Quondamatteo, Fabio

[["dc.bibliographiccitation.firstpage","195"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Annals of Anatomy - Anatomischer Anzeiger"],["dc.bibliographiccitation.lastpage","196"],["dc.bibliographiccitation.volume","188"],["dc.contributor.author","Quondamatteo, Fabio"],["dc.date.accessioned","2018-11-07T09:50:24Z"],["dc.date.available","2018-11-07T09:50:24Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1016/j.aanat.2005.12.002"],["dc.identifier.isi","000237606000001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35701"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","0940-9602"],["dc.title","In memoriam Rainer Herken"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","397"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","401"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Ellies, M."],["dc.contributor.author","Schutz, S."],["dc.contributor.author","Quondamatteo, T."],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T10:13:53Z"],["dc.date.available","2018-11-07T10:13:53Z"],["dc.date.issued","2006"],["dc.description.abstract","Purpose: We wanted to prove the hypothesis that local injections of botulinum toxin A have an influence on the immunoreactivity of neuronal nitric oxide synthase (nNOS) in parotid glands of adult rats. Materials and Methods: Our group carried out immunohistochemical reaction of neuronal nitric oxide synthase (nNOS) in the parotid gland of female adult Wistar rats, in native (untreated) glands and after intraglandular injection of botulinum toxin A under general anesthesia. The immunoreactivity of nNOS was investigated on different times after injection. Results: Compared with the untreated glands, there was a significant decrease of nNOS in the treated organs that became stronger with extended toxin exposure time. After our laboratory in a pilot study had already shown in general a decrease of nNOS immunoreactivity after injection of botulinum toxin A into the cephalic salivary glands of the rat, the present study shows more explicit data on the effect of botulinum toxin A injection on a higher number of examined parotid glands and analyzes a time course of the effect duration. Conclusions: in our study, it was shown that botulinum toxin A had an influence on the immunoreactivity of neuronal nitric oxide synthase (nNOS) in parotid glands. Participation of nitric oxide (NO) in the regulation of secretion from the parotid gland of the rat seems to be likely. It might be assumed that the influence of botulinum. toxin A on nNOS in the parotid gland of the rat is able to explain the sometimes longer duration of toxin effect at the neuroglandular junction than at the motor endplate. (c) 2006 American Association of Oral and Maxillofacial Surgeons."],["dc.identifier.doi","10.1016/j.joms.2005.11.029"],["dc.identifier.isi","000235786800008"],["dc.identifier.pmid","16487800"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40513"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","0278-2391"],["dc.title","Immunohistochemical investigations of the influence of botulinum toxin A on the immunoreactivity of nNOS in the parotid gland of the rat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","466"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Matrix Biology"],["dc.bibliographiccitation.lastpage","474"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Wu, X."],["dc.contributor.author","Quondamatteo, Fabio"],["dc.contributor.author","Brakebusch, Cord"],["dc.date.accessioned","2018-11-07T09:11:56Z"],["dc.date.available","2018-11-07T09:11:56Z"],["dc.date.issued","2006"],["dc.description.abstract","Cdc42 is a small GTPase, which acts as a molecular switch to regulate a wide variety of cellular functions, such as actin cytoskeleton organization, cell proliferation, apoptosis, cell migration and in particular, cell polarity. Formation and maintenance of the basement membrane is a polarized process, which requires directed secretion, deposition and organization of basement membrane components at the basal side of epithelial cells. In the current study, we analyzed the maintenance of skin basement membrane in mice with a keratinocyte-restricted deletion of the Cdc42 gene. In the absence of Cdc42, basement membrane components became aberrantly deposited and the processing of laminin 5 was impaired in parts of the dermal-epidermal junction. These impairments became more severe with age and corresponded to local defects of the basement membrane in 4.5-month-old mutant mice. However, both, structure and number of hemidesomosomes were not significantly changed in the Cdc42 mutant skin compared with the control mice and no blister formation was observed in mutant skin. These data indicate that Cdc42 in keratinocytes is important for maintenance of the basement membrane of skin. (c) 2006 Elsevier B.V./International Society of Matrix Biology. All rights reserved."],["dc.identifier.doi","10.1016/j.matbio.2006.09.001"],["dc.identifier.isi","000242859500002"],["dc.identifier.pmid","17049825"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26835"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0945-053X"],["dc.title","Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0945-053X(03)00016-7"],["dc.bibliographiccitation.firstpage","93"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Matrix Biology"],["dc.bibliographiccitation.lastpage","96"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Quondamatteo, Fabio"],["dc.contributor.author","Reinhardt, D. P."],["dc.contributor.author","Charbonneau, N. L."],["dc.contributor.author","Pophal, G."],["dc.contributor.author","Sakai, L. Y."],["dc.contributor.author","Herken, R."],["dc.date.accessioned","2018-11-07T10:40:41Z"],["dc.date.available","2018-11-07T10:40:41Z"],["dc.date.issued","2003"],["dc.identifier.doi","10.1016/S0945-053X(03)00016-7"],["dc.identifier.isi","000182967400010"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46358"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0945-053X"],["dc.title","Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development (vol 21, pg 637, 2002)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.contributor.author","Nico, B."],["dc.contributor.author","Corsi, P."],["dc.contributor.author","Frigeri, A."],["dc.contributor.author","Nicchia, G. P."],["dc.contributor.author","Mangieri, D."],["dc.contributor.author","Frontino, A."],["dc.contributor.author","Quondamatteo, Fabio"],["dc.contributor.author","Herken, R."],["dc.contributor.author","Ribatti, D."],["dc.contributor.author","Svelto, M."],["dc.contributor.author","Roncali, L."],["dc.date.accessioned","2018-11-07T10:36:31Z"],["dc.date.available","2018-11-07T10:36:31Z"],["dc.date.issued","2003"],["dc.format.extent","29"],["dc.identifier.isi","000184938300123"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45347"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.publisher.place","New york"],["dc.relation.conference","6th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","BERLIN, GERMANY"],["dc.relation.issn","0894-1491"],["dc.title","Blood-brain barrier alterations in dystrophic mdx mice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","221"],["dc.bibliographiccitation.volume","234"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Berger, Joachim"],["dc.contributor.author","Gersdorff, Nikolaus"],["dc.contributor.author","Cecconi, F."],["dc.contributor.author","Herken, R."],["dc.contributor.author","Quondamatteo, Fabio"],["dc.date.accessioned","2018-11-07T10:56:02Z"],["dc.date.available","2018-11-07T10:56:02Z"],["dc.date.issued","2005"],["dc.description.abstract","Apoptosis is an essential ubiquitous process that controls the duration of the life span of cells, thus playing a crucial role in morphogenetic, histogenetic, and phylogenetic developmental processes. Apaf1 (apoptosis protease activating factor 1) is one of the central mediators of the intrinsic apoptotic pathway and a part of the apoptosome, which activates procaspase-3 and promotes cell death. Gene knockout of Apaf1 in mice leads to late embryonic lethality with malformations such as the persistence of interdigital webs and hyperplasia of brain and retina. Therefore, Apaf1 is generally believed to play a crucial role in developmental apoptosis and have a widespread expression. However, its pattern of expression in early development remains unknown. To specify whether Apaf1 indeed plays this key role, we investigated the pattern of gene expression for Apaf1 in mouse embryos on day 7,9, and 12 of development. Our results show, that gene expression for Apafl first occurs within the embryo between day 7 and 9 of development, becoming more widespread toward day 12 and then includes structures, such as yolk sac, mesenchyme, cartilage, heart anlage, otic vesicle, peridermis, and anlagen of the spinal ganglia and vertebral bodies. Our results also show that gene expression for Apaf1 is not ubiquitous in early mouse development. This finding indicates that cell death processes are independent of or less dependent on Apaf1 during this time. Of interest, an active gene expression for Apafl is also present in organ anlagen such as heart or intestine, in which no obvious phenotype is seen after Apafl deletion. This finding suggests a possible role for Apafl in such anlagen as a putative alternative compensatory pathway, which could he switched on in the case of defects in the mediators that are normally involved in such organs. (c) 2005 Wiley-Liss, Inc."],["dc.description.sponsorship","Telethon [TCP99038]"],["dc.identifier.doi","10.1002/dvdy.20534"],["dc.identifier.isi","000231353700022"],["dc.identifier.pmid","16086359"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49920"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1058-8388"],["dc.title","Localization of Apafl1 gene expression in the early development of the mouse by means of in situ reverse transcriptase-polymerase chain reaction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Zweers, Manon C."],["dc.contributor.author","Zhang, Z."],["dc.contributor.author","Quondamatteo, Fabio"],["dc.contributor.author","Hallinger, Ralf"],["dc.contributor.author","Aumailley, M."],["dc.contributor.author","Davidson, Jeffrey M."],["dc.contributor.author","Pozzi, Ambra"],["dc.contributor.author","Krieg, Thomas"],["dc.contributor.author","Eckes, B."],["dc.date.accessioned","2018-11-07T10:02:34Z"],["dc.date.available","2018-11-07T10:02:34Z"],["dc.date.issued","2006"],["dc.format.extent","29"],["dc.identifier.isi","000242891500173"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38256"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.eventlocation","Philadelphia, PA"],["dc.relation.issn","0022-202X"],["dc.title","a2 beta 1 Integrin has versatile functions during skin wound healing"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","369"],["dc.bibliographiccitation.issue","8-9"],["dc.bibliographiccitation.journal","HISTOCHEMICAL JOURNAL"],["dc.bibliographiccitation.lastpage","381"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Quondamatteo, Fabio"],["dc.date.accessioned","2018-11-07T10:15:40Z"],["dc.date.available","2018-11-07T10:15:40Z"],["dc.date.issued","2002"],["dc.description.abstract","Basement membranes are layered structures of the extracellular matrix which separate cells of various kinds from the surrounding stroma. One of the frequently recurring questions about basement membranes is how these structures are formed in vivo. Up to a few years ago, it was thought that basement membranes were formed spontaneously by a process of self-assembly of their components. However, it has now become clear that cell membrane receptors for basement membrane components are essential factors for the formation and stability of basement membranes in vivo. The present review highlights the modern concepts of basement membrane formation."],["dc.identifier.doi","10.1023/A:1023675619251"],["dc.identifier.isi","000182581000001"],["dc.identifier.pmid","12814184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40854"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Kluwer Academic Publ"],["dc.relation.issn","0018-2214"],["dc.title","Assembly, stability and integrity of basement membranes in vivo"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","799"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","HISTOLOGY AND HISTOPATHOLOGY"],["dc.bibliographiccitation.lastpage","806"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Quondamatteo, Fabio"],["dc.contributor.author","Kempkensteffen, C."],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Sonnenberg, Anton S. M."],["dc.contributor.author","Herken, R."],["dc.date.accessioned","2018-11-07T10:47:40Z"],["dc.date.available","2018-11-07T10:47:40Z"],["dc.date.issued","2004"],["dc.description.abstract","Normal liver sinusoids are not lined by a basement membrane (BM). In contrast, in the course of development of liver cirrhosis, a structured BM is formed de novo in the space of Disse. This BM contributes to the inhibition of the metabolic function of the liver but the pathogenic background of the formation of this perisinusoidal BM is still unclear. Integrins of the beta1-class are generally essential for BM stability and some of them (such as alpha2beta1, alpha3beta1 and alpha6beta1) appear de novo in the perisinusoidal space of the cirrhotic liver. Their cellular distribution in capillarized sinusoids as well as the correlation between their cellular distribution and the formation of the microvascular BM in the cirrhotic liver has not been shown at the ultrastructural level. In the present work we aimed to clarify this issue. We focused on integrins alpha3beta1 and alpha6beta1 and localised them ultrastructurally in human cirrhotic liver microvessels using postembedding immunogold which allows the ultrastructural localization of antigens with high resolution in the tissue. The newly formed basement membrane of capillarized sinusoids was visualized by means of fixation with addition of tannic acid, which enables the visualization of structures of the extracellular matrix with the highest resolution. Also, we carried out laminin detection using postembedding immunogold. Our results show that both alpha3beta1 and alpha6beta1 are expressed on the surface of both hepatocytes and endothelial cells, i.e. on both sides of the newly formed basement membrane. This latter shows zones of higher density both in close proximity to the endothelial and to the hepatocytic surfaces which resemble laminae densae. We propose that hepatocytes and endothelial cells may, therefore, by expressing such integrins, contribute to the formation of this pathological BM in the microvessels of the human cirrhotic liver. On stellate cells, which are major producers of BM components, both integrins alpha3beta1 and alpha6beta1 were also localized."],["dc.identifier.isi","000222112300018"],["dc.identifier.pmid","15168343"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48015"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","F Hernandez"],["dc.relation.issn","0213-3911"],["dc.title","Ultrastructural localization of integrin subunits alpha 3 and alpha 6 in capillarized sinusoids of the human cirrhotic liver"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1199"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","HISTOLOGY AND HISTOPATHOLOGY"],["dc.bibliographiccitation.lastpage","1207"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Diedrich, A."],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Koenig, Fatima Barbara"],["dc.contributor.author","Schulz, Thomas G."],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Herken, R."],["dc.contributor.author","Quondamatteo, Fabio"],["dc.date.accessioned","2018-11-07T09:01:18Z"],["dc.date.available","2018-11-07T09:01:18Z"],["dc.date.issued","2006"],["dc.description.abstract","Glutathione S-transferases (GSTs) play a central role in a number of metabolic processes. Glutathione S-transferase T1 (GSTT1) is a polymorphic cytosolic enzyme and a member of the theta class of GSTs. Typical substrates for GSTT1 are industrial compounds, such as dichloromethane and ethylene oxide. It has been shown that also chemotherapeutic drugs such as BCNU [i.e. 1,3-bis(2-chloroethyl)-1nitrosourea] are efficiently inactivated by GSTT1. BCNU is a drug which is increasingly used locally in the chemotherapy of glioblastoma multiforme WHO grade IV. Therefore, if GSTT1 were expressed in neoplastic cells of brain tumours it could be a factor for chemoresistance. In order to clarify a possible role of GSTT1 in chemoresistance, as a first step, we localized this enzyme in malignant gliomas such as glioblastoma multiforme WHO grade IV and oligodendroglioma WHO grade II. Because of its polymorphism we first genotyped the samples for GSTT1 by PCR. Using in situ hybridization, we then demonstrated that GSTT1 transcripts are expressed in neoplastic cells of both tumour types. Immunohistochemistry revealed then that whereas neoplastic cells in glioblastoma multiforme WHO grade IV contain GSTT1, it was not localized in oligodendroglioma cells. Given the polymorphism of GSTT1 and its potential activity towards BCNU, the localization of GSTT1 in glioblastoma cells can be considered as a possible factor of non-homogeneous chemotherapy response among patients with different GSTT1 genotypes."],["dc.identifier.isi","000239239800008"],["dc.identifier.pmid","16874663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24391"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","F Hernandez"],["dc.relation.issn","0213-3911"],["dc.title","Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]