Poustka, Luise

[["dc.bibliographiccitation.artnumber","53"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Psychiatry"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Höfer, Juliana"],["dc.contributor.author","Hoffmann, Falk"],["dc.contributor.author","Kamp-Becker, Inge"],["dc.contributor.author","Küpper, Charlotte"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Roepke, Stefan"],["dc.contributor.author","Roessner, Veit"],["dc.contributor.author","Stroth, Sanna"],["dc.contributor.author","Wolff, Nicole"],["dc.contributor.author","Bachmann, Christian J"],["dc.date.accessioned","2019-07-09T11:49:55Z"],["dc.date.available","2019-07-09T11:49:55Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background Complementary and Alternative Medicine (CAM) is widely used both in the general population and for the treatment of somatic and psychiatric disorders. Studies on CAM use among patients with autism spectrum disorder (ASD) have so far only focused on children and adolescents. The aim of this study was to investigate patterns of CAM use among adults with ASD. Methods A questionnaire survey concerning current and lifetime use of CAM was distributed to adults with ASD between November 2015 and June 2016. Participants diagnosed by experienced clinicians using the current diagnostic gold standard were recruited from four ASD outpatient clinics in Germany. Questionnaire data was then linked to supplementary clinical data. Results The final sample consisted of 192 adults (response: 26.8%) with a mean age of 31.5 years (80% male; diagnoses: Asperger’s syndrome (58%), childhood autism (27%), atypical autism (12%)). 45% of the respondents stated that they were currently using or had used at least one CAM modality in their life. Among the participants with lifetime CAM use, almost half had used two or more different types of CAM. Alternative medical systems (e.g. homeopathy, acupuncture) were most frequently used, followed by mind-body interventions (e.g. yoga, biofeedback, animal assisted therapy). Overall, 20% of respondents stated that they would like to try at least one listed CAM modality in the future. Conclusions This is the first study on CAM use in adults with ASD, demonstrating considerable CAM use in this population. Given the popularity of CAM, patients should be informed about the effectiveness and potentially dangerous side effects of CAM treatments, as evidence for the majority of CAM methods in ASD is still limited."],["dc.identifier.doi","10.1186/s12888-019-2043-5"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15806"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59656"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Complementary and alternative medicine use in adults with autism spectrum disorder in Germany: results from a multi-center survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","489"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Public Health"],["dc.bibliographiccitation.lastpage","495"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Parchetka, Caroline"],["dc.contributor.author","Strache, Nicole"],["dc.contributor.author","Raffaelli, Bianca"],["dc.contributor.author","Gemmeke, Isabel"],["dc.contributor.author","Weiß, Katharina"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Buechel, Christian"],["dc.contributor.author","Conrod, Patricia"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Lemaitre, Herve"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Mennigen, Eva"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Paillère Martinot, Marie-Laure"],["dc.contributor.author","Papadopoulos, Dimitri"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Jurk, Sarah"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Vetter, Nora C."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Gallinat, Juergen"],["dc.date.accessioned","2018-06-04T09:18:35Z"],["dc.date.available","2018-06-04T09:18:35Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose The onset of substance use mostly occurs during adolescence. The aim of the present study is to investigate the relevance of personality on the basis of the NEO-Five-Factor Inventory (NEO-FFI) to future experiences with tobacco, alcohol and cannabis. Methods The test data were derived from the baseline assessment and first follow-up of the IMAGEN study, a European multicenter and multidisciplinary research project on adolescent mental health. In the present study 1004 participants were tested. The characterization of personality was conducted with the NEO-FFI at the age of 14 (T1). The data on substance use were collected with the European School Survey Project on Alcohol and Other Drugs (ESPAD) questionnaire at the age of 16 (T2). For the statistical analysis, t-tests and univariate analyses of variance were performed. Results The scores of Conscientiousness at T1 were significantly lower for adolescents with tobacco, alcohol and cannabis experiences at T2. We found lower scores of Agreeableness at T1 in participants with tobacco and cannabis use at T2. Extraversion at T1 was significantly higher for adolescents with smoking experiences at T2. No significant associations between Neuroticism or Openness and future substance use were observed. Conclusion Low scores of Conscientiousness and Agreeableness seem to have the greatest value for a prediction of later experiences with substance use. As the present study is the first one to examine the predictive value of the NEO-FFI for future substance use in an adolescent sample, further studies are necessary to enable a better applicability in a clinical context."],["dc.identifier.doi","10.1007/s10389-016-0747-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/14854"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Predictive utility of the NEO-FFI for later substance experiences among 16-year-old adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3395"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Autism and Developmental Disorders"],["dc.bibliographiccitation.lastpage","3396"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Bejarano-Martín, Álvaro"],["dc.contributor.author","Canal-Bedia, Ricardo"],["dc.contributor.author","Magán-Maganto, María"],["dc.contributor.author","Fernández-Álvarez, Clara"],["dc.contributor.author","Martín-Cilleros, María Victoria"],["dc.contributor.author","Sánchez-Gómez, María Cruz"],["dc.contributor.author","García-Primo, Patricia"],["dc.contributor.author","Rose-Sweeney, Mary"],["dc.contributor.author","Boilson, Andrew"],["dc.contributor.author","Linertová, Renata"],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Van der Paelt, Sara"],["dc.contributor.author","Schendel, Diana"],["dc.contributor.author","Warberg, Christine"],["dc.contributor.author","Cramer, Susanne"],["dc.contributor.author","Narzisi, Antonio"],["dc.contributor.author","Muratori, Filippo"],["dc.contributor.author","Scattoni, María Luisa"],["dc.contributor.author","Moilanen, Irma"],["dc.contributor.author","Yliherva, Anneli"],["dc.contributor.author","Saemundsen, Evald"],["dc.contributor.author","Loa Jónsdóttir, Sigríður"],["dc.contributor.author","Efrim-Budisteanu, Magdalena"],["dc.contributor.author","Arghir, Aurora"],["dc.contributor.author","Papuc, Sorina Mihaela"],["dc.contributor.author","Vicente, Astrid"],["dc.contributor.author","Rasga, Celia"],["dc.contributor.author","Rogé, Bernadette"],["dc.contributor.author","Guillon, Quentin"],["dc.contributor.author","Baduel, Sophie"],["dc.contributor.author","Kafka, Johanna Xenia"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Kothgassner, Oswald D."],["dc.contributor.author","Kawa, Rafal"],["dc.contributor.author","Pisula, Ewa"],["dc.contributor.author","Sellers, Tracey"],["dc.contributor.author","Posada de la Paz, Manuel"],["dc.date.accessioned","2020-12-10T14:11:38Z"],["dc.date.available","2020-12-10T14:11:38Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s10803-019-04303-7"],["dc.identifier.eissn","1573-3432"],["dc.identifier.issn","0162-3257"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71140"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.iserratumof","/handle/2/71139"],["dc.title","Correction to: Early Detection, Diagnosis and Intervention Services for Young Children with Autism Spectrum Disorder in the European Union (ASDEU): Family and Professional Perspectives"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","34"],["dc.bibliographiccitation.journal","Research in Autism Spectrum Disorders"],["dc.bibliographiccitation.lastpage","43"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Langmann, Anika"],["dc.contributor.author","Becker, Joachim"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Becker, Katja"],["dc.contributor.author","Kamp-Becker, Inge"],["dc.date.accessioned","2018-06-04T09:11:45Z"],["dc.date.available","2018-06-04T09:11:45Z"],["dc.date.issued","2017"],["dc.description.abstract","Background The Autism Diagnostic Observation Schedule (ADOS) Module 4 was investigated in an independent clinical sample of highfunctioning adolescent and adult males and females with suspected autism spectrum disorder. Special attention was paid to the performance of the ADOS in the subgroups autism spectrum disorders (ASD), personality disorders and disorders with onset usually occurring in childhood and adolescence. Method The recently revised algorithm and severity scores for Module 4 were used to analyze predictive values compared to the original algorithm in a sample of N = 356, 21% females, age range 12–68 yrs. Results Both algorithms have good sensitivity and specificity, with slightly better results for the revised algorithm. Diagnostic accuracy is lower for females, older individuals, and individuals with personality disorders or higher intellectual abilities. Conclusion The revised algorithm has good utility when used as part of a comprehensive assessment procedure conducted by an experienced examiner and including information on developmental history."],["dc.identifier.doi","10.1016/j.rasd.2016.11.012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/14852"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Diagnostic utility of the autism diagnostic observation schedule in a clinical sample of adolescents and adults"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","S0005796722000390"],["dc.bibliographiccitation.firstpage","104068"],["dc.bibliographiccitation.journal","Behaviour Research and Therapy"],["dc.bibliographiccitation.volume","152"],["dc.contributor.author","Kirst, Simone"],["dc.contributor.author","Diehm, Robert"],["dc.contributor.author","Bögl, Katharina"],["dc.contributor.author","Wilde-Etzold, Sabine"],["dc.contributor.author","Bach, Christiane"],["dc.contributor.author","Noterdaeme, Michele"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Ziegler, Matthias"],["dc.contributor.author","Dziobek, Isabel"],["dc.date.accessioned","2022-05-02T08:09:49Z"],["dc.date.available","2022-05-02T08:09:49Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.brat.2022.104068"],["dc.identifier.pii","S0005796722000390"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107474"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.issn","0005-7967"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Fostering socio-emotional competencies in children on the autism spectrum using a parent-assisted serious game: A multicenter randomized controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1680"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Autism Research"],["dc.bibliographiccitation.lastpage","1692"],["dc.bibliographiccitation.volume","12"],["dc.contributor.affiliation","Banaschewski, Tobias; 2\r\nDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim\r\nHeidelberg University\r\nMannheim Germany"],["dc.contributor.affiliation","Dziobek, Isabel; 3\r\nBerlin School of Mind and Brain and Institute of Psychology\r\nHumboldt‐Universität zu Berlin\r\nBerlin Germany"],["dc.contributor.affiliation","Brandeis, Daniel; 2\r\nDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim\r\nHeidelberg University\r\nMannheim Germany"],["dc.contributor.affiliation","Poustka, Luise; 2\r\nDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim\r\nHeidelberg University\r\nMannheim Germany"],["dc.contributor.affiliation","Freitag, Christine M.; 1\r\nDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy\r\nUniversity Hospital, Goethe University Frankfurt am Main\r\nFrankfurt Germany"],["dc.contributor.author","Bast, Nico"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Dziobek, Isabel"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Freitag, Christine M."],["dc.date.accessioned","2019-11-25T15:27:33Z"],["dc.date.accessioned","2021-10-27T13:21:35Z"],["dc.date.available","2019-11-25T15:27:33Z"],["dc.date.available","2021-10-27T13:21:35Z"],["dc.date.issued","2019"],["dc.date.updated","2022-02-09T13:22:08Z"],["dc.description.abstract","Progression of pupil dilation (PD) in response to visual stimuli may indicate distinct internal processes. No study has been performed on PD progression during a social cognition task. Here, we describe PD progression during the Movie for the Assessment of Social Cognition (MASC) test in n = 23 adolescents with Autism Spectrum Disorder (ASD) and n = 24 age, IQ and sex-matched neurotypical controls (NTC). The MASC consists of 43 video sequences depicting human social interactions, each followed by a multiple-choice question concerning characters' mental states. PD progression data were extracted by eye tracking and controlled for fixation behavior. Segmenting PD progression during video sequences by principal component analysis, three sequential PD components were unveiled. In ASD compared with NTC, a distinct PD progression was observed with increased constriction amplitude, increased dilation latency, and increased dilation amplitude that correlated with PD progression components. These components predicted social cognition performance. The first and second PD components correlated positively with MASC behavioral performance in ASD but negatively in NTC. These PD components may be interpreted as indicators of sensory-perceptual processing and attention function. In ASD, aberrant sensory-perceptual processing and attention function could contribute to attenuated social cognition performance. This needs to be tested by additional studies combining the respective cognitive tests and the outlined PD progression analysis. Phasic activity of the locus coeruleus-norepinephrine system is discussed as putatively shared underlying mechanism. Autism Res2019. © 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: In adolescents with autism, we found an altered pupil dilation during watching scenes of human interactions. Early pupil dilation correlated positively with the number of correct answers to questions about the shown human interactions. Our findings suggest that aberrant sensory processing and attention function may contribute to altered social cognition in autism."],["dc.description.sponsorship","Innovative Medicines Initiative Joint Undertaking"],["dc.identifier.doi","10.1002/aur.2178"],["dc.identifier.eissn","1939-3806"],["dc.identifier.issn","1939-3792"],["dc.identifier.pmid","31347301"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16726"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92033"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.publisher","John Wiley & Sons, Inc."],["dc.relation.eissn","1939-3806"],["dc.relation.issn","1939-3806"],["dc.relation.issn","1939-3792"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","O'Leary-Barrett, M."],["dc.contributor.author","Pihl, Robert O."],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Mann, Karl"],["dc.contributor.author","Paillere-Martinot, Marie-Laure"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Robbins, Trevor W."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Strohle, Andreas"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Conrod, Patricia J."],["dc.date.accessioned","2017-09-07T11:52:11Z"],["dc.date.available","2017-09-07T11:52:11Z"],["dc.date.issued","2015"],["dc.description.abstract","OBJECTIVE: To investigate the role of personality factors and attentional biases towards emotional faces, in establishing concurrent and prospective risk for mental disorder diagnosis in adolescence.; METHOD: Data were obtained as part of the IMAGEN study, conducted across 8 European sites, with a community sample of 2257 adolescents. At 14 years, participants completed an emotional variant of the dot-probe task, as well two personality measures, namely the Substance Use Risk Profile Scale and the revised NEO Personality Inventory. At 14 and 16 years, participants and their parents were interviewed to determine symptoms of mental disorders.; RESULTS: Personality traits were general and specific risk indicators for mental disorders at 14 years. Increased specificity was obtained when investigating the likelihood of mental disorders over a 2-year period, with the Substance Use Risk Profile Scale showing incremental validity over the NEO Personality Inventory. Attentional biases to emotional faces did not characterise or predict mental disorders examined in the current sample.; DISCUSSION: Personality traits can indicate concurrent and prospective risk for mental disorders in a community youth sample, and identify at-risk youth beyond the impact of baseline symptoms. This study does not support the hypothesis that attentional biases mediate the relationship between personality and psychopathology in a community sample. Task and sample characteristics that contribute to differing results among studies are discussed."],["dc.identifier.doi","10.1371/journal.pone.0128271"],["dc.identifier.gro","3151225"],["dc.identifier.pmid","26046352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8005"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1932-6203"],["dc.title","Personality, Attentional Biases towards Emotional Faces and Symptoms of Mental Disorders in an Adolescent Sample"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","435"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JAMA Psychiatry"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Luo, Qiang"],["dc.contributor.author","Chen, Qiang"],["dc.contributor.author","Wang, Wenjia"],["dc.contributor.author","Desrivières, Sylvane"],["dc.contributor.author","Quinlan, Erin Burke"],["dc.contributor.author","Jia, Tianye"],["dc.contributor.author","Macare, Christine"],["dc.contributor.author","Robert, Gabriel H."],["dc.contributor.author","Cui, Jing"],["dc.contributor.author","Guedj, Mickaël"],["dc.contributor.author","Palaniyappan, Lena"],["dc.contributor.author","Kherif, Ferath"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Büchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Paillère-Martinot, Marie-Laure"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Orfanos, Dimitri Papadopoulos"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Fröhner, Juliane H."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Walter, Henrik"],["dc.contributor.author","Whelan, Robert"],["dc.contributor.author","Callicott, Joseph H."],["dc.contributor.author","Mattay, Venkata S."],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Dartigues, Jean-François"],["dc.contributor.author","Tzourio, Christophe"],["dc.contributor.author","Crivello, Fabrice"],["dc.contributor.author","Berman, Karen F."],["dc.contributor.author","Li, Fei"],["dc.contributor.author","Paus, Tomáš"],["dc.contributor.author","Weinberger, Daniel R."],["dc.contributor.author","Murray, Robin M."],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Feng, Jianfeng"],["dc.date.accessioned","2019-07-09T11:51:24Z"],["dc.date.available","2019-07-09T11:51:24Z"],["dc.date.issued","2019"],["dc.description.abstract","Importance: Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology. Objective: To identify genetic variants associated with adolescent brain structure and explore psychopathologic relevance of such associations. Design, Setting, and Participants: Voxelwise genome-wide association study in a cohort of healthy adolescents aged 14 years and validation of the findings using 4 independent samples across the life span with allele-specific expression analysis of top hits. Group comparison of the identified gene-brain association among patients with schizophrenia, unaffected siblings, and healthy control individuals. This was a population-based, multicenter study combined with a clinical sample that included participants from the IMAGEN cohort, Saguenay Youth Study, Three-City Study, and Lieber Institute for Brain Development sample cohorts and UK biobank who were assessed for both brain imaging and genetic sequencing. Clinical samples included patients with schizophrenia and unaffected siblings of patients from the Lieber Institute for Brain Development study. Data were analyzed between October 2015 and April 2018. Main Outcomes and Measures: Gray matter volume was assessed by neuroimaging and genetic variants were genotyped by Illumina BeadChip. Results: The discovery sample included 1721 adolescents (873 girls [50.7%]), with a mean (SD) age of 14.44 (0.41) years. The replication samples consisted of 8690 healthy adults (4497 women [51.8%]) from 4 independent studies across the life span. A nonsynonymous genetic variant (minor T allele of rs13107325 in SLC39A8, a gene implicated in schizophrenia) was associated with greater gray matter volume of the putamen (variance explained of 4.21% in the left hemisphere; 8.66; 95% CI, 6.59-10.81; P = 5.35 × 10-18; and 4.44% in the right hemisphere; t = 8.90; 95% CI, 6.75-11.19; P = 6.80 × 10-19) and also with a lower gene expression of SLC39A8 specifically in the putamen (t127 = -3.87; P = 1.70 × 10-4). The identified association was validated in samples across the life span but was significantly weakened in both patients with schizophrenia (z = -3.05; P = .002; n = 157) and unaffected siblings (z = -2.08; P = .04; n = 149). Conclusions and Relevance: Our results show that a missense mutation in gene SLC39A8 is associated with larger gray matter volume in the putamen and that this association is significantly weakened in schizophrenia. These results may suggest a role for aberrant ion transport in the etiology of psychosis and provide a target for preemptive developmental interventions aimed at restoring the functional effect of this mutation."],["dc.identifier.doi","10.1001/jamapsychiatry.2018.4126"],["dc.identifier.pmid","30649180"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16122"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59943"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/720270/EU//HBP SGA1"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/695313/EU//STRATIFY"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/602450/EU//IMAGEMEND"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/603016/EU//MATRICS"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Bipolar disorders"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Holtmann, Martin"],["dc.contributor.author","Duketis, Eftichia"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Zepf, Florian Daniel"],["dc.contributor.author","Bolte, Sven"],["dc.date.accessioned","2017-09-07T11:46:58Z"],["dc.date.available","2017-09-07T11:46:58Z"],["dc.date.issued","2010"],["dc.description.abstract","OBJECTIVES: Increasing admission and prevalence rates of bipolar disorder (BD) are a matter of controversy in international child and adolescent psychiatry. We seek to contribute to this discussion by presenting data obtained in a population of German children and adolescents.; METHODS: Nationwide, whole population changes in inpatient admissions of BD and other psychiatric disorders between 2000 and 2007 were analyzed in individuals aged up to 19 years using registry data from the German Federal Health Monitoring System.; RESULTS: Inpatient admissions for BD in individuals aged up to 19 years increased from 1.13 to 1.91 per 100,000 or 68.5% between 2000 and 2007 (odds ratio: 1.69; 95% confidence interval: 1.41-2.02), with a nonsignificant decline in children less than 15 years and the largest relative increase in adolescents aged 15-19 years. Inpatient rates for depressive disorders increased by 219.6% and for hyperkinetic disorder by 111.3%. Conduct disorders increased by 18.1%, considerably less than the 38.1% general rise for all mental disorders in children and adolescents. The only significant decline in a diagnostic category occurred for psychotic disorders (-11.8%). BD inpatient admission represented only 0.22% of all mental disorder admissions in 2000 and 0.27% in 2007.; CONCLUSIONS: An elevation of inpatient admissions of BD in Germany in adolescents was detected, exceeding the general trend for increased mental disorder admissions. The results may indicate a higher clinical awareness and appreciation of mood symptoms at earlier ages and, in part, a reconceptualization of previously diagnosed psychotic disorders in youth. However, a diagnosis of BD in youngsters is still extremely rare in Germany. Diagnoses were based on the judgment of the treating physician. A correction for multiple admissions in the data set is not possible."],["dc.identifier.doi","10.1111/j.1399-5618.2010.00794.x"],["dc.identifier.gro","3151989"],["dc.identifier.pmid","20402708"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8832"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1399-5618"],["dc.title","Bipolar disorder in children and adolescents in Germany: national trends in the rates of inpatients, 2000-2007"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Restorative neurology and neuroscience"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Hohmann, Sarah"],["dc.contributor.author","Holtmann, Martin"],["dc.contributor.author","Bolte, Sven"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2017-09-07T11:46:56Z"],["dc.date.available","2017-09-07T11:46:56Z"],["dc.date.issued","2014"],["dc.description.abstract","Autism spectrum disorders (ASD) are heterogeneous, neurodevelopmental disorders with early onset, characterized by a triad of impairments in reciprocal interaction and communication as well as repetitive and restricted interests and activities. Though underlying causes still remain largely unknown, there is now evidence for abnormal growth trajectories in the early brain development in ASD during vulnerable periods and subsequent impairment of neuronal organization and differentiation of neuronal networks. A growing number of studies over the last 10 years support the efficacy of behaviorally based interventions in ASD for the improvement of social communication and behavioral functioning. In contrast, research on neurobiologically based therapies for ASD is still at its beginnings. In this article, we will provide a selective overview of novel interventions and trainings based on neurobiological principles. Directions and options for future research on treatment aiming at restoration of normal plasticity in disrupted brain circuits in ASD are discussed."],["dc.identifier.doi","10.3233/RNN-139010"],["dc.identifier.gro","3151962"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8802"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1878-3627"],["dc.title","Neurobiologically based interventions for autism spectrum disorders-rationale and new directions"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]