Müller, Katarina

[["dc.bibliographiccitation.firstpage","491"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY"],["dc.bibliographiccitation.lastpage","500"],["dc.bibliographiccitation.volume","290"],["dc.contributor.author","Mühlfeld, Christian"],["dc.contributor.author","Müller, Katharina"],["dc.contributor.author","Pallesen, Lars-Peder"],["dc.contributor.author","Sandhaus, Tim"],["dc.contributor.author","Madershahian, Navis"],["dc.contributor.author","Richter, Joachim"],["dc.contributor.author","Wahlers, Thorsten"],["dc.contributor.author","Wittwer, Thorsten"],["dc.contributor.author","Ochs, Matthias"],["dc.date.accessioned","2018-11-07T11:02:32Z"],["dc.date.available","2018-11-07T11:02:32Z"],["dc.date.issued","2007"],["dc.description.abstract","A major aim in lung transplantation is to prevent the loss of structural integrity due to ischemia and reperfusion (I/R) injury. Preservation solutions protect the lung against I/R injury to a variable extent. We compared the influence of two extracellular-type preservation solutions (Perfadex, or PX, and Celsior, or CE) on the morphological alterations induced by I/R. Pigs were randomly assigned to sham (n = 4), PX (n = 5), or CE (n = 2) group. After flush perfusion with PX or CE, donor lungs were excised and stored for 27 hr at 4 degrees C. The left donor lung was implanted into the recipient, reperfused for 6 hr, and, afterward, prepared for light and electron microscopy. Intra-alveolar, septal, and peribronchovascular edema as well as the integrity of the blood-air barrier were determined stereologically. Intra-alveolar edema was more pronounced in CE (219.80 +/- 207.55 ml) than in PX (31.46 +/- 15.75 ml). Peribronchovascular (sham: 13.20 +/- 4.99 ml; PX: 15.57 +/- 5.53 ml; CE: 31.56 +/- 5.78 ml) and septal edema (thickness of alveolar septal interstitium, sham: 98 +/- 33 nm; PX: 84 +/- 8 nm; CE: 249 +/- 85 mn) were only found in CE. The blood-air barrier was similarly well preserved in sham and PX but showed larger areas of swollen and fragmented epithelium or endothelium in CE. The present study shows that Perfadex effectively prevents intra-alveolar, septal, and peribronchovascular edema formation as well as injury of the blood-air barrier during I/R. Celsior was not effective in preserving the lung from morphological I/R injury."],["dc.identifier.doi","10.1002/ar.20518"],["dc.identifier.isi","000246275700008"],["dc.identifier.pmid","17377949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51407"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.title","Impact of preservation solution on the extent of blood-air barrier damage and edema formation in experimental lung transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","811"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Theriogenology"],["dc.bibliographiccitation.lastpage","816"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Hanazawa, K."],["dc.contributor.author","Mueller, T."],["dc.contributor.author","Becker, T."],["dc.contributor.author","Heistermann, M."],["dc.contributor.author","Behr, R."],["dc.contributor.author","Sasaki, E."],["dc.date.accessioned","2022-10-06T13:33:24Z"],["dc.date.available","2022-10-06T13:33:24Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1016/j.theriogenology.2012.03.029"],["dc.identifier.pii","S0093691X12002002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115624"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0093-691X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Minimally invasive transabdominal collection of preimplantation embryos from the common marmoset monkey (Callithrix jacchus)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","866"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Journal of Radiation Oncology*Biology*Physics"],["dc.bibliographiccitation.lastpage","874"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Schirmer, Markus Anton"],["dc.contributor.author","Brockmöller, Jürgen"],["dc.contributor.author","Rave-Fränk, Margret"],["dc.contributor.author","Virsik, Patricia"],["dc.contributor.author","Wilken, Barbara"],["dc.contributor.author","Kühnle, Elna"],["dc.contributor.author","Campean, Radu"],["dc.contributor.author","Hoffmann, Arne O."],["dc.contributor.author","Müller, Katarina"],["dc.contributor.author","Götze, Robert G."],["dc.contributor.author","Neumann, Michael"],["dc.contributor.author","Janke, Jörg H."],["dc.contributor.author","Nasser, Fatima"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Ghadimi, B. Michael"],["dc.contributor.author","Schmidberger, Heinz"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Hille, Andrea"],["dc.date.accessioned","2018-11-07T08:58:56Z"],["dc.date.available","2018-11-07T08:58:56Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose: To determine whether genetic variability in TGFB1 is related to circulating transforming growth factor(TGF-beta 1) plasma concentrations after radiotherapy and to radiosensitivity of lymphoid cells. Patients and Methods: Transforming growth factor-beta 1 plasma concentrations (n = 79) were measured in patients 1 year after radiotherapy and chromosomal aberrations (it = 71) ex vivo before therapy start. Furthermore, TGF-beta 1 secretion and apoptosis were measured in isolated peripheral blood mononuclear cells of 55 healthy volunteers. These phenotypes were analyzed in relation to five germline polymorphisms in the 5' region of the TGFB1 gene. Because of high linkage disequilibrium, these five polymorphisms reflect frequent genetic variation in this region. A presumed impact of TGF-beta 1 on DNA damage or repair was measured as micronucleus formation in 30 lymphoblastoid cell lines. Results: We identified a hypofunctional genetic haplotype termed H3 tagging the 5' region of the TGFB1 gene encoding TGF-beta 1. H3 was associated with lower TGF-beta 1 plasma concentrations in patients (p = 0.01) and reduced TGF-beta 1 secretion in irradiated peripheral blood mononuclear cells (p = 0.003). Furthermore, cells with H3 were less prone to induction of chromosomal aberrations (p = 0.001) and apoptosis (p = 0.003) by irradiation. The hypothesis that high TGF-beta 1 could sensitize cells to DNA damage was further supported by increased micronuclei formation in 30 lymphoblastoid cell lines when preincubated with TGF-beta 1 before irradiation (p = 0.04). Conclusions: On the basis of TGF-beta 1 plasma levels and radiation sensitivity of lymphoid cells, this study revealed a putatively hypofunctional TGFB1 haplotype. The significance of this haplotype and the suggested link between TGF-beta 1 function and DNA integrity should be further explored in other cell types, as well as other experimental and clinical conditions. (C) 2011 Elsevier Inc."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [KFO 179]"],["dc.identifier.doi","10.1016/j.ijrobp.2010.08.040"],["dc.identifier.isi","000287382400033"],["dc.identifier.pmid","21183289"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6275"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23765"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0360-3016"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A PUTATIVELY FUNCTIONAL HAPLOTYPE IN THE GENE ENCODING TRANSFORMING GROWTH FACTOR BETA-1 AS A POTENTIAL BIOMARKER FOR RADIOSENSITIVITY"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]