Tareen, Abdul Malik

[["dc.bibliographiccitation.firstpage","24"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","302"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Johann, C."],["dc.contributor.author","Strubel, A."],["dc.contributor.author","Busse, C."],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Schmidt-Ott, Ruprecht"],["dc.contributor.author","Gross, U."],["dc.date.accessioned","2018-11-07T09:06:02Z"],["dc.date.available","2018-11-07T09:06:02Z"],["dc.date.issued","2012"],["dc.identifier.isi","000311593300082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25464"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","64th Annual Meeting of the German-Society-for-Hygiene-and-Microbiology (DGHM)"],["dc.relation.eventlocation","Hamburg, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Serodiagnostic and Seroprevalence of Campylobacteriosis and post-Campylobacter-sequelae"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1019"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Journal of Clinical Microbiology & Infectious Diseases"],["dc.bibliographiccitation.lastpage","1027"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Johann, C."],["dc.contributor.author","Strubel, A."],["dc.contributor.author","Busse, C."],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Masanta, Wycliffe Omurwa"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Schmidt-Ott, Ruprecht"],["dc.contributor.author","Gross, U."],["dc.date.accessioned","2018-11-07T09:39:47Z"],["dc.date.available","2018-11-07T09:39:47Z"],["dc.date.issued","2014"],["dc.description.abstract","Post-infectious sequelea such as Guillain Barr, syndrome (GBS), reactive arthritis (RA), and inflammatory bowel disease (IBD) may arise as a consequence of acute Campylobacter-enteritis (AE). However, reliable seroprevalence data of Campylobacter-associated sequelae has not been established. The objectives of this study were, first, to identify the most specific and sensitive test antigen in an optimized ELISA assay for diagnosing a previous Campylobacter-infection and, second, to compare the prevalence of anti-Campylobacter antibodies in cohorts of healthy blood donors (BD), AE, GBS, RA, and IBD patients with antibodies against known GBS, RA and IBD triggering pathogens. Optimized ELISAs of single and combined Campylobacter-proteins OMP18 and P39 as antigens were prepared and sera from AE, GBS, RA and IBD patients and BD were tested for Campylobcter-specific IgA and IgG antibodies. The results were compared with MIKROGEN (TM)-recomLine Campylobacter IgA/IgG and whole cell lysate-immunoblot. Antibodies specific for Helicobacter pylori, Mycoplasma pneumoniae, Yersinia enterocolitica, and Borrelia afzelii were tested with commercial immunoblots. ROC plot analysis revealed AUC maxima in the combination of OMP18 and P39 for IgA and in the P39-antigen for IgG. As a result, 34-49 % GBS cases, 44-62 % RA cases and 23-40 % IBD cases were associated with Campylobacter-infection. These data show that Campylobcater-seropositivity in these patient groups is significantly higher than other triggering pathogens suggesting that it plays an important role in development of GBS and RA, and supports the hypothesis that recurrent acute campylobacteriosis triggers IBD."],["dc.identifier.doi","10.1007/s10096-013-2040-4"],["dc.identifier.isi","000335743500017"],["dc.identifier.pmid","24413899"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9697"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33365"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1435-4373"],["dc.relation.issn","0934-9723"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Seroprevalence of campylobacteriosis and relevant post-infectious sequelae"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2359"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Applied and Environmental Microbiology"],["dc.bibliographiccitation.lastpage","2365"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Herrmann, Sahra"],["dc.contributor.author","Corso, Jasmin"],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Alter, Thomas"],["dc.contributor.author","Gross, Uwe"],["dc.date.accessioned","2018-11-07T08:57:39Z"],["dc.date.available","2018-11-07T08:57:39Z"],["dc.date.issued","2011"],["dc.description.abstract","In this study, multilocus sequence typing (MLST) was combined with the genetic detection of six genetic markers, ansB, dmsA, ggt, cj1585c, cjj81176-1367/71 (cj1365c), and the two-gene marker tlp7 (cj0951c plus cj0952c), to assess if their presence correlated with different C. jejuni clonal groups. Using a collection of 266 C. jejuni isolates from (in decreasing order of sample size) humans, chickens, cattle, and turkeys, it was further investigated whether the resulting genotypes correlated with the isolation source. We found combinations of the six marker genes to be mutually exclusive, and their patterns of presence or absence correlated to some degree with animal source. Together with MLST results, the obtained genotypes could be segregated into six groups. An association was identified for ansB, dmsA, and ggt with the MLST-clonal complexes (MLST-CC) 22, 42, 45, and 283, which formed the most prominent group, in which chickens were the most prevalent animal source. Two other groups, characterized by the presence of cj1585c, cjj81176-1367/71, and the two-gene marker tlp7, associated with either MLST-CC 21 or 61, were overrepresented in isolates of bovine origin. Mutually exclusive marker gene combinations were observed for ansB, dmsA, and ggt, typically found in CC 45 and the related CC 22, 42, and 283, whereas the other three marker genes were found mostly in CC 21, 48, and 206. The presence of the two-gene marker tlp7, which is typical for MLST 21 and 53 as well as for MLST-CC 61, strongly correlates with a bovine host; this is interpreted as an example of host adaptation. In cases of C. jejuni outbreaks, these genetic markers could be helpful for more effective source tracking."],["dc.description.sponsorship","Universitatsmedizin Gottingen, Germany"],["dc.identifier.doi","10.1128/AEM.02403-10"],["dc.identifier.isi","000288855500021"],["dc.identifier.pmid","21278270"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23444"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","0099-2240"],["dc.title","Epidemiological Association of Different Campylobacter jejuni Groups with Metabolism-Associated Genetic Markers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","48"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","49"],["dc.bibliographiccitation.volume","299"],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Dasti, Javid Iqbal"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Gross, U."],["dc.contributor.author","Lugert, Raimond"],["dc.date.accessioned","2018-11-07T11:24:57Z"],["dc.date.available","2018-11-07T11:24:57Z"],["dc.date.issued","2009"],["dc.identifier.isi","000269650700202"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56527"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","61st Conference of the Deutschen-Gesellschaft-fur-Hygiene-und-Microbiologie"],["dc.relation.eventlocation","Gottingen, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Campylobacter jejuni genes cj0952c and cj0951c are important for the pathogen to invade host cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","80"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","81"],["dc.bibliographiccitation.volume","303"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Masanta, Wycliffe Omurwa"],["dc.contributor.author","Weig, Michael S."],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Gross, U."],["dc.contributor.author","Bader, Oliver"],["dc.date.accessioned","2018-11-07T09:20:05Z"],["dc.date.available","2018-11-07T09:20:05Z"],["dc.date.issued","2013"],["dc.identifier.isi","000331497600276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28794"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","65th Annual Meeting of the German-Society-for-Hygiene-and-Microbiology (DGHM) e V / Annual Meeting of the German-Society-for-Infectious-Diseases (DGI) e V"],["dc.relation.eventlocation","Univ Rostock, Rostock, GERMANY"],["dc.relation.issn","1618-0607"],["dc.relation.issn","1438-4221"],["dc.title","Phyloproteomics versus phylogenetics: a comparative approach for the Discrimination of Campylobacter jejuni Subpopulations"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.volume","301"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Dasti, Javid Iqbal"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Gross, U."],["dc.date.accessioned","2018-11-07T08:51:57Z"],["dc.date.available","2018-11-07T08:51:57Z"],["dc.date.issued","2011"],["dc.format.extent","61"],["dc.identifier.isi","000296990800217"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22056"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","63rd Annual Meeting of the German-Society-for-Hygiene-and-Microbiology (DGHM)"],["dc.relation.eventlocation","Essen, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Characterization of new virulence factors of Campylobacter jejuni"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","205"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","211"],["dc.bibliographiccitation.volume","300"],["dc.contributor.author","Dasti, Javid Iqbal"],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Gross, Uwe"],["dc.date.accessioned","2018-11-07T08:44:32Z"],["dc.date.available","2018-11-07T08:44:32Z"],["dc.date.issued","2010"],["dc.description.abstract","Campylobacter jejuni has long been recognized as a cause of bacterial food-borne illness, and surprisingly, it remains the most prevalent bacterial food-borne pathogen in the industrial world to date. Natural reservoirs for this Gram-negative, spiral-shaped bacterium are wild birds, whose intestines offer a suitable biological niche for the survival and dissemination of C. jejuni Chickens become colonized shortly after birth and are the most important source for human infection. In the last decade, effective intervention strategies to limit infections caused by this elusive pathogen were hindered mainly because of a paucity in understanding the virulence mechanisms of C. jejuni and in part, unavailability of an adequate animal model for the disease. However, recent developments in deciphering molecular mechanisms of virulence of C. jejuni made it clear that C. jejuni is a unique pathogen, being able to execute N-linked glycosylation of more than 30 proteins related to colonization, adherence, and invasion. Moreover, the flagellum is not only depicted to facilitate motility but as well secretion of Campylobacter invasive antigens (Cia). The only toxin of C. jejuni, the so-called cytolethal distending toxin (CdtA,B,C), seems to be important for cell cycle control and induction of host cell apoptosis and has been recognized as a major pathogenicity-associated factor. In contrast to other diarrhoea-causing bacteria, no other classical virulence factors have yet been identified in C. jejuni. Instead, host factors seem to play a major role for pathogenesis of campylobacteriosis of man. Indeed, several lines of evidence suggest exploitation of different adaptation strategies by this pathogen depending on its requirement, whether to establish itself in the natural avian reservoir or during the course of human infection. (C) 2009 Elsevier GmbH. All rights reserved."],["dc.identifier.doi","10.1016/j.ijmm.2009.07.002"],["dc.identifier.isi","000277676500001"],["dc.identifier.pmid","19665925"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20222"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","1438-4221"],["dc.title","Campylobacter jejuni: A brief overview on pathogenicity-associated factors and disease-mediating mechanisms"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e81069"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Lueder, Carsten Guenter Kurt"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Heimesaat, Markus M."],["dc.contributor.author","Bereswill, Stefan"],["dc.contributor.author","Lugert, Raimond"],["dc.date.accessioned","2018-11-07T09:17:27Z"],["dc.date.available","2018-11-07T09:17:27Z"],["dc.date.issued","2013"],["dc.description.abstract","Adherence of Campylobacter jejuni to its particular host cells is mediated by several pathogen proteins. We screened a transposon-based mutant library of C. jejuni in order to identify clones with an invasion deficient phenotype towards Caco2 cells and detected a mutant with the transposon insertion in gene cj0268c. In vitro characterization of a generated non-random mutant, the mutant complemented with an intact copy of cj0268c and parental strain NCTC 11168 confirmed the relevance of Cj0268c in the invasion process, in particular regarding adherence to host cells. Whereas Cj0268c does not impact autoagglutination or motility of C. jejuni, heterologous expression in E. coli strain DH5 alpha enhanced the potential of the complemented E. coli strain to adhere to Caco2 cells significantly and, thus, indicates that Cj0268c does not need to interact with other C. jejuni proteins to develop its adherence-mediating phenotype. Flow cytometric measurements of E. coli expressing Cj0268c indicate a localization of the protein in the periplasmic space with no access of its C-terminus to the bacterial surface. Since a respective knockout mutant possesses clearly reduced resistance to Triton X-100 treatment, Cj0268c contributes to the stability of the bacterial cell wall. Finally, we could show that the presence of cj0268c seems to be ubiquitous in isolates of C. jejuni and does not correlate with specific clonal groups regarding pathogenicity or pathogen metabolism."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2013"],["dc.identifier.doi","10.1371/journal.pone.0081069"],["dc.identifier.isi","000327546400048"],["dc.identifier.pmid","24303031"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9509"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28175"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","The Campylobacter jejuni Cj0268c Protein Is Required for Adhesion and Invasion In Vitro"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3123"],["dc.bibliographiccitation.journal","Microbiology"],["dc.bibliographiccitation.lastpage","3135"],["dc.bibliographiccitation.volume","156"],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Dasti, Javid Lqbal"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Lugert, Raimond"],["dc.date.accessioned","2018-11-07T08:38:42Z"],["dc.date.available","2018-11-07T08:38:42Z"],["dc.date.issued","2010"],["dc.description.abstract","Campylobacter jejuni, an important food-borne bacterial pathogen in industrialized countries and in the developing world, is one of the major causes of bacterial diarrhoea. To identify genes which are important for the invasion of host cells by the pathogen, we screened altogether 660 clones of a transposon-generated mutant library based on the clinical C. jejuni isolate B2. Thereby, we identified a clone with a transposon insertion in gene cj0952c. As in the well-characterized C. jejuni strain NCTC 11168, the corresponding protein together with the gene product of the adjacent gene cj0951c consists of two transmembrane domains, a HAMP domain and a putative MCP domain, which together are thought to act as a chemoreceptor, designated Tlp7. In this report we show that genes cj0952c and cj0951c (i) are important for the host cell invasion of the pathogen, (ii) are not translated as one protein in C. jejuni isolate B2, contradicting the idea of a postulated read-through mechanism, (iii) affect the motility of C. jejuni, (iv) alter the chemotactic behaviour of the pathogen towards formic acid, and (v) are not related to the utilization of formic acid by formate dehydrogenase."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [GRK 335/3, GR 906/13-1]"],["dc.identifier.doi","10.1099/mic.0.039438-0"],["dc.identifier.isi","000283454100023"],["dc.identifier.pmid","20656782"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18821"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc General Microbiology"],["dc.relation.issn","1350-0872"],["dc.title","Campylobacter jejuni proteins Cj0952c and Cj0951c affect chemotactic behaviour towards formic acid and are important for invasion of host cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","526860"],["dc.bibliographiccitation.journal","Clinical and Developmental Immunology"],["dc.contributor.author","Masanta, Wycliffe Omurwa"],["dc.contributor.author","Heimesaat, Markus M."],["dc.contributor.author","Bereswill, Stefan"],["dc.contributor.author","Tareen, Abdul Malik"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.date.accessioned","2018-11-07T09:29:31Z"],["dc.date.available","2018-11-07T09:29:31Z"],["dc.date.issued","2013"],["dc.description.abstract","Campylobacter jejuni is the leading cause of bacterial food-borne gastroenteritis in the world, and thus one of the most important public health concerns. The initial stage in its pathogenesis after ingestion is to overcome colonization resistance that is maintained by the human intestinal microbiota. But how it overcomes colonization resistance is unknown. Recently developed humanized gnotobiotic mouse models have provided deeper insights into this initial stage and host's immune response. These studies have found that a fat-rich diet modifies the composition of the conventional intestinal microbiota by increasing the Firmicutes and Proteobacteria loads while reducing the Actinobacteria and Bacteroidetes loads creating an imbalance that exposes the intestinal epithelial cells to adherence. Upon adherence, deoxycholic acid stimulates C. jejuni to synthesize Campylobacter invasion antigens, which invade the epithelial cells. In response, NF-kappa B triggers the maturation of dendritic cells. Chemokines produced by the activated dendritic cells initiate the clearance of C. jejuni cells by inducing the actions of neutrophils, B-lymphocytes, and various subsets of T-cells. This immune response causes inflammation. This review focuses on the progress that has been made on understanding the relationship between intestinal microbiota shift, establishment of C. jejuni infection, and consequent immune response."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2013"],["dc.identifier.doi","10.1155/2013/526860"],["dc.identifier.isi","000327262600001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9506"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31052"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hindawi Publishing Corporation"],["dc.relation.issn","1740-2530"],["dc.relation.issn","1740-2522"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Modification of Intestinal Microbiota and Its Consequences for Innate Immune Response in the Pathogenesis of Campylobacteriosis"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]