Staiger, Jochen

[["dc.bibliographiccitation.firstpage","15700"],["dc.bibliographiccitation.issue","46"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","15709"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Wagener, Robin Jan"],["dc.contributor.author","David, Csaba"],["dc.contributor.author","Zhao, Shanting"],["dc.contributor.author","Haas, Carola A."],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T08:36:49Z"],["dc.date.available","2018-11-07T08:36:49Z"],["dc.date.issued","2010"],["dc.description.abstract","Sensory information acquired via the large facial whiskers is processed and relayed in the whisker-to-barrel pathway, which shows multiple somatotopic maps of the receptor periphery. These maps consist of individual structural modules, the development of which may require intact cortical lamination. In the present study we examined the whisker-to-barrel pathway in the reeler mouse and thus used a model with disturbed cortical organization. A combination of histological (fluorescent Nissl and cytochrome oxidase staining) as well as molecular methods (c-Fos and laminar markers Rgs8, RORB, and ER81 expression) revealed wild type-equivalent modules in reeler. At the neocortical level, however, we found extensive alterations in the layout of the individual modules of the map. Nevertheless, they showed a columnar organization that included compartments equivalent to those of their wild-type counterparts. Moreover, all examined modules showed distinct activation as a consequence of behavioral whisker stimulation. Analysis of the magnitude of the cortical lamination defect surprisingly revealed an extensive disorganization, rather than an inversion, as assumed previously. Striking developmental plasticity of thalamic innervation, as suggested by vGluT2 immunohistochemistry, seems to ensure the proper formation of columnar modules and topological maps even under highly disorganized conditions."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB 780, TP C1]"],["dc.identifier.doi","10.1523/JNEUROSCI.3707-10.2010"],["dc.identifier.isi","000284358500036"],["dc.identifier.pmid","21084626"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6312"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18395"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The Somatosensory Cortex of reeler Mutant Mice Shows Absent Layering But Intact Formation and Behavioral Activation of Columnar Somatotopic Maps"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Sermet, B Semihcan"],["dc.contributor.author","Truschow, Pavel"],["dc.contributor.author","Feyerabend, Michael"],["dc.contributor.author","Mayrhofer, Johannes M"],["dc.contributor.author","Oram, Tess B"],["dc.contributor.author","Yizhar, Ofer"],["dc.contributor.author","Staiger, Jochen F"],["dc.contributor.author","Petersen, Carl CH"],["dc.date.accessioned","2020-12-10T18:48:09Z"],["dc.date.available","2020-12-10T18:48:09Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.7554/eLife.52665"],["dc.identifier.eissn","2050-084X"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17115"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/79036"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E1797"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","E1806"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Harsan, Laura-Adela"],["dc.contributor.author","David, Csaba"],["dc.contributor.author","Reisert, Marco"],["dc.contributor.author","Schnell, Susanne"],["dc.contributor.author","Hennig, Juergen"],["dc.contributor.author","von Elverfeldt, Dominik"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T09:24:45Z"],["dc.date.available","2018-11-07T09:24:45Z"],["dc.date.issued","2013"],["dc.description.abstract","A major challenge in neuroscience is to accurately decipher in vivo the entire brain circuitry (connectome) at a microscopic level. Currently, the only methodology providing a global noninvasive window into structural brain connectivity is diffusion tractography. The extent to which the reconstructed pathways reflect realistic neuronal networks depends, however, on data acquisition and postprocessing factors. Through a unique combination of approaches, we designed and evaluated herein a framework for reliable fiber tracking and mapping of the living mouse brain connectome. One important wiring scheme, connecting gray matter regions and passing fiber-crossing areas, was closely examined: the lemniscal thalamocortical (TC) pathway. We quantitatively validated the TC projections inferred from in vivo tractography with correlative histological axonal tracing in the same wild-type and reeler mutant mice. We demonstrated noninvasively that changes in patterning of the cortical sheet, such as highly disorganized cortical lamination in reeler, led to spectacular compensatory remodeling of the TC pathway."],["dc.identifier.doi","10.1073/pnas.1218330110"],["dc.identifier.isi","000319327700013"],["dc.identifier.pmid","23610438"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29900"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Mapping remodeling of thalamocortical projections in the living reeler mouse brain by diffusion tractography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","52"],["dc.bibliographiccitation.journal","Frontiers in Neuroanatomy"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Cauli, Bruno"],["dc.contributor.author","Zhou, X."],["dc.contributor.author","Tricoire, Ludovic"],["dc.contributor.author","Toussay, Xavier"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2018-11-07T09:38:49Z"],["dc.date.available","2018-11-07T09:38:49Z"],["dc.date.issued","2014"],["dc.description.abstract","Cortical calretinin (CR)-expressing interneurons represent a heterogeneous subpopulation of about 10-30% of GABAergic interneurons, which altogether total ca. 12-20% of all cortical neurons. In the rodent neocortex, CR cells display different somatodendritic morphologies ranging from bipolar to multipolar but the bipolar cells and their variations dominate. They are also diverse at the molecular level as they were shown to express numerous neuropeptides in different combinations including vasoactive intestinal polypeptide (VIP), cholecystokinin (CCK), neurokinin B (NKB) corticotrophin releasing factor (CRF), enkephalin (Enk) but also neuropeptide Y (NPY) and somatostatin (SOM) to a lesser extent. CR-expressing interneurons exhibit different firing behaviors such as adapting, bursting or irregular. They mainly originate from the caudal ganglionic eminence (CGE) but a subpopulation also derives from the dorsal part of the medial ganglionic eminence (MGE). Cortical GABAergic CR-expressing interneurons can be divided in two main populations: VIP-bipolar interneurons deriving from the CGE and SOM-Martinotti-like interneurons originating in the dorsal MGE. Although bipolar cells account for the majority of CR-expressing interneurons, the roles they play in cortical neuronal circuits and in the more general metabolic physiology of the brain remained elusive and enigmatic. The aim of this review is, firstly, to provide a comprehensive view of the morphological, molecular and electrophysiological features defining this cell type. We will, secondly, also summarize what is known about their place in the cortical circuit, their modulation by subcortical afferents and the functional roles they might play in neuronal processing and energy metabolism."],["dc.identifier.doi","10.3389/fnana.2014.00052"],["dc.identifier.isi","000339055400001"],["dc.identifier.pmid","25009470"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11805"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33143"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Media Sa"],["dc.relation.issn","1662-5129"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Revisiting enigmatic cortical calretinin-expressing interneurons"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Ruzicka, Thomas"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Bodemer, Christine"],["dc.contributor.author","Traupe, Heiko"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Hoegger, Patrick J."],["dc.contributor.author","Lacour, J."],["dc.contributor.author","Blume-Peytavi, Ulrike"],["dc.contributor.author","Mazereeuw-Hautier, J."],["dc.contributor.author","Dupuy, P."],["dc.date.accessioned","2018-11-07T09:06:56Z"],["dc.date.available","2018-11-07T09:06:56Z"],["dc.date.issued","2012"],["dc.format.extent","S55"],["dc.identifier.isi","000307814000310"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25672"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.conference","42nd Annual Meeting of the European-Society-for-Dermatological-Research (ESDR)"],["dc.relation.eventlocation","Venice, ITALY"],["dc.relation.issn","0022-202X"],["dc.title","Tazarotene cream in lamellar ichthyoses: a randomized, double-blind, vehicle-controlled and dose-finding clinical study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","607"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Nature Neuroscience"],["dc.bibliographiccitation.lastpage","612"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Gentet, Luc J."],["dc.contributor.author","Kremer, Yves"],["dc.contributor.author","Taniguchi, Hiroki"],["dc.contributor.author","Huang, Z. Josh"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Petersen, Carl C. H."],["dc.date.accessioned","2018-11-07T09:11:55Z"],["dc.date.available","2018-11-07T09:11:55Z"],["dc.date.issued","2012"],["dc.description.abstract","Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake behaving mice. SOM neurons were spontaneously active during periods of quiet wakefulness. However, SOM neurons hyperpolarized and reduced action potential firing in response to both passive and active whisker sensing, in contrast with all other recorded types of nearby neurons, which were excited by sensory input. Optogenetic inhibition of SOM neurons increased burst firing in nearby excitatory neurons. We hypothesize that the spontaneous activity of SOM neurons during quiet wakefulness provides a tonic inhibition to the distal dendrites of excitatory pyramidal neurons. Conversely, the inhibition of SOM cells during active cortical processing likely enhances distal dendritic excitability, which may be important for top-down computations and sensorimotor integration."],["dc.identifier.doi","10.1038/nn.3051"],["dc.identifier.isi","000302114500021"],["dc.identifier.pmid","22366760"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26828"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1097-6256"],["dc.title","Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","226"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Frontiers in Neuroscience"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Castro-Hernandez, Ricardo"],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Tuoc, Tran"],["dc.date.accessioned","2019-07-09T11:45:16Z"],["dc.date.available","2019-07-09T11:45:16Z"],["dc.date.issued","2018"],["dc.description.abstract","The generation of individual neurons (neurogenesis) during cortical development occurs in discrete steps that are subtly regulated and orchestrated to ensure normal histogenesis and function of the cortex. Notably, various gene expression programs are known to critically drive many facets of neurogenesis with a high level of specificity during brain development. Typically, precise regulation of gene expression patterns ensures that key events like proliferation and differentiation of neural progenitors, specification of neuronal subtypes, as well as migration and maturation of neurons in the developing cortex occur properly. ATP-dependent chromatin remodeling complexes regulate gene expression through utilization of energy fromATP hydrolysis to reorganize chromatin structure. These chromatin remodeling complexes are characteristically multimeric, with some capable of adopting functionally distinct conformations via subunit reconstitution to perform specific roles in major aspects of cortical neurogenesis. In this review, we highlight the functions of such chromatin remodelers during cortical development. We also bring together various proposed mechanisms by which ATP-dependent chromatin remodelers function individually or in concert, to specifically modulate vital steps in cortical neurogenesis."],["dc.identifier.doi","10.3389/fnins.2018.00226"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15084"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59196"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-453X"],["dc.relation.issn","1662-453X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3"],["dc.bibliographiccitation.journal","Progress in Neurobiology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","103"],["dc.contributor.author","Feldmeyer, Dirk"],["dc.contributor.author","Brecht, Michael"],["dc.contributor.author","Helmchen, Fritjof"],["dc.contributor.author","Petersen, Carl C. H."],["dc.contributor.author","Poulet, James F. A."],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Luhmann, Heiko J."],["dc.contributor.author","Schwarz, Cornelius"],["dc.date.accessioned","2018-11-07T09:26:21Z"],["dc.date.available","2018-11-07T09:26:21Z"],["dc.date.issued","2013"],["dc.description.abstract","Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals, is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns. A cortical column is considered the basic module of cortical processing present in all cortical areas. It is believed to contain a characteristic microcircuit composed of a few thousand neurons. The high degree of cortical segmentation into vertical columns and horizontal layers is a boon for scientific investigation because it eases the systematic dissection and functional analysis of intrinsic as well as extrinsic connections of the column. In this review we will argue that in order to understand neocortical function one needs to combine a microscopic view, elucidating the workings of the local columnar microcircuits, with a macroscopic view, which keeps track of the linkage of distant cortical modules in different behavioral contexts. We will exemplify this strategy using the model system of vibrissal touch in mice and rats. On the macroscopic level vibrissal touch is an important sense for the subterranean rodents and has been honed by evolution to serve an array of distinct behaviors. Importantly, the vibrissae are moved actively to touch - requiring intricate sensorimotor interactions. Vibrissal touch, therefore, offers ample opportunities to relate different behavioral contexts to specific interactions of distant columns. On the microscopic level, the cortical modules in primary somatosensory cortex process touch inputs at highest magnification and discreteness - each whisker is represented by its own so-called barrel column. The cellular composition, intrinsic connectivity and functional aspects of the barrel column have been studied in great detail. Building on the versatility of genetic tools available in rodents, new, highly selective and flexible cellular and molecular tools to monitor and manipulate neuronal activity have been devised. Researchers have started to combine these with advanced and highly precise behavioral methods, on par with the precision known from monkey preparations. Therefore, the vibrissal touch model system is exquisitely positioned to combine the microscopic with the macroscopic view and promises to be instrumental in our understanding of neocortical function. (C) 2012 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.pneurobio.2012.11.002"],["dc.identifier.isi","000318321400002"],["dc.identifier.pmid","23195880"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11339"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30281"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0301-0082"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Barrel cortex function"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S60"],["dc.bibliographiccitation.journal","Journal of Molecular Neuroscience"],["dc.bibliographiccitation.lastpage","S61"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Katz, Yonatan"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Lampl, I."],["dc.date.accessioned","2018-11-07T09:17:42Z"],["dc.date.available","2018-11-07T09:17:42Z"],["dc.date.issued","2013"],["dc.identifier.isi","000332833800151"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28231"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Humana Press Inc"],["dc.publisher.place","Totowa"],["dc.relation.conference","21st Annual Meeting of the Israel-Society-for-Neuroscience / 1st Binational Australian-Israeli Meeting on Neuroscience"],["dc.relation.eventlocation","Eilat, ISRAEL"],["dc.relation.issn","1559-1166"],["dc.relation.issn","0895-8696"],["dc.title","A special electrode holder for simultaneous intracellular patch recording and optical stimulation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Kolbaev, Sergey N."],["dc.contributor.author","Mohapatra, Namrata"],["dc.contributor.author","Chen, Rongqing"],["dc.contributor.author","Lombardi, Aniello"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Luhmann, Heiko J."],["dc.contributor.author","Jedlicka, Peter"],["dc.contributor.author","Kilb, Werner"],["dc.date.accessioned","2021-04-14T08:31:46Z"],["dc.date.available","2021-04-14T08:31:46Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41598-020-75382-1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83710"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2045-2322"],["dc.title","NKCC-1 mediated Cl− uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]