Malinova, Vesna

[["dc.bibliographiccitation.firstpage","407"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Translational Stroke Research"],["dc.bibliographiccitation.lastpage","414"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Atangana, Etienne Ndzie"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T09:39:47Z"],["dc.date.available","2018-11-07T09:39:47Z"],["dc.date.issued","2014"],["dc.description.abstract","The optimal management of spontaneous intracerebral hemorrhage (ICH), especially if deep-seated, remains a matter of discussion. Lysis of the blood clot applying recombinant tissue-type plasminogen activator (rtPA) by an intrahematomal catheter is a minimally invasive treatment option, currently being under investigation in a randomized trial. The center position of the catheter in the hematoma is believed to be crucial for an optimal clot lysis. To achieve this objective, frame-based stereotaxy and frameless stereotaxy with guidance of an articulated arm were used. Recently, a preregistered stylet for direct navigation, alleviating the need of guidance, became available. In this study, we evaluated the relative error (RE) describing the deviation of the catheter from the ideal center position in the clot and compared the accuracy of catheter placement using frameless stereotaxy or the novel preregistered stylet. The intrahematomal catheter position was evaluated in three dimensions in 89 patients with spontaneous supratentorial ICH. Frameless stereotaxy with guidance of an articulated arm was performed in 50 patients. The preregistered stylet was used in 39 patients. The catheter position was evaluated using a RE calculating the distance perpendicular to the center of the catheter in relation to the hematoma's diameter. The mean hematoma volume was 51.4 ml. Forty-four out of 89 hematomas were deep-seated. Intraventricular blood was found in 59 patients. The RE of the catheter position was lower in the stylet group in comparison to the frameless stereotaxy group (mean 0.57 vs. 0.90; p = 0.0018). There was no difference between deep-seated and lobar hematomas with regard to the accuracy of catheter placement (p = 0.62). The RE is a robust measure for describing intrahematomal catheter position. The preregistered stylet facilitates a satisfactory catheter placement and is a viable alternative to frameless stereotaxy and guidance with the articulated arm."],["dc.identifier.doi","10.1007/s12975-014-0326-1"],["dc.identifier.isi","000336336200011"],["dc.identifier.pmid","24470086"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33363"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1868-601X"],["dc.relation.issn","1868-4483"],["dc.title","Catheter Placement for Lysis of Spontaneous Intracerebral Hematomas: Is a Navigated Stylet Better Than Pointer-Guided Frameless Stereotaxy for Intrahematomal Catheter Positioning?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Translational Stroke Research"],["dc.contributor.author","Döring, Katja"],["dc.contributor.author","Schroeder, Henning"],["dc.contributor.author","Fischer, André"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Ninkovic, Milena"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Malinova, Vesna"],["dc.date.accessioned","2022-02-01T10:31:59Z"],["dc.date.available","2022-02-01T10:31:59Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Cerebral vasospasm is a highly investigated phenomenon in neurovascular research. Experimental vasospasm models are irreplaceable for the evaluation of new antivasospastic drugs. In this study, we assessed the reliability of in vivo vasospasm induction by ultrasound application in the chicken chorioallantoic membrane (CAM) model. After incubation of fertilized chicken eggs for four days, a fenestration was performed to enable examination of the CAM vessels. On the thirteenth day, continuous-wave ultrasound (3 MHz, 1 W/cm 2 ) was applied on the CAM vessels for 60 s. The ultrasound effect on the vessels was recorded by life imaging (5-MP HD-microscope camera, Leica®). The induced vessel diameter changes were evaluated in a defined time interval of 20 min using a Fiji macro. The vessel diameter before and after sonication was measured and the relative diameter reduction was determined. A first reduction of vessel diameter was observed after three minutes with an average vessel-diameter decrease to 77%. The maximum reduction in vessel diameter was reached eight minutes after sonication with an average vessel diameter decrease to 57% (mean relative diameter reduction of 43%, range 44–61%), ANOVA, p  = 0.0002. The vasospasm persisted for all 20 recorded minutes post induction. Vasospasm can be reliably induced by short application of 3 MHz-ultrasound to the CAM vessels. This might be a suitable in vivo model for the evaluation of drug effects on vasospasm in an experimental setting as intermediary in the transition process from in vitro to in vivo assessment using animal models."],["dc.description.abstract","Abstract Cerebral vasospasm is a highly investigated phenomenon in neurovascular research. Experimental vasospasm models are irreplaceable for the evaluation of new antivasospastic drugs. In this study, we assessed the reliability of in vivo vasospasm induction by ultrasound application in the chicken chorioallantoic membrane (CAM) model. After incubation of fertilized chicken eggs for four days, a fenestration was performed to enable examination of the CAM vessels. On the thirteenth day, continuous-wave ultrasound (3 MHz, 1 W/cm 2 ) was applied on the CAM vessels for 60 s. The ultrasound effect on the vessels was recorded by life imaging (5-MP HD-microscope camera, Leica®). The induced vessel diameter changes were evaluated in a defined time interval of 20 min using a Fiji macro. The vessel diameter before and after sonication was measured and the relative diameter reduction was determined. A first reduction of vessel diameter was observed after three minutes with an average vessel-diameter decrease to 77%. The maximum reduction in vessel diameter was reached eight minutes after sonication with an average vessel diameter decrease to 57% (mean relative diameter reduction of 43%, range 44–61%), ANOVA, p  = 0.0002. The vasospasm persisted for all 20 recorded minutes post induction. Vasospasm can be reliably induced by short application of 3 MHz-ultrasound to the CAM vessels. This might be a suitable in vivo model for the evaluation of drug effects on vasospasm in an experimental setting as intermediary in the transition process from in vitro to in vivo assessment using animal models."],["dc.identifier.doi","10.1007/s12975-021-00960-y"],["dc.identifier.pii","960"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98997"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1868-601X"],["dc.relation.issn","1868-4483"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","In Vivo Vasospasm Induction by Ultrasound Application in the Chicken Chorioallantoic Membrane Model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","84"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","90"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Voit, Martin"],["dc.contributor.author","Suntheim, Patricia"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2020-12-10T18:44:04Z"],["dc.date.available","2020-12-10T18:44:04Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3171/2017.3.JNS162505"],["dc.identifier.eissn","1933-0693"],["dc.identifier.issn","0022-3085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78317"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The impact of temporary clipping during aneurysm surgery on the incidence of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2021-04-14T08:25:15Z"],["dc.date.available","2021-04-14T08:25:15Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s12883-020-01792-3"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17436"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81571"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Angioplasty with the scepter C dual lumen balloon catheter and postprocedural result evaluation in patients with subarachnoid hemorrhage related vasospasms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hazaymeh, Mohammad"],["dc.contributor.author","Löber-Handwerker, Ronja"],["dc.contributor.author","Döring, Katja"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Malinova, Vesna"],["dc.date.accessioned","2022-12-01T08:30:57Z"],["dc.date.available","2022-12-01T08:30:57Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Approximately 25% of glioblastomas show at diagnosis a corpus callosum infiltration, which is associated with poor prognosis. The extent of corpus callosum involvement, however, ranges from partial unilateral to complete bilateral infiltration. The role of surgery in glioblastoma with corpus callosum involvement is controversial. In this study, we aimed to examine prognostic differences between glioblastoma with unilateral and glioblastoma with bilateral corpus callosum infiltration, and to evaluate possible treatment strategy implications. Patients with newly diagnosed glioblastoma from 2010 to 2019 were included. Corpus callosum infiltration was assessed in contrast-enhanced T1-weighted preoperative magnetic resonance imaging. Extent of resection, adjuvant treatments and overall survival were evaluated. Corpus callosum involvement was found in 96 (26.4%) out of 363 patients with newly diagnosed glioblastoma. Bilateral corpus callosum infiltration was found in 27 out of 96 patients (28%), and 69 patients had unilateral corpus callosum infiltration. Glioblastoma with corpus callosum affection had significantly lower median overall survival compared to glioblastoma without corpus callosum involvement (9 vs. 11 months,\n p\n  = 0.02). A subgroup analysis of glioblastoma with unilateral corpus callosum infiltration revealed a significant difference in median overall survival dependent on extent of resection (6.5 without gross total resection vs. 11 months with gross total resection, Log-rank test\n p\n  = 0.02). Our data confirms a shorter overall survival in glioblastoma subpopulation with corpus callosum involvement, especially for glioblastoma with bilateral corpus callosum infiltration. However, patients with partial corpus callosum infiltration undergoing gross total resection exhibited a significant survival benefit compared to their counterparts without gross total resection. Whenever reasonably achievable gross total resection should be considered as an integral part of the treatment strategy in glioblastoma with partial corpus callosum infiltration."],["dc.identifier.doi","10.1038/s41598-022-23794-6"],["dc.identifier.pii","23794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118028"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2045-2322"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Prognostic differences and implications on treatment strategies between butterfly glioblastoma and glioblastoma with unilateral corpus callosum infiltration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","315"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.bibliographiccitation.lastpage","323"],["dc.bibliographiccitation.volume","149"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","von Eckardstein, Kajetan"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2021-04-14T08:24:41Z"],["dc.date.available","2021-04-14T08:24:41Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s11060-020-03608-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81386"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1573-7373"],["dc.relation.issn","0167-594X"],["dc.title","Diagnostic yield of fluorescence-assisted frame-based stereotactic biopsies of intracerebral lesions in comparison with frozen-section analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.contributor.author","Löber-Handwerker, Ronja"],["dc.contributor.author","Döring, Katja"],["dc.contributor.author","Bock, Christoph"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Malinova, Vesna"],["dc.date.accessioned","2022-04-01T10:01:06Z"],["dc.date.available","2022-04-01T10:01:06Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Patients with inoperable glioblastoma (GBM) usually experience worse prognosis compared to those in whom gross total resection (GTR) is achievable. Considering the treatment duration and its side effects identification of patients with survival benefit from treatment is essential to guarantee the best achievable quality of life. The aim of this study was to evaluate the survival benefit from radio-chemotherapy and to identify clinical, molecular, and imaging parameters associated with better outcome in patients with biopsied GBMs. Consecutive patients with inoperable GBM who underwent tumor biopsy at our department from 2005 to 2019 were retrospectively analyzed. All patients had histologically confirmed GBM and were followed up until death. The overall survival (OS) was calculated from date of diagnosis to date of death. Clinical, radiological, and molecular predictors of OS were evaluated. A total of 95 patients with biopsied primary GBM were enrolled in the study. The mean age was 64.3 ± 13.2 years; 56.8% (54/95) were male, and 43.2% (41/95) female. Median OS in the entire cohort was 5.5 months. After stratification for adjuvant treatment, a higher median OS was found in the group with adjuvant treatment (7 months, range 2–88) compared to the group without treatment (1 month, range 1–5) log-rank test, p  < 0.0001. Patients with inoperable GBM undergoing biopsy indeed experience a very limited OS. Adjuvant treatment is associated with significantly longer OS compared to patients not receiving treatment and should be considered, especially in younger patients with good clinical condition at presentation."],["dc.identifier.doi","10.1007/s10143-022-01754-y"],["dc.identifier.pii","1754"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105601"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1437-2320"],["dc.relation.issn","0344-5607"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Defining the impact of adjuvant treatment on the prognosis of patients with inoperable glioblastoma undergoing biopsy only: does the survival benefit outweigh the treatment effort?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1531"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.bibliographiccitation.lastpage","1537"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Iliev, Bogdan"],["dc.contributor.author","Schlegel, Anna"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Malinova, Vesna"],["dc.date.accessioned","2020-12-10T14:11:13Z"],["dc.date.available","2020-12-10T14:11:13Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s10143-019-01170-9"],["dc.identifier.eissn","1437-2320"],["dc.identifier.issn","0344-5607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71004"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Intrahematomal catheter placement with connection to the ventricular system allows more effective thrombolysis of combined intracerebral and intraventricular hematomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","International Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","6"],["dc.contributor.author","Komboz, Fares"],["dc.contributor.author","Zechel, Sabrina"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Abboud, Tammam"],["dc.date.accessioned","2022-06-01T09:39:17Z"],["dc.date.available","2022-06-01T09:39:17Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1080/00207454.2022.2082965"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108430"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1543-5245"],["dc.relation.issn","0020-7454"],["dc.title","Infratentorial Ganglioglioma Mimicking a Cerebellar Metastasis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","397"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.bibliographiccitation.lastpage","402"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Malinova, Vesna"],["dc.contributor.author","Schlegel, Anna"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2020-12-10T14:11:12Z"],["dc.date.available","2020-12-10T14:11:12Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1007/s10143-016-0792-x"],["dc.identifier.eissn","1437-2320"],["dc.identifier.issn","0344-5607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70995"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Catheter placement for lysis of spontaneous intracerebral hematomas: does a catheter position in the core of the hematoma allow more effective and faster hematoma lysis?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]