Mey, Ingo P.

[["dc.bibliographiccitation.firstpage","126a"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Schön, Markus"],["dc.contributor.author","Kramer, Corinna"],["dc.contributor.author","Noeding, Helen"],["dc.contributor.author","Mey, Ingo"],["dc.contributor.author","Janshoff, Andreas"],["dc.contributor.author","Steinem, Claudia"],["dc.date.accessioned","2020-12-10T14:22:43Z"],["dc.date.available","2020-12-10T14:22:43Z"],["dc.date.issued","2016"],["dc.format.extent","126A"],["dc.identifier.doi","10.1016/j.bpj.2015.11.727"],["dc.identifier.isi","000375093800128"],["dc.identifier.issn","0006-3495"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71703"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.publisher.place","Cambridge"],["dc.relation.eventlocation","Los Angeles, CA"],["dc.relation.issn","1542-0086"],["dc.relation.issn","0006-3495"],["dc.title","Self-Organization of Actomyosin Networks Attached to Artificial Membranes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","8186"],["dc.bibliographiccitation.issue","27"],["dc.bibliographiccitation.journal","Langmuir"],["dc.bibliographiccitation.lastpage","8192"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Kuhlmann, Jan W."],["dc.contributor.author","Mey, Ingo P."],["dc.contributor.author","Steinem, Claudia"],["dc.date.accessioned","2017-09-07T11:45:42Z"],["dc.date.available","2017-09-07T11:45:42Z"],["dc.date.issued","2014"],["dc.description.abstract","The plasma membrane of animal cells is attached to the cytoskeleton, which significantly contributes to the lateral tension of the membrane. Lateral membrane tension has been shown to be an important physical regulator of cellular processes such as cell motility and morphology as well as exo- and endocytosis. Here, we report on lipid bilayers spanning highly ordered pore arrays, where we can control the lateral membrane tension by chemically varying the surface functionalization of the porous substrate. Surface functionalization was achieved by a gold coating on top of the pore rims of the hexagonal array of pores in silicon nitride substrates with pore radii of 600 nm followed by subsequent incubation with various n-propanolic mixtures of 6-mercapto-1-hexanol (6MH) and O-cholesteryl N-(8'-mercapto-3',6'-dioxaoctyl)carbamate (CPEO3). Pore-spanning membranes composed of 1,2-diphytanoyl-sn-glycero-3-phosphocholine were prepared by spreading giant unilarnellar vesicles on these functionalized porous silicon nitride substrates. Different mixtures of 6MH and CPEO3 provided self-assembled monolayers (SAMs) with different compositions as analyzed by contact angle and PM-IRRAS measurements. Site specific force-indentation experiments on the pore-spanning membranes attached to the different SAMs revealed a clear dependence of the amount of CPEO3 in the monolayer on the lateral membrane tension. While bilayers on pure 6MH monolayers show an average lateral membrane tension of 1.4 mN m(-1), a mixed monolayer of CPEO3 and 6MH obtained from a solution with 9.1 mol % CPEO3 exhibits a lateral tension of 5.0 mN m(-1). From contact angle and PM-IRRAS results, the mole fraction of CPEO3 in solution can be roughly translated into a CPEO3 surface concentration of 40 mol %. Our results clearly demonstrate that the free energy difference between the supported and freestanding part of the membrane depends on the chemical composition of the SAM, which controls the lateral membrane tension."],["dc.identifier.doi","10.1021/la5019086"],["dc.identifier.gro","3142088"],["dc.identifier.isi","000339229000031"],["dc.identifier.pmid","24950370"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4411"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: DFG [SFB 803]"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0743-7463"],["dc.title","Modulating the Lateral Tension of Solvent-Free Pore-Spanning Membranes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","140046"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Open Biology"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Rother, Jan"],["dc.contributor.author","Nöding, Helen"],["dc.contributor.author","Mey, Ingo"],["dc.contributor.author","Janshoff, Andreas"],["dc.date.accessioned","2019-07-09T11:41:15Z"],["dc.date.available","2019-07-09T11:41:15Z"],["dc.date.issued","2014-05-01"],["dc.description.abstract","Mechanical phenotyping of cells by atomic force microscopy (AFM) was proposed as a novel tool in cancer cell research as cancer cells undergo massive structural changes, comprising remodelling of the cytoskeleton and changes of their adhesive properties. In this work, we focused on the mechanical properties of human breast cell lines with different metastatic potential by AFM-based microrheology experiments. Using this technique, we are not only able to quantify the mechanical properties of living cells in the context of malignancy, but we also obtain a descriptor, namely the loss tangent, which provides model-independent information about the metastatic potential of the cell line. Including also other cell lines from different organs shows that the loss tangent (G″/G') increases generally with the metastatic potential from MCF-10A representing benign cells to highly malignant MDA-MB-231 cells."],["dc.identifier.doi","10.1098/rsob.140046"],["dc.identifier.fs","609535"],["dc.identifier.pmid","24850913"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58382"],["dc.language.iso","en"],["dc.relation.issn","2046-2441"],["dc.rights.access","openAccess"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Breast Neoplasms"],["dc.subject.mesh","Cell Line"],["dc.subject.mesh","Dogs"],["dc.subject.mesh","Elasticity"],["dc.subject.mesh","Female"],["dc.subject.mesh","Humans"],["dc.subject.mesh","MCF-7 Cells"],["dc.subject.mesh","Mice"],["dc.subject.mesh","Microscopy, Atomic Force"],["dc.subject.mesh","Models, Biological"],["dc.subject.mesh","NIH 3T3 Cells"],["dc.subject.mesh","Neoplasm Metastasis"],["dc.title","Atomic force microscopy-based microrheology reveals significant differences in the viscoelastic response between malign and benign cell lines."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","eabg2174"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Science Advances"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Antonschmidt, Leif"],["dc.contributor.author","Dervişoğlu, Rıza"],["dc.contributor.author","Sant, Vrinda"],["dc.contributor.author","Tekwani Movellan, Kumar"],["dc.contributor.author","Mey, Ingo P."],["dc.contributor.author","Riedel, Dietmar"],["dc.contributor.author","Steinem, Claudia"],["dc.contributor.author","Becker, Stefan T."],["dc.contributor.author","Andreas, Loren B."],["dc.contributor.author","Griesinger, Christian"],["dc.date.accessioned","2021-06-01T09:42:06Z"],["dc.date.available","2021-06-01T09:42:06Z"],["dc.date.issued","2021"],["dc.description.abstract","Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structures, yet little is known about the process of fibril aggregate formation. Characterization of intermediate species that form during aggregation is crucial; however, this has proven very challenging because of their transient nature, heterogeneity, and low population. Here, we investigate the aggregation of α-synuclein bound to negatively charged phospholipid small unilamellar vesicles. Through a combination of kinetic and structural studies, we identify key time points in the aggregation process that enable targeted isolation of prefibrillar and early fibrillar intermediates. By using solid-state nuclear magnetic resonance, we show the gradual buildup of structural features in an α-synuclein fibril filament, revealing a segmental folding process. We identify distinct membrane-binding domains in α-synuclein aggregates, and the combined data are used to present a comprehensive mechanism of the folding of α-synuclein on lipid membranes."],["dc.identifier.doi","10.1126/sciadv.abg2174"],["dc.identifier.pmid","33990334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85143"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/259"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","2375-2548"],["dc.relation.workinggroup","RG Griesinger"],["dc.relation.workinggroup","RG Steinem (Biomolecular Chemistry)"],["dc.rights","CC BY-NC 4.0"],["dc.title","Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18604"],["dc.bibliographiccitation.issue","52"],["dc.bibliographiccitation.journal","Journal of Biological Chemistry"],["dc.bibliographiccitation.lastpage","18613"],["dc.bibliographiccitation.volume","295"],["dc.contributor.author","Schäfer, Jonas"],["dc.contributor.author","Förster, Lucas"],["dc.contributor.author","Mey, Ingo"],["dc.contributor.author","Papadopoulos, Theofilos"],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Steinem, Claudia"],["dc.date.accessioned","2021-04-14T08:25:50Z"],["dc.date.available","2021-04-14T08:25:50Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1074/jbc.RA120.015347"],["dc.identifier.pmid","33127642"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81745"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/62"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | A09: SUMOylation und Neddylation in Synapsen"],["dc.relation","SFB 1286 | B04: In vitro Rekonstitution von inhibitorischen GABAergen Postsynapsen"],["dc.relation.issn","0021-9258"],["dc.relation.workinggroup","RG Brose"],["dc.relation.workinggroup","RG Steinem (Biomolecular Chemistry)"],["dc.rights","CC BY 4.0"],["dc.title","Neuroligin-2 dependent conformational activation of collybistin reconstituted in supported hybrid membranes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6831"],["dc.bibliographiccitation.issue","36"],["dc.bibliographiccitation.journal","CrystEngComm"],["dc.bibliographiccitation.lastpage","6837"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Harris, Joe"],["dc.contributor.author","Mey, Ingo"],["dc.contributor.author","Hajir, M."],["dc.contributor.author","Mondeshki, M."],["dc.contributor.author","Wolf, Stephan E."],["dc.date.accessioned","2018-11-07T10:02:57Z"],["dc.date.available","2018-11-07T10:02:57Z"],["dc.date.issued","2015"],["dc.description.abstract","Amorphous calcium carbonate films synthesized by the polymer-induced liquid-precursor (PILP) process convert into crystallographically complex calcite spherulites. Tuning the experimental parameters allows for the generation of crystal lattice tilting similar to that found in calcareous biominerals. This contribution evidences the role of spherulitic growth mechanisms in pseudomorphic transformations of calcium carbonate."],["dc.identifier.doi","10.1039/c5ce00441a"],["dc.identifier.isi","000361139300005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38340"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1466-8033"],["dc.title","Pseudomorphic transformation of amorphous calcium carbonate films follows spherulitic growth mechanisms and can give rise to crystal lattice tilting"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6329"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Nano Letters"],["dc.bibliographiccitation.lastpage","6335"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Hubrich, Hanna"],["dc.contributor.author","Mey, Ingo P."],["dc.contributor.author","Brückner, Bastian R."],["dc.contributor.author","Mühlenbrock, Peter"],["dc.contributor.author","Nehls, Stefan"],["dc.contributor.author","Grabenhorst, Lennart"],["dc.contributor.author","Oswald, Tabea"],["dc.contributor.author","Steinem, Claudia"],["dc.contributor.author","Janshoff, Andreas"],["dc.date.accessioned","2020-11-05T15:08:07Z"],["dc.date.available","2020-11-05T15:08:07Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1021/acs.nanolett.0c01769"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68468"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-352.7"],["dc.relation.eissn","1530-6992"],["dc.relation.issn","1530-6984"],["dc.title","Viscoelasticity of Native and Artificial Actin Cortices Assessed by Nanoindentation Experiments"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Biophysics Journal"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Gleisner, M."],["dc.contributor.author","Dreker, C."],["dc.contributor.author","Mey, Ingo"],["dc.contributor.author","Meinecke, Michael"],["dc.contributor.author","Steinem, Claudia"],["dc.date.accessioned","2018-11-07T09:22:32Z"],["dc.date.available","2018-11-07T09:22:32Z"],["dc.date.issued","2013"],["dc.format.extent","S122"],["dc.identifier.isi","000330215300334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29365"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.eventlocation","Lisbon, PORTUGAL"],["dc.relation.issn","1432-1017"],["dc.relation.issn","0175-7571"],["dc.relation.orgunit","Institut für Zellbiochemie"],["dc.title","Pore spanning membranes as a model system for the selective generation of membrane curvature"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1320"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Langmuir"],["dc.bibliographiccitation.lastpage","1328"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Schäfer, Jonas"],["dc.contributor.author","Nehls, Jessica"],["dc.contributor.author","Schön, Markus"],["dc.contributor.author","Mey, Ingo"],["dc.contributor.author","Steinem, Claudia"],["dc.date.accessioned","2020-12-10T15:22:49Z"],["dc.date.available","2020-12-10T15:22:49Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1021/acs.langmuir.9b03793"],["dc.identifier.pmid","31951413"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73545"],["dc.identifier.url","https://sfb1286.uni-goettingen.de/literature/publications/44"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1286: Quantitative Synaptologie"],["dc.relation","SFB 1286 | B04: In vitro Rekonstitution von inhibitorischen GABAergen Postsynapsen"],["dc.relation.workinggroup","RG Steinem (Biomolecular Chemistry)"],["dc.title","Leaflet-Dependent Distribution of PtdIns[4,5]P 2 in Supported Model Membranes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.seriesnr","260"],["dc.contributor.author","Berger, R."],["dc.contributor.author","Binder, K."],["dc.contributor.author","Diezemann, G."],["dc.contributor.author","Gauss, J."],["dc.contributor.author","Helm, M."],["dc.contributor.author","Hsu, H.-P."],["dc.contributor.author","Janshoff, Andreas"],["dc.contributor.author","Metzroth, T."],["dc.contributor.author","Mey, I."],["dc.contributor.author","Milchev, A."],["dc.contributor.author","Paul, W."],["dc.contributor.author","Rostiashvili, V. G."],["dc.contributor.author","Vilgis, T. A."],["dc.contributor.editor","Basché, Thomas"],["dc.contributor.editor","Müllen, Klaus"],["dc.contributor.editor","Schmidt, Manfred"],["dc.date.accessioned","2022-03-01T11:47:00Z"],["dc.date.available","2022-03-01T11:47:00Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1007/12_2013_266"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103881"],["dc.notes.intern","DOI-Import GROB-531"],["dc.publisher","Springer International Publishing"],["dc.publisher.place","Cham"],["dc.relation.crisseries","Advances in Polymer Science"],["dc.relation.eisbn","978-3-319-05828-3"],["dc.relation.isbn","978-3-319-05827-6"],["dc.relation.ispartof","From Single Molecules to Nanoscopically Structured Materials"],["dc.title","Mechanical Properties of Single Molecules and Polymer Aggregates"],["dc.type","book_chapter"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]