Radulovic, Jelena

[["dc.bibliographiccitation.firstpage","786"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.lastpage","798"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Schrick, Christina"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Srivastava, Deepak P."],["dc.contributor.author","Tronson, Natalie C."],["dc.contributor.author","Penzes, Peter"],["dc.contributor.author","Radulovic, Jelena"],["dc.date.accessioned","2017-09-07T11:49:25Z"],["dc.date.available","2017-09-07T11:49:25Z"],["dc.date.issued","2007"],["dc.description.abstract","Cadherin-mediated interactions are integral to synapse formation and potentiation. Here we show that N-cadherin is required for memory formation and regulation of a subset of underlying biochemical processes. N-cadherin antagonistic peptide containing the His-Ala-Val motif (HAV-N) transiently disrupted hippocampal N-cadherin dimerization and impaired the formation of long-term contextual fear memory while sparing short-term memory, retrieval, and extinction. HAV-N impaired the learning-induced phosphorylation of a distinctive, cytoskeletally associated fraction of hippocampal Erk-1/2 and altered the distribution of IQGAP1, a scaffold protein linking cadherin-mediated cell adhesion to the cytoskeleton. This effect was accompanied by reduction of N-cadherin/ IQGAP1/Erk-2 interactions. Similarly, in primary neuronal cultures, HAV-N prevented NMDA-induced dendritic Erk-1/2 phosphorylation and caused relocation of IQGAP1 from dendritic spines into the shafts. The data suggest that the newly identified role of hippocampal N-cadherin in memory consolidation may be mediated, at least in part, by cytoskeletal IQGAP1/Erk signaling."],["dc.identifier.doi","10.1016/j.neuron.2007.07.034"],["dc.identifier.gro","3143441"],["dc.identifier.isi","000249857000014"],["dc.identifier.pmid","17785185"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/955"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: NIMH NIH HHS [R01 MH073669, R01 MH073669-02]"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0896-6273"],["dc.title","N-cadherin regulates cytoskeletally associated lQGAP1/ERK signaling and memory formation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","52"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Eckart, Klaus"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Radulovic, Marko"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Blank, Thomas"],["dc.contributor.author","Stiedl, Oliver"],["dc.contributor.author","Spiess, Joachim"],["dc.date.accessioned","2021-12-08T12:28:35Z"],["dc.date.available","2021-12-08T12:28:35Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.199952286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95748"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Actions of CRF and Its Analogues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","209"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Magnetic Resonance Imaging"],["dc.bibliographiccitation.lastpage","215"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:27Z"],["dc.date.available","2017-09-07T11:45:27Z"],["dc.date.issued","2006"],["dc.description.abstract","This magnetic resonance imaging (MRI) study describes mapping of the habenulo-interpeduncular pathway in living mice based on manganese-induced contrast. Six hours after intracerebroventricular microinjection of MnCl2, T1-weighted 3D MRI (2.35 T) at 117 μm isotropic resolution revealed a continuous pattern of anterograde labeling from the habenula via the fasciculus retroflexus to the interpeduncular nucleus. Alternatively, the less invasive systemic administration of MnCl2 allowed for monitoring of the dynamic uptake pattern of respective neural components with even higher reproducibility across animals. Time courses covered the range from 42 min to 24 h after injection. In conclusion, manganese-enhanced MRI may open new ways for functional assessments of the habenulo-interpeduncular system in animal models with cognitive impairment."],["dc.identifier.doi","10.1016/j.mri.2005.10.034"],["dc.identifier.gro","3150377"],["dc.identifier.pmid","16563949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7135"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0730-725X"],["dc.subject","Habenula; Magnetic resonance imaging; Manganese; Mice; Neural pathways"],["dc.title","Mapping of the habenulo-interpeduncular pathway in living mice using manganese-enhanced 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","463"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular and Cellular Neuroscience"],["dc.bibliographiccitation.lastpage","476"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Sananbenesi, Farahnaz"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Schrick, Christina"],["dc.contributor.author","Spiess, Joachim"],["dc.contributor.author","Radulovic, Jelena"],["dc.date.accessioned","2017-09-07T11:45:13Z"],["dc.date.available","2017-09-07T11:45:13Z"],["dc.date.issued","2002"],["dc.description.abstract","The phosphorylation of proteins involved in the MAP kinase signal transduction pathway was investigated during associative learning of C57BL/6J mice. Context-dependent fear conditioning, consisting of a single exposure of mice to a context followed by foot shock, was employed as a learning paradigm. Control groups consisted of mice exposed to context only or an immediate shock in the context. Coincident up-regulation of phosphorylated Erk-1/2 and Elk-1 was observed in the CA3 hippocampal subfield and dentate gyrus 30 min after fear conditioning but not after the control paradigms. Phosphorylated Erk-1/2 and Elk-1 were associated and predominantly colocalized in the mossy fibers. In vitro kinase assays showed that hippocampal Erk-1/2 phosphorylates Elk-1. Notably, Elk-1 in turn enhances the phosphorylation of Erk-1/2 and its downstream target p90Rsk-1. Increased phosphorylation and nuclear translocation of p90Rsk-1 was also demonstrated in the CA3 hippocampal area in vivo during contextual fear conditioning. The observed interactions between hippocampal Elk-1 and Erk-1/2 proteins may affect the consolidation of contextual memories through activation of the downstream nuclear targets of Erk-1/2, such as p90Rsk-1, without requiring nuclear translocation of Elk-1 and Erk-1/2."],["dc.identifier.doi","10.1006/mcne.2002.1188"],["dc.identifier.gro","3144158"],["dc.identifier.isi","000180054800008"],["dc.identifier.pmid","12498787"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1751"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1044-7431"],["dc.title","Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: Interactions between Erk-1/2 and Elk-1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1962"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The Journal of neuroscience"],["dc.bibliographiccitation.lastpage","1966"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Sananbenesi, Farahnaz"],["dc.contributor.author","Schrick, Christina"],["dc.contributor.author","Spiess, Joachim"],["dc.contributor.author","Radulovic, Jelena"],["dc.date.accessioned","2017-09-07T11:43:59Z"],["dc.date.available","2017-09-07T11:43:59Z"],["dc.date.issued","2004"],["dc.description.abstract","It is believed that de novo protein synthesis is fundamentally linked to synaptic changes in neuronal circuits involved in acquisition and extinction of conditioned responses. Recent studies show that neuronal plasticity may be also altered by cytoskeletal rearrangement independently of protein synthesis. We investigated the role of these processes in the hippocampus during acquisition and extinction of context-dependent conditioned fear in mice. Intrahippocampal injections of the protein synthesis inhibitors anisomycin and puromycin, or of the actin rearrangement inhibitors cytochalasin D and latrunculin A, prevented the acquisition of context-dependent fear. Unexpectedly, anisomycin and puromycin enhanced extinction without erasing the fear memory. In contrast, cytochalasin D and latrunculin A prevented extinction of context-dependent freezing. On the basis of these findings, it is suggested that certain hippocampal mechanisms mediating extinction of conditioned contextual fear are inhibited by protein synthesis and involve actin rearrangement. Such mechanisms might predominantly elicit modifications of hippocampal circuits that store the conditioning memory."],["dc.identifier.doi","10.1523/JNEUROSCI.5112-03.2004"],["dc.identifier.gro","3144009"],["dc.identifier.isi","000189210300020"],["dc.identifier.pmid","14985438"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1586"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0270-6474"],["dc.title","Distinct roles of hippocampal de novo protein synthesis and actin rearrangement in extinction of contextual fear"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","860"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","867"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Spiess, Joachim"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:29Z"],["dc.date.available","2017-09-07T11:45:29Z"],["dc.date.issued","2004"],["dc.description.abstract","The morphology and function of the hippocampal system of C57BL/6J mice (n = 8) was studied in vivo using T1-weighted 3D magnetic resonance imaging (MRI) (117 μm isotropic resolution) after bilateral injection of MnCl2 (0.25 μl, 5 or 200 mM) into the posterior hippocampal formation. The neuronal uptake of the T1-shortening Mn2+ ions resulted in a pronounced MRI signal enhancement within the CA3 subfield and dentate gyrus with milder increases in CA1 and subiculum. This finding is in line with differences in the excitability of hippocampal neurons previously reported using electrophysiologic recordings. The subsequent axonal transport of Mn2+ highlighted the principal extrinsic projections from the posterior hippocampal formation via the fimbria and the precommissural fornix to the dorsal part of the lateral septal nucleus. A strong MRI signal enhancement was also observed in the ventral hippocampal commissure. A time-course analysis revealed unsaturated conditions of Mn2+ accumulation at about 2 h after injection and optimal contrast-to-noise ratios at about 6 h after injection. The present results using Mn2+-enhanced 3D MRI open new ways for studying the role of the hippocampal system in specific aspects of learning and memory in normal and mutant mice."],["dc.identifier.doi","10.1016/j.neuroimage.2004.01.028"],["dc.identifier.gro","3150384"],["dc.identifier.pmid","15193616"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7143"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1053-8119"],["dc.subject","Hippocampus; Efferent pathways; Fornix; Manganese-enhanced MRI; Neuroanatomic tracing"],["dc.title","In vivo 3D MRI staining of the mouse hippocampal system using intracerebral injection of MnCl2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3700"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","The Journal of neuroscience"],["dc.bibliographiccitation.lastpage","3707"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Sananbenesi, Farahnaz"],["dc.contributor.author","Schrick, Christina"],["dc.contributor.author","Spiess, Joachim"],["dc.contributor.author","Radulovic, Jelena"],["dc.date.accessioned","2017-09-07T11:45:54Z"],["dc.date.available","2017-09-07T11:45:54Z"],["dc.date.issued","2002"],["dc.description.abstract","Transient stressful experiences may persistently facilitate associative and nonassociative learning, possibly through alterations of gene expression. Here we identify, by subtractive hybridization, differential expression of the Cdk5 gene in response to stress. The Cdk5 protein is selectively induced in the fibers of septohippocampal cholinergic neurons but not in other regions of prominent Cdk5 production. This upregulation is accompanied by increased Cdk5 kinase activity, which is blocked completely by the Cdk5 inhibitor butyrolactone I. Microinjection of butyrolactone I into the lateral septum and hippocampus prevents the acquisition of conditioned context-dependent fear as well as its stress-induced facilitation. By demonstrating that a transient increase of Cdk5 activity within the septohippocampal system is required for associative learning, an important novel role of Cdk5 has been identified."],["dc.identifier.doi","10.1523/JNEUROSCI.22-09-03700.2002"],["dc.identifier.gro","3144203"],["dc.identifier.isi","000175296200047"],["dc.identifier.pmid","11978846"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1802"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0270-6474"],["dc.title","Cyclin-dependent kinase 5 is required for associative learning"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","203"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Michaelis, Thomas"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2002"],["dc.description.abstract","This work demonstrates technical approaches to high-quality magnetic resonance imaging (MRI) of small structures of the mouse brain in vivo. It turns out that excellent soft-tissue contrast requires the reduction of partial volume effects by using 3D MRI at high (isotropic) resolution with linear voxel dimensions of about 100–150 μm. The long T2 relaxation times at relatively low magnetic fields (2.35 T) offer the benefit of a small receiver bandwidth (increased signal-to-noise) at a moderate echo time which together with the small voxel size avoids visual susceptibility artifacts. For measuring times of 1–1.5 h both T1-weighted (FLASH) and T2-weighted (Fast Spin-Echo) 3D MRI acquisitions exhibit detailed anatomical insights in accordance with histological sections from a mouse brain atlas. Preliminary applications address the identification of neuroanatomical variations in different mouse strains and the use of Mn2+ as a T1 contrast agent for neuroaxonal tracing of fiber tracts within the mouse visual pathway."],["dc.identifier.doi","10.1016/s0165-0270(02)00211-x"],["dc.identifier.gro","3150389"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7148"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0165-0270"],["dc.title","High-resolution 3D MRI of mouse brain reveals small cerebral structures in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","271"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Molecular Brain Research"],["dc.bibliographiccitation.lastpage","280"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Radulovic, Jelena"],["dc.contributor.author","Blank, Thomas"],["dc.contributor.author","Nijholt, Ingrid"],["dc.contributor.author","Kammermeier, Jens"],["dc.contributor.author","Spiess, Joachim"],["dc.date.accessioned","2021-06-01T10:50:11Z"],["dc.date.available","2021-06-01T10:50:11Z"],["dc.date.issued","2000"],["dc.identifier.doi","10.1016/S0169-328X(99)00322-8"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86566"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0169-328X"],["dc.title","In vivo NMDA/dopamine interaction resulting in Fos production in the limbic system and basal ganglia of the mouse brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1089"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neuropharmacology"],["dc.bibliographiccitation.lastpage","1099"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Fischer, André"],["dc.contributor.author","Sananbenesi, Farahnaz"],["dc.contributor.author","Schrick, Christina"],["dc.contributor.author","Spiess, Joachim"],["dc.contributor.author","Radulovic, Jelena"],["dc.date.accessioned","2021-06-01T10:50:06Z"],["dc.date.available","2021-06-01T10:50:06Z"],["dc.date.issued","2003"],["dc.description.abstract","In this work, we confirm the novel role of cyclin-dependent kinase (Cdk) 5 in associative learning by demonstrating that injection of the Cdk5 inhibitor butyrolactone I into the lateral septum or hippocampus profoundly impaired context-dependent fear conditioning of C57BL/6J mice. However, unlike the inducible up regulation of Cdk5 and its regulator p35 observed in Balb/c mice, high baseline levels, which were not affected by fear conditioning, were found in C57BL/6J mice. Surprisingly, microinjections of butyrolactone I into the lateral septum or hippocampus significantly decreased baseline Cdk5 activity within the entire septohippocampal circuitry, suggesting a functional link between septal and hippocampal Cdk5 activity. Significantly higher levels of the transcription factor Sp4 in the septo-hippocampal system of C57BL/6J mice may account for the high baseline Cdk5/p35 production. On the other hand, the stronger cFos production observed in the lateral septum of fear conditioned Balb/c mice may be responsible, at least in part, for the inducible up-regulation of Cdk5 in this strain. These results suggest that the role of Cdk5 in memory consolidation is strain independent and functionally related to the septo-hippocampal circuitry. However, the molecular regulation of baseline and inducible Cdk5 protein might be different among individual mouse strains and possibly other species."],["dc.identifier.doi","10.1016/S0028-3908(03)00102-3"],["dc.identifier.gro","3144104"],["dc.identifier.isi","000183374900011"],["dc.identifier.pmid","12763101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86532"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0028-3908"],["dc.title","Regulation of contextual fear conditioning by baseline and inducible septo-hippocampal cyclin-dependent kinase 5"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]