Kron, Miriam

[["dc.bibliographiccitation.firstpage","315"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","327"],["dc.bibliographiccitation.volume","583"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T10:59:36Z"],["dc.date.available","2018-11-07T10:59:36Z"],["dc.date.issued","2007"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF), part of the respiratory network, is involved in the modulation of respiratory phase durations in response to peripheral and central afferent inputs. The KF is immature at birth. Developmental changes in its physiological and anatomical properties have yet to be investigated. Since brain-derived neurotrophic factor (BDNF) is of major importance for the maturation of neuronal networks, we investigated its effects on developmental changes in the KF on different postnatal days (neonatal, P1-5; intermediate, P6-13;juvenile, P14-21) by analysing single neurones in the in vitro slice preparation and network activities in the perfased brainstem preparation in situ. The BDNF had only weak effects on the frequency of mixed excitatory and inhibitory spontaneous postsynaptic currents (sPSCs) in neonatal slice preparations. Postnatally, in the intermediate and juvenile age groups, a significant augmentation of the sPSC frequency was observed in the presence of 100 pm BDNF (+23.5 +/- 12.6 and +76.7 +/- 28.4%, respectively). Subsequent analyses of BDNF effects on evoked excitatory postsynaptic currents (eEPSCs) revealed significant enhancement of eEPSC amplitude of +20.8 +/- 7.0% only in juvenile stages (intermediates, -13.2 +/- 4.8%). On the network level, significant modulation of phrenic nerve activity following BDNF microinjection into the KF was also observed only in juveniles. The data suggest that KF neurones are subject to BDNF-mediated fast synaptic modulation after completion of postnatal maturation. After maturation, BDNF contributes to modulation of fast excitatory neurotransmission in respiratory-related KF neurones. This may be important for network plasticity associated with the processing of afferent information."],["dc.identifier.doi","10.1113/jphysiol.2007.134726"],["dc.identifier.isi","000249178600024"],["dc.identifier.pmid","17569735"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50744"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0022-3751"],["dc.title","Developmental changes in brain-derived neurotrophic factor-mediated modulations of synaptic activities in the pontine Kolliker-Fuse nucleus of the rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Respiratory Physiology & Neurobiology"],["dc.bibliographiccitation.lastpage","79"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Gestreau, Christian"],["dc.contributor.author","Stettner, Georg M."],["dc.contributor.author","Kron, Miriam"],["dc.date.accessioned","2018-11-07T11:08:02Z"],["dc.date.available","2018-11-07T11:08:02Z"],["dc.date.issued","2008"],["dc.description.abstract","The shape of the three-phase respiratory motor pattern (inspiration, postinspiration, late expiration) is controlled by a central pattern generator (CPG) located in the ponto-medullary brainstem. Synaptic interactions between and within specific sub-compartments of the CPG are subject of intensive research. This review addresses the neural control of postinspiratory activity as the essential determinant of inspiratory/expiratory phase duration. The generation of the postinspiratory phase depends on synaptic interaction between neurones of the nucleus tractus solitarii (NTS), which relay afferent inputs from pulmonary stretch receptors, and the pontine Kolliker-Fuse nucleus (KF) as integral parts of the CPG. Both regions undergo significant changes during the first three postnatal weeks in rodents. Developmental changes in glutamatergic synaptic functions and its modulation by brain-derived neurotrophic factor may have implications in synaptic plasticity within the NTS/KF axis. We propose that dependent on these developmental changes, the CPG becomes permissive for short- and long-term plasticity associated with environmental, metabolic and behavioural adaptation of the breathing pattern. (C) 2008 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.resp.2008.06.013"],["dc.identifier.isi","000261248700010"],["dc.identifier.pmid","18620081"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52701"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1569-9048"],["dc.title","Postnatal emergence of synaptic plasticity associated with dynamic adaptation of the respiratory motor pattern"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","232"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Respiratory Physiology & Neurobiology"],["dc.bibliographiccitation.lastpage","235"],["dc.bibliographiccitation.volume","159"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Gestreau, Christian"],["dc.date.accessioned","2018-11-07T10:53:45Z"],["dc.date.available","2018-11-07T10:53:45Z"],["dc.date.issued","2007"],["dc.description.abstract","Orexins (splice variants A and B) are hypothalamic neuropeptides that have essential functions in control of arousal and nutrition. Lack of Orexins is strongly associated with narcolepsy and sleep disordered breathing. However, the role of Orexins and particularly that of Orexin-B (OXB), in respiratory centres controlling upper-airway patency are less defined. In the present study we performed microinjections of OXB into the pontine Kolliker-Fuse nucleus (KF) of the dorsolateral pons, since this nucleus is particularly involved in the pre-motor control of upper airway muscles. The OXB mediated effects on heart, phrenic (PNA) and hypoglossal (XII-A) nerve activities were analysed in an in situ perfused brainstem preparation. Injection Of OXB into the KF evoked significant augmentation of the respiratory frequency. Importantly, OXB provoked particularly prolonged pre-inspiratory discharge of the XII nerve, while no cardiovascular response was observed after KF microinjections. In summary, OXB in the KF exerts an excitatory effect on XII pre-motoneurones. Since pre-inspiratory activity of the XII is important for the decrease in upper airway resistance during inspiration, we conclude that OXB release in the KF has strong implications in the state-dependent control of upper airway patency under physiological and pathophysiological conditions. (C) 2007 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.resp.2007.06.004"],["dc.identifier.isi","000251070900017"],["dc.identifier.pmid","17652033"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49412"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1569-9048"],["dc.title","Activation of Orexin B receptors in the pontine Kolliker-Fuse nucleus modulates pre-inspiratory hypoglossal motor activity in rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2395"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Neurophysiology"],["dc.bibliographiccitation.lastpage","2410"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Funke, Frank"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Mueller, Michael"],["dc.date.accessioned","2018-11-07T08:30:23Z"],["dc.date.available","2018-11-07T08:30:23Z"],["dc.date.issued","2009"],["dc.description.abstract","Funke F, Kron M, Dutschmann M, Muller M. Infant brain stem is prone to the generation of spreading depression during severe hypoxia. J Neurophysiol 101: 2395-2410, 2009. First published March 4, 2009; doi:10.1152/jn.91260.2008. Spreading depression (SD) resembles a concerted, massive neuronal/glial depolarization propagating within the gray matter. Being associated with cerebropathology, such as cerebral ischemia or hemorrhage, epileptic seizures, and migraine, it is well studied in cortex and hippocampus. We have now analyzed the susceptibility of rat brain stem to hypoxia-induced spreading depression-like depolarization (HSD), which could critically interfere with cardiorespiratory control. In rat brain stem slices, severe hypoxia (oxygen withdrawal) triggered HSD within minutes. The sudden extracellular DC potential shift of approximately -20 mV showed the typical profile known from other brain regions and was accompanied by an intrinsic optical signal (IOS). Spatiotemporal IOS analysis revealed that in infant brain stem, HSD was preferably ignited within the spinal trigeminal nucleus and then mostly spread out medially, invading the hypoglossal nucleus, the nucleus of the solitary tract (NTS), and the ventral respiratory group (VRG). The neuronal hypoxic depolarizations underlying the generation of HSD were massive, but incomplete. The propagation velocity of HSD and the associated extracellular K+ rise were also less marked than in other brain regions. In adult brain stem, HSD was mostly confined to the NTS and its occurrence was facilitated by hypotonic solutions, but not by glial poisoning or block of GABAergic and glycinergic synapses. In conclusion, brain stem tissue reliably generates propagating HSD episodes, which may be of interest for basilar-type migraine and brain stem infarcts. The preferred occurrence of HSD in the infant brain stem and its propagation into the VRG may be of importance for neonatal brain stem pathology such as sudden infant death syndrome."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.1152/jn.91260.2008"],["dc.identifier.isi","000265398100023"],["dc.identifier.pmid","19261708"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16886"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physiological Soc"],["dc.relation.issn","0022-3077"],["dc.title","Infant Brain Stem Is Prone to the Generation of Spreading Depression During Severe Hypoxia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","International Journal of Clinical Pharmacology and Therapeutics"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Himmel, Wolfgang"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Thies-Zajonc, S."],["dc.contributor.author","Kochen, Michael M."],["dc.creator.author","Himmel, W."],["dc.creator.author","Kron, M."],["dc.creator.author","Thies-Zajonc, S."],["dc.creator.author","Kochen, M.M."],["dc.date.accessioned","2022-11-28T13:55:47Z"],["dc.date.available","2022-11-28T13:55:47Z"],["dc.date.issued","1997"],["dc.identifier.scopus","2-s2.0-0030905375"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117793"],["dc.identifier.url","http://www.scopus.com/inward/record.url?eid=2-s2.0-0030905375&partnerID=MN8TOARS"],["dc.title","Erratum: Changes in drug prescribing under the public health reform law - A survey of general practioners' attitudes in East and West Germany (Journal of Clinical Pharmacology (1997) 35 (164-168))"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2331"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","2343"],["dc.bibliographiccitation.volume","586"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Gerhardt, Ellen"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T11:15:39Z"],["dc.date.available","2018-11-07T11:15:39Z"],["dc.date.issued","2008"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF) contributes essentially to respiratory pattern formation and adaptation of breathing to afferent information. Systems physiology suggests that these KF functions depend on NMDA receptors (NMDA-R). Recent investigations revealed postnatal changes in the modulation of glutamatergic neurotransmission by brain-derived neurotrophic factor (BDNF) in the KF. Therefore, we investigated postnatal changes in NMDA-R subunit composition and postsynaptic modulation of NMDA-R-mediated currents by BDNF in KF slice preparations derived from three age groups (neonatal: postnatal day (P) 1-5; intermediate: P6-13; juvenile: P14-21). Immunohistochemistry showed a developmental up-regulation of the NR2D subunit. This correlated with a developmental increase in decay time of NMDA currents and a decline of desensitization in response to repetitive exogenous NMDA applications. Thus, developmental up-regulation of the NR2D subunit, which reduces the Mg2+ block of NMDA-R, causes these specific changes in NMDA current characteristics. This may determine the NMDA-R-dependent function of the mature KF in the control of respiratory phase transition. Subsequent experiments revealed that bath-application of BDNF progressively potentiated these repetitively evoked NMDA currents only in intermediate and juvenile age groups. Pharmacological inhibition of protein kinase C (PKC), as a downstream component of the BDNF-tyrosine kinase B receptor (trkB) signalling, prevented BDNF-induced potentiation of NMDA currents. BDNF-induced potentiation of NMDA currents in later developmental stages might be essential for synaptic plasticity during the adaptation of the breathing pattern in response to peripheral/central commands. The lack of plasticity in neonatal neurones strengthens the hypothesis that the respiratory network becomes permissive for activity-dependent plasticity with ongoing postnatal development."],["dc.identifier.doi","10.1113/jphysiol.2007.148916"],["dc.identifier.isi","000255497900011"],["dc.identifier.pmid","18339694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54416"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0022-3751"],["dc.title","Emergence of brain-derived neurotrophic factor-induced postsynaptic potentiation of NMDA currents during the postnatal maturation of the Kolliker-Fuse nucleus of rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3067"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neurophysiology"],["dc.bibliographiccitation.lastpage","3079"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Zimmermann, Jasper L."],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Funke, Frank"],["dc.contributor.author","Müller, Michael"],["dc.date.accessioned","2018-09-28T10:28:17Z"],["dc.date.available","2018-09-28T10:28:17Z"],["dc.date.issued","2011"],["dc.description.abstract","Rett syndrome (RTT) patients suffer from respiratory arrhythmias with frequent apneas causing intermittent hypoxia. In a RTT mouse model (methyl-CpG-binding protein 2-deficient mice; Mecp2(-/y)) we recently discovered an enhanced hippocampal susceptibility to hypoxia and hypoxia-induced spreading depression (HSD). In the present study we investigated whether this also applies to infant Mecp2(-/y) brain stem, which could become life-threatening due to failure of cardiorespiratory control. HSD most reliably occurred in the nucleus of the solitary tract (NTS) and the spinal trigeminal nucleus (Sp5). HSD susceptibility of the Mecp2(-/y) NTS and Sp5 was increased on 8 mM K(+)-mediated conditioning. 5-HT(1A) receptor stimulation with 8-hydroxy-2-(di-propylamino)tetralin (8-OH-DPAT) postponed HSD by up to 40%, mediating genotype-independent protection. The deleterious impact of HSD on in vitro respiration became obvious in rhythmically active slices, where HSD propagation into the pre-Bötzinger complex (pre-BötC) immediately arrested the respiratory rhythm. Compared with wild-type, the Mecp2(-/y) pre-BötC was invaded less frequently by HSD, but if so, HSD occurred earlier. On reoxygenation, in vitro rhythms reappeared with increased frequency, which was less pronounced in Mecp2(-/y) slices. 8-OH-DPAT increased respiratory frequency but failed to postpone HSD in the pre-BötC. Repetitive hypoxia facilitated posthypoxic recovery only if HSD occurred. In 57% of Mecp2(-/y) slices, however, HSD spared the pre-BötC. Although this occasionally promoted residual hypoxic respiratory activity (\"gasping\"), it also prolonged the posthypoxic recovery, and thus the absence of central inspiratory drive, which in vivo would lengthen respiratory arrest. In view of the breathing disorders in RTTs, the increased hypoxia susceptibility of MeCP2-deficient brain stem potentially contributes to life-threatening disturbances of cardiorespiratory control."],["dc.identifier.doi","10.1152/jn.00822.2010"],["dc.identifier.pmid","21471397"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15858"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1522-1598"],["dc.title","Altered responses of MeCP2-deficient mouse brain stem to severe hypoxia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","164"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Clinical Pharmacology and Therapeutics"],["dc.bibliographiccitation.lastpage","169"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Himmel, Wolfgang"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Thies-Zajonc, S."],["dc.contributor.author","Kochen, Michael M."],["dc.creator.author","Himmel W"],["dc.creator.author","Kron M"],["dc.creator.author","Thies-Zajonc S"],["dc.creator.author","Kochen MM"],["dc.date.accessioned","2022-11-28T13:55:41Z"],["dc.date.available","2022-11-28T13:55:41Z"],["dc.date.issued","1997"],["dc.identifier.pmid","9112138"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117790"],["dc.identifier.url","http://europepmc.org/abstract/med/9112138"],["dc.title","Changes in drug prescribing under the Public Health Reform Law--a survey of general practitioners' attitudes in East and West Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","37"],["dc.bibliographiccitation.lastpage","41"],["dc.bibliographiccitation.seriesnr","669"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.editor","Homma, Ikuo"],["dc.date.accessioned","2018-11-07T08:48:16Z"],["dc.date.available","2018-11-07T08:48:16Z"],["dc.date.issued","2010"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF) is an integral part of the central pattern generator for breathing and shows postnatal development of synaptic functions and cyto-architectural structure. Here, we analyzed the postnatal changes in cell morphology of biocytin-labelled KF neurones. Developmental analyses revealed an increasing size of somas and dendritic length. These changes were accompanied by changes in the orientation of the main dendritic branches from a diffuse orientation in neonates to a predominant medio-lateral orientation in juveniles. These developmental changes may allow for synaptic contacts with multiple ascending fibre tracts required for the processing of multi-modal respiratory inputs in the KF."],["dc.description.sponsorship","BMBF (BCCN) [01GQ0432]"],["dc.identifier.doi","10.1007/978-1-4419-5692-7_8"],["dc.identifier.isi","000277995200008"],["dc.identifier.pmid","20217317"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21162"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Berlin"],["dc.relation.conference","11th Oxford Conference on Modeling and Control of Breathing"],["dc.relation.crisseries","Advances in Experimental Medicine and Biology"],["dc.relation.doi","10.1007/978-1-4419-5692-7"],["dc.relation.eventend","2009-07-26"],["dc.relation.eventlocation","Nara, JAPAN"],["dc.relation.eventstart","2009-07-23"],["dc.relation.isbn","978-1-4419-5691-0"],["dc.relation.ispartof","New Frontiers in Respiratory Control"],["dc.relation.ispartofseries","Advances in Experimental Medicine and Biology; 669"],["dc.relation.issn","0065-2598"],["dc.title","Postnatal Changes in Morphology and Dendritic Organization of Neurones Located in the Area of the Kolliker-Fuse Nucleus of Rat"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3449"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","3457"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T10:47:25Z"],["dc.date.available","2018-11-07T10:47:25Z"],["dc.date.issued","2007"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF), part of the pontine respiratory group, is involved in the control of respiratory phase duration, and receives both excitatory and inhibitory afferent input from various other brain regions. There is evidence for developmental changes in the modulation of excitatory inputs to the KF by the neurotrophin brain-derived neurotrophic factor (BDNF). In the present study we investigated if BDNF exerts developmental effects on inhibitory synaptic transmission in the KF. Recordings of inhibitory postsynaptic currents (IPSCs) in KF neurons in a pontine slice preparation revealed general developmental changes. Recording of spontaneous and evoked IPSCs (sIPSCs, eIPSCS) revealed that neonatally the gamma-aminobutyric acid (GABA)ergic fraction of IPSCs was predominant, while in later developmental stages glycinergic neurotransmission significantly increased. Bath-application of BDNF significantly reduced sIPSC frequency in all developmental stages, while BDNF-mediated modulation on eIPSCs showed developmental differences. The eIPSCs mean amplitude was uniformly and significantly reduced following BDNF application only in neurons from rats younger than postnatal day 10. At later postnatal stages the response pattern became heterogeneous, and both augmentations and reductions of eIPSC amplitudes occurred. All BDNF effects on eIPSCs and sIPSCs were reversed with the tyrosine kinase receptor-B inhibitor K252a. We conclude that developmental changes in inhibitory neurotransmission, including the BDNF-mediated modulation of eIPSCs, relate to the postnatal maturation of the KF. The changes in BDNF-mediated modulation of IPSCs in the KF may have strong implications for developmental changes in synaptic plasticity and the adaptation of the breathing pattern to afferent inputs."],["dc.identifier.doi","10.1111/j.1460-9568.2007.05960.x"],["dc.identifier.isi","000251552200012"],["dc.identifier.pmid","18052976"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47957"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0953-816X"],["dc.title","Developmental changes in the BDNF-induced modulation of inhibitory synaptic transmission in the Kolliker-Fuse nucleus of rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]