Institut für Auditorische Neurowissenschaften

[["dc.bibliographiccitation.firstpage","7587"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","The Journal of neuroscience"],["dc.bibliographiccitation.lastpage","7597"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Buran, Bradley N."],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Neef, Andreas"],["dc.contributor.author","Gundelfinger, Eckart D."],["dc.contributor.author","Moser, Tobias"],["dc.contributor.author","Liberman, M. Charles"],["dc.date.accessioned","2017-09-07T11:45:59Z"],["dc.date.available","2017-09-07T11:45:59Z"],["dc.date.issued","2010"],["dc.description.abstract","Synaptic ribbons, found at the presynaptic membrane of sensory cells in both ear and eye, have been implicated in the vesicle-pool dynamics of synaptic transmission. To elucidate ribbon function, we characterized the response properties of single auditory nerve fibers in mice lacking Bassoon, a scaffolding protein involved in anchoring ribbons to the membrane. In bassoon mutants, immunohistochemistry showed that fewer than 3% of the hair cells' afferent synapses retained anchored ribbons. Auditory nerve fibers from mutants had normal threshold, dynamic range, and postonset adaptation in response to tone bursts, and they were able to phase lock with normal precision to amplitude-modulated tones. However, spontaneous and sound-evoked discharge rates were reduced, and the reliability of spikes, particularly at stimulus onset, was significantly degraded as shown by an increased variance of first-spike latencies. Modeling based on in vitro studies of normal and mutant hair cells links these findings to reduced release rates at the synapse. The degradation of response reliability in these mutants suggests that the ribbon and/or Bassoon normally facilitate high rates of exocytosis and that its absence significantly compromises the temporal resolving power of the auditory system."],["dc.identifier.doi","10.1523/JNEUROSCI.0389-10.2010"],["dc.identifier.gro","3142908"],["dc.identifier.isi","000278288200016"],["dc.identifier.pmid","20519533"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/364"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Onset Coding Is Degraded in Auditory Nerve Fibers from Mutant Mice Lacking Synaptic Ribbons"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","35"],["dc.bibliographiccitation.journal","Acta Physiologica"],["dc.bibliographiccitation.lastpage","36"],["dc.bibliographiccitation.volume","213"],["dc.contributor.author","Keppeler, Daniel"],["dc.contributor.author","Jeschke, Marcus"],["dc.contributor.author","Wrobel, C."],["dc.contributor.author","Hoch, Gerhard"],["dc.contributor.author","Gossler, Christian"],["dc.contributor.author","Schwarz, U. T."],["dc.contributor.author","Ruther, P."],["dc.contributor.author","Schwaerzle, M."],["dc.contributor.author","Hessler, R."],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Kügler, Sebastian"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2018-11-07T09:59:50Z"],["dc.date.available","2018-11-07T09:59:50Z"],["dc.date.issued","2015"],["dc.identifier.isi","000362554200073"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37681"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.title","In vivo application of optogenetics in the auditory system"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Moore, Sharlen"],["dc.contributor.author","Meschkat, Martin"],["dc.contributor.author","Ruhwedel, Torben"],["dc.contributor.author","Trevisiol, Andrea"],["dc.contributor.author","Tzvetanova, Iva D."],["dc.contributor.author","Battefeld, Arne"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Kole, Maarten H. P."],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","de Hoz, Livia"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.date.accessioned","2021-04-14T08:31:48Z"],["dc.date.available","2021-04-14T08:31:48Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41467-020-19152-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83719"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2041-1723"],["dc.title","A role of oligodendrocytes in information processing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2005114"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","PLoS Biology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Cruces-Solís, Hugo"],["dc.contributor.author","Jing, Zhizi"],["dc.contributor.author","Babaev, Olga"],["dc.contributor.author","Rubin, Jonathan"],["dc.contributor.author","Gür, Burak"],["dc.contributor.author","Krueger-Burg, Dilja"],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","de Hoz, Livia"],["dc.date.accessioned","2020-11-24T10:40:59Z"],["dc.date.available","2020-11-24T10:40:59Z"],["dc.date.issued","2018"],["dc.description.abstract","Detecting regular patterns in the environment, a process known as statistical learning, is essential for survival. Neuronal adaptation is a key mechanism in the detection of patterns that are continuously repeated across short (seconds to minutes) temporal windows. Here, we found in mice that a subcortical structure in the auditory midbrain was sensitive to patterns that were repeated discontinuously, in a temporally sparse manner, across windows of minutes to hours. Using a combination of behavioral, electrophysiological, and molecular approaches, we found changes in neuronal response gain that varied in mechanism with the degree of sound predictability and resulted in changes in frequency coding. Analysis of population activity (structural tuning) revealed an increase in frequency classification accuracy in the context of increased overlap in responses across frequencies. The increase in accuracy and overlap was paralleled at the behavioral level in an increase in generalization in the absence of diminished discrimination. Gain modulation was accompanied by changes in gene and protein expression, indicative of long-term plasticity. Physiological changes were largely independent of corticofugal feedback, and no changes were seen in upstream cochlear nucleus responses, suggesting a key role of the auditory midbrain in sensory gating. Subsequent behavior demonstrated learning of predictable and random patterns and their importance in auditory conditioning. Using longer timescales than previously explored, the combined data show that the auditory midbrain codes statistical learning of temporally sparse patterns, a process that is critical for the detection of relevant stimuli in the constant soundscape that the animal navigates through."],["dc.identifier.doi","10.1371/journal.pbio.2005114"],["dc.identifier.pmid","30048446"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15664"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69155"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1545-7885"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Auditory midbrain coding of statistical learning that results from discontinuous sensory stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","712"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biochemical and Biophysical Research Communications"],["dc.bibliographiccitation.lastpage","716"],["dc.bibliographiccitation.volume","362"],["dc.contributor.author","Yamaguchi, Yoshiki"],["dc.contributor.author","Hirao, Takeshi"],["dc.contributor.author","Sakata, Eri"],["dc.contributor.author","Kamiya, Yukiko"],["dc.contributor.author","Kurimoto, Eiji"],["dc.contributor.author","Yoshida, Yukiko"],["dc.contributor.author","Suzuki, Tadashi"],["dc.contributor.author","Tanaka, Keiji"],["dc.contributor.author","Kato, Koichi"],["dc.date.accessioned","2022-03-01T11:44:48Z"],["dc.date.available","2022-03-01T11:44:48Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1016/j.bbrc.2007.08.056"],["dc.identifier.pii","S0006291X0701755X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103123"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0006-291X"],["dc.title","Fbs1 protects the malfolded glycoproteins from the attack of peptide:N-glycanase"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","411"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","413"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Nouvian, Régis"],["dc.contributor.author","Neef, Jakob"],["dc.contributor.author","Bulankina, Anna V"],["dc.contributor.author","Reisinger, Ellen"],["dc.contributor.author","Pangršič, Tina"],["dc.contributor.author","Frank, Thomas"],["dc.contributor.author","Sikorra, Stefan"],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Binz, Thomas"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2017-09-07T11:44:19Z"],["dc.date.available","2017-09-07T11:44:19Z"],["dc.date.issued","2011"],["dc.description.abstract","SNARE proteins mediate membrane fusion. Neurosecretion depends on neuronal soluble NSF attachment protein receptors ( SNAREs; SNAP-25, syntaxin-1, and synaptobrevin-1 or synaptobrevin-2) and is blocked by neurotoxin-mediated cleavage or genetic ablation. We found that exocytosis in mouse inner hair cells (IHCs) was insensitive to neurotoxins and genetic ablation of neuronal SNAREs. mRNA, but no synaptically localized protein, of neuronal SNAREs was present in IHCs. Thus, IHC exocytosis is unconventional and may operate independently of neuronal SNAREs."],["dc.identifier.doi","10.1038/nn.2774"],["dc.identifier.gro","3142757"],["dc.identifier.isi","000288849400007"],["dc.identifier.pmid","21378973"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/196"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1097-6256"],["dc.title","Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","795"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biochemical and Biophysical Research Communications"],["dc.bibliographiccitation.lastpage","799"],["dc.bibliographiccitation.volume","363"],["dc.contributor.author","Sasakawa, Hiroaki"],["dc.contributor.author","Sakata, Eri"],["dc.contributor.author","Yamaguchi, Yoshiki"],["dc.contributor.author","Masuda, Masami"],["dc.contributor.author","Mori, Tetsuya"],["dc.contributor.author","Kurimoto, Eiji"],["dc.contributor.author","Iguchi, Takeshi"],["dc.contributor.author","Hisanaga, Shin-ichi"],["dc.contributor.author","Iwatsubo, Takeshi"],["dc.contributor.author","Hasegawa, Masato"],["dc.contributor.author","Kato, Koichi"],["dc.date.accessioned","2022-03-01T11:44:48Z"],["dc.date.available","2022-03-01T11:44:48Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1016/j.bbrc.2007.09.048"],["dc.identifier.pii","S0006291X07020074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103125"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0006-291X"],["dc.title","Ultra-high field NMR studies of antibody binding and site-specific phosphorylation of α-synuclein"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","673"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neuroscience"],["dc.bibliographiccitation.lastpage","684"],["dc.bibliographiccitation.volume","149"],["dc.contributor.author","Pauli-Magnus, D."],["dc.contributor.author","Hoch, G."],["dc.contributor.author","Strenzke, N."],["dc.contributor.author","Anderson, S."],["dc.contributor.author","Jentsch, T. J."],["dc.contributor.author","Moser, T."],["dc.date.accessioned","2017-09-07T11:49:23Z"],["dc.date.available","2017-09-07T11:49:23Z"],["dc.date.issued","2007"],["dc.description.abstract","Sensorineural hearing loss (SNHL) comprises hearing disorders with diverse pathologies of the inner ear and the auditory nerve. To date, an unambiguous phenotypical characterization of the specific pathologies in an affected individual remains impossible. Here, we evaluated the use of scalp-recorded auditory steady-state responses (ASSR) and transient auditory brainstem responses (ABR) for differentiating the disease mechanisms underlying sensorineural hearing loss in well-characterized mouse models. We first characterized the ASSR evoked by sinusoidally amplitude-modulated tones in wild-type mice. ASSR were robustly elicited within three ranges of modulation frequencies below 200 Hz, from 200 to 600 Hz and beyond 600 Hz in most recordings. Using phase information we estimated the apparent ASSR latency to be about 3 ms, suggesting generation in the auditory brainstem. Auditory thresholds obtained by automated and visual analysis of ASSR recordings were comparable to those found with tone-burst evoked ABR in the same mice. We then recorded ASSR and ABR from mouse mutants bearing defects of either outer hair cell amplification (KC NQ4- knockout) or inner hair cell synaptic transmission (Bassoon-mutant). Both mutants showed an increase of ASSR and ABR thresholds of approximately 40 dB versus wild-type when investigated at 8 weeks of age. Mice with defective amplification displayed a steep rise of ASSR and ABR amplitudes with increasing sound intensity, presumably reflecting a strong recruitment of synchronously activated neural elements beyond threshold. In contrast, the amplitudes of ASSR and ABR responses of mice with impaired synaptic transmission grew very little with sound intensity. In summary, ASSR allow for a rapid, objective and frequency-specific hearing assessment and together with ABR and otoacoustic emissions can contribute to the differential diagnosis of SNHL. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroscience.2007.08.010"],["dc.identifier.gro","3143413"],["dc.identifier.isi","000251022900020"],["dc.identifier.pmid","17869440"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/925"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0306-4522"],["dc.title","Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S243"],["dc.bibliographiccitation.issue","S02"],["dc.bibliographiccitation.journal","Laryngo-Rhino-Otologie"],["dc.bibliographiccitation.lastpage","S244"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Wrobel, Christian"],["dc.contributor.author","Zerche, Maria"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Mager, Thomas"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2022-08-24T05:35:55Z"],["dc.date.available","2022-08-24T05:35:55Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1055/s-0042-1746830"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113151"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/490"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.issn","1438-8685"],["dc.relation.workinggroup","RG Mager (Advanced Optogenes)"],["dc.relation.workinggroup","RG Moser (Molecular Anatomy, Physiology and Pathology of Sound Encoding)"],["dc.title","In vivo investigation of f-Chrimson variants for optogenetic hearing restoration"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3396"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Pack, Chan-Gi"],["dc.contributor.author","Yukii, Haruka"],["dc.contributor.author","Toh-e, Akio"],["dc.contributor.author","Kudo, Tai"],["dc.contributor.author","Tsuchiya, Hikaru"],["dc.contributor.author","Kaiho, Ai"],["dc.contributor.author","Sakata, Eri"],["dc.contributor.author","Murata, Shigeo"],["dc.contributor.author","Yokosawa, Hideyoshi"],["dc.contributor.author","Sako, Yasushi"],["dc.contributor.author","Saeki, Yasushi"],["dc.date.accessioned","2022-03-01T11:45:51Z"],["dc.date.available","2022-03-01T11:45:51Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1038/ncomms4396"],["dc.identifier.pii","BFncomms4396"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103477"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","2041-1723"],["dc.title","Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]