Seehase, Matthias

[["dc.bibliographiccitation.artnumber","e0165397"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Herberg, Ulrike"],["dc.contributor.author","Linden, Katharina"],["dc.contributor.author","Dewald, Oliver"],["dc.contributor.author","Gatzweiler, Eva"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Duerr, Georg Daniel"],["dc.contributor.author","Dörner, Jonas"],["dc.contributor.author","Kleppe, Stephanie"],["dc.contributor.author","Ladage, Dennis"],["dc.contributor.author","Breuer, Johannes"],["dc.date.accessioned","2019-07-09T11:42:58Z"],["dc.date.available","2019-07-09T11:42:58Z"],["dc.date.issued","2016"],["dc.description.abstract","Background Pressure-volume loops (PVL) provide vital information regarding ventricular performance and pathophysiology in cardiac disease. Unfortunately, acquisition of PVL by conductance technology is not feasible in neonates and small children due to the available human catheter size and resulting invasiveness. The aim of the study was to validate the accuracy of PVL in small hearts using volume data obtained by real-time three-dimensional echocardiography (3DE) and simultaneously acquired pressure data. Methods In 17 piglets (weight range: 3.6–8.0 kg) left ventricular PVL were generated by 3DE and simultaneous recordings of ventricular pressure using a mini pressure wire (PVL3D). PVL3D were compared to conductance catheter measurements (PVLCond) under various hemodynamic conditions (baseline, alpha-adrenergic stimulation with phenylephrine, beta-adrenoreceptor-blockage using esmolol). In order to validate the accuracy of 3D volumetric data, cardiac magnetic resonance imaging (CMR) was performed in another 8 piglets. Results Correlation between CMR- and 3DE-derived volumes was good (enddiastolic volume: mean bias -0.03ml ±1.34ml). Computation of PVL3D in small hearts was feasible and comparable to results obtained by conductance technology. Bland-Altman analysis showed a low bias between PVL3D and PVLCond. Systolic and diastolic parameters were closely associated (Intraclass-Correlation Coefficient for: systolic myocardial elastance 0.95, arterial elastance 0.93, diastolic relaxation constant tau 0.90, indexed end-diastolic volume 0.98). Hemodynamic changes under different conditions were well detected by both methods (ICC 0.82 to 0.98). Inter- and intra-observer coefficients of variation were below 5% for all parameters. Conclusions PVL3D generated from 3DE combined with mini pressure wire represent a novel, feasible and reliable method to assess different hemodynamic conditions of cardiac function in hearts comparable to neonate and infant size. This methodology may be integrated into clinical practice and cardiac catheterization programs and has the capability to contribute to clinical decision making even in small hearts."],["dc.identifier.doi","10.1371/journal.pone.0165397"],["dc.identifier.pmid","27776179"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58799"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","3D Real-Time Echocardiography Combined with Mini Pressure Wire Generate Reliable Pressure-Volume Loops in Small Hearts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular and Cellular Pediatrics"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Jennekens, Ward"],["dc.contributor.author","Zwanenburg, Alex"],["dc.contributor.author","Andriessen, Peter"],["dc.contributor.author","Collins, Jennifer J. P."],["dc.contributor.author","Kuypers, Elke"],["dc.contributor.author","Zimmermann, Luc J."],["dc.contributor.author","Vles, Johan S. H."],["dc.contributor.author","Gavilanes, Antonio W. D."],["dc.contributor.author","Kramer, Boris W."],["dc.date.accessioned","2019-07-09T11:42:33Z"],["dc.date.available","2019-07-09T11:42:33Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Term and near-term infants are at high risk of developing brain injury and life-long disability if they have suffered from severe perinatal asphyxia. We hypothesized that propofol administration to the maternal-fetal unit can diminish cerebral injury in term and near-term infant fetuses in states of progressive severe asphyxia. Methods: Forty-four late preterm lambs underwent total umbilical cord occlusion (UCO) or sham treatment in utero. UCO resulted in global asphyxia and cardiac arrest. After emergency cesarean section under either maternal propofol or isoflurane anesthesia, the fetuses were resuscitated and subsequently anesthetized the same way as their mothers. Results: Asphyctic lambs receiving isoflurane showed a significant increase of total and low-frequency spectral power in bursts indicating seizure activity and more burst-suppression with a marked increase of interburst interval length during UCO. Asphyctic lambs receiving propofol showed less EEG changes. Propofol increased levels of anti-apoptotic B-cell lymphoma-extra large (Bcl-xL) and phosphorylated STAT-3 and reduced the release of cytochrome c from the mitochondria and the protein levels of activated cysteinyl aspartate-specific protease (caspase)-3, -9, and N-methyl-d-aspartate (NMDA) receptor. Conclusions: Improvement of fetal EEG during and after severe asphyxia could be achieved by propofol treatment of the ovine maternal-fetal unit. The underlying mechanism is probably the reduction of glutamate-induced cytotoxicity by down-regulation of NMDA receptors and an inhibition of the mitochondrial apoptotic pathway."],["dc.identifier.doi","10.1186/s40348-015-0016-4"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13563"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58690"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2194-7791"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Propofol administration to the maternal-fetal unit improved fetal EEG and influenced cerebral apoptotic pathway in preterm lambs suffering from severe asphyxia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Stümpfig, T."],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Brinkkoetter, Paul T."],["dc.date.accessioned","2020-05-13T13:45:08Z"],["dc.date.available","2020-05-13T13:45:08Z"],["dc.date.issued","2019"],["dc.description.abstract","Objectives: Surgical correction of tetralogy of Fallot (cTOF) frequently results in residual pulmonary valve stenosis/regurgitation and impaired right ventricular (RV) function. Reduced capacity in cardiopulmonary exercise testing (CPET) in cTOF patients, however, cannot entirely be explained by these findings. The present study sought to assess biventricular cardiac function during exercise using a comprehensive CPET and real-time cardiovascular magnetic resonance exercise testing (CMR-ET) protocol. Methods: A total of 33 cTOF patients (age 35.6 + 11.3 years) and 33 matched healthy controls (age 34.4 +11.9 years) underwent CPET and CMR-ET. Real-time SSFP and phase contrast sequences were obtained during supine bicycle in scanner CMR-ET at 50, 70, and 90 W. RV and LV volumetry and flow quantification of the pulmonary trunk (Qp) were performed. Correlation between CPET and CMR-ET parameters was investigated using Spearman’s rank test. Results: Exercise capacity on CPET was significantly lower in cTOF than in healthy controls. With incremental exercise levels on CMR-ET, cTOF patients failed to recruit both RV and LV functions and Qp (Table 1). Correlation analysis revealed higher CPET values in those cTOF patients with higher Qp (Qp 90 W vs. VE/VCO2%: r = −0.519, p < 0.05), higher LV EDVi (LV EDVi at 50 W vs. VO2% r = 0.452, p < 0.05) and less change in LV EF (LV-EF at 90 W vs. W % r = −0.463, p < 0.05). No correlation was found with RV EF. Significant RV–LV interaction was observed at 70 W CMR-ET (correlation of RV and LF EF r = 0.52, p < 0.05). Conclusion: Compared with healthy controls, cTOF patients displayed impaired exercise capacity due to a lack in recruitment of both RV function and pulmonary blood flow but also of LV function. RV and LV functions during exercise showed significant interdependence. CMR-ET may be a helpful tool in the assessment of cardiac function in cTOF patients."],["dc.identifier.doi","10.1055/s-0039-1679069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/65370"],["dc.language.iso","en"],["dc.relation.issn","1439-1902"],["dc.title","Impaired Exercise Tolerance after Repair of Tetralogy of Fallot—Insights from Real-Time Cardiovascular Magnetic Resonance Imaging"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","748"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pediatric Research"],["dc.bibliographiccitation.lastpage","753"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Houthuizen, Patrick"],["dc.contributor.author","Collins, Jennifer J. P."],["dc.contributor.author","Zimmermann, Luc J."],["dc.contributor.author","Kramer, Boris W."],["dc.date.accessioned","2018-11-07T10:15:03Z"],["dc.date.available","2018-11-07T10:15:03Z"],["dc.date.issued","2016"],["dc.description.abstract","BACKGROUND: Little is known about the effects of propofol on oxidative stress and its effect on key structures of the contractile apparatus as the myosin light chain 2 (MLC2) and the p38MAPK survival pathway in the preterm heart. We hypothesized that propofol administration could attenuate the hypoxic myocardial injury after birth asphyxia. METHODS: Pregnant ewes were randomized to receive either propofol or isoflurane anesthesia. A total of 44 late-preterm lambs were subjected to in utero umbilical cord occlusion (UCO), resulting in asphyxia and cardiac arrest, or sham treatment. After emergency cesarean delivery, each fetus was resuscitated, mechanically ventilated, and supported under anesthesia for 8 h using the same anesthetic as the one received by its mother. RESULTS: At 8h after UCO, occurrence of reactive oxygen species and activation of inducible nitric oxide synthase in the heart were lower in association with propofol anesthesia than with isoflurane. This was accompanied by less degradation of MLC2 but higher p38MAPK level and in echocardiography with a trend toward a higher median left ventricular fractional shortening. CONCLUSION: The use of propofol resulted in less oxidative stress and was associated with less cytoskeletal damage of the contractile apparatus than the use of isoflurane anesthesia."],["dc.identifier.doi","10.1038/pr.2016.10"],["dc.identifier.isi","000375891600012"],["dc.identifier.pmid","26761124"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40735"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1530-0447"],["dc.relation.issn","0031-3998"],["dc.title","Propofol administration to the fetal-maternal unit reduces cardiac oxidative stress in preterm lambs subjected to prenatal asphyxia and cardiac arrest"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Circulation: Cardiovascular Imaging"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Stümpfig, Thomas"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Kowallick, Johannes"],["dc.contributor.author","Müller, Matthias"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2021-09-01T06:42:57Z"],["dc.date.available","2021-09-01T06:42:57Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular (RV) dysfunction. Reduced exercise capacity in cTOF patients cannot be explained by these findings alone. We aimed to explore why cTOF patients exhibit impaired exercise capacity with the aid of a comprehensive cardiopulmonary exercise testing (CPET) and real-time cardiovascular magnetic resonance exercise testing (CMR-ET) protocol. Methods: Thirty three cTOF patients and 35 matched healthy controls underwent CPET and CMR-ET in a prospective case-control study. Real-time steady-state free precession cine and phase-contrast sequences were obtained during incremental supine in-scanner cycling at 50, 70, and 90 W. RV and left ventricle (LV) volumes and pulmonary blood flow (Qp) were calculated. Differences of CPET and CMR-ET between cTOF versus controls and correlations between CPET and CMR-ET parameters in cTOF were evaluated statistically for all CMR exercise levels using Mann-Whitney U and Spearman rank-order correlation tests. Results: CPET capacity was significantly lower in cTOF than in controls. cTOF patients exhibited not only significantly reduced Qp and RV function but also lower LV function on CMR-ET. Higher CPET values in cTOF correlated with higher Qp (Qp 90 W versus carbon dioxide ventilatory equivalent %: R =−0.519, P <0.05), higher LV–end-diastolic volume indexed to body surface area (LV–end-diastolic volume indexed to body surface area at 50 W versus oxygen uptake in % at maximum exercise on CPET R =0.452, P <0.05), and change in LV ejection fraction (EF; LV-EF at 90 W versus Watt %: r =−0.463, P <0.05). No correlation was found with regard to RV-EF. Significant RV-LV interaction was observed during CMR-ET (RV-EF versus LV-EF at 50 W and 70 W: r =0.66, P <0.02 and r =0.52, P <0.05, respectively). Conclusions: Impaired exercise capacity in cTOF resulted from a reduction in not only RV, but also LV function. cTOF with good exercise capacity on CPET demonstrated higher LV reserve and pulmonary blood flow during incremental CMR-ET. Apart from RV parameters, CMR-ET–derived LV function could be a valuable tool to stratify cTOF patients for pulmonary valve replacement."],["dc.description.abstract","Background: Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular (RV) dysfunction. Reduced exercise capacity in cTOF patients cannot be explained by these findings alone. We aimed to explore why cTOF patients exhibit impaired exercise capacity with the aid of a comprehensive cardiopulmonary exercise testing (CPET) and real-time cardiovascular magnetic resonance exercise testing (CMR-ET) protocol. Methods: Thirty three cTOF patients and 35 matched healthy controls underwent CPET and CMR-ET in a prospective case-control study. Real-time steady-state free precession cine and phase-contrast sequences were obtained during incremental supine in-scanner cycling at 50, 70, and 90 W. RV and left ventricle (LV) volumes and pulmonary blood flow (Qp) were calculated. Differences of CPET and CMR-ET between cTOF versus controls and correlations between CPET and CMR-ET parameters in cTOF were evaluated statistically for all CMR exercise levels using Mann-Whitney U and Spearman rank-order correlation tests. Results: CPET capacity was significantly lower in cTOF than in controls. cTOF patients exhibited not only significantly reduced Qp and RV function but also lower LV function on CMR-ET. Higher CPET values in cTOF correlated with higher Qp (Qp 90 W versus carbon dioxide ventilatory equivalent %: R =−0.519, P <0.05), higher LV–end-diastolic volume indexed to body surface area (LV–end-diastolic volume indexed to body surface area at 50 W versus oxygen uptake in % at maximum exercise on CPET R =0.452, P <0.05), and change in LV ejection fraction (EF; LV-EF at 90 W versus Watt %: r =−0.463, P <0.05). No correlation was found with regard to RV-EF. Significant RV-LV interaction was observed during CMR-ET (RV-EF versus LV-EF at 50 W and 70 W: r =0.66, P <0.02 and r =0.52, P <0.05, respectively). Conclusions: Impaired exercise capacity in cTOF resulted from a reduction in not only RV, but also LV function. cTOF with good exercise capacity on CPET demonstrated higher LV reserve and pulmonary blood flow during incremental CMR-ET. Apart from RV parameters, CMR-ET–derived LV function could be a valuable tool to stratify cTOF patients for pulmonary valve replacement."],["dc.identifier.doi","10.1161/CIRCIMAGING.120.011823"],["dc.identifier.pmid","34384226"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89183"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/427"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1942-0080"],["dc.relation.issn","1941-9651"],["dc.relation.workinggroup","RG Uecker"],["dc.title","Impaired Exercise Tolerance in Repaired Tetralogy of Fallot Is Associated With Impaired Biventricular Contractile Reserve: An Exercise-Stress Real-Time Cardiovascular Magnetic Resonance Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","174"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","BIOLOGY OF THE NEONATE"],["dc.bibliographiccitation.lastpage","184"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Wiludda, Elke"],["dc.contributor.author","Hellige, Gerhard"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Schiffmann, Holger"],["dc.date.accessioned","2018-11-07T10:30:50Z"],["dc.date.available","2018-11-07T10:30:50Z"],["dc.date.issued","2006"],["dc.description.abstract","Background: Neonatal hearts are less susceptible to developing myocardial dysfunction after hypoxia and/or ischemia than adult hearts. Differences in intracellular calcium homeostasis may be responsible for reduced calcium overload of the immature myocardium leading to the observed protection against ischemia. Objective: To assess differences in baseline and post-ischemic gene expression of calcium handling proteins after ischemia in neonatal and adult rabbit hearts. Methods: We used isolated antegrade perfused rabbit hearts (age 2 days, 28 days, n = 32), which were exposed to ischemia and hypothermia simulating myocardial stunning comparable to neonatal asphyxia. Gene and protein expression of the sodium-calcium exchanger (NCX), the sarco-endoplasmatic reticulum Ca(2+)-ATPase 2a (SERCA) and calsequestrin (CSQ) were measured using quantitative real-time PCR and Western blotting. Results: After ischemia and reperfusion in neonatal and adult hearts, a significant decrease in myocardial performance was re-corded. At the mRNA level, significant differences in the baseline expression of NCX, SERCA and CSQ between neonatal and adult hearts were observed. In neonatal post-ischemic hearts, NCX and CSQ expression were significantly higher at the mRNA level than in controls. In contrast, SERCA expression remained unchanged in neonatal hearts and decreased in adult hearts compared to the non-ischemic controls. Conclusion: These findings suggest that changes in gene expression of calcium handling proteins may be involved in the different susceptibility of neonatal compared to adult hearts to developing myocardial dysfunction after ischemia. Copyright (c) 2006 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000092888"],["dc.identifier.isi","000240711400006"],["dc.identifier.pmid","16645265"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43958"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0006-3126"],["dc.title","Gene expression of the Na(+)-Ca(2+) exchanger, SERCA2a and calsequestrin after myocardial ischemia in the neonatal rabbit heart"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","791"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Applied Physiology"],["dc.bibliographiccitation.lastpage","798"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Seehase, S."],["dc.contributor.author","Schlepütz, M."],["dc.contributor.author","Switalla, S."],["dc.contributor.author","Mätz-Rensing, K."],["dc.contributor.author","Kaup, F. J."],["dc.contributor.author","Zöller, M."],["dc.contributor.author","Schlumbohm, C."],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Lauenstein, H.-D."],["dc.contributor.author","Winkler, C."],["dc.contributor.author","Martin, C."],["dc.date.accessioned","2022-10-06T13:25:49Z"],["dc.date.available","2022-10-06T13:25:49Z"],["dc.date.issued","2011"],["dc.description.abstract","Bronchoconstriction is a characteristic symptom of various chronic obstructive respiratory diseases such as chronic obstructive pulmonary disease and asthma. Precision-cut lung slices (PCLS) are a suitable ex vivo model to study physiological mechanisms of bronchoconstriction in different species. In the present study, we established an ex vivo model of bronchoconstriction in nonhuman primates (NHPs). PCLS prepared from common marmosets, cynomolgus macaques, rhesus macaques, and anubis baboons were stimulated with increasing concentrations of representative bronchoconstrictors: methacholine, histamine, serotonin, leukotriene D\n 4\n (LTD\n 4\n ), U46619, and endothelin-1. Alterations in the airway caliber were measured and compared with previously published data from rodents, guinea pigs, and humans. Methacholine induced maximal airway constriction, varying between 74 and 88% in all NHP species, whereas serotonin was ineffective. Histamine induced maximal bronchoconstriction of 77 to 90% in rhesus macaques, cynomolgus macaques, and baboons and a lesser constriction of 53% in marmosets. LTD\n 4\n was ineffective in marmosets and rhesus macaques but induced a maximum constriction of 44 to 49% in cynomolgus macaques and baboons. U46619 and endothelin-1 caused airway constriction in all NHP species, with maximum constrictions of 65 to 91% and 70 to 81%, respectively. In conclusion, PCLS from NHPs represent a valuable ex vivo model for studying bronchoconstriction. All NHPs respond to mediators relevant to human airway disorders such as methacholine, histamine, U46619, and endothelin-1 and are insensitive to the rodent mast cell product serotonin. Only PCLS from cynomolgus macaques and baboons, however, responded also to leukotrienes, suggesting that among all compared species, these two NHPs resemble the human airway mechanisms best."],["dc.identifier.doi","10.1152/japplphysiol.00162.2011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114922"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1522-1601"],["dc.relation.issn","8750-7587"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Bronchoconstriction in nonhuman primates: a species comparison"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","315A"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.lastpage","316A"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Seehase, M."],["dc.contributor.author","Quentin, Thomas"],["dc.contributor.author","Wiludda, E."],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Schiffmann, H."],["dc.date.accessioned","2018-11-07T08:28:57Z"],["dc.date.available","2018-11-07T08:28:57Z"],["dc.date.issued","2005"],["dc.identifier.isi","000226808201363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.eventlocation","Orlando, FL"],["dc.title","Effects of the sodium channel modulator BDF 9148 on the developing rabbit heart after myocardial stunning"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","353"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Clinical Monitoring and Computing"],["dc.bibliographiccitation.lastpage","360"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Linden, Katharina"],["dc.contributor.author","Ladage, Dennis"],["dc.contributor.author","Dewald, Oliver"],["dc.contributor.author","Gatzweiler, Eva"],["dc.contributor.author","Pieper, Andrea"],["dc.contributor.author","Seehase, Matthias"],["dc.contributor.author","Duerr, Georg Daniel"],["dc.contributor.author","Breuer, Johannes"],["dc.contributor.author","Herberg, Ulrike"],["dc.date.accessioned","2018-10-11T05:57:39Z"],["dc.date.available","2018-10-11T05:57:39Z"],["dc.date.issued","2017-04"],["dc.description.abstract","To compare stroke volumes (SV) in small hearts assessed by real-time three-dimensional echocardiography (3DE) with SV measured by transpulmonary thermodilution (TPTD) and continuous pulse contour analysis (PC) under various hemodynamic conditions. In thirteen anesthetized piglets (range 3.6-7.1 kg) SV were measured by 3DE, TPTD and PC at baseline and during phenylephrine and esmolol administration. 3DE and TPTD measurements were done successively while SV calculated by PC was documented at the time of 3DE. 3DE and TPTD showed a good correlation (r2 = 0.74) and a bias of -1.3 ml (limits of agreement -4.1 to 1.5 ml). While TPTD measured higher SV than 3DE, both methods tracked SV changes with a concordance rate of 91 %. PC and 3DE showed a lower correlation coefficient of r2 = 0.57 and a bias of -2.1 ml (limits of agreement -5.9 to 1.8 ml). Inter- and intra-observer variability of SV measured by 3DE was good with a mean bias <5 %. SV3DE showed a small variance and tracked acute small changes in SV in acceptable concordance with TPTD. PC measured SV with a higher variance and mean difference compared to 3DE. In an experimental setting 3DE has the possibility to offer non-invasive assessments of ventricular volumes volume changes. To determine whether 3DE could be used for SV assessment in a clinical routine our results need confirmation in a clinical setting."],["dc.identifier.doi","10.1007/s10877-016-9843-7"],["dc.identifier.pmid","26886899"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15965"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1573-2614"],["dc.title","Comparison of stroke volumes assessed by three-dimensional echocardiography and transpulmonary thermodilution in a pediatric animal model"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]