Paulus, Walter

[["dc.bibliographiccitation.artnumber","pyv102"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The International Journal of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Schade, Sebastian"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T10:15:46Z"],["dc.date.available","2018-11-07T10:15:46Z"],["dc.date.issued","2016"],["dc.description.abstract","D-Cycloserine, known from tuberculosis therapy, has been widely introduced to neuropsychiatric studies, since its central active mechanism as a partial NMDA-agonist has been found. In this review, we evaluate its therapeutic potential in neuropsychological disorders and discuss its pitfalls in terms of dosing and application frequency as well as its safety in low-dose therapy. Therefore, we identified 91 clinical trials by performing a Medline search. We demonstrate in part preliminary but increasing evidence that D-cycloserine may be effective in various psychiatric diseases, including schizophrenia, anxiety disorders, addiction, eating disorders, major depression, and autism as well as in neurological diseases, including dementia, Alzheimer's disease, and spinocerebellar degeneration. D-Cycloserine in low-dose therapy is safe, but there is still a need for new drugs with higher specificity to the different N-methyl-D-aspartate-receptor subunits."],["dc.identifier.doi","10.1093/ijnp/pyv102"],["dc.identifier.isi","000377111100001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13518"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40882"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1469-5111"],["dc.relation.issn","1461-1457"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","14442"],["dc.bibliographiccitation.issue","52"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","14447"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Grosch, Jan"],["dc.contributor.author","Fregni, Felipe"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T10:43:58Z"],["dc.date.available","2018-11-07T10:43:58Z"],["dc.date.issued","2007"],["dc.description.abstract","Cholinergic neuromodulation is pivotal for arousal, attention, and cognitive processes. Loss or dysregulation of cholinergic inputs leads to cognitive impairments like those manifested in Alzheimer's disease. Such dysfunction can be at least partially restored by an increase of acetylcholine (ACh). In animal studies, ACh selectively facilitates long-term excitability changes induced by feed-forward afferent input. Consequently, it has been hypothesized that ACh enhances the signal-to-noise ratio of input processing. However, the neurophysiological foundation for its ability to enhance cognition in humans is not well documented. In this study we explore the effects of rivastigmine, a cholinesterase inhibitor, on global and synapse-specific forms of cortical plasticity induced by transcranial direct current stimulation (tDCS) and paired associative stimulation (PAS) on 10-12 healthy subjects, respectively. Rivastigmine essentially blocked the induction of the global excitability enhancement elicited by anodal tDCS and revealed a tendency to first reduce and then stabilize cathodal tDCS-induced inhibitory aftereffects. However, ACh enhanced the synapse-specific excitability enhancement produced by facilitatory PAS and consolidated the inhibitory PAS-induced excitability diminution. These findings are in line with a cholinergic focusing effect that optimizes the detection of relevant signals during information processing in humans."],["dc.identifier.doi","10.1523/JNEUROSCI.4104-07.2007"],["dc.identifier.isi","000251911100024"],["dc.identifier.pmid","18160652"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47168"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Focusing effect of acetylcholine on neuroplasticity in the human motor cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of the Neurological Sciences"],["dc.bibliographiccitation.lastpage","109"],["dc.bibliographiccitation.volume","354"],["dc.contributor.author","Wickmann, Franziska"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Czesnik, Dirk"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Timaeus, Charles"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.date.accessioned","2018-11-07T09:54:38Z"],["dc.date.available","2018-11-07T09:54:38Z"],["dc.date.issued","2015"],["dc.description.abstract","The present study aimed to investigate the efficacy of repetitive cathodal direct current stimulation (rctDCS) over the visual cortex as a prophylactic treatment in patients with menstrual migraine. 20 female patients were recruited in this double-blind, placebo-controlled study and were assigned to receive either cathodal or sham stimulation. Over 3 menstrual cycles, tDCS with 2 mA intensity and 20 min duration was applied to the visual cortex of the patients, in 5 consecutive sessions 1-5 days prior to the first day of their menstruation. The primary endpoint of the study was the frequency of the migraine attacks at the end of the treatment period, however, additional parameters, such as the number of migraine related days and the intensity of pain were also recorded 3 months before, during and 3 months post-treatment Visual cortex excitability was determined by measuring the phosphene thresholds (PTs) using single pulse transcranial magnetic stimulation (TMS) over the visual cortex. Sixteen patients completed the study. A significant decrease in the number of migraine attacks (p = 0.04) was found in the cathodal group compared to baseline but not compared to sham (p = 0.053). In parallel the PTs increased significantly in this group, compared to the sham group (p < 0.05). Our results indicate that prophylactic treatment with rctDCS over the visual cortex might be able to decrease the number of attacks in patients with menstrual migraine, probably by modifying cortical excitability. (C) 2015 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Migraine Foundation"],["dc.identifier.doi","10.1016/j.jns.2015.05.009"],["dc.identifier.isi","000356978600018"],["dc.identifier.pmid","26003225"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36574"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1878-5883"],["dc.relation.issn","0022-510X"],["dc.title","Prophylactic treatment in menstrual migraine: A proof-of-concept study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","140"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","150"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Opitz, Alexander"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Will, Susanne"],["dc.contributor.author","Antunes, Andre"],["dc.contributor.author","Thielscher, Axel"],["dc.date.accessioned","2018-10-10T11:22:46Z"],["dc.date.available","2018-10-10T11:22:46Z"],["dc.date.issued","2015"],["dc.description.abstract","Transcranial direct current stimulation (tDCS) causes a complex spatial distribution of the electric current flow in the head which hampers the accurate localization of the stimulated brain areas. In this study we show how various anatomical features systematically shape the electric field distribution in the brain during tDCS. We constructed anatomically realistic finite element (FEM) models of two individual heads including conductivity anisotropy and different skull layers. We simulated a widely employed electrode montage to induce motor cortex plasticity and moved the stimulating electrode over the motor cortex in small steps to examine the resulting changes of the electric field distribution in the underlying cortex. We examined the effect of skull thickness and composition on the passing currents showing that thinner skull regions lead to higher electric field strengths. This effect is counteracted by a larger proportion of higher conducting spongy bone in thicker regions leading to a more homogenous current over the skull. Using a multiple regression model we could identify key factors that determine the field distribution to a significant extent, namely the thicknesses of the cerebrospinal fluid and the skull, the gyral depth and the distance to the anode and cathode. These factors account for up to 50% of the spatial variation of the electric field strength. Further, we demonstrate that individual anatomical factors can lead to stimulation \"hotspots\" which are partly resistant to electrode positioning. Our results give valuable novel insights in the biophysical foundation of tDCS and highlight the importance to account for individual anatomical factors when choosing an electrode montage."],["dc.identifier.doi","10.1016/j.neuroimage.2015.01.033"],["dc.identifier.pmid","25613437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15956"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1095-9572"],["dc.title","Determinants of the electric field during transcranial direct current stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","10701"],["dc.bibliographiccitation.issue","32"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","10709"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Fresnoza, Shane"],["dc.contributor.author","Stiksrud, Elisabeth"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Liebetanz, David"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Kuo, Min-Fang"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T09:36:45Z"],["dc.date.available","2018-11-07T09:36:45Z"],["dc.date.issued","2014"],["dc.description.abstract","The neuromodulator dopamine plays an important role in synaptic plasticity. The effects depend on receptor subtypes, affinity, concentration level, and the kind of neuroplasticity induced. In animal experiments, dopamine D-2-like receptor stimulation revealed partially antagonistic effects on plasticity, which might be explained by dosage dependency. In humans, D-2 receptor block abolishes plasticity, and the D-2/D-3, but predominantly D-3, receptor agonist ropinirol has a dosage-dependent nonlinear affect on plasticity. Here we aimed to determine the specific affect of D-2 receptor activation on neuroplasticity in humans, because physiological effects of D-2 and D-3 receptors might differ. Therefore, we combined application of the selective D-2 receptor agonist bromocriptine (2.5, 10, and 20 mg or placebo medication) with anodal and cathodal transcranial direct current stimulation (tDCS), which induces nonfocal plasticity, and with paired associative stimulation (PAS) generating a more focal kind of plasticity in the motor cortex of healthy humans. Plasticity was monitored by transcranial magnetic stimulation-induced motor-evoked potential amplitudes. For facilitatory tDCS, bromocriptine prevented plasticity induction independent from drug dosage. However, its application resulted in an inverted U-shaped dose-response curve on inhibitory tDCS, excitability-diminishing PAS, and to a minor degree on excitability-enhancing PAS. These data support the assumption that modulation of D-2-like receptor activity exerts a nonlinear dose-dependent effect on neuroplasticity in the human motor cortex that differs from predominantly D-3 receptor activation and that the kind of plasticity-induction procedure is relevant for its specific impact."],["dc.description.sponsorship","German Research Foundation [NI 683/6-1]"],["dc.identifier.doi","10.1523/JNEUROSCI.0832-14.2014"],["dc.identifier.isi","000341017300023"],["dc.identifier.pmid","25100602"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32687"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Dosage-Dependent Effect of Dopamine D-2 Receptor Activation on Motor Cortex Plasticity in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2287"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","2296"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Polania, Rafael"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Nitsche, Michael A."],["dc.date.accessioned","2018-11-07T08:59:55Z"],["dc.date.available","2018-11-07T08:59:55Z"],["dc.date.issued","2011"],["dc.description.abstract","Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that alters cortical excitability and activity in a polarity-dependent way. Stimulation for a few minutes has been shown to induce plastic alterations of cortical excitability and to improve cognitive performance. These effects might be related to stimulation-induced alterations of functional cortical network connectivity. We aimed to investigate the impact of tDCS on cortical network function by functional connectivity and graph theoretical analysis of the BOLD fMRI spontaneous activity. fMRI resting-state datasets were acquired immediately before and after 10-min bipolar tDCS during rest, with the anode placed over the left primary motor cortex (M1) and the cathode over the contralateral frontopolar cortex. For each dataset, grey matter voxel-based synchronization matrices were calculated and thresholded to construct undirected graphs. Nodal connectivity degree and minimum path length maps were calculated and compared before and after tDCS. Nodal minimum path lengths significantly increased in the left somatomotor (SM1) cortex after anodal tDCS, which means that the number of direct functional connections from the left SM1 to topologically distant grey matter voxels significantly decreased. In contrast, functional coupling between premotor and superior parietal areas with the left SM1 significantly increased. Additionally, the nodal connectivity degree in the left posterior cingulate cortex (PCC) area as well as in the right dorsolateral prefrontal cortex (right DLPFC) significantly increased. In summary, we provide initial support that tDCS-induced neuroplastic alterations might be related to functional connectivity changes in the human brain. Additionally, we propose our approach as a powerful method to track for neuroplastic changes in the human brain. (C) 2010 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","Rose Foundation"],["dc.identifier.doi","10.1016/j.neuroimage.2010.09.085"],["dc.identifier.isi","000286302000051"],["dc.identifier.pmid","20932916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24019"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","Introducing graph theory to track for neuroplastic alterations in the resting human brain: A transcranial direct current stimulation study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","987"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","991"],["dc.bibliographiccitation.volume","121"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T08:41:34Z"],["dc.date.available","2018-11-07T08:41:34Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1016/j.clinph.2010.01.029"],["dc.identifier.isi","000278222300001"],["dc.identifier.pmid","20181514"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19500"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","1388-2457"],["dc.title","On the difficulties of separating retinal from cortical origins of phosphenes when using transcranial alternating current stimulation (tACS)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","275"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Restorative Neurology and Neuroscience"],["dc.bibliographiccitation.lastpage","285"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Turi, Zsolt"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Janacsek, Karolina"],["dc.contributor.author","Emmert, K."],["dc.contributor.author","Hahn, L."],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.date.accessioned","2018-11-07T09:30:04Z"],["dc.date.available","2018-11-07T09:30:04Z"],["dc.date.issued","2013"],["dc.description.abstract","Purpose: Transcranial alternating current stimulation (tACS) is a non-invasive stimulation technique for shaping neuroplastic processes and possibly entraining ongoing neural oscillations in humans. Despite the growing number of studies using tACS, we know little about the procedural sensations caused by stimulation. In order to fill this gap, we explored the cutaneous sensation and phosphene perception during tACS. Methods: Twenty healthy participants took part in a randomized, single-blinded, sham-controlled study, where volunteers received short duration stimulation at 1.0 mA intensity between 2 to 250 Hz using the standard left motor cortex - contralateral supraorbital montage. We recorded the perception onset latency and the strength of the sensations assessed by visual rating scale as dependent variables. Results: We found that tACS evoked both cutaneous sensation and phosphene perception in a frequency-dependent manner. Our results show that the most perceptible procedural sensations were induced in the beta and gamma frequency range, especially at 20 Hz, whereas minimal procedural sensations were indicated in the ripple range (140 and 250 Hz). Conclusions: We believe that our results provide a relevant insight into the procedural sensations caused by oscillatory currents, and will offer a basis for developing more sophisticated stimulation protocols and study designs for future investigations."],["dc.identifier.doi","10.3233/RNN-120297"],["dc.identifier.isi","000318266400006"],["dc.identifier.pmid","23478342"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31214"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","0922-6028"],["dc.title","Both the cutaneous sensation and phosphene perception are modulated in a frequency-specific manner during transcranial alternating current stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1797"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Leukemia"],["dc.bibliographiccitation.lastpage","1807"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Deckert, M."],["dc.contributor.author","Engert, Andreas"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Ferreri, Andres J. M."],["dc.contributor.author","Finke, Juergen"],["dc.contributor.author","Illerhaus, Gerald"],["dc.contributor.author","Klapper, Wolfram"],["dc.contributor.author","Korfel, A."],["dc.contributor.author","Kueppers, Ralf"],["dc.contributor.author","Maarouf, M."],["dc.contributor.author","Montesinos-Rongen, Manuel"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Schlegel, Uwe"],["dc.contributor.author","Lassmann, Hans"],["dc.contributor.author","Wiestler, Otmar D."],["dc.contributor.author","Siebert, Reiner"],["dc.contributor.author","DeAngelis, L. M."],["dc.date.accessioned","2018-11-07T08:49:14Z"],["dc.date.available","2018-11-07T08:49:14Z"],["dc.date.issued","2011"],["dc.description.abstract","Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL. Leukemia (2011) 25, 1797-1807; doi:10.1038/leu.2011.169; published online 5 August 2011"],["dc.identifier.doi","10.1038/leu.2011.169"],["dc.identifier.isi","000298405500002"],["dc.identifier.pmid","21818113"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21408"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0887-6924"],["dc.title","Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","55"],["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.lastpage","56"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Hering, Diana"],["dc.contributor.author","Koch, R."],["dc.contributor.author","Nitsche, M. A."],["dc.contributor.author","Potschka, Heidrun"],["dc.contributor.author","Loscher, W."],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Tergau, Frithjof"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T11:06:29Z"],["dc.date.available","2018-11-07T11:06:29Z"],["dc.date.issued","2007"],["dc.identifier.isi","000246578400172"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52321"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","5th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy"],["dc.relation.eventlocation","Basle, SWITZERLAND"],["dc.relation.issn","0013-9580"],["dc.title","Anticonvulsive aftereffects of cathodal transcranial direct current stimulation (tDCS) in the rat transcranial ramp model of focal epilepsy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]