Haupt, Luis Peter

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.journal","Stem Cell Research"],["dc.bibliographiccitation.lastpage","131"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Noack, Claudia"],["dc.contributor.author","Haupt, Luis Peter"],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.contributor.author","Streckfuss-Bömeke, Katrin"],["dc.contributor.author","Zelarayán, Laura Cecilia"],["dc.date.accessioned","2018-04-23T11:49:22Z"],["dc.date.available","2018-04-23T11:49:22Z"],["dc.date.issued","2017"],["dc.description.abstract","Krueppel-like factor 15 (KLF15) is abundantly expressed in liver, kidney, and muscle, including myocardium. In the adult heart KLF15 is important to maintain homeostasis and to repress hypertrophic remodeling. We generated a homozygous hESC KLF15 knockout (KO) line using paired CRISPR/Cas9n. KLF15-KO cells maintained full pluripotency and differentiation potential as well as genomic integrity. We demonstrated that KLF15-KO cells can be differentiated into morphologically normal cardiomyocytes turning them into a valuable tool for studying human KLF15-mediated mechanisms resulting in human cardiac dysfunction."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1016/j.scr.2017.07.007"],["dc.identifier.gro","3142524"],["dc.identifier.pmid","28925362"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14618"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13680"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/175"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien"],["dc.relation","SFB 1002 | C07: Kardiomyozyten Wnt/β-catenin Komplex Aktivität im pathologischen Herz-Remodeling - als gewebespezifischer therapeutischer Ansatz"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation.issn","1873-5061"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","13"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Basic Research in Cardiology"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Haupt, Luis Peter"],["dc.contributor.author","Rebs, Sabine"],["dc.contributor.author","Maurer, Wiebke"],["dc.contributor.author","Hübscher, Daniela"],["dc.contributor.author","Tiburcy, Malte"],["dc.contributor.author","Pabel, Steffen"],["dc.contributor.author","Maus, Andreas"],["dc.contributor.author","Köhne, Steffen"],["dc.contributor.author","Tappu, Rewati"],["dc.contributor.author","Haas, Jan"],["dc.contributor.author","Streckfuss-Bömeke, Katrin"],["dc.date.accessioned","2022-04-01T10:01:09Z"],["dc.date.available","2022-04-01T10:01:09Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Cancer therapies with anthracyclines have been shown to induce cardiovascular complications. The aims of this study were to establish an in vitro induced pluripotent stem cell model (iPSC) of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and to examine whether doxorubicin (DOX)-treated ACT-iPSC cardiomyocytes (CM) can recapitulate the clinical features exhibited by patients, and thus help uncover a DOX-dependent pathomechanism. ACT-iPSC CM generated from individuals with CD20 + B-cell lymphoma who had received high doses of DOX and suffered cardiac dysfunction were studied and compared to control-iPSC CM from cancer survivors without cardiac symptoms. In cellular studies, ACT-iPSC CM were persistently more susceptible to DOX toxicity including augmented disorganized myofilament structure, changed mitochondrial shape, and increased apoptotic events. Consistently, ACT-iPSC CM and cardiac fibroblasts isolated from fibrotic human ACT myocardium exhibited higher DOX-dependent reactive oxygen species. In functional studies, Ca 2+ transient amplitude of ACT-iPSC CM was reduced compared to control cells, and diastolic sarcoplasmic reticulum Ca 2+ leak was DOX-dependently increased. This could be explained by overactive CaMKIIδ in ACT CM. Together with DOX-dependent augmented proarrhythmic cellular triggers and prolonged action potentials in ACT CM, this suggests a cellular link to arrhythmogenic events and contractile dysfunction especially found in ACT engineered human myocardium. CamKIIδ inhibition prevented proarrhythmic triggers in ACT. In contrast, control CM upregulated SERCA2a expression in a DOX-dependent manner, possibly to avoid heart failure conditions. In conclusion, we developed the first human patient-specific stem cell model of DOX-induced cardiac dysfunction from patients with B-cell lymphoma. Our results suggest that DOX-induced stress resulted in arrhythmogenic events associated with contractile dysfunction and finally in heart failure after persistent stress activation in ACT patients."],["dc.identifier.doi","10.1007/s00395-022-00918-7"],["dc.identifier.pii","918"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105613"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1435-1803"],["dc.relation.issn","0300-8428"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","59"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Alloys and Compounds"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.volume","354"],["dc.contributor.author","Yang, C. P."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Han, X. F."],["dc.contributor.author","Morchshakov, V."],["dc.contributor.author","Haupt, L."],["dc.contributor.author","Baerner, K."],["dc.date.accessioned","2018-11-07T10:38:59Z"],["dc.date.available","2018-11-07T10:38:59Z"],["dc.date.issued","2003"],["dc.description.abstract","A Y-3(Fe, Cr)(29) single crystal which has a Nd-3(Fe, Ti)(29)-type monoclinic structure has been prepared using the Czochralski method followed by heat treatment of an initial Y-2(Fe, Cr)(17) crystal. The magnetization curves were measured along the easy and hard magnetization directions in the range from 1.5 to 293 K for crystals of Y-3(Fe, Cr)(29) and Y-2(Fe, Cr)(17). The saturation magnetization of Y-3(Fe, Cr)(29) decreases with increasing temperature and is in good agreement with a T-3/2 spin-wave relation law. The magnetic properties of the two crystals are compared. (C) 2002 Elsevier Science B.V. All rights reserved."],["dc.identifier.doi","10.1016/S0925-8388(02)01366-X"],["dc.identifier.isi","000182879800013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45937"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Sa"],["dc.relation.issn","0925-8388"],["dc.title","Comparison of the magnetic properties between Y-3(Fe, Cr)(29) and Y2Fe15Cr2 single crystals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","593"],["dc.bibliographiccitation.lastpage","596"],["dc.bibliographiccitation.seriesnr","373-376"],["dc.contributor.author","Kattwinkel, A."],["dc.contributor.author","Braunstein, R."],["dc.contributor.author","Haupt, L."],["dc.contributor.author","Hamad, N."],["dc.contributor.author","Barner, K."],["dc.contributor.author","Gommert, E."],["dc.contributor.author","Wecker, J."],["dc.contributor.author","von Helmolt, R."],["dc.contributor.author","Medvedeva, I. V."],["dc.date.accessioned","2018-11-07T09:31:53Z"],["dc.date.available","2018-11-07T09:31:53Z"],["dc.date.issued","2001"],["dc.description.abstract","The time-resolved photoresponse of oxygen deficient Nd0.67Sr0.33MnO3-delta epitaxial layers is observed in TTE measurements in different regimes using different light intensities and spectral windows in the visible. In the regime of the metal - insulator transition the photoresponse increases sharply and shows saturation with increasing light intensity, suggesting a light-induced transition. We also present evindence of nucleation and growth of the light-induced phase."],["dc.identifier.isi","000172513500139"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31630"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Trans Tech Publications"],["dc.publisher.place","Zurich"],["dc.relation.conference","8th European Magnetic Materials and Applications Conference (EMMA 2000)"],["dc.relation.crisseries","Materials Science Forum"],["dc.relation.eventend","2000-06-10"],["dc.relation.eventlocation","Kiev, Ukraine"],["dc.relation.eventstart","2000-06-07"],["dc.relation.isbn","0-87849-880-X"],["dc.relation.ispartof","European magnetic materials and applications"],["dc.relation.ispartofseries","Materials Science Forum; 373-376"],["dc.title","Spectral and time-resolved photoresponse in Nd2/3Sr1/3MnO3-d epitaxial layers"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Streckfuss-Boemeke, Katrin"],["dc.contributor.author","Haupt, L."],["dc.contributor.author","Fomin, V. M."],["dc.contributor.author","Wagner, S."],["dc.contributor.author","Sossalla, Samuel T."],["dc.contributor.author","Cyganek, L."],["dc.contributor.author","Linke, W."],["dc.contributor.author","Maier, Lars. S."],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T09:53:32Z"],["dc.date.available","2018-11-07T09:53:32Z"],["dc.date.issued","2015"],["dc.identifier.isi","000361205104367"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36347"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","London, ENGLAND"],["dc.title","A model of anthracycline-induced cardiotoxicity using induced pluripotent stem cell-derived cardiomyocytes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","145"],["dc.bibliographiccitation.journal","Journal of Alloys and Compounds"],["dc.bibliographiccitation.lastpage","148"],["dc.bibliographiccitation.volume","317"],["dc.contributor.author","Hamad, N."],["dc.contributor.author","El-Kassab, I."],["dc.contributor.author","Haupt, L."],["dc.contributor.author","Kasper, N."],["dc.contributor.author","Barner, K."],["dc.contributor.author","Rao, Gowravaram Mohan"],["dc.contributor.author","Sondermann, U."],["dc.contributor.author","Gmelin, E."],["dc.date.accessioned","2018-11-07T09:10:10Z"],["dc.date.available","2018-11-07T09:10:10Z"],["dc.date.issued","2001"],["dc.description.abstract","We present X-ray diffraction, magnetization, electrical resistivity, and magnetoresistance data for Nd-0.66(Sr1-yLiy)(0.34)MnO3 ceramics with y = 0, 0.05, 0.1, 0.2 and 0.3 in the temperature range 50 < T < 400 K and in fields up to 0.5 T. We find that Li substitution is possible up to y less than or equal to0.3 and generally enhances the resistivity and the magnetic randomization. Nevertheless, the resistivity curves still show the characteristic hump-like structure indicative of a combined ferromagnetic-paramagnetic metal-insulator transition, and a significant magnetoresistance is observed. The increase of the resistivity with Li content is ascribed to a blocking of Zener bonds associated with the charge unbalancing effect of Li+. (C) 2001 Elsevier Science B.V. AU rights reserved."],["dc.identifier.doi","10.1016/S0925-8388(00)01336-0"],["dc.identifier.isi","000168157200026"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26429"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Sa"],["dc.publisher.place","Lausanne"],["dc.relation.conference","13th InTernational Conference on Solid Compounds of Transition Elements"],["dc.relation.eventlocation","STRESA, ITALY"],["dc.relation.issn","0925-8388"],["dc.title","Magnetic and electrical properties of Nd-0.66(Sr1-yLiy)(0.34)MnO3 manganites"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Stem Cells International"],["dc.bibliographiccitation.lastpage","11"],["dc.bibliographiccitation.volume","2019"],["dc.contributor.author","Hübscher, Daniela"],["dc.contributor.author","Rebs, Sabine"],["dc.contributor.author","Haupt, Luis"],["dc.contributor.author","Borchert, Thomas"],["dc.contributor.author","Guessoum, Celina Isabell"],["dc.contributor.author","Treu, Franziska"],["dc.contributor.author","Köhne, Steffen"],["dc.contributor.author","Maus, Andreas"],["dc.contributor.author","Hambrecht, Mario"],["dc.contributor.author","Sossalla, Samuel"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Uy, Angela"],["dc.contributor.author","Jakob, Mark"],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Streckfuss-Bömeke, Katrin"],["dc.date.accessioned","2020-12-10T18:37:41Z"],["dc.date.available","2020-12-10T18:37:41Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1155/2019/2181437"],["dc.identifier.pmid","31467559"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16503"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77068"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/330"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","173"],["dc.bibliographiccitation.issue","1-6"],["dc.bibliographiccitation.journal","High Pressure Research"],["dc.bibliographiccitation.lastpage","179"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Medvedeva, I. V."],["dc.contributor.author","Bersenev, Y. S."],["dc.contributor.author","Haupt, L."],["dc.contributor.author","Hamad, N."],["dc.contributor.author","Barner, K."],["dc.contributor.author","Rao, Gowravaram Mohan"],["dc.contributor.author","Sun, J. R."],["dc.date.accessioned","2018-11-07T11:06:04Z"],["dc.date.available","2018-11-07T11:06:04Z"],["dc.date.issued","2000"],["dc.description.abstract","The temperature dependences of the resistivity of La0.7Ca0.3Mn1-xFexO3 and La0.7Ca0.3Mn1-xGexO3 (0 < x < 0.04) mixed crystals were studied under hydrostatic pressures up to 15 kbar. The substitution of Fe for Mn results in an increase of the resistivity and a continuous decrease of the metal-insulator transition temperature T-mb while the substitution of Ge for Mn leads to a more complicated T-mi(x)-curve. In all cases T-mi shifts under pressure with a rate between 1.6 and 2.9 K/kbar and a correlation between T-mi and its pressure derivative dT(mi)/dP is observed which is in accordance with the general trend of dT(mi)/dP versus T-mi as derived for other manganites and is discussed in terms of a competition between superexchange and double exchange."],["dc.identifier.doi","10.1080/08957950008200965"],["dc.identifier.isi","000166184700027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52218"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Gordon Breach Sci Publ Ltd"],["dc.publisher.place","Reading"],["dc.relation.conference","XXXVIIth Meeting of the European-High-Pressure-Research-Group (EHPRG)"],["dc.relation.eventlocation","UNIV MONTPELLIER, MONTPELLIER, FRANCE"],["dc.relation.issn","0895-7959"],["dc.title","Hydrostatic pressure effect on the metal-insulator transition in La0.7Ca0.3Mn1-x(Fe/Ge)(x)O-3 perovskites"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","116"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.lastpage","117"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Haupt, L."],["dc.contributor.author","Wojnowski, Leszek"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Streckfuss-Boemeke, Katrin"],["dc.date.accessioned","2018-11-07T10:10:25Z"],["dc.date.available","2018-11-07T10:10:25Z"],["dc.date.issued","2016"],["dc.identifier.isi","000383869500377"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39853"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Rome, ITALY"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Assessing the influence of the genetic background on anthracycline induced cardiotoxicity with hiPSC derived cardiomyocytes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","30"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Yang, C. P."],["dc.contributor.author","Wang, Y. Z."],["dc.contributor.author","Han, X. F."],["dc.contributor.author","Morchshakov, V."],["dc.contributor.author","Haupt, L."],["dc.contributor.author","Baerner, K."],["dc.date.accessioned","2021-12-08T12:29:07Z"],["dc.date.available","2021-12-08T12:29:07Z"],["dc.date.issued","2003"],["dc.identifier.doi","10.1002/chin.200330019"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95963"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Comparison of the Magnetic Properties Between Y3(Fe,Cr)29 and Y2Fe15Cr2 Single Crystals."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]