Reinhardt, Manuel

[["dc.bibliographiccitation.firstpage","1535"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Biogeosciences"],["dc.bibliographiccitation.lastpage","1548"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","Thiel, Volker"],["dc.contributor.author","Bauersachs, Thorsten"],["dc.contributor.author","Mißbach, Helge"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Schäfer, Nadine"],["dc.contributor.author","Van Kranendonk, Martin J."],["dc.contributor.author","Reitner, Joachim"],["dc.date.accessioned","2019-07-09T11:45:21Z"],["dc.date.available","2019-07-09T11:45:21Z"],["dc.date.issued","2018"],["dc.description.abstract","Archaean hydrothermal chert veins commonly contain abundant organic carbon of uncertain origin (abiotic vs. biotic). In this study, we analysed kerogen contained in a hydrothermal chert vein from the ca. 3.5 Ga Dresser Formation (Pilbara Craton, Western Australia). Catalytic hydropyrolysis (HyPy) of this kerogen yielded n-alkanes up to n-C22, with a sharp decrease in abundance beyond n-C18. This distribution ( n-C18) is very similar to that observed in HyPy products of recent bacterial biomass, which was used as reference material, whereas it differs markedly from the unimodal distribution of abiotic compounds experimentally formed via Fischer–Tropsch-type synthesis. We therefore propose that the organic matter in the Archaean chert veins has a primarily microbial origin. The microbially derived organic matter accumulated in anoxic aquatic (surface and/or subsurface) environments and was then assimilated, redistributed and sequestered by the hydrothermal fluids (“hydrothermal pump hypothesis”)"],["dc.identifier.doi","10.5194/bg-15-1535-2018"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15113"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59212"],["dc.language.iso","en"],["dc.relation.issn","1726-4189"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.subject.ddc","550"],["dc.title","Ideas and perspectives: hydrothermally driven redistribution and sequestration of early Archaean biomass – the “hydrothermal pump hypothesis”"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","237"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Geobiology"],["dc.bibliographiccitation.lastpage","251"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","Blumenberg, Martin"],["dc.contributor.author","Ostertag-Henning, Christian"],["dc.contributor.author","Reitner, Joachim"],["dc.contributor.author","Heim, Christine N."],["dc.contributor.author","Thiel, Volker"],["dc.date.accessioned","2019-07-22T14:14:22Z"],["dc.date.available","2019-07-22T14:14:22Z"],["dc.date.issued","2018"],["dc.description.abstract","Fossil derivatives of isorenieratene, an accessory pigment in brown-colored green sulfur bacteria, are often used as tracers for photic zone anoxia through Earth's history, but their diagenetic behavior is still incompletely understood. Here, we assess the preservation of isorenieratene derivatives in organic-rich shales (1.5-8.4 wt.% TOC) from two Lower Jurassic anoxic systems (Bächental oil shale, Tyrol, Austria; Posidonia Shale, Baden-Württemberg, Germany). Bitumens and kerogens were investigated using catalytic hydropyrolysis (HyPy), closed-system hydrous pyrolysis (in gold capsules), gas chromatography-mass spectrometry (GC-MS) and gas chromatography combustion isotope ratio-mass spectrometry (GC-C-IRMS). Petrography and biomarkers indicate a syngenetic relationship between bitumens and kerogens. All bitumens contain abundant isorenieratane, diverse complex aromatized isorenieratene derivatives, and a pseudohomologous series of 2,3,6-trimethyl aryl isoprenoids. In contrast, HyPy and mild closed-system hydrous pyrolysis of the kerogens yielded only minor amounts of these compounds. Given the overall low maturity of the organic matter (below oil window), it appears that isorenieratene and its abundant derivatives from the bitumen had not been incorporated into the kerogens. Accordingly, sulfur cross-linking, the key mechanism for sequestration of functionalized lipids into kerogens in anoxic systems, was not effective in the Jurassic environments studied. We explain this by (i) early cyclization/aromatization and (ii) hydrogenation reactions that have prevented effective sulfurization. In addition, (iii) sulfide was locally removed via anoxygenic photosynthesis and efficiently trapped by the reaction with sedimentary iron, as further indicated by elevated iron contents (4.0-8.7 wt.%) and the presence of abundant pyrite aggregates in the rock matrix. Although the combined processes have hampered the kerogen incorporation of isorenieratene and its derivatives, they may have promoted the long-term preservation of these biomarkers in the bitumen fraction via early defunctionalization. This particular taphonomy of aromatic carotenoids has to be considered in studies of anoxic iron-rich environments (e.g., the Proterozoic ocean)."],["dc.identifier.doi","10.1111/gbi.12284"],["dc.identifier.pmid","29569335"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61823"],["dc.language.iso","en"],["dc.relation.eissn","1472-4669"],["dc.relation.issn","1472-4677"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.title","The taphonomic fate of isorenieratene in Lower Jurassic shales-controlled by iron?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S149"],["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.lastpage","S150"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Ladewig, G."],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Reinhardt, M."],["dc.contributor.author","Bendzsus, M."],["dc.contributor.author","Hauff, Peter"],["dc.contributor.author","Wiendl, Heinz"],["dc.contributor.author","Maurer, M."],["dc.date.accessioned","2018-11-07T10:56:28Z"],["dc.date.available","2018-11-07T10:56:28Z"],["dc.date.issued","2005"],["dc.identifier.isi","000232249900544"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50017"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hodder Arnold, Hodder Headline Plc"],["dc.publisher.place","London"],["dc.relation.conference","21st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/10th Annual Meeting of Rehabilitation in MS"],["dc.relation.eventlocation","Thessaloniki, GREECE"],["dc.relation.issn","1352-4585"],["dc.title","Molecular imaging and quantification of adhesion molecules in living animals with experimental autoimmune encephalomyelitis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Paläontologische Zeitschrift"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","König, Hannah"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Shuvalova, Julia"],["dc.contributor.author","Parkhaev, Pavel"],["dc.date.accessioned","2021-12-09T08:18:59Z"],["dc.date.available","2021-12-09T08:18:59Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s12542-021-00593-4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/96607"],["dc.language.iso","en"],["dc.relation.issn","0031-0220"],["dc.relation.issn","1867-6812"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.rights","CC BY 4.0"],["dc.title","Molecular fossils within bitumens and kerogens from the ~ 1 Ga Lakhanda Lagerstätte (Siberia, Russia) and their significance for understanding early eukaryote evolution"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Goetz, Walter"],["dc.contributor.author","Duda, Jan-Peter"],["dc.contributor.author","Heim, Christine"],["dc.contributor.author","Reitner, Joachim"],["dc.contributor.author","Thiel, Volker"],["dc.date.accessioned","2019-11-12T13:13:18Z"],["dc.date.available","2019-11-12T13:13:18Z"],["dc.date.issued","2019"],["dc.description.abstract","Lake Magadi cherts, analogs for Archean hydrothermal deposits, reveal archeal biomarkers in their kerogens despite deposition in an overall destructive hydrothermal environment."],["dc.identifier.doi","10.3997/2214-4609.201902897"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62601"],["dc.language.iso","en"],["dc.relation.conference","29th International Meeting on Organic Geochemistry (IMOG)"],["dc.relation.eventend","2019-09-06"],["dc.relation.eventlocation","Gothenburg, Sweden"],["dc.relation.eventstart","2019-09-01"],["dc.relation.isbn","978-94-6282-304-4"],["dc.relation.ispartof","29th International Meeting on Organic Geochemistry"],["dc.relation.issn","2214-4609"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.title","Characterizing Bitumens and Kerogens from Lake Magadi Cherts, Pleistocene Analogs for Archean Hydrothermal Deposits"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Immunology"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Reinhardt, M."],["dc.contributor.author","Bendszus, M."],["dc.contributor.author","Ladewig, G."],["dc.contributor.author","Hauff, Peter"],["dc.contributor.author","Maurer, M."],["dc.date.accessioned","2018-11-07T08:36:10Z"],["dc.date.available","2018-11-07T08:36:10Z"],["dc.date.issued","2005"],["dc.format.extent","S40"],["dc.identifier.isi","000229104400107"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18246"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.publisher.place","San diego"],["dc.relation.conference","5th Annual Meeting of the Federation-of-Clinical-Immunology-Society"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1521-6616"],["dc.title","Molecular imaging of adhesion molecules in experimental autoimmune encephalomyelitis (EAE)."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","267"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","278"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Reinhardt, M."],["dc.contributor.author","Hauff, Peter"],["dc.contributor.author","Linker, Ralf Andreas"],["dc.contributor.author","Briel, A."],["dc.contributor.author","Gold, Ralf"],["dc.contributor.author","Rieckmann, Peter"],["dc.contributor.author","Becker, G."],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Maurer, M."],["dc.contributor.author","Schirner, M."],["dc.date.accessioned","2018-11-07T10:56:48Z"],["dc.date.available","2018-11-07T10:56:48Z"],["dc.date.issued","2005"],["dc.description.abstract","Molecular imaging requires, not only the identification of an appropriate marker, but also its quantitative analysis. We used the Sensitive Particle Acoustic Quantification (SPAQ) technology - a novel ultrasound technique - for detection and quantification of cell adhesion molecules in isolated tissue and in live animals. By conjugating gasfilled microparticles (MPs) with antibodies to intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), we were able to depict and quantify ICAM-1 and VCAM-I in isolated brain and spinal cord from rats with autoimmune encephalomyelitis (EAE), an established inflammatory disease model of human multiple sclerosis (MS). Depiction and quantification of specific MPs were also feasible in living animals with AT-EAE with similar results. After treatment with methylprednisolone, the measured number of targeted anti-ICAM-1 and VCAM-1-MPs was significantly lower (P < 0.01) compared to untreated animals demonstrating the high sensitivity of this imaging technique. Depending on the antibody linked to the surface of the MPs, the technique can be used to quantify the expression of any accessible antigen expressed on the luminal surface of endothelial cells and is therefore a promising tool for the noninvasive and dynamic assessment of disease-related molecules. (c) 2005 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2005.04.019"],["dc.identifier.isi","000231154900002"],["dc.identifier.pmid","15905104"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50101"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","Ultrasound derived imaging and quantification of cell adhesion molecules in experimental autoimmune encephalomyelitis (EAE) by Sensitive Particle Acoustic Quantification (SPAQ)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Communications Earth & Environment"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Drake, Henrik"],["dc.contributor.author","Roberts, Nick M. W."],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Whitehouse, Martin"],["dc.contributor.author","Ivarsson, Magnus"],["dc.contributor.author","Karlsson, Andreas"],["dc.contributor.author","Kooijman, Ellen"],["dc.contributor.author","Kielman-Schmitt, Melanie"],["dc.date.accessioned","2021-12-03T16:48:14Z"],["dc.date.available","2021-12-03T16:48:14Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1038/s43247-021-00170-2"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95235"],["dc.relation.issn","2662-4435"],["dc.title","Biosignatures of ancient microbial life are present across the igneous crust of the Fennoscandian shield"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","415"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Astrobiology"],["dc.bibliographiccitation.lastpage","428"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Reinhardt, Manuel"],["dc.contributor.author","Goetz, Walter"],["dc.contributor.author","Thiel, Volker"],["dc.date.accessioned","2020-12-10T18:16:01Z"],["dc.date.available","2020-12-10T18:16:01Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1089/ast.2019.2143"],["dc.identifier.eissn","1557-8070"],["dc.identifier.issn","1531-1074"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75029"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.orgunit","Abteilung Geobiologie"],["dc.title","Testing Flight-like Pyrolysis Gas Chromatography–Mass Spectrometry as Performed by the Mars Organic Molecule Analyzer Onboard the ExoMars 2020 Rover on Oxia Planum Analog Samples"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1188"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.lastpage","1192"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Lutterotti, A."],["dc.contributor.author","Jelcic, Ilijas"],["dc.contributor.author","Schulze, Catharina"],["dc.contributor.author","Schippling, Sven"],["dc.contributor.author","Breiden, P."],["dc.contributor.author","Mazzanti, B."],["dc.contributor.author","Reinhardt, S."],["dc.contributor.author","DiGioia, M."],["dc.contributor.author","Repice, A."],["dc.contributor.author","Massacesi, L."],["dc.contributor.author","Sputtek, A."],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Kroeger, Nicolaus M."],["dc.contributor.author","Sospedra, Mireia"],["dc.contributor.author","Saccardi, R."],["dc.contributor.author","Zander, A."],["dc.contributor.author","Martin, R."],["dc.date.accessioned","2018-11-07T09:07:56Z"],["dc.date.available","2018-11-07T09:07:56Z"],["dc.date.issued","2012"],["dc.description.abstract","Autologous hematopoietic stem cell transplantation (aHSCT) has been used as a therapeutic approach in multiple sclerosis (MS). However, it is still unclear if the immune system that emerges from autologous CD34+ hematopoietic progenitor cells (HPC) of MS patients is pre-conditioned to re-develop the proinflammatory phenotype. The objective of this article is to compare the whole genome gene and microRNA expression signature in CD34+ HPC of MS patients and healthy donors (HD). CD34+ HPC were isolated from peripheral blood of eight MS patients and five HD and analyzed by whole genome gene expression and microRNA expression microarray. Among the differentially expressed genes (DEGs) only TNNT1 reached statistical significance (logFC=3.1, p < 0.01). The microRNA expression was not significantly different between MS patients and HD. We did not find significant alterations of gene expression or microRNA profiles in CD34+ HPCs of MS patients. Our results support the use of aHSCT for treatment of MS."],["dc.identifier.doi","10.1177/1352458511434067"],["dc.identifier.isi","000306510600019"],["dc.identifier.pmid","22252466"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10622"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25911"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.relation.issn","1352-4585"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","No proinflammatory signature in CD34+ hematopoietic progenitor cells in multiple sclerosis patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]