Erpenbeck, Luise

[["dc.bibliographiccitation.firstpage","9104-9115"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","Nanoscale"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Meyer, Daniel"],["dc.contributor.author","Telele, Saba"],["dc.contributor.author","Zelená, Anna"],["dc.contributor.author","Gillen, Alice J."],["dc.contributor.author","Antonucci, Alessandra"],["dc.contributor.author","Neubert, Elsa"],["dc.contributor.author","Nißler, Robert"],["dc.contributor.author","Mann, Florian A."],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Boghossian, Ardemis A."],["dc.contributor.author","Köster, Sarah"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2020-06-26T11:13:39Z"],["dc.date.available","2020-06-26T11:13:39Z"],["dc.date.issued","2020"],["dc.description.abstract","Cells can take up nanoscale materials, which has important implications for understanding cellular functions, biocompatibility as well as biomedical applications. Controlled uptake, transport and triggered release of nanoscale cargo is one of the great challenges in biomedical applications of nanomaterials. Here, we study how human immune cells (neutrophilic granulocytes, neutrophils) take up nanomaterials and program them to release this cargo after a certain time period. For this purpose, we let neutrophils phagocytose DNA-functionalized single-walled carbon nanotubes (SWCNTs) in vitro that fluoresce in the near infrared (980 nm) and serve as sensors for small molecules. Cells still migrate, follow chemical gradients and respond to inflammatory signals after uptake of the cargo. To program release, we make use of neutrophil extracellular trap formation (NETosis), a novel cell death mechanism that leads to chromatin swelling, subsequent rupture of the cellular membrane and release of the cell's whole content. By using the process of NETosis, we can program the time point of cargo release via the initial concentration of stimuli such as phorbol 12-myristate-13-acetate (PMA) or lipopolysaccharide (LPS). At intermediate stimulation, cells continue to migrate, follow gradients and surface cues for around 30 minutes and up to several hundred micrometers until they stop and release the SWCNTs. The transported and released SWCNT sensors are still functional as shown by subsequent detection of the neurotransmitter dopamine and reactive oxygen species (H2O2). In summary, we hijack a biological process (NETosis) and demonstrate how neutrophils transport and release functional nanomaterials."],["dc.identifier.doi","10.1039/d0nr00864h"],["dc.identifier.pmid","32286598"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66755"],["dc.language.iso","en"],["dc.relation.eissn","2040-3372"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Köster (Cellular Biophysics)"],["dc.rights","CC BY 3.0"],["dc.subject.gro","cellular biophysics"],["dc.title","Transport and programmed release of nanoscale cargo from cells by using NETosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E54"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.lastpage","E55"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Senger-Sander, S. N."],["dc.contributor.author","Grandke, J."],["dc.contributor.author","Neubert, E."],["dc.contributor.author","Erdelt, S."],["dc.contributor.author","Manzke, V. S."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Erpenbeck, Luise"],["dc.date.accessioned","2018-11-07T10:26:27Z"],["dc.date.available","2018-11-07T10:26:27Z"],["dc.date.issued","2017"],["dc.identifier.isi","000397284200129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43048"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.publisher.place","Hoboken"],["dc.relation.conference","44th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Gottingen, GERMANY"],["dc.relation.issn","1600-0625"],["dc.relation.issn","0906-6705"],["dc.title","In vitro formation of neutrophil extracellular traps (NETs) is inhibited by the presence of serum and serum albumin in culture media"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","121"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.lastpage","128"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Priebe, Marie K."],["dc.contributor.author","Dewert, Nadin"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Heinzerling, Lucie"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Lorenz, Verena N."],["dc.date.accessioned","2020-12-10T18:28:40Z"],["dc.date.available","2020-12-10T18:28:40Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1111/exd.13848"],["dc.identifier.issn","0906-6705"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76375"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","c-Rel is a cell cycle modulator in human melanoma cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","528"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular Cancer Research"],["dc.bibliographiccitation.lastpage","542"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Kossmann, Eugen"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Schill, Tillmann"],["dc.contributor.author","Schön, Margarete"],["dc.contributor.author","Möckel, Sigrid M.C."],["dc.contributor.author","Spatz, Joachim P."],["dc.contributor.author","Schön, Michael P."],["dc.date.accessioned","2020-12-10T18:37:47Z"],["dc.date.available","2020-12-10T18:37:47Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1158/1541-7786.MCR-17-0272"],["dc.identifier.eissn","1557-3125"],["dc.identifier.issn","1541-7786"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77091"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Nanoscale Tuning of VCAM-1 Determines VLA-4–Dependent Melanoma Cell Plasticity on RGD Motifs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","795"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","807"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Biedermann, Tilo"],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Eyerich, Kilian"],["dc.contributor.author","Eyerich, Stefanie"],["dc.contributor.author","Ghoreschi, Kamran"],["dc.contributor.author","Goebeler, Matthias"],["dc.contributor.author","Ludwig, Ralf J."],["dc.contributor.author","Schäkel, Knut"],["dc.contributor.author","Schilling, Bastian"],["dc.contributor.author","Schlapbach, Christoph"],["dc.contributor.author","Stary, Georg"],["dc.contributor.author","Stebut, Esther"],["dc.contributor.author","Steinbrink, Kerstin"],["dc.date.accessioned","2021-04-14T08:24:09Z"],["dc.date.available","2021-04-14T08:24:09Z"],["dc.date.issued","2020"],["dc.description.abstract","Summary The COVID‐19 pandemic caused by SARS‐CoV‐2 has far‐reaching direct and indirect medical consequences. These include both the course and treatment of diseases. It is becoming increasingly clear that infections with SARS‐CoV‐2 can cause considerable immunological alterations, which particularly also affect pathogenetically and/or therapeutically relevant factors. Against this background we summarize here the current state of knowledge on the interaction of SARS‐CoV‐2/COVID‐19 with mediators of the acute phase of inflammation (TNF, IL‐1, IL‐6), type 1 and type 17 immune responses (IL‐12, IL‐23, IL‐17, IL‐36), type 2 immune reactions (IL‐4, IL‐13, IL‐5, IL‐31, IgE), B‐cell immunity, checkpoint regulators (PD‐1, PD‐L1, CTLA4), and orally druggable signaling pathways (JAK, PDE4, calcineurin). In addition, we discuss in this context non‐specific immune modulation by glucocorticosteroids, methotrexate, antimalarial drugs, azathioprine, dapsone, mycophenolate mofetil and fumaric acid esters, as well as neutrophil granulocyte‐mediated innate immune mechanisms. From these recent findings we derive possible implications for the therapeutic modulation of said immunological mechanisms in connection with SARS‐CoV‐2/COVID‐19. Although, of course, the greatest care should be taken with patients with immunologically mediated diseases or immunomodulating therapies, it appears that many treatments can also be carried out during the COVID‐19 pandemic; some even appear to alleviate COVID‐19."],["dc.identifier.doi","10.1111/ddg.14169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81179"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes."],["dc.title","COVID‐19 and immunological regulations – from basic and translational aspects to clinical implications"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Spear, Stephen F."],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T09:43:01Z"],["dc.date.available","2018-11-07T09:43:01Z"],["dc.date.issued","2014"],["dc.format.extent","E11"],["dc.identifier.isi","000332335500079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34086"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","41st Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Cologne, GERMANY"],["dc.relation.issn","1600-0625"],["dc.relation.issn","0906-6705"],["dc.title","Adhesion maturation of neutrophils on nanoscopically presented integrin ligands"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Kossmann, E."],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Spear, Stephen F."],["dc.contributor.author","Kruss, Sebastian"],["dc.contributor.author","Schoen, Michael Peter"],["dc.date.accessioned","2018-11-07T09:43:00Z"],["dc.date.available","2018-11-07T09:43:00Z"],["dc.date.issued","2014"],["dc.format.extent","E46"],["dc.identifier.isi","000332335500287"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34084"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","41st Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Cologne, GERMANY"],["dc.relation.issn","1600-0625"],["dc.relation.issn","0906-6705"],["dc.title","Melanoma cell function regulated by VCAM-1 presented on tunable nano-structured surfaces"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","857"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Thrombosis and Haemostasis"],["dc.bibliographiccitation.lastpage","859"],["dc.bibliographiccitation.volume","103"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Rubant, Simone"],["dc.contributor.author","Hardt, Katja"],["dc.contributor.author","Santoso, Sentot"],["dc.contributor.author","Boehncke, Wolf-Henning"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Ludwig, Ralf J."],["dc.date.accessioned","2018-11-07T08:44:57Z"],["dc.date.available","2018-11-07T08:44:57Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1160/TH09-08-0572"],["dc.identifier.isi","000277031700025"],["dc.identifier.pmid","20135068"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20316"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0340-6245"],["dc.title","Constitutive and functionally relevant expression of JAM-C on platelets"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","17693"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","ACS Applied Materials & Interfaces"],["dc.bibliographiccitation.lastpage","17703"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Polo, Elena"],["dc.contributor.author","Nitka, Tadeusz T."],["dc.contributor.author","Neubert, Elsa"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Vuković, Lela"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2020-12-10T15:22:29Z"],["dc.date.available","2020-12-10T15:22:29Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1021/acsami.8b04373"],["dc.identifier.eissn","1944-8252"],["dc.identifier.issn","1944-8244"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73418"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Control of Integrin Affinity by Confining RGD Peptides on Fluorescent Carbon Nanotubes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Biophotonics"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Spreinat, Alexander"],["dc.contributor.author","Selvaggio, Gabriele"],["dc.contributor.author","Erpenbeck, Luise"],["dc.contributor.author","Kruss, Sebastian"],["dc.date.accessioned","2019-12-05T14:29:38Z"],["dc.date.accessioned","2021-10-27T13:12:48Z"],["dc.date.available","2019-12-05T14:29:38Z"],["dc.date.available","2021-10-27T13:12:48Z"],["dc.date.issued","2019"],["dc.description.abstract","Multispectral imaging combines the spectral resolution of spectroscopy with the spatial resolution of imaging and is therefore very useful for biomedical applications. Currently, histological diagnostics use mainly stainings with standard dyes (eg, hematoxylin + eosin) to identify tumors. This method is not applicable in vivo and provides low amounts of chemical information. Biomolecules absorb near infrared light (NIR, 800-1700 nm) at different wavelengths, which could be used to fingerprint tissue. Here, we built a NIR multispectral absorption imaging setup to study skin tissue samples. NIR light (900-1500 nm) was used for homogenous wide-field transmission illumination and detected by a cooled InGaAs camera. In this setup, images I(x, y, λ) from dermatological samples (melanoma, nodular basal-cell carcinoma, squamous-cell carcinoma) were acquired to distinguish healthy from diseased tissue regions. In summary, we show the potential of multispectral NIR imaging for cancer diagnostics."],["dc.description.sponsorship","life@nano"],["dc.identifier.doi","10.1002/jbio.201960080"],["dc.identifier.eissn","1864-0648"],["dc.identifier.isbn","31602799"],["dc.identifier.issn","1864-063X"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16850"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91723"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.publisher","WILEY‐VCH Verlag GmbH \\u0026 Co. KGaA"],["dc.relation.eissn","1864-0648"],["dc.relation.issn","1864-0648"],["dc.relation.issn","1864-063X"],["dc.relation.orgunit","Fakultät für Chemie"],["dc.rights","CC BY 4.0"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","diagnostics; histology; multispectral imaging; near infrared spectroscopy; skin cancer"],["dc.subject.ddc","540"],["dc.title","Multispectral near infrared absorption imaging for histology of skin cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]