Fiebig, Anja

[["dc.bibliographiccitation.firstpage","1105"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular Phylogenetics and Evolution"],["dc.bibliographiccitation.lastpage","1114"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Heinrichs, Jochen"],["dc.contributor.author","Hentschel, Jörn"],["dc.contributor.author","Bombosch, Andrea"],["dc.contributor.author","Fiebig, Anja"],["dc.contributor.author","Reise, Judith"],["dc.contributor.author","Edelmann, Michel"],["dc.contributor.author","Kreier, Hans-Peter"],["dc.contributor.author","Schäfer-Verwimp, Alfons"],["dc.contributor.author","Caspari, Steffen"],["dc.contributor.author","Schmidt, Alexander R."],["dc.contributor.author","Zhu, Rui-Liang"],["dc.contributor.author","Von Konrat, Matthew"],["dc.contributor.author","Shaw, Blanka"],["dc.contributor.author","Shaw, A. Jonathan"],["dc.date.accessioned","2018-11-07T08:39:59Z"],["dc.date.available","2018-11-07T08:39:59Z"],["dc.date.issued","2010"],["dc.description.abstract","Frullania tamarisci is usually regarded as a polymorphic, holarctic-Asian liverwort species with four allopatric subspecies [subsp. asagrayana, moniliata, nisquallensis and tamarisci]. This hypothesis is examined using a dataset including sequences of the nuclear internal transcribed spacer region and the plastid trnL-trnF and atpB-rbcL regions of 88 accessions of F. tamarisci and putatively related taxa. Maximum parsimony and maximum likelihood analyses indicate the presence of at least eight main lineages within F. tamarisci s. l. The long branches leading to the tip nodes of the different F. tamarisci s. l. clades and their partly sympatric distribution reinforce species rank. Within F. tamarisci s. I. we recognize the Asian F. moniliata, the western North American F. californica and F. nisquallensis, the eastern North American F. asagrayana, the eastern North American-European F. tamarisci s. str., the Macaronesian F. sergiae, and two newly identified European lineages assigned to as F. calcarifera and F. tamarisci var. azorica. The considerable sequence differences are not reflected in conspicuous morphological disparities, rendering F. tamarisci s. I. the most explicit example of a complex of semi-cryptic and cryptic liverwort species. The temperate Frunania clades of this study likely went through recent extinction and expansion processes as indicated by the bottleneck pattern of genetic diversity. Species from tropical regions or regions with an Atlantic climate usually contain several geographical lineages. Our findings support frequent short-distance migration, rare successful long-distance dispersal events, extinction and recolonization as an explanation for the range formation in these Frullania species. (C) 2010 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ympev.2010.05.004"],["dc.identifier.isi","000280245300025"],["dc.identifier.pmid","20460161"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19126"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","1095-9513"],["dc.relation.issn","1055-7903"],["dc.title","One species or at least eight? Delimitation and distribution of Frullania tamarisci (L.) Dumort. s. l. (Jungermanniopsida, Porellales) inferred from nuclear and chloroplast DNA markers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1414"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","British Journal of Pharmacology"],["dc.bibliographiccitation.lastpage","1423"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Lienenluke, B."],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Fiebig, T."],["dc.contributor.author","Fayyazi, Afshin"],["dc.contributor.author","Germann, T."],["dc.contributor.author","Hecker, M."],["dc.date.accessioned","2018-11-07T08:46:46Z"],["dc.date.available","2018-11-07T08:46:46Z"],["dc.date.issued","2001"],["dc.description.abstract","1 Immune response-modulating drugs such as thalidomide may be of therapeutic value in the treatment of chronic inflammatory bowel diseases including Crohn's disease (CD). In the present study, we have investigated whether thalidomide exerts this effect by impairing endothelial cell-leukocyte interaction through down-regulation of the expression of pro-inflammatory gene products in these cells. 2 Transient CD-like colitis was induced in male Wistar rats by single enema with trinitrobenzene sulphonic acid (TNBS) in ethanol followed by macroscopic scoring, histology, intravital microscopy, RT-PCR and immunohistochemistry (IHC) analyses. Thalidomide or its analogue supidimide were administered in olive oil by intragastric instillation 6 h prior to the induction of colitis and then daily for one week. 3 Both thalidomide and supidimide (200 mg kg(-1) d(-1)) significantly attenuated TNBS-induced colitis as compared to vehicle-treated control animals (44 and 37% inhibition, respectively), and this effect persisted for 7 days post cessation of thalidomide treatment (46% inhibition). 4 Moreover. thalidomide significantly reduced leukocyte sticking to postcapillary venular endothelial cells in the submucosa (by 45%), improved functional capillary density and perfusion, and attenuated endothelial interleukin-8 expression, as judged by IHC analysis. According to RT-PCR analysis, both thalidomide and supidimide also significantly reduced vascular cell adhesion molecule-1 mRNA expression in the affected part of the descending colon. 5 These findings suggest that thalidomide and one of its derivatives impairs CD-like TNBS-induced colitis in the rat by down-regulating endothelial adhesion molecule and chemokine expression and, as a consequence, the interaction of these cells with circulating leukocytes."],["dc.identifier.doi","10.1038/sj.bjp.0704193"],["dc.identifier.isi","000170549300027"],["dc.identifier.pmid","11498529"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20774"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0007-1188"],["dc.title","Thalidomide impairment of trinitrobenzene sulphonic acid-induced colitis in the rat-role of endothelial cell-leukocyte interaction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4100"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","The Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","4114"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Kozhushkov, S."],["dc.contributor.author","Spath, T."],["dc.contributor.author","Fiebig, T."],["dc.contributor.author","Galland, B."],["dc.contributor.author","Ruasse, M. F."],["dc.contributor.author","Xavier, P."],["dc.contributor.author","Apeloig, Y."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T10:25:47Z"],["dc.date.available","2018-11-07T10:25:47Z"],["dc.date.issued","2002"],["dc.description.abstract","The bromine additions to methylenecyclopropane (1), bicyclopropylidene (2), and spirocyclopropanated methylenecyclopropanes and bicyclopropylidenes 3-6 in methanol at 25 degreesC proceed essentially with the same rate as those to the corresponding oligomethyl-substituted ethylenes. An increasing number of spiroannelated three-membered rings enhances the rate of bromination and stabilizes the intermediate cyclopropyl bromonium cations against ring opening in the course of bromine addition. Calculations at the B3LYP/6-311G(d,p) level show that unsymmetrical bromonium ions are the intermediates, and that they are stabilized by the spiroannelation with cyclopropane rings. The bromonium ion derived from 1 is less stable by 6.3 kcal mol(-1) than that from isobutene. One or two spirocyclopropane rings as in 3 and 4 stabilize the corresponding bromonium. ion by 9.6 and 16.4 kcal mol(-1), respectively, while one or two alpha-cyclopropyl substituents as in ethenylcyclopropane (7) and 1,1-dicyclopropylethene (8) stabilize the corresponding bromonium ions by 13 and 29 kcal mol-1, respectively. The experimental bromination rates of all the studied alkenes correlate reasonably well (r(2) = 0.93) With calculated relative energies of the corresponding bromonium ions. The correlation is even better within the series of methylenecyclopropanes 1, 3, and 4 (r(2) = 0.974) and bicyclopropylidenes 2, 5, and 6 (r(2) = 0.999). The experimental bromination rates also correlate fairly well with the first ionization energies of the corresponding alkenes 1-12 (with r(2) = 0.963) and 13-19 (with r(2) = 0.991). The calculated preferred nucleophilic attack of a water molecule at both the C-1' and C-1 atoms of representative bromonium ions conforms well to the experimentally observed product distribution."],["dc.identifier.doi","10.1021/jo0162686"],["dc.identifier.isi","000176173700016"],["dc.identifier.pmid","12054944"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42922"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","0022-3263"],["dc.title","Reactivities of methylenetriangulanes and spirocyclopropanated bicyclopropylidenes toward bromine. Relative stabilities of spirocyclopropanated versus methyl-substituted bromonium ions"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]