Kurth, Christoph

[["dc.bibliographiccitation.firstpage","1362"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Annals of Biomedical Engineering"],["dc.bibliographiccitation.lastpage","1369"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Gillam, F."],["dc.contributor.author","Steinhoff, B. J."],["dc.date.accessioned","2018-11-07T11:06:46Z"],["dc.date.available","2018-11-07T11:06:46Z"],["dc.date.issued","2000"],["dc.description.abstract","Artificial neural networks are widely used for pattern recognition tasks. For spike detection in electroencephalography (EEC;), feedforward networks trained by the back-propagation algorithm are preferred by most authors. Opposed to this. we examined the off-line spike detection abilities of a Kohonen feature map (KFM), which is different from feedforward networks in certain aspects. The EEG data for the training set were obtained from patients with intractable partial epilepsies of mesiotemporal (n=2) or extratemporal (n=2) origin. For each patient the training set for the KFM included the same patterns of background activity and artifacts as well as the typical individual spike patterns. Three different-sized networks were examined ( 15X15 cells, 25X25 cells, and 60X60 cells in the Kohonen layer). To investigate the quality of spike detection the results obtained with the KFM were compared with the findings of two board-certified electroencephalographers. Application of a threshold based on the partial invariance of spike recognition against translation of the EEG provided an average sensitivity and selectivity of 80.2% at crossover threshold (71%-86%) depending on the networksize and noise. Multichannel EEG processing in real time will be available soon. In conclusion, pattern-based automated spike detection with a KFM is a promising approach in clinical epileptology and stems to be at least as accurate as other more-established methods of spike detection. (C) 2000 Biomedical Engineering Society. [S0090-6964(00)01011-0]."],["dc.identifier.doi","10.1114/1.1331312"],["dc.identifier.isi","000166492500008"],["dc.identifier.pmid","11212954"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52396"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Inst Physics"],["dc.relation.issn","0090-6964"],["dc.title","EEG spike detection with a Kohonen feature map"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","19"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Metabolic Brain Disease"],["dc.bibliographiccitation.lastpage","28"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Bahn, Erik"],["dc.contributor.author","Nolte, Wilhelm"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Ramadori, G."],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Wiltfang, Jens"],["dc.date.accessioned","2017-11-21T09:21:38Z"],["dc.date.available","2017-11-21T09:21:38Z"],["dc.date.issued","2002"],["dc.description.abstract","The aim of the study was the quantification of metabolically caused electroencephalo- graphic changes of portal-systemic encephalopathy, a prototype of hepatic encephalopathy. We examined 12 patients with liver cirrhosis before and after implantation of a transjugular intrahepatic portosystemic stent shunt (TIPSS) by means of quantitative digital electroen- cephalography (EEG). One month after TIPSS implantation, all patients showed an increase in the power of the theta frequency band as well as a decrease in the power of the alpha fre- quency band. To reduce the error variance, we formed the quotient of the relative power of the theta and alpha frequency band. Theta/alpha quotient values over 0.7 indicate a general change of the EEG with a sensitivity of 93% and a specificity of 87%. The results we have to hand indicate a correlation between the albumin concentration and the theta/alpha quotient 1 and 3 months after TIPSS. No significant correlation was revealed with regard to the Child- Pugh score or the liver function parameters cholinesterase, bilirubin, and prothrombin time. Neither the arterial ammonia concentration nor the performance in the psychometric test showed significance in relation to the theta/alpha quotient. Substances with a high albumin bond and potential neurotoxicity may—in the case of lower albumin levels—be absorbed with increased frequency in the CNS and may be responsible for the observed EEG change."],["dc.identifier.doi","10.1023/A:1014048229754"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/10123"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0885-7490"],["dc.relation.issn","1573-7365"],["dc.title","Quantification of the electroencephalographic theta/alpha ratio for the assessment of portal-systemic encephalopathy following implantation of transjugular intrahepatic portosystemic stent shunt (TIPSS)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Metabolic Brain Disease"],["dc.bibliographiccitation.lastpage","6"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Bahn, Erik"],["dc.contributor.author","Wiltfang, J."],["dc.contributor.author","Nolte, W."],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Steinhoff, B."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Kurth, C."],["dc.date.accessioned","2018-11-07T11:20:57Z"],["dc.date.available","2018-11-07T11:20:57Z"],["dc.date.issued","2005"],["dc.description.abstract","We examined a 41-year-old female with a subacute Budd-Chiari Syndrome (BCS) before and after implantation of a transjugular intrahepatic portosystemic stent shunt (TIPSS) by means of digital electroencephalography (EEG). After TIPSS implantation hepatic decompression had been achieved and the liver function as well as the clinical status improved daily. Simultaneously, the digital EEG showed a decrease in the power of the theta band and an increase in the physiological alpha frequency band. The theta/alpha ratio decreased after TIPSS, despite an elevated arterial ammonia level. The patient had a well-preserved liver parenchyma before the occurrence of the BCS. After portal decompression by TIPSS, the liver function normalized and the liver resumed efficient synthesis and parts of its detoxification task. This regeneration capacity was documented by a rise in cholinesterase after TIPSS. After temporary substitution of albumin the serum albumin concentration returned to normal. Thus, some neurotoxic substances with high albumin-binding capacity may not be absorbed by the central nervous system (CNS). Furthermore, it appears likely that the length of time the brain is exposed to neurotoxic substances plays a role in the clinical and electroencephalographic changes. Compared to the conventional EEG the theta/alpha ratio reflected better metabolically conditioned electroencephalographic changes after TIPSS."],["dc.identifier.doi","10.1007/s11011-005-2471-4"],["dc.identifier.isi","000228973300001"],["dc.identifier.pmid","15918545"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55660"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0885-7490"],["dc.title","Quantification of changes in electroencephalographic power spectra in a patient with Budd-Chiari-syndrome after implantation of a transjugular intrahepatic portosystemic stent shunt (TIPSS)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","276"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","AKTUELLE NEUROLOGIE"],["dc.bibliographiccitation.lastpage","282"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Gaida-Hommernick, B."],["dc.contributor.author","Hagemann, Georg"],["dc.contributor.author","Kerling, F."],["dc.contributor.author","Kowalik, A."],["dc.contributor.author","Tergau, Frithjof"],["dc.date.accessioned","2018-11-07T11:01:31Z"],["dc.date.available","2018-11-07T11:01:31Z"],["dc.date.issued","2007"],["dc.description.abstract","The current role of topiramate (TPM) in the treatment of epilepsy is described in this article. Data from randomized, double blind, controlled clinical trials are presented together with those from open label, non-interventional studies and interpreted in the context of the guidelines of the German Neurological Society (DGN). TPM is approved in Germany as a monotherapy for epilepsy in adults and children aged 2 and above since 2001. The guidelines of the DGN for the treatment of the first seizure list TPM as a therapy of choice for partial and idiopathic generalized epilepsy. The effectiveness and tolerability were to be considered high based on results of several randomised controlled studies for the treatment of partial epilepsy, generalised tonic-clonic seizures as well as various seizure types in the Lennox-Gastaut syndrome. The broad efficacy was regarded as especially advantageous due to the fact, that early in the treatment seizure type or epilepsy syndrome may be ambiguous. An initial target dose of 100 mg TPM is effective and well tolerated. Several studies including recent onset epilepsy in the elderly as well as elderly patients with epilepsy suggest that even lower doses, e.g. 50-75 mg/day can be sufficient to achieve seizure control with good tolerability. Tolerability had been an issue in early trials using high doses of TPM, however, with the use of lower doses, especially in monotherapy, the side effect profile has become favorable which was shown in controlled trials and is reflected in daily clinical routine as well."],["dc.identifier.doi","10.1055/s-2007-970890"],["dc.identifier.isi","000248367400007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51168"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0302-4350"],["dc.title","Impact of low-dose topiramate monotherapy for epilepsy in adults with focal and generalised seizures"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","947"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Epilepsia"],["dc.bibliographiccitation.lastpage","949"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Bittermann, H. J."],["dc.contributor.author","Wegerer, V."],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Steinhoff, B. J."],["dc.date.accessioned","2018-11-07T08:54:41Z"],["dc.date.available","2018-11-07T08:54:41Z"],["dc.date.issued","2001"],["dc.description.abstract","An adult patient had EEG occipital spike fixation off sensitivity and spontaneous occipital seizures due to perinatal asphyxia with bioccipital hemorrhage. EEG abnormalities consisted of repetitive posterior spikes that occurred when the eyes were closed and other conditions of fixation-off. Magnetic resonance imaging (MRI) documented severe posterior lesions with wallerian degeneration of the optic radiation. Electron capture detector single-photon emission computed tomography (ECD-SPECT) during the state of fixation-off showed regional hyperperfusion in the right posterior regions. We suggest that partial denervation of the primary visual cortex in this patient resulted in an increased cortical excitability and that the inhibitory effect of central vision and fixation leads to a suppression of spontaneous epileptic activity. This unusual symptomatic case may serve as a-model for the pathophysiology in the more often reported cases of idiopathic benign epilepsy syndrome of childhood."],["dc.identifier.doi","10.1046/j.1528-1157.2001.042007947.x"],["dc.identifier.isi","000170661000021"],["dc.identifier.pmid","11488898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22725"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0013-9580"],["dc.title","Fixation-off sensitivity in an adult with symptomatic occipital epilepsy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1235"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuroreport"],["dc.bibliographiccitation.lastpage","1238"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Wegerer, V."],["dc.contributor.author","Degner, Detlef"],["dc.contributor.author","Sperling, W."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Bleich, Stefan"],["dc.date.accessioned","2018-11-07T09:04:14Z"],["dc.date.available","2018-11-07T09:04:14Z"],["dc.date.issued","2001"],["dc.description.abstract","Recently, it has been suggested that alcohol-induced hyperhomocysteinaemia in patients suffering from chronic alcoholism might be a risk factor for alcohol withdrawal seizures. In the present follow-up study 12 patients with chronic alcoholism who suffered from withdrawal seizures had significantly higher revers of homocysteine (Hcy) on admission (71.43 +/- 25.84 mol/l) than patients (n=37) who did not develop seizures (32.60+/-24.87 mol/l; U=37.50, p=0.0003). Using a logistic regression analysis, withdrawal seizures were best predicted by a high Hcy level on admission (p<0.01; odds ratio 2.07). Based on these findings we developed an artificial neural network system (Kohonen feature map, KFM) for an improved prediction of the risk of alcohol withdrawal seizures. Forty-nine patients with chronic alcoholism (12 with alcohol withdrawal seizures and 37 without seizures) were randomized into a training set and a test set. Best results for sensitivity of the KFM was 83.3% (five of six seizure patients were predicted correctly) with a specificity of 94.4% (one false positive prediction of 19 patients). We conclude that in patients with alcohol-induced hyperhomocysteinaemia the KFM is a useful tool to predict alcohol withdrawal seizures. NeuroReport 12:1235-1238 (C) 2001 Lippincott Williams & Wilkins."],["dc.identifier.doi","10.1097/00001756-200105080-00036"],["dc.identifier.isi","000168260200037"],["dc.identifier.pmid","11338198"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25071"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0959-4965"],["dc.title","Risk assessment of alcohol withdrawal seizures with a Kohonen feature map"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","367"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neuroreport"],["dc.bibliographiccitation.lastpage","371"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Wegerer, V."],["dc.contributor.author","Reulbach, Udo"],["dc.contributor.author","Lewczuk, Piotr"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Steinhoff, B. J."],["dc.contributor.author","Bleich, Stefan"],["dc.date.accessioned","2018-11-07T10:51:11Z"],["dc.date.available","2018-11-07T10:51:11Z"],["dc.date.issued","2004"],["dc.description.abstract","We investigated the correlation of hippocampal volume with homocysteine, folate, vitamin B12 and 136 in alcoholic patients and healthy controls applying a Kohonen feature map (KFM) and conventional statistics. Representation of subjects on the KFM suggested an inverse correlation of hippocampal volume with blood levels of homocysteine and correlation with folate and vitamin B6. In conventional statistical analyses (t-test) reduced folate and increased homocysteine was found in alcoholics compared to healthy controls (p<0.01). In female alcoholics vitamin 136 was reduced significantly (p=0.03). Multiple linear regression analyses showed a significant correlation between average hippocampal volume and homocysteine (p<0.001). KFM proved to be a sensitive tool for visualisation of statistical correlations in data sets even if no further statistical information is available."],["dc.identifier.doi","10.1097/00001756-200402090-00031"],["dc.identifier.isi","000225139900031"],["dc.identifier.pmid","15076770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48833"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0959-4965"],["dc.title","Analysis of hippocampal atrophy in alcoholic patients by a Kohonen feature map"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","171"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neuroscience Letters"],["dc.bibliographiccitation.lastpage","174"],["dc.bibliographiccitation.volume","293"],["dc.contributor.author","Bleich, S."],["dc.contributor.author","Spilker, K."],["dc.contributor.author","Kurth, C."],["dc.contributor.author","Degner, D."],["dc.contributor.author","Quintela-Schneider, M."],["dc.contributor.author","Javaheripour, K."],["dc.contributor.author","Rüther, E."],["dc.contributor.author","Kornhuber, J."],["dc.contributor.author","Wiltfang, J. G."],["dc.date.accessioned","2017-09-07T11:44:37Z"],["dc.date.available","2017-09-07T11:44:37Z"],["dc.date.issued","1999"],["dc.description.abstract","The exact mechanism of brain atrophy in patients with chronic alcoholism remains unknown. There is growing evidence that chronic alcoholism is associated with oxidative stress and with a derangement in sulphur amino acid metabolism (e.g. ethanol-induced hyperhomocysteinemia). Furthermore, it has been reported that homocysteine induces neuronal cell death by stimulating N-methyl-d-aspartate receptors as well as by producing free radicals. To further evaluate this latter hypothesis we analysed serum levels of both homocysteine and markers of oxidative stress (malondialdehyde) in alcoholic patients who underwent withdrawal from alcohol. Homocysteine and malondialdehyde were quantified by high performance liquid chromatography (HPLC) in serum samples of 35 patients (active drinkers). There was a significant correlation (P<0.01) between blood alcohol concentration and elevated homocysteine (Spearman's r=0.71) and malondialdehyde (r=0.90) levels on admission. In addition, homocysteine and malondialdehyde levels were found to be significant decreased after 3 days of withdrawal treatment (Wilcoxon test: homocysteine, Z=−5.127; malondialdehyde, Z=−3.120; P<0.01). We postulate that excitatory neurotransmitters and mechanisms of oxidative stress in patients with chronic alcoholism may partly mediate excitotoxic neuronal damage and hereby cause brain shrinkage."],["dc.identifier.doi","10.1016/s0304-3940(00)01505-6"],["dc.identifier.gro","3151717"],["dc.identifier.pmid","11036188"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8537"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","0304-3940"],["dc.title","Oxidative stress and an altered methionine metabolism in alcoholism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]