Schomburg, Eike Dieter

[["dc.bibliographiccitation.firstpage","203"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","PHYSIOLOGICAL RESEARCH"],["dc.bibliographiccitation.lastpage","214"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Steffens, Heinz"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Schomburg, Eike D."],["dc.date.accessioned","2018-11-07T09:15:11Z"],["dc.date.available","2018-11-07T09:15:11Z"],["dc.date.issued","2012"],["dc.description.abstract","Electrophysiological investigations in mice, particularly with altered myelination, require reference data of the nerve conduction velocity (CV). CVs of different fibre groups were determined in the hindlimb of anaesthetized adult mice. Differentiation between afferent and efferent fibres was performed by recording at dorsal roots and stimulating at ventral roots, respectively. Correspondingly, recording or stimulation was performed at peripheral hindlimb nerves. Stimulation was performed with graded strength to differentiate between fibre groups. CVs of the same fibre groups were different in different nerves of the hindlimb. CVs for motor fibres were for the tibial nerve (Tib) 38.5 +/- 4.0 m/s (A gamma: 16.7 +/- 3.0 m/s), the sural nerve (Sur) 39.3 +/- 3.1 m/s (12.0 +/- 0.8 m/s) and the common peroneal nerve (Per) 46.7 +/- 4.7 m/s (22.2 +/- 4.4 m/s). CVs for group I afferents were 47.4 +/- 3.1 m/s (Tib), 43.8 +/- 3.8 m/s (Sur), 55.2 +/- 6.1 m/s (Per) and 42.9 +/- 4.3 m/s for the posterior biceps (PB). CVs of higher threshold afferents, presumably muscle and cutaneous, cover a broad range and do not really exhibit nerve specific differences. Ranges are for group II 22-38 m/s, for group III 9-19 m/s, and for group IV 0.8-0.9 m/s. Incontrovertible evidence was found for the presence of motor fibres in the sural nerve. The results are useful as references for further electrophysiological investigations particularly in genetically modified mice with myelination changes."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SCHO 37/16]"],["dc.identifier.isi","000306507400010"],["dc.identifier.pmid","22292724"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27616"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Acad Sciences Czech Republic, Inst Physiology"],["dc.relation.issn","0862-8408"],["dc.title","In Vivo Measurement of Conduction Velocities in Afferent and Efferent Nerve Fibre Groups in Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","693"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neurological Research"],["dc.bibliographiccitation.lastpage","702"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Schomburg, Eike D."],["dc.contributor.author","Steffens, Heinz"],["dc.date.accessioned","2018-11-07T09:54:21Z"],["dc.date.available","2018-11-07T09:54:21Z"],["dc.date.issued","2015"],["dc.description.abstract","Objectives: In the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS), a selective degeneration of fast-fatigable motor units and consequently an early decline of contractile force in individual fast-twitch muscles have been observed in the preclinical stage. However, most human muscles include fast and slow motor units. Gastrocnemius-soleus group (GS) contains such a mixture of units. Methods: We have investigated changes in the mechanical properties of GS at different SOD1G93A stages in mice. For this purpose, the tibial nerve was repetitively stimulated with rectangular pulses and the force of GS twitches was recorded using a strain gauge fixed to the Achilles tendon. Results: Isometric and tetanic force were attenuated but not before the first clinical signs developed. However, already at preclinical stages, single twitches showed a slower decay compared to control. Consequently, fusion of GS twitches occurred at lower stimulus rates. Furthermore, already preclinically, the temporal course of successive twitch amplitudes changed during repetitive stimulation at increasing rates. The peak amplitudes as well as the potentiation following decay (fatigue) were lower in preclinical mice than in control. Discussion: The time-lapse analysis of the contractile pattern as well as of the twitch configuration of the mixed muscle GS have revealed distinctive differences between wild-type controls and preclinical SOD1G93A mice. It would be of interest to know whether these preclinical changes are also detectable in ALS patients."],["dc.identifier.doi","10.1179/1743132815Y.0000000039"],["dc.identifier.isi","000356891600006"],["dc.identifier.pmid","25917373"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36519"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","1743-1328"],["dc.relation.issn","0161-6412"],["dc.title","Contractile characteristics of gastrocnemius-soleus muscle in the SOD1G93A ALS mouse model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","44"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuroscience Research"],["dc.bibliographiccitation.lastpage","54"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Steffens, Heinz"],["dc.contributor.author","Schomburg, Eike D."],["dc.date.accessioned","2018-11-07T08:56:19Z"],["dc.date.available","2018-11-07T08:56:19Z"],["dc.date.issued","2011"],["dc.description.abstract","For further evaluation of opioidergic spinal motor functions the action of the mu-opioid receptor agonist DAMGO was tested on transmission in different non-nociceptive and nociceptive spinal reflex pathways from flexor reflex afferents (FRA), and in non-FRA reflex pathways in spinal cats. The action of DAMGO was complex, not following a simple pattern with selective depression of nociceptive pathways compared to non-nociceptive ones. Monosynaptic reflexes of the flexor posterior biceps semitendinosus (PBSt) and transmission in nociceptive as well as non-nociceptive excitatory FRA pathways to PBSt were depressed, while the specific excitatory nociceptive non-FRA pathway from the central foot pad to foot extensors was mainly not depressed but rather facilitated by DAMGO. DAMGO caused a facilitation of monosynaptic reflexes to the extensor gastrocnemius soleus (GS) and partly a reversal of inhibitory to excitatory conditioning effects from cutaneous afferents to GS. FRA interneurones could show either an increase or a cessation of their spontaneous activity, but responsiveness to nociceptive and non-nociceptive afferent activation was blocked by DAMGO. The main DAMGO action is generated via interneuronal systems rather than on motoneurones themselves. The results indicate that opioidergic spinal functions are extensively involved in spinal motor control exceeding a mere suppression of nociceptive motor withdrawal reactions. (C) 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SCHO 37/16]"],["dc.identifier.doi","10.1016/j.neures.2011.01.011"],["dc.identifier.isi","000291179500008"],["dc.identifier.pmid","21276826"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23120"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0168-0102"],["dc.title","Spinal motor actions of the mu-opioid receptor agonist DAMGO in the cat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","605"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","613"],["dc.bibliographiccitation.volume","536"],["dc.contributor.author","Schomburg, Eike D."],["dc.contributor.author","Steffens, Heinz"],["dc.contributor.author","Wada, N."],["dc.date.accessioned","2018-11-07T08:32:31Z"],["dc.date.available","2018-11-07T08:32:31Z"],["dc.date.issued","2001"],["dc.description.abstract","1. Nociceptive reflex pathways to foot extensors were investigated with particular attention given to those not following a flexor reflex (FRA) or withdrawal pattern. 2. In anaemically decapitated, high spinal paralysed cats nociceptive afferents of the foot pad were activated by noxious radiant heat (48-60 degreesC), while for comparison non-nociceptive afferents were activated by weak mechanical stimulation of the skin or graded electrical nerve stimulation. The reflex action of the afferents on hindlimb motoneurones, innervating plantaris and intrinsic foot extensors (tibial nerve), was investigated by intracellular recording, by monosynaptic reflex testing and by recording of neurograms during fictive locomotion. A possible descending control of the nociceptive and non-nociceptive pathways was tested by application of opioidergic and monoaminergic compounds. 3. Beside the typical FRA pattern evoked in the majority of hindlimb motoneurone pools by nociceptive afferents from different skin areas of the foot, the results revealed parallel excitatory and inhibitory nociceptive reflex pathways from the central pad and partly from the toe pads to foot extensors. The excitatory pathways, which did not follow the FRA pattern, were predominantly to plantaris and intrinsic foot extensors. They were distinctly less depressed by opioids and monoaminergic compounds than FRA pathways. 4. While the nociceptive FRA pathways have a general nocifensive withdrawal function, the nociceptive excitatory non-FRA pathway to the foot extensors causes a movement of the affected area towards the stimulus or at least a resistance against the stimulus, i.e. it mediates a positive feedback."],["dc.identifier.doi","10.1111/j.1469-7793.2001.0605c.xd"],["dc.identifier.isi","000171807700025"],["dc.identifier.pmid","11600693"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17357"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.relation.issn","0022-3751"],["dc.title","Parallel nociceptive reflex pathways with negative and positive feedback functions to foot extensors in the cat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Acta Physiologica"],["dc.bibliographiccitation.volume","211"],["dc.contributor.author","Schomburg, Eike D."],["dc.contributor.author","Steffens, Heinz"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Sears, Thomas A."],["dc.date.accessioned","2018-11-07T09:36:48Z"],["dc.date.available","2018-11-07T09:36:48Z"],["dc.date.issued","2014"],["dc.format.extent","32"],["dc.identifier.isi","000349466000033"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32698"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1748-1716"],["dc.relation.issn","1748-1708"],["dc.title","Chronic muscle pain provokes bilateral flexion reflex pattern in the feline spinal cord"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2431"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Neuroscience Research"],["dc.bibliographiccitation.lastpage","2440"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Steffens, Heinz"],["dc.contributor.author","Nadrigny, Fabien"],["dc.contributor.author","Neusch, Clemens"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Schomburg, Eike D."],["dc.date.accessioned","2018-11-07T08:40:21Z"],["dc.date.available","2018-11-07T08:40:21Z"],["dc.date.issued","2010"],["dc.description.abstract","As CNS macrophages, microglia show a high spontaneous motility of their processes, continuously surveying their microenvironment. Upon CNS injury, microglia react by immediate cellular polarization and process extension toward the lesion site as well as by subsequent amoeboid lesion-directed migration and phagocytosis. To determine the ability of microglia to fulfill their role within distinctively lesioned tissue in the absence of life support, we investigated microglial activity and responsiveness to laser-induced axonal injuries in the spinal dorsal columns in situ after cardiac and respiratory arrest, i.e., post-mortem, in the progressively degrading nervous tissue. For this purpose, we used time-lapse two-photon laser scanning microscopy in double transgenic mice expressing enhanced green fluorescent protein in microglia and enhanced yellow fluorescent protein in projection neurons. Depending on the premortal condition of the animal, microglial activity and responsiveness remain for up to 5-10 hr post-mortem. Thereby, the continuously decreasing glial reaction is independent of oxygen and glucose supply but requires residual ATP, suggesting a parasitic form of energy, such as a transmembrane uptake of ATP released from injured nervous tissue. Even though initially microglia are able to detect axonal injury after disruption of the blood supply, the later aspects of glial reaction, for example amoeboid conversion and migration, are absent postmortem, corresponding to the failure of microglia to prevent secondary damage after injury of nervous tissue. (C) 2010 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/jnr.22402"],["dc.identifier.isi","000280436600012"],["dc.identifier.pmid","20623536"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19215"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0360-4012"],["dc.title","Long-Lasting Post-Mortem Activity of Spinal Microglia In Situ in Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","148"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neuroscience Letters"],["dc.bibliographiccitation.lastpage","151"],["dc.bibliographiccitation.volume","497"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Steffens, Heinz"],["dc.contributor.author","Zschuentzsch, Jana"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Schomburg, Eike D."],["dc.contributor.author","Neusch, Clemens"],["dc.date.accessioned","2018-11-07T08:54:58Z"],["dc.date.available","2018-11-07T08:54:58Z"],["dc.date.issued","2011"],["dc.description.abstract","Pathophysiology of the motoneuron disease amyotrophic lateral sclerosis (ALS) is non-cell-autonomous. In mouse models of familiar ALS, neurotoxicity is derived not only from mutant motor neurons but also from mutant neighbouring glial cells. In vivo imaging by two-photon laser-scanning microscopy was used to study rapid morphological reactions of astroglial cells towards laser-induced axonal transection in ALS-linked transgenic SOD1(G93A) mice. In the affected lateral spinal cord, mutated astroglial cells extended branches towards injured axons within a time frame of minutes to hours post lesion while in control animals astrocytes lack any rapid morphological alteration within the studied time frame. This suggests that astrocytes partially contribute to the rapid response of non-neuronal cells to acute axonal lesions in ALS mice. (C) 2011 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.neulet.2011.04.049"],["dc.identifier.isi","000292404400016"],["dc.identifier.pmid","21539893"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22797"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0304-3940"],["dc.title","In vivo imaging reveals rapid morphological reactions of astrocytes towards focal lesions in an ALS mouse model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","134P"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","135P"],["dc.bibliographiccitation.volume","527"],["dc.contributor.author","Schomburg, Eike D."],["dc.contributor.author","Marx, B."],["dc.contributor.author","Steffens, Heinz"],["dc.date.accessioned","2018-11-07T10:31:24Z"],["dc.date.available","2018-11-07T10:31:24Z"],["dc.date.issued","2000"],["dc.identifier.isi","000089787600176"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44101"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.issn","0022-3751"],["dc.title","Opioidergic action on nociceptive reflex components evoked by TTX-resistant C-fibres in the cat"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","230"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Muscle & Nerve"],["dc.bibliographiccitation.lastpage","236"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Schomburg, Eike D."],["dc.contributor.author","Steffens, Heinz"],["dc.contributor.author","Zschuentzsch, Jana"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Keller, Bernhard U."],["dc.date.accessioned","2018-11-07T08:59:54Z"],["dc.date.available","2018-11-07T08:59:54Z"],["dc.date.issued","2011"],["dc.description.abstract","Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons. To analyze the progressive motor deficits during the course of this disease, we investigated fatigability and ability of recovery of spinal motor neurons by testing monosynaptic reflex transmission with increasing stimulus frequencies in the lumbar spinal cord of the SOD1(G93A) mouse model for ALS in a comparison with wild-type (WT) mice. Monosynaptic reflexes in WT and SOD1(G93A) mice without behavioral deficits showed no difference with respect to their resistance to increasing stimulus frequencies. During the progression of motor deficits in SOD1(G93A) mice, the vulnerability of monosynaptic reflexes to higher frequencies-increased, the required time for reflex recovery was extended, and recovery was often incomplete. Fatigability and demand for recovery of spinal motor neurons in SOD1(G93A) mice rose with increasing motor deficits. This supports the assumption that impairment of the energy supply may contribute to the pathogenesis of ALS. Muscle Nerve 43: 230-236, 2011"],["dc.identifier.doi","10.1002/mus.21835"],["dc.identifier.isi","000286558300013"],["dc.identifier.pmid","21254088"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24015"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0148-639X"],["dc.title","FATIGABILITY OF SPINAL REFLEX TRANSMISSION IN A MOUSE MODEL (SOD1(G93A)) OF AMYOTROPHIC LATERAL SCLEROSIS"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","545"],["dc.bibliographiccitation.journal","Physiological Research"],["dc.bibliographiccitation.lastpage","548"],["dc.contributor.author","DIBAJ, P."],["dc.contributor.author","SCHOMBURG, E. D."],["dc.date.accessioned","2020-12-10T18:44:19Z"],["dc.date.available","2020-12-10T18:44:19Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.33549/physiolres"],["dc.identifier.eissn","1802-9973"],["dc.identifier.issn","0862-8408"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78406"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","In Vivo Recording of Nerve Conduction Velocity of Spinal CNS Fibers in the Mouse"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]