Leyhe, Johanna Rosemarie

[["dc.bibliographiccitation.firstpage","1253"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of NeuroInterventional Surgery"],["dc.bibliographiccitation.lastpage","1257"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Leyhe, Johanna Rosemarie"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Hesse, Amélie Carolina"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Papageorgiou, Ismini"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2020-12-10T18:37:18Z"],["dc.date.available","2020-12-10T18:37:18Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1136/neurintsurg-2016-012866"],["dc.identifier.eissn","1759-8486"],["dc.identifier.issn","1759-8478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76904"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Latest generation of flat detector CT as a peri-interventional diagnostic tool: a comparative study with multidetector CT"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0202592"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Scalzo, Fabien"],["dc.contributor.author","Leyhe, Johanna R."],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Liebeskind, David S."],["dc.date.accessioned","2019-07-09T11:46:07Z"],["dc.date.available","2019-07-09T11:46:07Z"],["dc.date.issued","2018"],["dc.description.abstract","BACKGROUND: The pivotal impact of collateral circulation on outcomes in endovascular therapy has fueled the development of numerous CTA collateral scales, yet synchronized validation with conventional angiography has never occurred. We validated multiphase flat-detector CTA (mpFDCTA) for collateral imaging in patients undergoing endovascular stroke treatment. MATERIALS AND METHODS: Consecutive acute ischemic stroke patient data, including mpFDCTA shortly followed by digital subtraction angiography (DSA), in the setting of acute ICA- or MCA-occlusions were analyzed. An independent core lab scored mpFDCTA with an established collateral scale and separately graded American Society of Interventional and Therapeutic Neuroradiology (ASITN) collateral score on DSA, blind to all other data. RESULTS: 24 consecutive cases (age 76.7 ± 7.3 years; 58.3% women; baseline NIHSS median 17 (4-23)) of acute ICA- or MCA-occlusion were analyzed. Time from mpFDCTA to intracranial DSA was 23.04 ± 7.6 minutes. Median mpFDCTA collateral score was 3 (0-5) and median DSA ASITN collateral score was 2 (0-3), including the full range of potential collateral grades. mpFDCTA and ASITN collateral score were strongly correlated (r = 0.86, p<0.001). mpFDCTA provided more complete collateral data compared to selective DSA injections in cases of ICA-occlusion. ROC analyses for prediction of clinical outcomes revealed an AUC of 0.76 for mpFDCTA- and 0.70 for DSA ASITN collaterals. CONCLUSIONS: mpFDCTA in the angiography suite provides a validated measure of collaterals, offering distinct advantages over conventional angiography. Direct patient transfer to the angiography suite and mpFDCTA collateral grading provides a novel and reliable triage paradigm for acute ischemic stroke."],["dc.identifier.doi","10.1371/journal.pone.0202592"],["dc.identifier.pmid","30142167"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15394"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59377"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15695 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Validation of collateral scoring on flat-detector multiphase CT angiography in patients with acute ischemic stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3152"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","3155"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Leyhe, Johanna Rosemarie"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Tran, Julia"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2021-06-01T10:47:50Z"],["dc.date.available","2021-06-01T10:47:50Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1161/STROKEAHA.117.018077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85732"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1524-4628"],["dc.relation.issn","0039-2499"],["dc.title","One-Stop Management of Acute Stroke Patients"],["dc.title.alternative","Minimizing Door-to-Reperfusion Times"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Medical Imaging"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Amelung, Nadine"],["dc.contributor.author","Maus, Volker"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Papageorgiou, Ismini E."],["dc.contributor.author","Leyhe, Johanna Rosemarie"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios Nikos"],["dc.date.accessioned","2020-12-10T18:38:53Z"],["dc.date.available","2020-12-10T18:38:53Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1186/s12880-019-0352-2"],["dc.identifier.eissn","1471-2342"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77466"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Evaluation of an optimized metal artifact reduction algorithm for flat-detector angiography compared to DSA imaging in follow-up after neurovascular procedures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3152"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Stroke"],["dc.bibliographiccitation.lastpage","3155"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Leyhe, Johanna Rosemarie"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Tran, Julia"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-04-23T11:49:30Z"],["dc.date.available","2018-04-23T11:49:30Z"],["dc.date.issued","2017"],["dc.description.abstract","Background and Purpose: Intrahospital time delays significantly affect the neurological outcome of stroke patients with large-vessel occlusion. This study was conducted to determine whether a one-stop management can reduce intrahospital times of patients with acute large-vessel occlusion. Methods: In this observational study, we report the first 30 consecutive stroke patients imaged and treated in the same room. As part of our protocol, we transported patients with a National Institutes of Health Stroke Scale score of ≥10 directly to the angio suite, bypassing multidetector computed tomography (CT). Preinterventional imaging consisted of noncontrast flat detector CT and flat detector CT angiography, acquired with an angiography system. Patients with large-vessel occlusions remained on the angio table and were treated with mechanical thrombectomy; patients with small artery occlusions were treated with intravenous thrombolysis, whereas patients with an intracranial hemorrhage and stroke mimics were treated as per guidelines. Door-to-groin puncture times were recorded and compared with our past results. Results: Thirty patients were transferred directly to our angio suite from June to December 2016. The time from symptom onset to admission was 105 minutes. Ischemic stroke was diagnosed in 22 of 30 (73%) patients, 4 of 30 (13.5%) had an intracranial hemorrhage, and 4 of 30 (13.5) were diagnosed with a Todd’s paresis. Time from admission to groin puncture was 20.5 minutes. Compared with 44 patients imaged with multidetector CT in the first 6 months of 2016, door-to-groin times were significantly reduced (54.5 minutes [95% confidence interval, 47–61] versus 20.5 minutes [95% confidence interval, 17–26]). Conclusions: In this small series, a one-stop management protocol of selected stroke patients using latest generation flat detector CT led to a significant reduction of intrahospital times."],["dc.identifier.doi","10.1161/strokeaha.117.018077"],["dc.identifier.gro","3142069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13713"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0039-2499"],["dc.title","One-Stop Management of Acute Stroke Patients: Minimizing Door-to-Reperfusion Times"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0196174"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Becker, Johannes C."],["dc.contributor.author","Leyhe, Johanna Rosemarie"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2019-07-09T11:45:41Z"],["dc.date.available","2019-07-09T11:45:41Z"],["dc.date.issued","2018"],["dc.description.abstract","BACKGROUND: Stroke-induced immunodepression is a well characterized complication of acute ischemic stroke. In experimental studies beta-blocker therapy reversed stroke-induced immunodepression, reduced infection rates and mortality. Recent, heterogeneous studies in stroke patients could not provide evidence of a protective effect of beta-blocker therapy. Aim of this study is to investigate the potential preventive effect of beta-blockers in subgroups of patients at high risk for stroke-induced immunodepression. METHODS: Data from a prospectively derived registry of major stroke patients receiving endovascular therapy between 2011-2017 in a tertiary stroke center (University Medical Center Göttingen. Germany) was used. The effect of beta-blocker therapy on pneumonia, urinary tract infection, sepsis and mortality was assessed using multivariate logistic regression analysis. RESULTS: Three hundred six patients with a mean age of 72 ± 13 years and a median NIHSS of 16 (IQR 10.75-20) were included. 158 patients (51.6%) had pre-stroke- and continued beta-blocker therapy. Beta-blocker therapy did not reduce the incidence of pneumonia (OR 0.78, 95% CI 0.31-1.92, p = 0.584), urinary tract infections (OR 1.51, 0.88-2.60, p = 0.135), sepsis (OR 0.57, 0.18-1.80, p = 0.334) or mortality (OR 0.59, 0.16-2.17, p = 0.429). Strokes involving the insula and anterio-medial cortex increased the risk for pneumonia (OR 4.55, 2.41-8.56, p<0.001) and sepsis (OR 4.13, 1.81-9.43, p = 0.001), while right hemispheric strokes increased the risk for pneumonia (OR 1.60, 0.92-2.77, p = 0.096). There was a non-significantly increased risk for urinary tract infections in patients with beta-blocker therapy and insula/anterio-medial cortex strokes (OR 3.12, 95% CI 0.88-11.05, p = 0.077) with no effect of beta-blocker therapy on pneumonia, sepsis or mortality in both subgroups. CONCLUSIONS: In major ischemic stroke patients, beta-blocker therapy did not lower post-stroke infection rates and was associated with urinary tract infections in a subgroup with insula/anterio-medial strokes."],["dc.identifier.doi","10.1371/journal.pone.0196174"],["dc.identifier.pmid","29694433"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15285"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59286"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.subject.mesh","Adrenergic beta-Antagonists"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Aged, 80 and over"],["dc.subject.mesh","Death"],["dc.subject.mesh","Female"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Incidence"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Pneumonia"],["dc.subject.mesh","Prospective Studies"],["dc.subject.mesh","Registries"],["dc.subject.mesh","Sepsis"],["dc.subject.mesh","Stroke"],["dc.subject.mesh","Tertiary Care Centers"],["dc.subject.mesh","Urinary Tract Infections"],["dc.title","Influence of beta-blocker therapy on the risk of infections and death in patients at high risk for stroke induced immunodepression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]