn","1939-4586"],["dc.relation.issn","1059-1524"],["dc.title","Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Arndt-Jovin, Donna J."],["dc.contributor.author","Lidke, Diane S."],["dc.contributor.author","Chizhik, Alexey I."],["dc.contributor.author","Karedla, Narain V. R."],["dc.contributor.author","Jovin, Thomas M."],["dc.date.accessioned","2018-11-07T09:44:57Z"],["dc.date.available","2018-11-07T09:44:57Z"],["dc.date.issued","2014"],["dc.format.extent","237A"],["dc.identifier.isi","000337000401317"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34509"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.publisher.place","Cambridge"],["dc.relation.conference","58th Annual Meeting of the Biophysical-Society"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","1542-0086"],["dc.relation.issn","0006-3495"],["dc.title","Flim-FRET, a Structural Tool for ErbB Receptor Studies in the Living Cell"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3249"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Lab on a Chip"],["dc.bibliographiccitation.lastpage","3257"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Ghosh, Siddharth"],["dc.contributor.author","Karedla, Narain"],["dc.contributor.author","Gregor, Ingo"],["dc.date.accessioned","2021-04-14T08:23:11Z"],["dc.date.available","2021-04-14T08:23:11Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1039/d0lc00398k"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80820"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1473-0189"],["dc.relation.issn","1473-0197"],["dc.title","Single-molecule confinement with uniform electrodynamic nanofluidics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3320"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Nano Letters"],["dc.bibliographiccitation.lastpage","3326"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Baronsky, Thilo"],["dc.contributor.author","Ruhlandt, Daja"],["dc.contributor.author","Brückner, Bastian Rouven"],["dc.contributor.author","Schäfer, Jonas"],["dc.contributor.author","Karedla, Narain"],["dc.contributor.author","Isbaner, Sebastian"],["dc.contributor.author","Hähnel, Dirk"],["dc.contributor.author","Gregor, Ingo"],["dc.contributor.author","Enderlein, Jörg"],["dc.contributor.author","Janshoff, Andreas"],["dc.contributor.author","Chizhik, Alexey I."],["dc.date.accessioned","2018-04-23T11:48:51Z"],["dc.date.available","2018-04-23T11:48:51Z"],["dc.date.issued","2017"],["dc.description.abstract","The biological process of the epithelial-to-mesenchymal transition (EMT) allows epithelial cells to enhance their migratory and invasive behavior and plays a key role in embryogenesis, fibrosis, wound healing, and metastasis. Among the multiple biochemical changes from an epithelial to a mesenchymal phenotype, the alteration of cellular dynamics in cell–cell as well as cell–substrate contacts is crucial. To determine these variations over the whole time scale of the EMT, we measure the cell–substrate distance of epithelial NMuMG cells during EMT using our newly established metal-induced energy transfer (MIET) microscopy, which allows one to achieve nanometer axial resolution. We show that, in the very first hours of the transition, the cell–substrate distance increases substantially, but later in the process after reaching the mesenchymal state, this distance is reduced again to the level of untreated cells. These findings relate to a change in the number of adhesion points and will help to better understand remodeling processes associated with wound healing, embryonic development, cancer progression, or tissue regeneration."],["dc.identifier.doi","10.1021/acs.nanolett.7b01558"],["dc.identifier.gro","3142100"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13588"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","1530-6984"],["dc.title","Cell–Substrate Dynamics of the Epithelial-to-Mesenchymal Transition"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","40007"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","EPL (Europhysics Letters)"],["dc.bibliographiccitation.volume","108"],["dc.contributor.author","Karedla, N."],["dc.contributor.author","Gregor, I."],["dc.contributor.author","Enderlein, J."],["dc.date.accessioned","2018-04-23T11:49:26Z"],["dc.date.available","2018-04-23T11:49:26Z"],["dc.date.issued","2014"],["dc.description.abstract","We present a path-integral approach for finding solutions of the convection-diffusion equation with inhomogeneous fluid flow, which are notoriously difficult to solve. We derive a general approximate analytical solution of the convection-diffusion equation which is in principle applicable to arbitrary flow profiles. As examples, we apply this approximation to the diffusion in a linear shear flow and in a parabolic flow in infinite space, and to the diffusion in a linear shear flow over an impenetrable interface. This last case is particularly important for problems involving diffusive transport towards an interface with advection. We compare the analytical approximation with numerical solutions which are obtained from a conventional finite-element time-difference method."],["dc.identifier.doi","10.1209/0295-5075/108/40007"],["dc.identifier.gro","3142115"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13695"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0295-5075"],["dc.title","Analytical approximations of the diffusive dispersion in fluid flows"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Autophagy"],["dc.bibliographiccitation.lastpage","21"],["dc.contributor.author","Munzel, Lena"],["dc.contributor.author","Neumann, Piotr"],["dc.contributor.author","Otto, Florian B."],["dc.contributor.author","Krick, Roswitha"],["dc.contributor.author","Metje-Sprink, Janina"],["dc.contributor.author","Kroppen, Benjamin"],["dc.contributor.author","Karedla, Narain"],["dc.contributor.author","Enderlein, Jörg"],["dc.contributor.author","Meinecke, Michael"],["dc.contributor.author","Ficner, Ralf"],["dc.contributor.author","Thumm, Michael"],["dc.date.accessioned","2021-03-05T08:58:48Z"],["dc.date.available","2021-03-05T08:58:48Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1080/15548627.2020.1766332"],["dc.identifier.pmid","32515645"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80259"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/114"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-393"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P06: Das Zusammenspiel von Organellen-Kontaktstellen und Autophagie in S. cerevisiae"],["dc.relation.eissn","1554-8635"],["dc.relation.issn","1554-8627"],["dc.relation.orgunit","Institut für Zellbiochemie"],["dc.relation.workinggroup","RG Meinecke (Molecular Membrane Biology)"],["dc.relation.workinggroup","RG Thumm (Autophagy)"],["dc.title","Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","32"],["dc.bibliographiccitation.journal","Methods"],["dc.bibliographiccitation.lastpage","39"],["dc.bibliographiccitation.volume","140-141"],["dc.contributor.author","Ghosh, Arindam"],["dc.contributor.author","Karedla, Narain"],["dc.contributor.author","Thiele, Jan Christoph"],["dc.contributor.author","Gregor, Ingo"],["dc.contributor.author","Enderlein, Jörg"],["dc.date.accessioned","2020-12-10T15:21:49Z"],["dc.date.available","2020-12-10T15:21:49Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.ymeth.2018.02.009"],["dc.identifier.issn","1046-2023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73174"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.orgunit","III. Physikalisches Institut - Biophysik"],["dc.title","Fluorescence lifetime correlation spectroscopy: Basics and applications"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]