Klapsing, Philipp

[["dc.bibliographiccitation.firstpage","184"],["dc.bibliographiccitation.journal","Journal of Critical Care"],["dc.bibliographiccitation.lastpage","191"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Klapsing, Philipp"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Moerer, Onnen"],["dc.date.accessioned","2020-12-10T14:25:02Z"],["dc.date.available","2020-12-10T14:25:02Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.jcrc.2016.11.001"],["dc.identifier.issn","0883-9441"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72417"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Automatic quantitative computed tomography segmentation and analysis of aerated lung volumes in acute respiratory distress syndrome—A comparative diagnostic study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0186481"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Petzoldt, Martin"],["dc.contributor.author","Trepte, Constantin J."],["dc.contributor.author","Ridder, Jan"],["dc.contributor.author","Maisch, Stefan"],["dc.contributor.author","Klapsing, Philipp"],["dc.contributor.author","Kersten, Jan F."],["dc.contributor.author","Richter, Hans Peter"],["dc.contributor.author","Kubitz, Jens C."],["dc.contributor.author","Reuter, Daniel A"],["dc.contributor.author","Goepfert, Matthias S."],["dc.date.accessioned","2019-02-27T09:55:54Z"],["dc.date.available","2019-02-27T09:55:54Z"],["dc.date.issued","2017"],["dc.description.abstract","Monitoring cardiac output (CO) is important to optimize hemodynamic function in critically ill patients. The prevalence of aortic valve insufficiency (AI) is rising in the aging population. However, reliability of CO monitoring techniques in AI is unknown. The aim of this study was to investigate the impact of AI on accuracy, precision, and trending ability of transcardiopulmonary thermodilution-derived COTCPTD in comparison with pulmonary artery catheter thermodilution COPAC."],["dc.identifier.doi","10.1371/journal.pone.0186481"],["dc.identifier.eissn","1932-6203"],["dc.identifier.pmid","29049339"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57636"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Reliability of transcardiopulmonary thermodilution cardiac output measurement in experimental aortic valve insufficiency"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Somnologie"],["dc.bibliographiccitation.lastpage","133"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Scharfe, S."],["dc.contributor.author","Ludwig, A."],["dc.contributor.author","Russo, S.G."],["dc.contributor.author","Klapsing, P."],["dc.contributor.author","Engelke, W."],["dc.date.accessioned","2019-07-09T11:42:26Z"],["dc.date.available","2019-07-09T11:42:26Z"],["dc.date.issued","2016"],["dc.description.abstract","ackground Early studies report on different calibers of the mesopharynx opening in the states of wakefulness and sedation. Objectives Is it possible to manipulate the widening of the mesopharyngeal isthmus by particular maneuvers in the states of wakefulness and sedation? Methods The mesopharyngeal isthmus of 50 healthy subjects was examined endoscopically in wakefulness and under sedation. The intraoral negative pressure was controlled by a vacuum activator. The following maneuvers were performed and widening of the isthmus was documented pictorially: spontaneous breathing with closed lips (SB), mandibular advancement (MA), tongue repositioning maneuver (TRM), and mandibular advancement combined with TRM (MA, TRM). While performing the tongue repositioning maneuver with closed lips, the tongue is adapted closely to the row of teeth and also to the hard and soft palate. Results In wakefulness, 123 endoscopic pictures were analyzed, 35 with SB, 34 with MA, 35 with TRM, 19 with TRM and MA. In sedation there were 125 pictures, 35 with SB, 32 with MA, 34 with TRM, 24 with TRM and MA. The results represent that in sedation the TRM has a significant widening effect on the opening of the mesopharyngeal isthmus compared to SB without TRM (p < 0.05). Compared to SB in sedation, the combined maneuver of TRM and MA had an additional effect on the widening of the mesopharyngeal isthmus (p < 0.05). Conclusions In sedation, the mesopharyngeal isthmus is stabilized by the TRM and the combined maneuver with MA and TRM because of the forward displacement of the tongue out of the pharynx with closed contact to the hard palate and apposition of the velum to dorsum of the tongue."],["dc.description.abstract","Hintergrund. Frühere Studien berichten über unterschiedlicheWeitstellungen des Mesopharynx im Wachzustand und in Sedierung. Fragestellung. Lässt sich der mesopharyngeale Isthmus imWachzustand und in Sedierung durch bestimmteManöver beeinflussen? Material und Methoden. Bei 50 gesunden Probanden (18 m, 32 w) wurde der mesopharyngeale Isthmus imWachzustand und in Sedierung endoskopisch untersucht und der intraorale Unterdruckmit einemVakuumaktivator kontrolliert. Folgende Manöver wurden durchgeführt und dabei der Isthmus bildlich dokumentiert: Spontanatmungmit anteriorem Lippenschluss (SA), Unterkieferprotrusion (UP), Zungenrepositionsmanöver (ZRM), Unterkieferprotrusion mit ZRM (UP, ZRM). Während des ZRM ist – bei geschlossenen Lippen – die Zunge an den Zahnreihen, den Hartgaumen und an das Velum angelagert. Ergebnisse. Im Wachzustand wurden 123 Bilder analysiert, davon 35 mit SA, 34 mit UP, 35 mit ZRM, 19 mit ZRM und UP. In Sedierung waren es 125, davon 35 mit SA, 32 mit UP, 34 mit ZRM, 24 mit ZRM und UP. Die Resultate zeigen, dass in Sedierung das ZRM einen signifikant erweiternden Effekt auf die Weite des mesopharyngealen Isthmus imVergleich zur sedierten SA ohne ZRM (p < 0,05) hatte. Das kombinierteManöver mit ZRM und UP hatte im Vergleich zur sedierten SA einen additiven Effekt auf die Weitstellung des mesopharyngealen Isthmus (p < 0,05). Schlussfolgerung. In Sedierung wird mittels ZRM und kombiniertemManöver mit UP und ZRM der mesopharyngeale Isthmus durch Vorverlagerung der Zunge aus dem Pharynxraum mit enger Zungengaumenkontaktposition sowie durch Anlagerung des Velums am Zungenrücken stabilisiert."],["dc.identifier.doi","10.1007/s11818-016-0052-x"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13420"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58665"],["dc.language.iso","de"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1439-054X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Somnoendoskopie"],["dc.title.alternative","Endoskopische Untersuchung des Mesopharynx im Wachzustand und in Sedierung"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","121"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Critical Care"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Klapsing, Philipp"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Wende, Christoph"],["dc.contributor.author","Herrmann, Peter"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Heuer, Jan F."],["dc.date.accessioned","2019-07-09T11:45:28Z"],["dc.date.available","2019-07-09T11:45:28Z"],["dc.date.issued","2018"],["dc.description.abstract","BACKGROUND: Recent clinical studies have not shown an overall benefit of high-frequency oscillatory ventilation (HFOV), possibly due to injurious or non-individualized HFOV settings. We compared conventional HFOV (HFOVcon) settings with HFOV settings based on mean transpulmonary pressures (PLmean) in an animal model of experimental acute respiratory distress syndrome (ARDS). METHODS: ARDS was induced in eight pigs by intrabronchial installation of hydrochloric acid (0.1 N, pH 1.1; 2.5 ml/kg body weight). The animals were initially ventilated in volume-controlled mode with low tidal volumes (6 ml kg- 1) at three positive end-expiratory pressure (PEEP) levels (5, 10, 20 cmH2O) followed by HFOVcon and then HFOV PLmean each at PEEP 10 and 20. The continuous distending pressure (CDP) during HFOVcon was set at mean airway pressure plus 5 cmH2O. For HFOV PLmean it was set at mean PL plus 5 cmH2O. Baseline measurements were obtained before and after induction of ARDS under volume controlled ventilation with PEEP 5. The same measurements and computer tomography of the thorax were then performed under all ventilatory regimens at PEEP 10 and 20. RESULTS: Cardiac output, stroke volume, mean arterial pressure and intrathoracic blood volume index were significantly higher during HFOV PLmean than during HFOVcon at PEEP 20. Lung density, total lung volume, and normally and poorly aerated lung areas were significantly greater during HFOVcon, while there was less over-aerated lung tissue in HFOV PLmean. The groups did not differ in oxygenation or extravascular lung water index. CONCLUSION: HFOV PLmean is associated with less hemodynamic compromise and less pulmonary overdistension than HFOVcon. Despite the increase in non-ventilated lung areas, oxygenation improved with both regimens. An individualized approach with HFOV settings based on transpulmonary pressure could be a useful ventilatory strategy in patients with ARDS. Providing alveolar stabilization with HFOV while avoiding harmful distending pressures and pulmonary overdistension might be a key in the context of ventilator-induced lung injury."],["dc.identifier.doi","10.1186/s13054-018-2028-7"],["dc.identifier.pmid","29743121"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15219"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59236"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","High-frequency oscillatory ventilation guided by transpulmonary pressure in acute respiratory syndrome: an experimental study in pigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]