Döring, Wolf K. H.

[["dc.bibliographiccitation.firstpage","849"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Alcoholism Clinical and Experimental Research"],["dc.bibliographiccitation.lastpage","861"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Doring, WKH"],["dc.contributor.author","Herzenstiel, M. N."],["dc.contributor.author","Krampe, Henning"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Pralle, L."],["dc.contributor.author","Sieg, S."],["dc.contributor.author","Wegerle, E."],["dc.contributor.author","Poser, Wolfgang"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2018-11-07T10:39:00Z"],["dc.date.available","2018-11-07T10:39:00Z"],["dc.date.issued","2003"],["dc.description.abstract","Background: During alcohol withdrawal and early abstinence, severe alterations of electrolyte and water homeostasis and their regulating hormones are well recognized. Almost nothing is known about regeneration of these functions with long-term abstinence. This cohort study was designed to monitor determinants of electrolyte and water balance over 280 days of abstinence in alcohol-dependent men compared with healthy controls. Methods: Vasopressin (AVP), N-terminal proatrial natriuretic peptide, aldosterone, angiotensin II, and electrolytes, together with major parameters of kidney and liver function, were monitored in 35 male alcoholics aged 44+/-8 years. Of these, 21 could be followed up to 280 days of strictly controlled abstinence due to their participation in the Outpatient Long-Term Intensive Therapy for Alcoholics. The control group comprised 20 healthy male volunteers aged 39+/-7 years. Results: Basal AVP levels were found to be suppressed over the whole study period. In contrast, N-terminal proatrial natriuretic peptide remained increased over all 280 days. No persistent alterations were found for aldosterone or angiotensin II. Sodium and potassium in plasma and urine returned to normal within a few weeks. Creatinine clearance, urea nitrogen in plasma and urine, urinary osmolality, hematocrit, and hemoglobin remained low as compared with controls over the entire study. Conclusions: Chronic alcohol abuse causes severe and persistent alterations in the hormonal regulatory systems of electrolyte and water balance. The suppressed basal secretion of AVP may reflect a dysregulation in the brain that influences the hypothalamic-pituitary-adrenal axis function, mood, memory, addiction behavior, and craving during alcohol abstinence. These findings may provide a ground for future therapeutic approaches to stable abstinence."],["dc.identifier.doi","10.1097/01.ALC.0000065433.17403.DE"],["dc.identifier.isi","000183083500015"],["dc.identifier.pmid","12766631"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45942"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0145-6008"],["dc.title","Persistent alterations of vasopressin and N-terminal proatrial natriuretic peptide plasma levels in long-term abstinent alcoholics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1925"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Alcoholism: Clinical and Experimental Research"],["dc.bibliographiccitation.lastpage","1930"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Jahn, Henriette"],["dc.contributor.author","Döring, Wolf K. H."],["dc.contributor.author","Krampe, Henning"],["dc.contributor.author","Sieg, Sonja"],["dc.contributor.author","Werner, Carola"],["dc.contributor.author","Poser, Wolfgang"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:45:44Z"],["dc.date.available","2017-09-07T11:45:44Z"],["dc.date.issued","2004"],["dc.description.abstract","Background: Basal arginine vasopressin (AVP) plasma levels in alcoholic patients are persistently decreased over months of controlled alcohol abstinence. As a potential explanation of this phenomenon, a reduction of AVP immunoreactive neurons was described in the hypothalamus of alcohol-dependent humans and rodents. This study was therefore designed to examine whether long-term abstinent alcoholics have a compromised response of AVP to osmostimulation.Methods: Fifteen male alcoholics, aged 42 ± 2 years, were examined (1) over 12 months of strictly controlled abstinence (longitudinal study) and (2) during an osmostimulation test (5% NaCl infusion at 0.06 ml/kg/min over 2 hr) and were compared with 15 healthy male subjects, aged 41 ± 2 years. AVP and routine laboratory parameters, including electrolytes and osmolality, were measured.Results: Starting from lower basal concentrations, alcoholics showed increases similar to those of controls in AVP and plasma osmolality after osmostimulation. The first sensation of thirst was announced significantly later by alcoholics than by controls. Twenty-hour-posttest urine volume and sodium excretion were reduced in alcoholics compared with controls.Conclusions: Despite their persistently decreased basal AVP plasma levels, long-term abstinent alcoholics have a well preserved AVP response to osmostimulation. This finding indicates a peripheral suppression of AVP levels that is most likely due to a regulatory set-point shift toward hypotonic hyperhydration, rather than to a reduced central capacity of AVP secretion."],["dc.identifier.gro","3150442"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7206"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0145-6008"],["dc.subject","Alcoholism; Abstinence; Antidiuretic Hormone; AVP; Osmolality"],["dc.title","Preserved vasopressin response to osmostimulation despite decreased basal vasopressin levels in long-term abstinent alcoholics"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]