Hübner, Christine

[["dc.bibliographiccitation.firstpage","1140"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","1148"],["dc.bibliographiccitation.volume","233"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Otto, S."],["dc.contributor.author","Poschadel, R."],["dc.contributor.author","Hubner, S."],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-11-07T09:01:16Z"],["dc.date.available","2018-11-07T09:01:16Z"],["dc.date.issued","2005"],["dc.description.abstract","Basement membranes (BM) are specialized structures of the extracellular matrix known to be involved in various early developmental processes. Despite numerous investigations on the localization of BM components, it remains unknown which molecules are expressed in early developmental stages and by which germ layers these proteins are produced. Therefore, we tested for all known laminin chains, nidogens, collagen type IV, and perlecan by means of light microscopic immunostaining and performed in situ reverse transcriptase-polymerase chain reaction to detect the mRNAs specific for laminin alpha 1, laminin beta 1, the alpha 1 chain of collagen type TV, nidogen-2, and perlecan in the early mouse embryo, day 7, in vivo. Only the laminin chains alpha 1, beta 1, and gamma 1 were detected immunohistochemically throughout the entire endodermal and ectodermal BM zones of the embryo proper. The mRNA of laminin alpha 1, laminin beta 1, collagen type IV, nidogen-2 and perlecan were expressed in the ectoderm-derived mesoderm, in the endoderm. as well as in the ectoderm. In contrast, Reichert's membrane was positive for all laminin chains except for the alpha 4, alpha 5, beta 3, and gamma 3 chains. Moreover, maternal epithelial as well as mesenchymal cells expressed laminins, nidogen-1 and nidogen-2, collagen type IV, and perlecan. In conclusion, laminin-1 might be the only laminin isoform in the early mouse embryo that, together with the other main BM components, nidogens, collagen type IV, and perlecan, is synthesized by all three germ layers. (c) 2005 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/dvdy.20425"],["dc.identifier.isi","000229892100048"],["dc.identifier.pmid","15895400"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24379"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","Basement membrane composition in the early mouse embryo day 7"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1043"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Pediatric Research"],["dc.bibliographiccitation.lastpage","1043"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Kohlschütter, A"],["dc.contributor.author","Hübner, C"],["dc.contributor.author","Gärtner, Jutta"],["dc.date.accessioned","2022-03-01T11:44:00Z"],["dc.date.available","2022-03-01T11:44:00Z"],["dc.date.issued","1986"],["dc.identifier.doi","10.1203/00006450-198610000-00113"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/102895"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1530-0447"],["dc.relation.issn","0031-3998"],["dc.title","59 Low Plasma Membrane Fluidity in Juvenile Neuronal Ceroid Lipofuscinosis (NCL) Lymphocytes"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","106"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Zeitschrift für Pädagogische Psychologie"],["dc.bibliographiccitation.lastpage","115"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Hager, W."],["dc.contributor.author","Hubner, S."],["dc.contributor.author","Hasselhorn, Marcus"],["dc.date.accessioned","2018-11-07T10:43:19Z"],["dc.date.available","2018-11-07T10:43:19Z"],["dc.date.issued","2000"],["dc.description.abstract","Effects of social interaction during training intervention can lead to unspecific enhancements of performances. This may result in overestimating the effectiveness of a program. Those effects of social interaction are well-known, however, they tend to be neglected in actual program evaluations. Moreover, the effectiveness of a program can be overestimated because of coaching which is to be expected when the tasks of the criterion measures are very similar to the tasks in the program. Two studies are reported aiming at testing some hypotheses concerning the effects of social interaction and of coaching. Several programs to foster children's reasoning abilities and a memory training are evaluated with some tests of general intelligence, a test of visual perception, and a task developed to assess children's reasoning abilities (concept formation tasks). The data lends support to the expected effects of social interaction and coaching regarding the tests of general intelligence and the test of visual perception, although it cannot be said in general that those effects will show up inevitably. In contrast, the concept formation tasks show differential patterns of results under the various programs. Moreover, effects of social interaction should not be eliminated because they usually lead to (unspecific) enhancements of performances which might be an important prerequisite of successful trainings."],["dc.identifier.doi","10.1024//1010-0652.14.23.106"],["dc.identifier.isi","000088629900006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47020"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Verlag Hans Huber"],["dc.relation.issn","1010-0652"],["dc.title","The meaning of social interaction in evaluations of cognitive training programs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1411"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","1416"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Henneke, M."],["dc.contributor.author","Preuss, N."],["dc.contributor.author","Engelbrecht, V."],["dc.contributor.author","Aksu, F."],["dc.contributor.author","Bertini, E."],["dc.contributor.author","Bibat, G."],["dc.contributor.author","Brockmann, K."],["dc.contributor.author","Hubner, C."],["dc.contributor.author","Mayer, M."],["dc.contributor.author","Mejaski-Bosnjak, V."],["dc.contributor.author","Gärtner, J."],["dc.date.accessioned","2022-03-01T11:44:03Z"],["dc.date.available","2022-03-01T11:44:03Z"],["dc.date.issued","2005"],["dc.description.abstract","Objective: To describe a distinctive syndrome of nonprogressive encephalopathy, normo- or microcephaly, and early onset of severe psychomotor impairment in 15 white patients, including two siblings and two first cousins. Methods and Results: MRI revealed bilateral cysts in the anterior part of the temporal lobe and white matter abnormalities with pericystic abnormal myelination and symmetric lesions in frontal and occipital periventricular regions. None of the usual inborn errors of metabolism/ infectious diseases associated with leukoencephalopathy and bilateral anterior temporal lobe cysts were detected. Conclusions: These patients' clinical signs and cranial MRI abnormalities are strikingly similar and may represent a distinctive disease with autosomal-recessive inheritance: cystic leukoencephalopathy without megalencephaly."],["dc.identifier.doi","10.1212/01.WNL.0000158472.82823.01"],["dc.identifier.gro","3143863"],["dc.identifier.isi","000228660600019"],["dc.identifier.pmid","15851732"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/102915"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1526-632X"],["dc.title","Cystic leukoencephalopathy without megalencephaly: A distinct disease entity in 15 children"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","251"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American journal of human genetics"],["dc.bibliographiccitation.lastpage","260"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Uhlenberg, B."],["dc.contributor.author","Schuelke, Markus"],["dc.contributor.author","Ruschendorf, F"],["dc.contributor.author","Ruf, N"],["dc.contributor.author","Kaindl, A. M."],["dc.contributor.author","Henneke, Marco"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Stoltenburg-Didinger, G"],["dc.contributor.author","Aksu, F."],["dc.contributor.author","Topaloglu, H."],["dc.contributor.author","Nürnberg, Peter"],["dc.contributor.author","Hübner, Christine"],["dc.contributor.author","Weschke, B"],["dc.contributor.author","Gärtner, Jutta"],["dc.date.accessioned","2017-09-07T11:43:19Z"],["dc.date.available","2017-09-07T11:43:19Z"],["dc.date.issued","2004"],["dc.description.abstract","The hypomyelinating leukodystrophies X-linked Pelizaeus-Merzbacher disease (PMD) and Pelizaeus-Merzbacher like disease (PMLD) are characterized by nystagmus, progressive spasticity, and ataxia. In a consanguineous family with PMLD, we performed a genomewide linkage scan using the GeneChip Mapping EA 10K Array (Affymetrix) and detected a single gene locus on chromosome 1q41-q42. This region harbors the GJA12 gene, which encodes gap junction protein alpha12 (or connexin 46.6). Gap junction proteins assemble into intercellular channels through which signaling ions and small molecules are exchanged. GJA12 is highly expressed in oligodendrocytes, and, therefore, it serves as an excellent candidate for hypomyelination in PMLD. In three of six families with PMLD, we detected five different GJA12 mutations, including missense, nonsense, and frameshift mutations. We thereby confirm previous assumptions that PMLD is genetically heterogeneous. Although the murine Gja12 ortholog is not expressed in sciatic nerve, we did detect GJA12 transcripts in human sciatic and sural nerve tissue by reverse-transcriptase polymerase chain reaction. These results are in accordance with the electrophysiological finding of reduced motor and sensory nerve conduction velocities in patients with PMLD, which argues for a demyelinating neuropathy. In this study, we demonstrate that GJA12 plays a key role in central myelination and is involved in peripheral myelination in humans."],["dc.identifier.doi","10.1086/422763"],["dc.identifier.gro","3143959"],["dc.identifier.isi","000222702000009"],["dc.identifier.pmid","15192806"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1530"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Univ Chicago Press"],["dc.relation.issn","0002-9297"],["dc.title","Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]