Gallwas, Julia

[["dc.bibliographiccitation.artnumber","e42"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Gynecologic Oncology"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Kolben, Theresa Maria"],["dc.contributor.author","Etzel, Lea T"],["dc.contributor.author","Bergauer, Florian"],["dc.contributor.author","Hagemann, Ingke"],["dc.contributor.author","Hillemanns, Peter"],["dc.contributor.author","Repper, Monika"],["dc.contributor.author","Kaufmann, Andreas M"],["dc.contributor.author","Sotlar, Karl"],["dc.contributor.author","Kolben, Thomas"],["dc.contributor.author","Helms, Hans Joachim"],["dc.contributor.author","Gallwas, Julia"],["dc.contributor.author","Mahner, Sven"],["dc.contributor.author","Dannecker, Christian"],["dc.date.accessioned","2020-06-15T14:32:58Z"],["dc.date.available","2020-06-15T14:32:58Z"],["dc.date.issued","2019-05"],["dc.description.abstract","To show noninferiority of a limited-excision (resection of the dysplastic lesion only) vs. classical Large Loop Excision of the Transformation Zone (LLETZ)."],["dc.identifier.doi","10.3802/jgo.2019.30.e42"],["dc.identifier.pmid","30887760"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66281"],["dc.language.iso","en"],["dc.relation.eissn","2005-0399"],["dc.relation.issn","2005-0380"],["dc.title","A randomized trial comparing limited-excision conisation to Large Loop Excision of the Transformation Zone (LLETZ) in cervical dysplasia patients"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","341"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Langenbeck's Archives of Surgery"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","400"],["dc.contributor.author","Sommerey, Sandra"],["dc.contributor.author","Foroghi, Yalda"],["dc.contributor.author","Chiapponi, Costanza"],["dc.contributor.author","Baumbach, Sebastian F"],["dc.contributor.author","Hallfeldt, Klaus K J"],["dc.contributor.author","Ladurner, Roland"],["dc.contributor.author","Gallwas, Julia K. S."],["dc.date.accessioned","2020-06-15T14:33:21Z"],["dc.date.available","2020-06-15T14:33:21Z"],["dc.date.issued","2015-04"],["dc.description.abstract","Minimally invasive adrenalectomy has been adopted as the treatment of choice for benign adrenal tumors. This study aimed to investigate the outcome of laparoscopic adrenalectomies performed over a 10-year period at a teaching hospital."],["dc.identifier.doi","10.1007/s00423-015-1287-x"],["dc.identifier.pmid","25721680"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66286"],["dc.language.iso","en"],["dc.relation.eissn","1435-2451"],["dc.relation.issn","1435-2443"],["dc.title","Laparoscopic adrenalectomy 10-year experience at a teaching hospital"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","654"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Lasers in Surgery and Medicine"],["dc.bibliographiccitation.lastpage","659"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Ladurner, Roland"],["dc.contributor.author","Hallfeldt, Klaus K J"],["dc.contributor.author","Al Arabi, Norah"],["dc.contributor.author","Stepp, Herbert"],["dc.contributor.author","Mueller, Susanna"],["dc.contributor.author","Gallwas, Julia K. S."],["dc.date.accessioned","2020-06-15T14:34:02Z"],["dc.date.available","2020-06-15T14:34:02Z"],["dc.date.issued","2013-12"],["dc.description.abstract","The identification of parathyroid glands can be a major problem in parathyroid surgery. The purpose of this study was to evaluate the feasibility of optical coherence tomography (OCT) in distinguishing between parathyroid tissue, thyroid tissue, lymph nodes, and adipose tissue."],["dc.identifier.doi","10.1002/lsm.22195"],["dc.identifier.pmid","24249200"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66296"],["dc.language.iso","en"],["dc.relation.eissn","1096-9101"],["dc.relation.issn","0196-8092"],["dc.title","Optical coherence tomography as a method to identify parathyroid glands"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Geburtshilfe und Frauenheilkunde"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Götze, TO"],["dc.contributor.author","Al-Batran, S-E"],["dc.contributor.author","Bankstahl, US"],["dc.contributor.author","Fleckenstein, A-S"],["dc.contributor.author","Engel, JB"],["dc.contributor.author","Aktas, B"],["dc.contributor.author","Martin, M"],["dc.contributor.author","Weisgerber, C"],["dc.contributor.author","Hunold, P"],["dc.contributor.author","Gallwas, J"],["dc.contributor.author","Kulenkampff, D"],["dc.contributor.author","Maintz, D"],["dc.contributor.author","Morgenstern, B"],["dc.contributor.author","Püsken, M"],["dc.contributor.author","Keim, S"],["dc.contributor.author","Matzko, M"],["dc.contributor.author","Düx, M"],["dc.date.accessioned","2022-11-01T10:16:51Z"],["dc.date.available","2022-11-01T10:16:51Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1055/s-0042-1756822"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116670"],["dc.notes.intern","DOI-Import GROB-605"],["dc.publisher","Georg Thieme Verlag"],["dc.relation.conference","64. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e. V."],["dc.relation.eventend","2022-10-15"],["dc.relation.eventlocation","München"],["dc.relation.eventstart","2022-10-12"],["dc.title","Multizentrische, randomisierte Phase III-Studie zur Magnetresonanztomographie-gesteuerten hochfokussierten Ultraschalltherapie zur Behandlung des Uterusmyoms (MRgFUS-TUF) im Vergleich zur Myomektomie bei symptomatischen und medikamentös nicht ausreichend therapierbaren Uterusmyomen (MARGI-T)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","27"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Gynaecological Oncology"],["dc.bibliographiccitation.lastpage","30"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Gallwas, J."],["dc.contributor.author","Ditsch, N"],["dc.contributor.author","Hillemanns, P"],["dc.contributor.author","Friese, K"],["dc.contributor.author","Thaler, C"],["dc.contributor.author","Dannecker, C"],["dc.date.accessioned","2020-06-15T14:35:16Z"],["dc.date.available","2020-06-15T14:35:16Z"],["dc.date.issued","2010"],["dc.description.abstract","High-risk anogenital human papillomavirus (HPV) infections are causally related to cervical cancer. Successful treatment of cervical intraepithelial neoplasia (CIN) results in complete eradication of HPV in most cases. There is an increasing interest regarding the role of HPV testing in the follow-up period after treatment for CIN."],["dc.identifier.pmid","20349777"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66313"],["dc.language.iso","en"],["dc.relation.issn","0392-2936"],["dc.title","The significance of HPV in the follow-up period after treatment for CIN"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","7"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Epigenetics"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Pantelaiou-Prokaki, Garyfallia"],["dc.contributor.author","Mieczkowska, Iga"],["dc.contributor.author","Schmidt, Geske E."],["dc.contributor.author","Fritzsche, Sonja"],["dc.contributor.author","Prokakis, Evangelos"],["dc.contributor.author","Gallwas, Julia"],["dc.contributor.author","Wegwitz, Florian"],["dc.date.accessioned","2022-02-01T10:31:32Z"],["dc.date.accessioned","2022-08-18T12:33:13Z"],["dc.date.available","2022-02-01T10:31:32Z"],["dc.date.available","2022-08-18T12:33:13Z"],["dc.date.issued","2022-01-11"],["dc.date.updated","2022-07-29T12:00:15Z"],["dc.description.abstract","Background Basal-like breast cancer (BLBC) is one of the most aggressive malignant diseases in women with an increased metastatic behavior and poor prognosis compared to other molecular subtypes of breast cancer. Resistance to chemotherapy is the main cause of treatment failure in BLBC. Therefore, novel therapeutic strategies counteracting the gain of aggressiveness underlying therapy resistance are urgently needed. The epithelial-to-mesenchymal transition (EMT) has been established as one central process stimulating cancer cell migratory capacity but also acquisition of chemotherapy-resistant properties. In this study, we aimed to uncover epigenetic factors involved in the EMT-transcriptional program occurring in BLBC cells surviving conventional chemotherapy. Results Using whole transcriptome data from a murine mammary carcinoma cell line (pG-2), we identified upregulation of Hdac4 , 7 and 8 in tumor cells surviving conventional chemotherapy. Subsequent analyses of human BLBC patient datasets and cell lines established HDAC8 as the most promising factor sustaining tumor cell viability. ChIP-sequencing data analysis identified a pronounced loss of H3K27ac at regulatory regions of master transcription factors (TFs) of epithelial phenotype like Gata3 , Elf5 , Rora and Grhl2 upon chemotherapy. Interestingly, impairment of HDAC8 activity reverted epithelial-TFs levels. Furthermore, loss of HDAC8 activity sensitized tumor cells to chemotherapeutic treatments, even at low doses. Conclusion The current study reveals a previously unknown transcriptional repressive function of HDAC8 exerted on a panel of transcription factors involved in the maintenance of epithelial cell phenotype, thereby supporting BLBC cell survival to conventional chemotherapy. Our data establish HDAC8 as an attractive therapeutically targetable epigenetic factor to increase the efficiency of chemotherapeutics. Graphical abstract"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","Clinical Epigenetics. 2022 Jan 11;14(1):7"],["dc.identifier.doi","10.1186/s13148-022-01228-4"],["dc.identifier.pii","1228"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98885"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112916"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1868-7083"],["dc.relation.issn","1868-7075"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","HDAC8"],["dc.subject","MET"],["dc.subject","EMT"],["dc.subject","BLBC"],["dc.subject","TNBC"],["dc.subject","Chemotherapy"],["dc.subject","Epigenetics"],["dc.subject","H3K27ac"],["dc.subject","Epithelial transcription factors"],["dc.title","HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","87"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","In Vivo"],["dc.bibliographiccitation.lastpage","92"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Ditsch, N"],["dc.contributor.author","Vrekoussis, T"],["dc.contributor.author","Lenhard, M"],["dc.contributor.author","Rühl, I"],["dc.contributor.author","Gallwas, J."],["dc.contributor.author","Weissenbacher, T"],["dc.contributor.author","Friese, K"],["dc.contributor.author","Mayr, D"],["dc.contributor.author","Makrigiannakis, A"],["dc.contributor.author","Jeschke, U"],["dc.date.accessioned","2020-06-15T14:34:52Z"],["dc.date.available","2020-06-15T14:34:52Z"],["dc.date.issued","2012"],["dc.description.abstract","The role of retinoid X receptor alpha (RXRα) and peroxisome proliferator-activated receptor gamma (PPARγ) in breast cancer has been well studied in vitro. The aim of the study was to assess the presence of these molecules in human breast cancer specimens and correlate them with major clinicopathological features."],["dc.identifier.pmid","22210720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66307"],["dc.language.iso","en"],["dc.relation.eissn","1791-7549"],["dc.title","Retinoid X receptor alpha (RXRα) and peroxisome proliferator-activated receptor gamma (PPARγ) expression in breast cancer: an immunohistochemical study"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","416"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Chirurg"],["dc.bibliographiccitation.lastpage","422"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Ladurner, R"],["dc.contributor.author","Hallfeldt, K"],["dc.contributor.author","Al Arabi, N"],["dc.contributor.author","Gallwas, J."],["dc.contributor.author","Mortensen, U"],["dc.contributor.author","Sommerey, S"],["dc.date.accessioned","2020-06-15T14:34:37Z"],["dc.date.available","2020-06-15T14:34:37Z"],["dc.date.issued","2016-05"],["dc.description.abstract","Optical coherence tomography (OCT) is a high-resolution imaging technique that allows the identification of microarchitectural features in real-time."],["dc.identifier.doi","10.1007/s00104-015-0120-y"],["dc.identifier.pmid","26661948"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66304"],["dc.language.iso","other"],["dc.relation.eissn","1433-0385"],["dc.relation.issn","0009-4722"],["dc.title","Optical coherence tomography for differentiation of parathyroid gland tissue"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2428"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","World Journal of Surgery"],["dc.bibliographiccitation.lastpage","2431"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Chiapponi, C"],["dc.contributor.author","Stocker, U"],["dc.contributor.author","Mussack, Th"],["dc.contributor.author","Gallwas, J."],["dc.contributor.author","Hallfeldt, K"],["dc.contributor.author","Ladurner, R"],["dc.date.accessioned","2020-06-15T14:35:04Z"],["dc.date.available","2020-06-15T14:35:04Z"],["dc.date.issued","2011-11"],["dc.description.abstract","Surgery as definitive treatment of pediatric Graves' disease is recommended for children and adolescents experiencing adverse effects of thionamides or disease relapse after at least 2 years of medical treatment. In addition, it is indicated in patients with a large goiter or with suspicious nodules. Total or near-total thyroidectomy should be performed, since subtotal thyroidectomy is associated with a high risk of relapse in this group. Patients should be referred to surgeons experienced in thyroid surgery because studies show that children and adolescents have a higher complication rate than adults."],["dc.identifier.doi","10.1007/s00268-011-1238-9"],["dc.identifier.pmid","21879423"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66310"],["dc.language.iso","en"],["dc.relation.eissn","1432-2323"],["dc.relation.issn","0364-2313"],["dc.title","The surgical treatment of Graves' disease in children and adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1659"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Archives of Gynecology and Obstetrics"],["dc.bibliographiccitation.lastpage","1665"],["dc.bibliographiccitation.volume","299"],["dc.contributor.author","Eggersmann, T K"],["dc.contributor.author","Sharaf, K"],["dc.contributor.author","Baumeister, P"],["dc.contributor.author","Thaler, C"],["dc.contributor.author","Dannecker, C J"],["dc.contributor.author","Jeschke, U"],["dc.contributor.author","Mahner, S"],["dc.contributor.author","Weyerstahl, K"],["dc.contributor.author","Weyerstahl, T"],["dc.contributor.author","Bergauer, F"],["dc.contributor.author","Gallwas, J."],["dc.date.accessioned","2020-06-15T14:32:33Z"],["dc.date.available","2020-06-15T14:32:33Z"],["dc.date.issued","2019"],["dc.description.abstract","Human papillomavirus (HPV) infection represents the primary cause of anogenital premalignant and malignant disease. Regarding the high prevalence of cervical HPV infection and the increasing incidence of HPV associated oropharyngeal cancer in recent years, a significant viral transmission from the cervical to the oral site, possibly depending on the sexual behavior must be considered. The present study aims to determine the prevalence of oral HPV infection in cervical HPV positive and negative women and their sexual partners."],["dc.identifier.doi","10.1007/s00404-019-05135-7"],["dc.identifier.pmid","30953186"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66275"],["dc.language.iso","en"],["dc.relation.eissn","1432-0711"],["dc.relation.issn","0932-0067"],["dc.title","Prevalence of oral HPV infection in cervical HPV positive women and their sexual partners"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]