Larionov, Oleg V.

[["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Lygin, Alexander V."],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Korotkov, Vadim S."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2021-12-08T12:29:43Z"],["dc.date.available","2021-12-08T12:29:43Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1002/chin.200918119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/96186"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Oligosubstituted Pyrroles Directly from Substituted Methyl Isocyanides and Acetylenes."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Kozhushkov, Sergei I."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2021-12-08T12:29:21Z"],["dc.date.available","2021-12-08T12:29:21Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1002/chin.200521082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/96049"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Facile Preparation of tert-Butyl 1-tert-Butoxycarbonylaminocyclopent-3-enecarboxylate from Inexpensive Starting Materials."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6363"],["dc.bibliographiccitation.issue","31"],["dc.bibliographiccitation.journal","Organic & Biomolecular Chemistry"],["dc.bibliographiccitation.lastpage","6374"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Korotkov, Vadim S."],["dc.contributor.author","Lygin, Alexander V."],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Sokolov, Viktor V."],["dc.contributor.author","Graef, Tine"],["dc.contributor.author","Es-Sayed, Mazen"],["dc.date.accessioned","2018-11-07T09:15:11Z"],["dc.date.available","2018-11-07T09:15:11Z"],["dc.date.issued","2012"],["dc.description.abstract","Successful biochemical studies of the natural products belactosin A and C and their acylated congeners have shown a beta-lactonecarboxamide moiety to be a possible core structure of powerful proteasome inhibitors. As a part of further investigations, variously decorated simplified beta-lactonecarboxamides have been synthesized in order to understand structure-biological activity relations in detail, to find ways of improving their biological activity and stability and to reduce the complexity of their preparation. Biological tests showed that the best compounds possess a high potential against phytopathogenic fungi in the greenhouse."],["dc.identifier.doi","10.1039/c2ob25586c"],["dc.identifier.isi","000306480100015"],["dc.identifier.pmid","22735304"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10202"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27613"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1477-0520"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Synthesis and biological activity of simplified belactosin C analogues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","869"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","877"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Savel'eva, T. F."],["dc.contributor.author","Kochetkov, K. A."],["dc.contributor.author","Ikonnokov, N. S."],["dc.contributor.author","Kozhushkov, Sergei I."],["dc.contributor.author","Yufit, Dmitry S."],["dc.contributor.author","Howard, JAK"],["dc.contributor.author","Khrustalev, V. N."],["dc.contributor.author","Belokon, Y. N."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T10:40:20Z"],["dc.date.available","2018-11-07T10:40:20Z"],["dc.date.issued","2003"],["dc.description.abstract","All four diastereomers of 3 - (trans-2-nitrocyclopropyl) alanine (3) were prepared by asymmetrically induced a-C alkylation of the glycine moiety in the [(S)- or (R)-Schiff base]Ni-II complex 7, employing racemic trans-1-(iodomethyl)-2-nitrocyclopropane (8) as the alkylating agent. A notable difference in solubility between the two diastereomeric products 9a/9b [when (S)-7 was used as starting material] or 9d/9e [when (R)-7 was employed] allowed for their separation from the same reaction mixture. All the diastereomers of 3-(trans-2nitrocyclopropyl)alanine (3) were produced upon brief exposure of the alkylation products 9 to dilute hydrochloric acid, with subsequent purification by ion-exchange chromatography and crystallization. The absolute configurations of the nickel complexes 9a-e were established by X-ray crystallographic analyses. In addition, the X-ray crystal structure of (2S,1'S,2'R)-3 was determined to confirm the convergence of the configurations of the parent nickel complexes 9 with those of the amino acids 3 derived from them. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003."],["dc.identifier.isi","000181301200010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46282"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1434-193X"],["dc.title","Productive asymmetric synthesis of all four diastereomers of 3-(trans-2-nitrocyclopropyl)alanine from glycine with (S)- or (R)-2-[(N-benzylprolyl)amino]benzophenone as a reusable chiral auxiliary"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5664"],["dc.bibliographiccitation.issue","35"],["dc.bibliographiccitation.journal","Angewandte Chemie International Edition"],["dc.bibliographiccitation.lastpage","5667"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T08:33:43Z"],["dc.date.available","2018-11-07T08:33:43Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1002/anie.200502140"],["dc.identifier.isi","000231769300017"],["dc.identifier.pmid","16118829"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17647"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1433-7851"],["dc.title","Versatile direct synthesis of oligosubstituted pyrroles by cycloaddition of alpha-metalated isocyanides to acetylenes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","158"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Synthesis"],["dc.bibliographiccitation.lastpage","160"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Kozhushkov, S."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T08:32:52Z"],["dc.date.available","2018-11-07T08:32:52Z"],["dc.date.issued","2005"],["dc.description.abstract","1,5-C,C-Cycloalkylation of tert-butyl acetoacetate (1) with cis-1,4-dichloro-2-butene (2) followed by the haloform reaction of the product in NaOH solution and subsequent Curtius degradation in tert-butyl alcohol furnished tert-butyl 1-tert-butoxycarbonylaminocyclopent-3-enecarboxylate (5) in 32% overall yield."],["dc.identifier.doi","10.1055/s-2004-831218"],["dc.identifier.isi","000226258700023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17436"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0039-7881"],["dc.title","Facile preparation of tert-butyl 1-tert-butoxycarbonylaminocyclopent-3-enecarboxylate from inexpensive starting materials"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1071"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Advanced Synthesis & Catalysis"],["dc.bibliographiccitation.lastpage","1078"],["dc.bibliographiccitation.volume","348"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T09:42:02Z"],["dc.date.available","2018-11-07T09:42:02Z"],["dc.date.issued","2006"],["dc.description.abstract","A facile three-step synthesis of racemic cyclopropylglycine in multigram quantities from inexpensive cyclopropyl methyl ketone has been elaborated. Enzymatic hydrolysis of the N-Boc-protected methyl ester of cyclopropylglycine 9 with the inexpensive enzyme papain from Carica papaya affords both enantiomers of cyclopropylglycine (8) with enantiomeric excesses of 99% or better after deprotection under acidic conditions. Furthermore, the new cyclopropyl group-containing building block methyl 2-cyclopropyl-2-N-Boc-iminoacetate (13) was prepared by N-chlorination and subsequent dehydrochlorination with 1.8-diazabicyclo[5.4.0]undec-7-ene (DBU). Addition of nucleophiles to 13 offers a ready access to an unusual. orthogonally bisprotected alpha,alpha-diamino acid derivative and interesting components of rigid peptide backbones."],["dc.identifier.doi","10.1002/adsc.200606038"],["dc.identifier.isi","000238845900013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33868"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1615-4150"],["dc.title","Practical syntheses of both enantiomers of cyclopropylglycine and of methyl 2-cyclopropyl-2-N-Boc-iminoacetate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Korotkov, Vadim S."],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2021-12-08T12:29:33Z"],["dc.date.available","2021-12-08T12:29:33Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1002/chin.200712053"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/96119"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Cyclopropyl Building Blocks for Organic Synthesis. Part 128. Ln(OTf)3-Catalyzed Insertion of Aryl Isocyanides into the Cyclopropane Ring."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","137"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Physiology and Biochemistry"],["dc.bibliographiccitation.lastpage","146"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Muthny, T."],["dc.contributor.author","Kovarik, M."],["dc.contributor.author","Sispera, L."],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Tilser, I."],["dc.contributor.author","Holecek, M."],["dc.date.accessioned","2018-11-07T08:29:28Z"],["dc.date.available","2018-11-07T08:29:28Z"],["dc.date.issued","2009"],["dc.description.abstract","T. MUTHNY, M. KOVARIK, L. SISPERA, A. DE-MEIJERE, ON. LARIONOV, I. TILSER and M. HOLECEK. The effect of new proteasome inbibitors, belactosin A and Q on protein metabolism in isolated rat skeletal muscle. J Physiol Biochem, 65 (2), 137-146, 2009. The proteasome inhibitors are used as research tools to study of the ATP-dependent ubiquitin-proteasome system. Some of them are at present undergoing clinical trials to be used as therapeutic agents for cancer or inflammation. These diseases are often accompanied by muscle wasting. We herein demonstrate findings about new proteasome inhibitors, belactosin A and C, and their direct effect on protein metabolism in rat skeletal muscle. M. soleus (SOL) and in. extensor digitorum longus (EDL) were dissected from both legs of male rats (40-60g) and incubated in a buffer containing belactosin A or C (30 mu M) or no inhibitor. The release of amino acids into the medium was estimated using high performance liquid chromatography to calculate total and myofibrillar proteolysis. Chymotrypsin-like activity (CTLA) of proteasome and cathepsin B, L activity were determined by fluorometric assay. Protein synthesis and leucine oxidation were detected using specific activity of L-[1-C-14] leucine added to medium. Inhibited and control muscles from the same rat were compared using paired t-test. The results indicate that after incubation with both belactosin A and C total proteolysis and CTLA of proteasome decreased while cathepsin B, L activity did not change in both SOL and EDL. Leucine oxidation was significantly enhanced in SOL, protein synthesis decreased in EDL. Myofibrillar proteolysis was reduced in both muscles in the presence of belactosin A only. In summary, belactosin A and C affected basic parameters of protein metabolism in rat skeletal muscle. The response was both muscle- and belactosin-type-dependent."],["dc.description.sponsorship","MSM [0021620820]"],["dc.identifier.isi","000270603700004"],["dc.identifier.pmid","19886392"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16661"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Servicio Publicaciones Universidad Navarra"],["dc.relation.issn","1877-8755"],["dc.relation.issn","1138-7548"],["dc.title","The effect of new proteasome inhibitors, belactosin A and C, on protein metabolism in isolated rat skeletal muscle"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2153"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Organic Letters"],["dc.bibliographiccitation.lastpage","2156"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T10:48:01Z"],["dc.date.available","2018-11-07T10:48:01Z"],["dc.date.issued","2004"],["dc.description.abstract","Enantioselective total syntheses of belactosin A, belactosin C, and its homoanalogue have been accomplished in high overall yields (32% for belactosin A from the amino acid 10, and 35 and 36% for belactosin C and its homoanalogue, respectively). This concise approach comprises a novel sequential acylation/beta-lactonization reaction and allows a facile alteration of the substituents, thus providing a flexible route to a new family of highly active belactosin-based proteasome inhibitors."],["dc.identifier.doi","10.1021/ol049409"],["dc.identifier.isi","000222119400019"],["dc.identifier.pmid","15200308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48100"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.relation.issn","1523-7060"],["dc.title","Enantioselective total syntheses of belactosin A, belactosin C, and its homoanalogue"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]