Göpfert, Martin C.

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Pathogens and Global Health"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Andres, Marta"],["dc.contributor.author","Karak, Somdatta"],["dc.contributor.author","Joo, Seol-hee"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:16:41Z"],["dc.date.available","2018-11-07T09:16:41Z"],["dc.date.issued","2013"],["dc.format.extent","406"],["dc.identifier.isi","000335056200021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27988"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Maney Publishing"],["dc.publisher.place","Leeds"],["dc.relation.issn","2047-7732"],["dc.relation.issn","2047-7724"],["dc.title","DROSOPHILA MELANOGASTER AS A MODEL TO UNDERSTAND HEARING IN DISEASE VECTORS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20130528"],["dc.bibliographiccitation.issue","1759"],["dc.bibliographiccitation.journal","Proceedings of the Royal Society B: Biological Sciences"],["dc.bibliographiccitation.volume","280"],["dc.contributor.author","Greggers, Uwe"],["dc.contributor.author","Koch, Gesche"],["dc.contributor.author","Schmidt, Viola"],["dc.contributor.author","Dürr, Aron"],["dc.contributor.author","Floriou-Servou, Amalia"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Menzel, Randolf"],["dc.date.accessioned","2022-03-01T11:46:53Z"],["dc.date.available","2022-03-01T11:46:53Z"],["dc.date.issued","2013"],["dc.description.abstract","Honeybees, like other insects, accumulate electric charge in flight, and when their body parts are moved or rubbed together. We report that bees emit constant and modulated electric fields when flying, landing, walking and during the waggle dance. The electric fields emitted by dancing bees consist of low- and high-frequency components. Both components induce passive antennal movements in stationary bees according to Coulomb's law. Bees learn both the constant and the modulated electric field components in the context of appetitive proboscis extension response conditioning. Using this paradigm, we identify mechanoreceptors in both joints of the antennae as sensors. Other mechanoreceptors on the bee body are potentially involved but are less sensitive. Using laser vibrometry, we show that the electrically charged flagellum is moved by constant and modulated electric fields and more strongly so if sound and electric fields interact. Recordings from axons of the Johnston organ document its sensitivity to electric field stimuli. Our analyses identify electric fields emanating from the surface charge of bees as stimuli for mechanoreceptors, and as biologically relevant stimuli, which may play a role in social communication."],["dc.description.abstract","Honeybees, like other insects, accumulate electric charge in flight, and when their body parts are moved or rubbed together. We report that bees emit constant and modulated electric fields when flying, landing, walking and during the waggle dance. The electric fields emitted by dancing bees consist of low- and high-frequency components. Both components induce passive antennal movements in stationary bees according to Coulomb's law. Bees learn both the constant and the modulated electric field components in the context of appetitive proboscis extension response conditioning. Using this paradigm, we identify mechanoreceptors in both joints of the antennae as sensors. Other mechanoreceptors on the bee body are potentially involved but are less sensitive. Using laser vibrometry, we show that the electrically charged flagellum is moved by constant and modulated electric fields and more strongly so if sound and electric fields interact. Recordings from axons of the Johnston organ document its sensitivity to electric field stimuli. Our analyses identify electric fields emanating from the surface charge of bees as stimuli for mechanoreceptors, and as biologically relevant stimuli, which may play a role in social communication."],["dc.identifier.doi","10.1098/rspb.2013.0528"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103834"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1471-2954"],["dc.relation.issn","0962-8452"],["dc.rights.uri","https://royalsociety.org/journals/ethics-policies/data-sharing-mining/"],["dc.title","Reception and learning of electric fields in bees"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","17085"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Karak, Somdatta"],["dc.contributor.author","Jacobs, Julie S."],["dc.contributor.author","Kittelmann, Maike"],["dc.contributor.author","Spalthoff, Christian"],["dc.contributor.author","Katana, Radoslaw"],["dc.contributor.author","Sivan-Loukianova, Elena"],["dc.contributor.author","Schon, Michael A."],["dc.contributor.author","Kernan, Maurice J."],["dc.contributor.author","Eberl, Daniel F."],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:48:47Z"],["dc.date.available","2018-11-07T09:48:47Z"],["dc.date.issued","2015"],["dc.description.abstract","Much like vertebrate hair cells, the chordotonal sensory neurons that mediate hearing in Drosophila are motile and amplify the mechanical input of the ear. Because the neurons bear mechanosensory primary cilia whose microtubule axonemes display dynein arms, we hypothesized that their motility is powered by dyneins. Here, we describe two axonemal dynein proteins that are required for Drosophila auditory neuron function, localize to their primary cilia, and differently contribute to mechanical amplification in hearing. Promoter fusions revealed that the two axonemal dynein genes Dmdnah3 (=CG17150) and Dmdnai2 (=CG6053) are expressed in chordotonal neurons, including the auditory ones in the fly's ear. Null alleles of both dyneins equally abolished electrical auditory neuron responses, yet whereas mutations in Dmdnah3 facilitated mechanical amplification, amplification was abolished by mutations in Dmdnai2. Epistasis analysis revealed that Dmdnah3 acts downstream of Nan-Iav channels in controlling the amplificatory gain. Dmdnai2, in addition to being required for amplification, was essential for outer dynein arms in auditory neuron cilia. This establishes diverse roles of axonemal dyneins in Drosophila auditory neuron function and links auditory neuron motility to primary cilia and axonemal dyneins. Mutant defects in sperm competition suggest that both dyneins also function in sperm motility."],["dc.description.sponsorship","Open-Access Publikationsfonds 2015"],["dc.identifier.doi","10.1038/srep17085"],["dc.identifier.isi","000365389300001"],["dc.identifier.pmid","26608786"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12601"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35376"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","511"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Biophysics Journal"],["dc.bibliographiccitation.lastpage","516"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Stoop, R."],["dc.contributor.author","Kern, A."],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Smirnov, D. A."],["dc.contributor.author","Dikanev, T. V."],["dc.contributor.author","Bezrucko, B. P."],["dc.date.accessioned","2022-03-01T11:44:34Z"],["dc.date.available","2022-03-01T11:44:34Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1007/s00249-006-0059-5"],["dc.identifier.pii","59"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103052"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1432-1017"],["dc.relation.issn","0175-7571"],["dc.title","A generalization of the van-der-Pol oscillator underlies active signal amplification in Drosophila hearing"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1042"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Cell"],["dc.bibliographiccitation.lastpage","1054"],["dc.bibliographiccitation.volume","150"],["dc.contributor.author","Senthilan, Pingkalai R."],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Ovezmyradov, Guvanch"],["dc.contributor.author","Nadrowski, Bjoern"],["dc.contributor.author","Bechstedt, Susanne"],["dc.contributor.author","Pauls, Stephanie"],["dc.contributor.author","Winkler, Margret"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Howard, Jonathon"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:07:03Z"],["dc.date.available","2018-11-07T09:07:03Z"],["dc.date.issued","2012"],["dc.description.abstract","The Drosophila auditory organ shares equivalent transduction mechanisms with vertebrate hair cells, and both are specified by atonal family genes. Using a whole-organ knockout strategy based on atonal, we have identified 274 Drosophila auditory organ genes. Only four of these genes had previously been associated with fly hearing, yet one in five of the genes that we identified has a human cognate that is implicated in hearing disorders. Mutant analysis of 42 genes shows that more than half of them contribute to auditory organ function, with phenotypes including hearing loss, auditory hypersusceptibility, and ringing ears. We not only discover ion channels and motors important for hearing, but also show that auditory stimulus processing involves chemoreceptor proteins as well as phototransducer components. Our findings demonstrate mechanosensory roles for ionotropic receptors and visual rhodopsins and indicate that different sensory modalities utilize common signaling cascades."],["dc.identifier.doi","10.1016/j.cell.2012.06.043"],["dc.identifier.isi","000308500200017"],["dc.identifier.pmid","22939627"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25700"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0092-8674"],["dc.title","Drosophila Auditory Organ Genes and Genetic Hearing Defects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Psychiatry"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Corthals, Kristina"],["dc.contributor.author","Heukamp, Alina Sophia"],["dc.contributor.author","Kossen, Robert"],["dc.contributor.author","Großhennig, Isabel"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Gras, Heribert"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Heinrich, Ralf"],["dc.contributor.author","Geurten, Bart R. H."],["dc.date.accessioned","2019-07-09T11:43:34Z"],["dc.date.available","2019-07-09T11:43:34Z"],["dc.date.issued","2017"],["dc.description.abstract","The genome of Drosophila melanogaster includes homologs to approximately one-third of the currently known human disease genes. Flies and humans share many biological processes, including the principles of information processing by excitable neurons, synaptic transmission, and the chemical signals involved in intercellular communication. Studies on the molecular and behavioral impact of genetic risk factors of human neuro- developmental disorders [autism spectrum disorders (ASDs), schizophrenia, attention deficit hyperactivity disorders, and Tourette syndrome] increasingly use the well-studied social behavior of D. melanogaster, an organism that is amenable to a large variety of genetic manipulations. Neuroligins (Nlgs) are a family of phylogenetically conserved postsynaptic adhesion molecules present (among others) in nematodes, insects, and mammals. Impaired function of Nlgs (particularly of Nlg 3 and 4) has been associated with ASDs in humans and impaired social and communication behavior in mice. Making use of a set of behavioral and social assays, we, here, analyzed the impact of two Drosophila Nlgs, Dnlg2 and Dnlg4, which are differentially expressed at excitatory and inhibitory central nervous synapses, respectively. Both Nlgs seem to be associated with diurnal activity and social behavior. Even though deficiencies in Dnlg2 and Dnlg4 appeared to have no effects on sensory or motor systems, they differentially impacted on social interactions, suggesting that social behavior is distinctly regulated by these Nlgs."],["dc.identifier.doi","10.3389/fpsyt.2017.00113"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58919"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-0640"],["dc.relation.issn","1664-0640"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Neuroligins Nlg2 and Nlg4 Affect Social Behavior in Drosophila melanogaster"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","28"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuroforum"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Moser, Tobias"],["dc.contributor.author","Löwel, Siegrid"],["dc.contributor.author","Goepfert, Martin C."],["dc.date.accessioned","2018-11-07T09:28:18Z"],["dc.date.available","2018-11-07T09:28:18Z"],["dc.date.issued","2013"],["dc.identifier.isi","000321725500008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30741"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Spektrum Akademischer Verlag-springer-verlag Gmbh"],["dc.relation.issn","0947-0875"],["dc.title","Cellular Mechanisms of Sensory Processing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","619"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychological Medicine"],["dc.bibliographiccitation.lastpage","628"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Wood, G. C."],["dc.contributor.author","Bentall, R. P."],["dc.contributor.author","Göpfert, M."],["dc.contributor.author","Edwards, R. H. T."],["dc.date.accessioned","2022-03-01T11:45:37Z"],["dc.date.available","2022-03-01T11:45:37Z"],["dc.date.issued","2009"],["dc.description.abstract","SYNOPSIS The psychiatric status of patients with chronic fatigue syndrome ( N = 34) and muscle disease ( N = 24) attending a general medical clinic was studied. Among fatigue patients 14 (41·2%) were cases and a further 9 (26·5%) were subcases of psychiatric disorder as defined by CATEGO. A variety of diagnoses was found. Significantly fewer of the muscle patients had a psychiatric disorder with 3 (12·5%) being cases and 1 (4%) a subcase. The relative risk of psychiatric disorder in patients with chronic fatigue syndrome compared to patients with muscle disease was 3·3:1."],["dc.description.abstract","SYNOPSIS The psychiatric status of patients with chronic fatigue syndrome ( N = 34) and muscle disease ( N = 24) attending a general medical clinic was studied. Among fatigue patients 14 (41·2%) were cases and a further 9 (26·5%) were subcases of psychiatric disorder as defined by CATEGO. A variety of diagnoses was found. Significantly fewer of the muscle patients had a psychiatric disorder with 3 (12·5%) being cases and 1 (4%) a subcase. The relative risk of psychiatric disorder in patients with chronic fatigue syndrome compared to patients with muscle disease was 3·3:1."],["dc.identifier.doi","10.1017/S003329170002225X"],["dc.identifier.pii","S003329170002225X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103396"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1469-8978"],["dc.relation.issn","0033-2917"],["dc.title","A comparative psychiatric assessment of patients with chronic fatigue syndrome and muscle disease"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","105"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Disease Models & Mechanisms"],["dc.bibliographiccitation.lastpage","118"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Seco, Celia Zazo"],["dc.contributor.author","Castells-Nobau, Anna"],["dc.contributor.author","Joo, Seol-hee"],["dc.contributor.author","Schraders, Margit"],["dc.contributor.author","Foo, Jia Nee"],["dc.contributor.author","van der Voet, Monique"],["dc.contributor.author","Velan, S. Sendhil"],["dc.contributor.author","Nijhof, Bonnie"],["dc.contributor.author","Oostrik, Jaap"],["dc.contributor.author","de Vrieze, Erik"],["dc.contributor.author","Katana, Radoslaw"],["dc.contributor.author","Mansoor, Atika"],["dc.contributor.author","Huynen, Martijn"],["dc.contributor.author","Szklarczyk, Radek"],["dc.contributor.author","Oti, Martin"],["dc.contributor.author","Tranebjaerg, Lisbeth"],["dc.contributor.author","van Wijk, Erwin"],["dc.contributor.author","Scheffer-de Gooyert, Jolanda M."],["dc.contributor.author","Siddique, Saadat"],["dc.contributor.author","Baets, Jonathan"],["dc.contributor.author","de Jonghe, Peter"],["dc.contributor.author","Kazmi, Syed Ali Raza"],["dc.contributor.author","Sadananthan, Suresh Anand"],["dc.contributor.author","van de Warrenburg, Bart P."],["dc.contributor.author","Khor, Chiea Chuen"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Qamar, Raheel"],["dc.contributor.author","Schenck, Annette"],["dc.contributor.author","Kremer, Hannie"],["dc.contributor.author","Siddiqi, Saima"],["dc.date.accessioned","2018-11-07T10:27:59Z"],["dc.date.available","2018-11-07T10:27:59Z"],["dc.date.issued","2017"],["dc.description.abstract","A consanguineous family from Pakistan was ascertained to have a novel deafness-dystonia syndrome with motor regression, ichthyosis-like features and signs of sensory neuropathy. By applying a combined strategy of linkage analysis and whole-exome sequencing in the presented family, a homozygous nonsense mutation, c.4G>T (p.Glu2 ), in FITM2 was identified. FITM2 and its paralog FITM1 constitute an evolutionary conserved protein family involved in partitioning of triglycerides into cellular lipid droplets. Despite the role of FITM2 in neutral lipid storage and metabolism, no indications for lipodystrophy were observed in the affected individuals. In order to obtain independent evidence for the involvement of FITM2 in the human pathology, downregulation of the single Fitm ortholog, CG10671, in Drosophila melanogaster was pursued using RNA interference. Characteristics of the syndrome, including progressive locomotor impairment, hearing loss and disturbed sensory functions, were recapitulated in Drosophila, which supports the causative nature of the FITM2 mutation. Mutation-based genetic counseling can now be provided to the family and insight is obtained into the potential impact of genetic variation in FITM2."],["dc.identifier.doi","10.1242/dmm.026476"],["dc.identifier.isi","000393913800003"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14385"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43329"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Company Of Biologists Ltd"],["dc.relation.issn","1754-8411"],["dc.relation.issn","1754-8403"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","A homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Abstracts of Papers of the American Chemical Society"],["dc.bibliographiccitation.volume","248"],["dc.contributor.author","Salgado, Vincent L."],["dc.contributor.author","Nesterov, Alexandre"],["dc.contributor.author","Kandasamy, Ramani A."],["dc.contributor.author","Spalthoff, Christian"],["dc.contributor.author","Göpfert, Martin C."],["dc.date.accessioned","2018-11-07T09:36:41Z"],["dc.date.available","2018-11-07T09:36:41Z"],["dc.date.issued","2014"],["dc.identifier.isi","000349165100596"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32673"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.publisher.place","Washington"],["dc.relation.eventlocation","San Francisco, CA"],["dc.relation.issn","0065-7727"],["dc.title","Action of insecticides on chordotonal organs"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]