Pooryasin, Atefeh

[["dc.bibliographiccitation.firstpage","3992"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","The Journal of Comparative Neurology"],["dc.bibliographiccitation.lastpage","4026"],["dc.bibliographiccitation.volume","521"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Birman, Serge"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:17:25Z"],["dc.date.available","2018-11-07T09:17:25Z"],["dc.date.issued","2013"],["dc.description.abstract","The mushroom body of the insect brain represents a neuronal circuit involved in the control of adaptive behavior, e.g., associative learning. Its function relies on the modulation of Kenyon cell activity or synaptic transmitter release by biogenic amines, e.g., octopamine, dopamine, or serotonin. Therefore, for a comprehensive understanding of the mushroom body, it is of interest not only to determine which modulatory neurons interact with Kenyon cells but also to pinpoint where exactly in the mushroom body they do so. To accomplish the latter, we made use of the GRASP technique and created transgenic Drosophila melanogaster that carry one part of a membrane-bound splitGFP in Kenyon cells, along with a cytosolic red fluorescent marker. The second part of the splitGFP is expressed in distinct neuronal populations using cell-specific Gal4 drivers. GFP is reconstituted only if these neurons interact with Kenyon cells in close proximity, which, in combination with two-photon microscopy, provides a very high spatial resolution. We characterize spatially and microstructurally distinct contact regions between Kenyon cells and dopaminergic, serotonergic, and octopaminergic/tyraminergic neurons in all subdivisions of the mushroom body. Subpopulations of dopaminergic neurons contact complementary lobe regions densely. Octopaminergic/tyraminergic neurons contact Kenyon cells sparsely and are restricted mainly to the calyx, the -lobes, and the -lobes. Contacts of Kenyon cells with serotonergic neurons are heterogeneously distributed over the entire mushroom body. In summary, the technique enables us to localize precisely a segmentation of the mushroom body by differential contacts with aminergic neurons. J. Comp. Neurol. 521:3992-4026, 2013. (c) 2013 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/cne.23388"],["dc.identifier.isi","000325461300008"],["dc.identifier.pmid","23784863"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28161"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0021-9967"],["dc.title","Localization of the Contacts Between Kenyon Cells and Aminergic Neurons in the Drosophila melanogaster Brain Using SplitGFP Reconstitution"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","12792"],["dc.bibliographiccitation.issue","37"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","12812"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:51:36Z"],["dc.date.available","2018-11-07T09:51:36Z"],["dc.date.issued","2015"],["dc.description.abstract","Animals show different levels of activity that are reflected in sensory responsiveness and endogenously generated behaviors. Biogenic amines have been determined to be causal factors for these states of arousal. It is well established that, in Drosophila, dopamine and octopamine promote increased arousal. However, little is known about factors that regulate arousal negatively and induce states of quiescence. Moreover, it remains unclear whether global, diffuse modulatory systems comprehensively affecting brain activity determine general states of arousal. Alternatively, individual aminergic neurons might selectively modulate the animals' activity in a distinct behavioral context. Here, we show that artificially activating large populations of serotonin-releasing neurons induces behavioral quiescence and inhibits feeding and mating. We systematically narrowed down a role of serotonin in inhibiting endogenously generated locomotor activity to neurons located in the posterior medial protocerebrum. We identified neurons of this cell cluster that suppress mating, but not feeding behavior. These results suggest that serotonin does not uniformly act as global, negative modulator of general arousal. Rather, distinct serotoninergic neurons can act as inhibitory modulators of specific behaviors."],["dc.description.sponsorship","German Research Foundation [FI 821/3-1]"],["dc.identifier.doi","10.1523/JNEUROSCI.1638-15.2015"],["dc.identifier.isi","000363659500017"],["dc.identifier.pmid","26377467"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35947"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Identified Serotonin-Releasing Neurons Induce Behavioral Quiescence and Suppress Mating in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","52"],["dc.bibliographiccitation.journal","Journal of Neurogenetics"],["dc.bibliographiccitation.lastpage","53"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:02:27Z"],["dc.date.available","2018-11-07T09:02:27Z"],["dc.date.issued","2012"],["dc.identifier.isi","000314975100132"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24686"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.publisher.place","London"],["dc.relation.issn","0167-7063"],["dc.title","A thermogenetic approach to analyze neuronal functions in Drosophila"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Maglione, Marta"],["dc.contributor.author","Schubert, Marco"],["dc.contributor.author","Matkovic-Rachid, Tanja"],["dc.contributor.author","Hasheminasab, Sayed-mohammad"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Fiala, André"],["dc.contributor.author","Mielke, Thorsten"],["dc.contributor.author","Sigrist, Stephan J."],["dc.date.accessioned","2021-06-01T09:41:40Z"],["dc.date.available","2021-06-01T09:41:40Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract The physical distance between presynaptic Ca 2+ channels and the Ca 2+ sensors triggering the release of neurotransmitter-containing vesicles regulates short-term plasticity (STP). While STP is highly diversified across synapse types, the computational and behavioral relevance of this diversity remains unclear. In the Drosophila brain, at nanoscale level, we can distinguish distinct coupling distances between Ca 2+ channels and the (m)unc13 family priming factors, Unc13A and Unc13B. Importantly, coupling distance defines release components with distinct STP characteristics. Here, we show that while Unc13A and Unc13B both contribute to synaptic signalling, they play distinct roles in neural decoding of olfactory information at excitatory projection neuron (ePN) output synapses. Unc13A clusters closer to Ca 2+ channels than Unc13B, specifically promoting fast phasic signal transfer. Reduction of Unc13A in ePNs attenuates responses to both aversive and appetitive stimuli, while reduction of Unc13B provokes a general shift towards appetitive values. Collectively, we provide direct genetic evidence that release components of distinct nanoscopic coupling distances differentially control STP to play distinct roles in neural decoding of sensory information."],["dc.identifier.doi","10.1038/s41467-021-22180-6"],["dc.identifier.pmid","33771998"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84997"],["dc.identifier.url","https://for2705.de/literature/publications/38"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation","FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body"],["dc.relation","FOR 2705 | TP 5: Postsynaptic receptor plasticity and transsynaptic communication in storage of memory components in the mushroom bodies"],["dc.relation.eissn","2041-1723"],["dc.relation.workinggroup","RG Fiala"],["dc.relation.workinggroup","RG Sigrist (Genetics)"],["dc.rights","CC BY 4.0"],["dc.title","Unc13A and Unc13B contribute to the decoding of distinct sensory information in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurogenetics"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Jauch, Mandy"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:02:29Z"],["dc.date.available","2018-11-07T09:02:29Z"],["dc.date.issued","2012"],["dc.format.extent","63"],["dc.identifier.isi","000314975100159"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24691"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.publisher.place","London"],["dc.relation.issn","0167-7063"],["dc.title","Analysis of camp signaling in olfactory transduction in Drosophila larvae"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","174"],["dc.bibliographiccitation.journal","Frontiers in Behavioral Neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Vasmer, David"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:40:14Z"],["dc.date.available","2018-11-07T09:40:14Z"],["dc.date.issued","2014"],["dc.description.abstract","Drosophila represents a model organism to analyze neuronal mechanisms underlying learning and memory. Kenyon cells of the Drosophila mushroom body are required for associative odor learning and memory retrieval. But is the mushroom body sufficient to acquire and retrieve an associative memory? To answer this question we have conceived an experimental approach to bypass olfactory sensory input and to thermogenetically activate sparse and random ensembles of Kenyon cells directly. We found that if the artifical activation of Kenyon cell ensembles coincides with a salient, aversive stimulus learning was induced. The animals adjusted their behavior in a subsequent test situation and actively avoided reactivation of these Kenyon cells. Our results show that Kenyon cell activity in coincidence with a salient aversive stimulus can suffice to form an associative memory. Memory retrieval is characterized by a closed feedback loop between a behavioral action and the reactivation of sparse ensembles of Kenyon cells."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.3389/fnbeh.2014.00174"],["dc.identifier.isi","000335956300001"],["dc.identifier.pmid","24860455"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33463"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Research Foundation"],["dc.relation.issn","1662-5153"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Induction of aversive learning through thermogenetic activation of Kenyon cell ensembles in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","464"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.lastpage","478"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Martelli, Carlotta"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Kobbenbring, Simon"],["dc.contributor.author","Pauls, Dennis"],["dc.contributor.author","Bahl, Britta"],["dc.contributor.author","Sommer, Mirjam Vanessa"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Barth, Jonas"],["dc.contributor.author","Arias, Carmina Warth Perez"],["dc.contributor.author","Vassiliou, Chrystalleni"],["dc.contributor.author","Luna, Abud Jose Farca"],["dc.contributor.author","Poppinga, Haiko"],["dc.contributor.author","Richter, Florian Gerhard"],["dc.contributor.author","Wegener, Christian"],["dc.contributor.author","Fiala, André"],["dc.contributor.author","Riemensperger, Thomas"],["dc.date.accessioned","2020-12-10T14:23:00Z"],["dc.date.available","2020-12-10T14:23:00Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.celrep.2017.06.043"],["dc.identifier.issn","2211-1247"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71799"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]