Zhang, Weiqi

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Pharmacology & Therapeutics"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Meibohm, B."],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Elshoff, J."],["dc.contributor.author","Behn, F."],["dc.contributor.author","Hulpke-Wette, Martin"],["dc.contributor.author","Laer, S."],["dc.date.accessioned","2018-11-07T10:41:10Z"],["dc.date.available","2018-11-07T10:41:10Z"],["dc.date.issued","2003"],["dc.format.extent","P71"],["dc.identifier.isi","000181170100264"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46474"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby, Inc"],["dc.publisher.place","St louis"],["dc.relation.conference","Annual Meeting of the American-Society-for-Clinical-Pharmacology-and-Therapeutics"],["dc.relation.eventlocation","WASHINGTON, D.C."],["dc.relation.issn","0009-9236"],["dc.title","Population pharmacokinetics and pharmacodynamics of sotalol in infants and children with tachycardia."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7238"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Nano Letters"],["dc.bibliographiccitation.lastpage","7244"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Lehmann, Sebastian"],["dc.contributor.author","Mergenthaler, Kilian"],["dc.contributor.author","Wallentin, Jesper"],["dc.contributor.author","Borgstrom, Magnus T."],["dc.contributor.author","Pistol, Mats-Erik"],["dc.contributor.author","Yartsev, Arkady"],["dc.date.accessioned","2018-11-07T09:49:35Z"],["dc.date.available","2018-11-07T09:49:35Z"],["dc.date.issued","2015"],["dc.description.abstract","Measuring lifetime of photogenerated charges in semiconductor nanowires (NW) is important for understanding light-induced processes in these materials and is relevant for their photovoltaic and photodetector applications. In this paper, we investigate the dynamics of photogenerated charge carriers in a series of as-grown InP NW with different levels of sulfur (S) doping. We observe that photoluminescence (PL) decay time as well as integrated PL intensity decreases with increasing S doping. We attribute these observations to hole trapping with the trap density increased due to S-doping level followed by nonradiative recombination of trapped charges. This assignment is proven by observation of the trap saturation in three independent experiments: via excitation power and repetition rate PL lifetime dependencies and by PL pump-probe experiment."],["dc.identifier.doi","10.1021/acs.nanolett.5b02022"],["dc.identifier.isi","000364725400011"],["dc.identifier.pmid","26421505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35537"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","1530-6992"],["dc.relation.issn","1530-6984"],["dc.title","Carrier Recombination Dynamics in Sulfur-Doped InP Nanowires"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","315"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","327"],["dc.bibliographiccitation.volume","583"],["dc.contributor.author","Kron, Miriam"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Dutschmann, Mathias"],["dc.date.accessioned","2018-11-07T10:59:36Z"],["dc.date.available","2018-11-07T10:59:36Z"],["dc.date.issued","2007"],["dc.description.abstract","The Kolliker-Fuse nucleus (KF), part of the respiratory network, is involved in the modulation of respiratory phase durations in response to peripheral and central afferent inputs. The KF is immature at birth. Developmental changes in its physiological and anatomical properties have yet to be investigated. Since brain-derived neurotrophic factor (BDNF) is of major importance for the maturation of neuronal networks, we investigated its effects on developmental changes in the KF on different postnatal days (neonatal, P1-5; intermediate, P6-13;juvenile, P14-21) by analysing single neurones in the in vitro slice preparation and network activities in the perfased brainstem preparation in situ. The BDNF had only weak effects on the frequency of mixed excitatory and inhibitory spontaneous postsynaptic currents (sPSCs) in neonatal slice preparations. Postnatally, in the intermediate and juvenile age groups, a significant augmentation of the sPSC frequency was observed in the presence of 100 pm BDNF (+23.5 +/- 12.6 and +76.7 +/- 28.4%, respectively). Subsequent analyses of BDNF effects on evoked excitatory postsynaptic currents (eEPSCs) revealed significant enhancement of eEPSC amplitude of +20.8 +/- 7.0% only in juvenile stages (intermediates, -13.2 +/- 4.8%). On the network level, significant modulation of phrenic nerve activity following BDNF microinjection into the KF was also observed only in juveniles. The data suggest that KF neurones are subject to BDNF-mediated fast synaptic modulation after completion of postnatal maturation. After maturation, BDNF contributes to modulation of fast excitatory neurotransmission in respiratory-related KF neurones. This may be important for network plasticity associated with the processing of afferent information."],["dc.identifier.doi","10.1113/jphysiol.2007.134726"],["dc.identifier.isi","000249178600024"],["dc.identifier.pmid","17569735"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50744"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0022-3751"],["dc.title","Developmental changes in brain-derived neurotrophic factor-mediated modulations of synaptic activities in the pontine Kolliker-Fuse nucleus of the rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1129"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Natural Product Research"],["dc.bibliographiccitation.lastpage","1135"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Jin, Yulan"],["dc.contributor.author","Fotso, Serge"],["dc.contributor.author","Yongtang, Z."],["dc.contributor.author","Sevvana, Madhumati"],["dc.contributor.author","Laatsch, Hartmut"],["dc.contributor.author","Zhang, W."],["dc.date.accessioned","2018-11-07T09:12:05Z"],["dc.date.available","2018-11-07T09:12:05Z"],["dc.date.issued","2006"],["dc.description.abstract","A new sulfur-containing guanidino derivative, halichondria sulfonic acid (1) showing anti-HIV-1 activity, and halistanol trisulfate (2) with anti-tumor activity have been isolated from the marine sponge Halichondria rugosa Ridley & Dendy collected in the Chinese Southern Sea. The structure of 1 was elucidated by analysis of spectroscopic and crystal data."],["dc.identifier.doi","10.1080/14786410600879748"],["dc.identifier.isi","000242898600016"],["dc.identifier.pmid","17127667"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26868"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","1478-6419"],["dc.title","Halichondria sulfonic acid, a new HIV-1 inhibitory guanidino-sulflonic acid, and halistanol sulfate isolated from the marine sponge Halichondria rugosa Ridley & Dendy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","741"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.lastpage","754"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Varoqueaux, Frederique"],["dc.contributor.author","Aramuni, Gayane"],["dc.contributor.author","Rawson, Randi L."],["dc.contributor.author","Mohrmann, Ralf"],["dc.contributor.author","Missler, Markus"],["dc.contributor.author","Gottmann, Kurt"],["dc.contributor.author","Zhang, Weiqi"],["dc.contributor.author","Suedhof, Thomas C."],["dc.contributor.author","Brose, Nils"],["dc.date.accessioned","2017-09-07T11:52:32Z"],["dc.date.available","2017-09-07T11:52:32Z"],["dc.date.issued","2006"],["dc.description.abstract","Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to respiratory failure. This respiratory failure is a consequence of reduced GABAergic/glycinergic and glutamatergic synaptic transmission and network activity in brainstem centers that control respiration. However, the density of synaptic contacts is not altered in neuroligin-deficient brains and cultured neurons. Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts."],["dc.identifier.doi","10.1016/j.neuron.2006.09.003"],["dc.identifier.gro","3143623"],["dc.identifier.isi","000240997900013"],["dc.identifier.pmid","16982420"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1158"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: NIMH NIH HHS [MH52804-08]"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Cell Press"],["dc.relation.issn","0896-6273"],["dc.title","Neuroligins determine synapse maturation and function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2915"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","2930"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Kobe, Fritz"],["dc.contributor.author","Guseva, Daria"],["dc.contributor.author","Jensen, Thomas P."],["dc.contributor.author","Wirth, Alexander"],["dc.contributor.author","Renner, Ute"],["dc.contributor.author","Hess, Dietmar"],["dc.contributor.author","Müller, Michael"],["dc.contributor.author","Medrihan, Lucian"],["dc.contributor.author","Zhang, Weiqi"],["dc.contributor.author","Zhang, Mingyue"],["dc.contributor.author","Braun, Katharina"],["dc.contributor.author","Westerholz, Sören"],["dc.contributor.author","Herzog, Andreas"],["dc.contributor.author","Radyushkin, Konstantin"],["dc.contributor.author","El-Kordi, Ahmed"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Richter, Diethelm W."],["dc.contributor.author","Rusakov, Dmitri A."],["dc.contributor.author","Ponimaskin, Evgeni"],["dc.date.accessioned","2017-09-07T11:46:22Z"],["dc.date.available","2017-09-07T11:46:22Z"],["dc.date.issued","2012"],["dc.description.abstract","The common neurotransmitter serotonin controls different aspects of early neuronal differentiation, although the underlying mechanisms are poorly understood. Here we report that activation of the serotonin 5-HT7 receptor promotes synaptogenesis and enhances synaptic activity in hippocampal neurons at early postnatal stages. An analysis of Gα12-deficient mice reveals a critical role of G12-protein for 5-HT7 receptor-mediated effects in neurons. In organotypic preparations from the hippocampus of juvenile mice, stimulation of 5-HT7R/G12 signaling potentiates formation of dendritic spines, increases neuronal excitability, and modulates synaptic plasticity. In contrast, in older neuronal preparations, morphogenetic and synaptogenic effects of 5-HT7/G12 signaling are abolished. Moreover, inhibition of 5-HT7 receptor had no effect on synaptic plasticity in hippocampus of adult animals. Expression analysis reveals that the production of 5-HT7 and Gα12-proteins in the hippocampus undergoes strong regulation with a pronounced transient increase during early postnatal stages. Thus, regulated expression of 5-HT7 receptor and Gα12-protein may represent a molecular mechanism by which serotonin specifically modulates formation of initial neuronal networks during early postnatal development."],["dc.identifier.doi","10.1523/JNEUROSCI.2765-11.2012"],["dc.identifier.gro","3150488"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7258"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.title","5-HT₇R/G₁₂ signaling regulates neuronal morphology and function in an age-dependent manner"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","374"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Brain Research Bulletin"],["dc.bibliographiccitation.lastpage","379"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Hu, Wen"],["dc.contributor.author","Zhang, M."],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Fluegge, Gabriele"],["dc.date.accessioned","2018-11-07T08:54:17Z"],["dc.date.available","2018-11-07T08:54:17Z"],["dc.date.issued","2011"],["dc.description.abstract","Chronic stress, a risk factor for the development of psychiatric disorders, is known to induce alterations in neuronal networks in many brain areas. Previous studies have shown that chronic stress changes the expression of the cannabinoid receptor 1 (CB1) in the brains of adult rats, but neurophysiological consequences of these changes remained unclear. Here we demonstrate that chronic restraint stress causes a dysfunction in CBI mediated modulation of GABAergic transmission in the hippocampus. Using an established protocol, adult male Sprague Dawley rats were daily restrained for 21 days and whole-cell voltage clamp was performed at CA1 pyramidal neurons. When recording carbachol-evoked inhibitory postsynaptic currents (IPSCs) which presumably originate from CBI expressing cholecystokinin (CCK) interneurons, we found that depolarization-induced suppression of inhibition (DSI) was impaired by the stress. DSI is a form of short-term plasticity at GABAergic synapses that is known to be CB1 mediated and has been suggested to be involved in hippocampal information encoding. Chronic stress attenuated the depolarization-induced suppression of the frequency of carbachol-evoked IPSCs. Incubation with a CBI receptor antagonist prevented this DSI effect in control but not in chronically stressed animals. The stress-induced impairment of CB1-mediated short-term plasticity at GABAergic synapses may underlie cognitive deficits which are commonly observed in animal models of stress as well as in patients with stress-related psychiatric disorders. (C) 2011 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft; Ministry of Lower Saxony, Germany"],["dc.identifier.doi","10.1016/j.brainresbull.2011.04.005"],["dc.identifier.isi","000293719700009"],["dc.identifier.pmid","21527320"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22636"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0361-9230"],["dc.title","Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.volume","523"],["dc.contributor.author","Sudhoelter, J."],["dc.contributor.author","Ciccolini, F."],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Berridge, M. J."],["dc.contributor.author","Bootman, M. D."],["dc.contributor.author","Lipp, P."],["dc.date.accessioned","2018-11-07T10:38:05Z"],["dc.date.available","2018-11-07T10:38:05Z"],["dc.date.issued","2000"],["dc.format.extent","197P"],["dc.identifier.isi","000085937100283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45724"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.issn","0022-3751"],["dc.title","Characterisation of neurosphere-derived neuronal precursor cells from E14 mouse striatum"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Respiratory Physiology & Neurobiology"],["dc.bibliographiccitation.lastpage","79"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Dutschmann, Mathias"],["dc.contributor.author","Moerschel, Michael"],["dc.contributor.author","Reuter, Julia"],["dc.contributor.author","Zhang, W."],["dc.contributor.author","Gestreau, Christian"],["dc.contributor.author","Stettner, Georg M."],["dc.contributor.author","Kron, Miriam"],["dc.date.accessioned","2018-11-07T11:08:02Z"],["dc.date.available","2018-11-07T11:08:02Z"],["dc.date.issued","2008"],["dc.description.abstract","The shape of the three-phase respiratory motor pattern (inspiration, postinspiration, late expiration) is controlled by a central pattern generator (CPG) located in the ponto-medullary brainstem. Synaptic interactions between and within specific sub-compartments of the CPG are subject of intensive research. This review addresses the neural control of postinspiratory activity as the essential determinant of inspiratory/expiratory phase duration. The generation of the postinspiratory phase depends on synaptic interaction between neurones of the nucleus tractus solitarii (NTS), which relay afferent inputs from pulmonary stretch receptors, and the pontine Kolliker-Fuse nucleus (KF) as integral parts of the CPG. Both regions undergo significant changes during the first three postnatal weeks in rodents. Developmental changes in glutamatergic synaptic functions and its modulation by brain-derived neurotrophic factor may have implications in synaptic plasticity within the NTS/KF axis. We propose that dependent on these developmental changes, the CPG becomes permissive for short- and long-term plasticity associated with environmental, metabolic and behavioural adaptation of the breathing pattern. (C) 2008 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.resp.2008.06.013"],["dc.identifier.isi","000261248700010"],["dc.identifier.pmid","18620081"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52701"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1569-9048"],["dc.title","Postnatal emergence of synaptic plasticity associated with dynamic adaptation of the respiratory motor pattern"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","628"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.lastpage","642"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Poulopoulos, Alexandros"],["dc.contributor.author","Aramuni, Gayane"],["dc.contributor.author","Meyer, Guido"],["dc.contributor.author","Soykan, Tolga"],["dc.contributor.author","Hoon, Mrinalini"],["dc.contributor.author","Papadopoulos, Theofilos"],["dc.contributor.author","Zhang, Mingyue"],["dc.contributor.author","Paarmann, Ingo"],["dc.contributor.author","Fuchs, Celine"],["dc.contributor.author","Harvey, Kirsten"],["dc.contributor.author","Jedlicka, Peter"],["dc.contributor.author","Schwarzacher, Stephan W."],["dc.contributor.author","Betz, Heinrich"],["dc.contributor.author","Harvey, Robert J."],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Zhang, Weiqi"],["dc.contributor.author","Varoqueaux, Frederique"],["dc.date.accessioned","2017-09-07T11:46:51Z"],["dc.date.available","2017-09-07T11:46:51Z"],["dc.date.issued","2009"],["dc.description.abstract","In the mammalian CNS, each neuron typically receives thousands of synaptic inputs from diverse classes of neurons. Synaptic transmission to the postsynaptic neuron relies on localized and transmitter-specific differentiation of the plasma membrane with postsynaptic receptor, scaffolding, and adhesion proteins accumulating in precise apposition to presynaptic sites of transmitter release. We identified protein interactions of the synaptic adhesion molecule neuroligin 2 that drive postsynaptic differentiation at inhibitory synapses. Neuroligin 2 binds the scaffolding protein gephyrin through a conserved cytoplasmic motif and functions as a specific activator of collybistin, thus guiding membrane tethering of the inhibitory postsynaptic scaffold. Complexes of neuroligin 2, gephyrin and collybistin are sufficient for cell-autonomous clustering of inhibitory neurotransmitter receptors. Deletion of neuroligin 2 in mice perturbs GABAergic and glycinergic synaptic transmission and leads to a loss of postsynaptic specializations specifically at perisomatic inhibitory synapses."],["dc.identifier.doi","10.1016/j.neuron.2009.08.023"],["dc.identifier.gro","3143057"],["dc.identifier.isi","000269852300010"],["dc.identifier.pmid","19755106"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/529"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Cell Press"],["dc.relation.issn","0896-6273"],["dc.title","Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]