Eggert, Kai

[["dc.bibliographiccitation.firstpage","972"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Proteomics"],["dc.bibliographiccitation.lastpage","985"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Eggert, Kai"],["dc.contributor.author","Pawelzik, Elke"],["dc.date.accessioned","2018-09-10T08:50:26Z"],["dc.date.available","2018-09-10T08:50:26Z"],["dc.date.issued","2011"],["dc.description.abstract","The effect of artificial Fusarium graminearum and F. culmorum infection at the level of the proteome on grains of naked barley (Hordeum vulgare subsp. nudum) was investigated in comparison to naturally infected samples. Fusarium infection in barley led to numerous host-specific biochemical responses. NEPHGE 2-D PAGE and MS were used to identify proteins that were differentially expressed in response to fungal infection and growing location of the plants. Moreover, the mycotoxin concentration of the grains was evaluated to characterize the infection degree. Inoculation of naked barley with Fusarium led to grain deoxynivalenol concentrations of up to 1.2 mg/kg. The carbon and nitrogen grain concentrations were not significantly changed after fungal infection, but differed between growing locations. Eleven proteins related to fungal infection were detected as were three proteins with effects based on growing location. These proteins belong to different protein groups involved in various cell functions: transcription regulation, defence response, nutrient reservoirs and starch biosynthesis. The results gave indications on plant defence strategies and changes as response to Fusarium infection in mature grains after a long infection period as well as being influenced by the growing location."],["dc.identifier.doi","10.1002/pmic.201000322"],["dc.identifier.pmid","21271677"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15687"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1615-9861"],["dc.title","Proteome analysis of Fusarium head blight in grains of naked barley (Hordeum vulgare subsp. nudum)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","893"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Food Research and Technology"],["dc.bibliographiccitation.lastpage","902"],["dc.bibliographiccitation.volume","230"],["dc.contributor.author","Eggert, Kai"],["dc.contributor.author","Wieser, Herbert"],["dc.contributor.author","Pawelzik, Elke"],["dc.date.accessioned","2018-11-07T08:44:29Z"],["dc.date.available","2018-11-07T08:44:29Z"],["dc.date.issued","2010"],["dc.description.abstract","The effect of the fungal infection Fusarium graminearum and Fusarium culmorum on naked barley cultivars (n = 7) with respect to the barley's total protein content and the content of the protein fractions albumins + globulins, prolamins (hordeins) and glutelins (hordenins) was investigated. A summer barley cultivar (n = 1) was used for comparison. The total protein content of the whole grain flours was very variable, ranging from 125 to 225 g kg(-1). The influence of Fusarium infection showed that the content of hordeins and hordenins was slightly reduced, while the albumins and globulins were not affected. In addition, the effect of the two different growing locations on the protein content of the naked barley was also evaluated. It could be shown that the C-hordeins, gamma-hordeins and D-hordenins were significantly positively affected by increasing nitrogen supply, whereas the B-hordenin content was significantly negatively influenced. Nitrogen availability seems to be a factor that promotes gene expression for hordeins but reduces the synthesis of the main B-hordenins."],["dc.description.sponsorship","Ministry of Science and Culture of Lower Saxony, Germany"],["dc.identifier.doi","10.1007/s00217-010-1234-6"],["dc.identifier.isi","000275538100011"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20209"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1438-2377"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The influence of Fusarium infection and growing location on the quantitative protein composition of (Part II) naked barley (Hordeum vulgare nudum)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","177"],["dc.bibliographiccitation.journal","Journal of Applied Botany and Food Quality"],["dc.bibliographiccitation.lastpage","185"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Kreuzberger, Marie"],["dc.contributor.author","Limsuwan, Sasithorn"],["dc.contributor.author","Eggert, Kai"],["dc.contributor.author","Karlovsky, Petr"],["dc.contributor.author","Pawelzik, Elke"],["dc.date.accessioned","2018-09-10T08:33:22Z"],["dc.date.available","2018-09-10T08:33:22Z"],["dc.date.issued","2015"],["dc.description.abstract","Contamination of grain with mycotoxins such as deoxynivalenol (DON) is the major threat after Fusarium head blight (FHB) infection of wheat, however technological quality can also be impaired. The European Union has established maximum levels (ML) of DON for wheat grain and foodstuffs. The composition (starch, gluten proteins) and quality (protein content, sedimentation value, wet gluten, water absorption, mixing properties of dough, baking volume) of 72 flour Type 550 samples from two years either fulfilling or exceeding ML of 0.75 mg kg-1 were investigated. DO content of flours ranged widely from below limit of quantification to 11.84 mg kg-1. Aside from a slight loss of loaf shape in flours highly exceeding ML, no negative effect on composition and quality of flour was observed in flours exceeding ML compared to those fulfilling ML. A significant decrease in total glutenin and LMW-GS content did not correlate with any quality trait. Hence, if flours fulfill ML for DON, reduced technological quality due to FHB is not significant."],["dc.identifier.doi","10.5073/JABFQ.2015.088.025"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12271"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15681"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","1613-9216"],["dc.rights","CC BY-SA 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-sa/4.0"],["dc.title","Impact of Fusarium spp. infection of bread wheat (Triticum aestivum L.) on composition and quality of flour in association with EU maximum level for deoxynivalenol"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","837"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Food Research and Technology"],["dc.bibliographiccitation.lastpage","847"],["dc.bibliographiccitation.volume","230"],["dc.contributor.author","Eggert, Kai"],["dc.contributor.author","Wieser, Herbert"],["dc.contributor.author","Pawelzik, Elke"],["dc.date.accessioned","2018-09-04T09:28:59Z"],["dc.date.available","2018-09-04T09:28:59Z"],["dc.date.issued","2010"],["dc.description.abstract","The effect of the fungal infection by Fusarium graminearum and Fusarium culmorum of emmer and wheat cultivars on their total protein content and the protein fractions albumins + globulins, gliadins and glutenins and their different protein types was investigated. In addition, the influence of two different locations on the quantitative protein composition was evaluated. The results showed that Fusarium infection changed the content of gliadins and glutenins in emmer and wheat. The wheat glutenin fractions and types were found to be more strongly affected by the Fusarium spp. infection than the glutenin fractions and types in emmer cultivars in spite of the wheat’s lower degree of infection. The nitrogen supply at the two locations was associated with an increase in the gliadin content in emmer and an increase in the glutenin content in emmer and wheat. Nitrogen availability, a factor which promotes gene expression, resulted here in a species-specific effect on the gliadin/glutenin ratio."],["dc.identifier.doi","10.1007/s00217-010-1229-3"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4170"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15642"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The influence of Fusarium infection and growing location on the quantitative protein composition of (part I) emmer (Triticum dicoccum)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","867"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.lastpage","874"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Jordan, W."],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Eggert, S."],["dc.contributor.author","Rodenbeck, Andrea"],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Hajak, Goran"],["dc.date.accessioned","2018-11-07T10:47:06Z"],["dc.date.available","2018-11-07T10:47:06Z"],["dc.date.issued","2004"],["dc.description.abstract","Study Objectives: The prostaglandin D system plays an important role in animal sleep. In humans, alterations in the prostaglandin D system have been found in diseases exhibiting sleep disturbances as a prominent symptom, such as trypanosoma infection, systemic mastocytosis, bacterial meningitis, major depression, or obstructive sleep apnea. Assessment of this system's activity in relation to human physiologic sleep was the target of the present study. Design: Serum concentrations of lipocalin-type prostaglandin D synthase (L-PGDS, former P-trace), and plasma levels of the pineal hormone melatonin were measured in 20 healthy humans (10 women, 10 men; aged: 23.3 +/- 2.39 years) at 4-hour intervals over a period of 5 days and nights, which included physiologic sleep, rapid eye movement sleep deprivation, and total sleep deprivation. In addition, the serum L-PGDS and plasma melatonin levels of 6 subjects were determined under conditions of bright white (10,000 lux) or dark red light (< 50 lux) in a crossover design during total sleep deprivation. Nocturnal blood sampling was performed by a through-the-wall tube system. L-PGDS was measured by an automated immunonephelometric assay, and melatonin was analyzed by direct radioimmunoassay. Results: Serum L-PGDS concentrations showed marked time-dependent changes with evening increases and the highest values at night (P < .0005). This nocturnal increase was suppressed during total sleep deprivation (P < .05), independent of external light conditions and melatonin secretion. Rapid eye movement sleep deprivation had no impact on circulating L-PGDS levels. Conclusions: The circadian L-PGDS pattern and its suppression by total sleep deprivation indicate an interaction of the prostaglandin D system and human sleep regulation. L-PGDS measurements may well provide new insights into physiologic and pathologic sleep regulation in humans."],["dc.identifier.isi","000223451400008"],["dc.identifier.pmid","15453544"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47897"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Academy Sleep Medicine"],["dc.relation.issn","0161-8105"],["dc.title","Prostaglandin D synthase (beta-trace) in healthy human sleep"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","918"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Plant Pathology"],["dc.bibliographiccitation.lastpage","928"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Eggert, K."],["dc.contributor.author","Zörb, C."],["dc.contributor.author","Mühling, K. H."],["dc.contributor.author","Pawelzik, E."],["dc.date.accessioned","2018-09-04T09:30:19Z"],["dc.date.available","2018-09-04T09:30:19Z"],["dc.date.issued","2011"],["dc.description.abstract","The fungal infection of emmer grain (Triticum dicoccum) with Fusarium graminearum and Fusarium culmorum was investigated at the level of the proteome. High‐resolution two‐dimensional gel electrophoresis and mass spectrometry were used to identify proteins that were differentially expressed in response to fungal infection of emmer. Moreover, the effects of natural field conditions at two locations on the carbon and nitrogen contents and the mycotoxin concentration of emmer grains were evaluated. Inoculation of emmer with a mixture of the two Fusarium species led to infection of the ears, with deoxynivalenol concentrations up to 10 mg kg−1 in the grain. Carbon concentration and crude protein content were not significantly changed, but 10 distinct proteins changed in abundance. Stress‐related proteins, such as a serine protease inhibitor, a thaumatin‐like protein that reduced fungal growth and the starch hydrolysis β‐amylase increased upon infection, whereas the stress‐related proteins peroxidase, peroxiredoxin, a starch‐synthesis protein (a glycosyltransferase) and a fungal cell wall degrading protein (a chitinase) decreased. Furthermore, levels of three storage proteins in emmer grains were affected by Fusarium infection: α‐gliadin decreased and two globulins increased upon infection."],["dc.identifier.doi","10.1111/j.1365-3059.2011.02442.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15643"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Proteome analysis of Fusarium infection in emmer grains (Triticum dicoccum)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","697"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Food Research and Technology"],["dc.bibliographiccitation.lastpage","705"],["dc.bibliographiccitation.volume","233"],["dc.contributor.author","Eggert, Kai"],["dc.contributor.author","Rawel, Hashadrai M."],["dc.contributor.author","Pawelzik, Elke"],["dc.date.accessioned","2018-09-04T09:31:39Z"],["dc.date.available","2018-09-04T09:31:39Z"],["dc.date.issued","2011"],["dc.description.abstract","Fusarium spp. infection of cereal grain is a common problem, which leads to a dramatic loss of grain quality. The aim of the present study was to investigate the effect of Fusarium infection on the wheat storage protein gluten and its fractions, the gliadins and glutenins, in an in vitro model system. Gluten proteins were digested by F. graminearum proteases for 2, 4, 8 and 24 h, separated by Osborne fractionation and characterised by chromatographic (RP-HPLC) and electrophoretic analysis (SDS-Page). Gluten digestion by F. graminearum proteases showed in comparison with gliadins a preference for the glutenins whereas the HMW subfraction was at most affected. In comparison with a untreated control, the HMW subfraction was degraded of about 97% after 4 h incubation with Fusarium proteases. Separate digestion of gliadin and glutenin underlined the preference for HMW-GS. Analogue to the observed change in the gluten composition, the yield of the proteins extracted changed. A higher amount of glutenin fragments was found in the gliadin extraction solution after digestion and could mask a gliadin destruction at the same time. This observation can contribute to explain the frequently reported reduced glutenin amount parallel to an increase in gliadin quantity after Fusarium infection in grains."],["dc.identifier.doi","10.1007/s00217-011-1566-x"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15644"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","In vitro degradation of wheat gluten fractions by Fusarium graminearum proteases"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3043"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of agricultural and food chemistry"],["dc.bibliographiccitation.lastpage","3049"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Eggert, Kai"],["dc.contributor.author","Hollmann, Jürgen"],["dc.contributor.author","Hiller, Beate"],["dc.contributor.author","Kruse, Hans-Peter"],["dc.contributor.author","Rawel, Hashadrai M."],["dc.contributor.author","Pawelzik, Elke"],["dc.date.accessioned","2018-09-04T09:27:25Z"],["dc.date.available","2018-09-04T09:27:25Z"],["dc.date.issued","2010"],["dc.description.abstract","Inoculated or non-inoculated naked barley and emmer cultivars were investigated with regard to their influence on phenolic acid profiles and their arabinoxylan content. Two groups of phenolic compounds were differentiated-methanol-soluble and hydrolyzable covalent-bound phenolic compounds. Chromatographic methods were applied for their analysis. The results showed ferulic acid as the predominant phenol in both total and covalent-bound fractions. The inoculation significantly reduced the ferulic acid content within a range of 5.6-6.6% in the two cereals and all their cultivars. Naked barley cultivars additionally contained the flavonoid catechin in the soluble fraction. The innoculation led here to a significant increase in the catechin content of about 4.5%. These results document an induction of the synthesis of catechin in naked barley after artificial Fusarium infection, whereas the ferulic acid content declined."],["dc.identifier.doi","10.1021/jf903545j"],["dc.identifier.pmid","20143853"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15641"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1520-5118"],["dc.title","Effects of fusarium infection on the phenolics in emmer and naked barley"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Current Neuropharmacology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Gomez-Mancilla, Baltazar"],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Godau, Jana"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Eggert, K."],["dc.contributor.author","Csoti, Ilona"],["dc.contributor.author","Storch, Alexander"],["dc.contributor.author","Huber, Heiko"],["dc.contributor.author","Morelli-Canelo, Monica"],["dc.contributor.author","Stamelou, Maria"],["dc.contributor.author","Ries, Vincent"],["dc.contributor.author","Wolz, Martin"],["dc.contributor.author","Schneider, C."],["dc.contributor.author","Di Paolo, Therese"],["dc.contributor.author","Gasparini, Fabrizio"],["dc.contributor.author","Hariry, Sam"],["dc.contributor.author","Vandemeulebroecke, Marc"],["dc.contributor.author","Abi-Saab, Walid"],["dc.contributor.author","Johns, Donald"],["dc.date.accessioned","2018-11-07T08:51:51Z"],["dc.date.available","2018-11-07T08:51:51Z"],["dc.date.issued","2011"],["dc.format.extent","25"],["dc.identifier.isi","000299627200070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22033"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bentham Science Publ Ltd"],["dc.publisher.place","Sharjah"],["dc.relation.issn","1570-159X"],["dc.title","AFQ056 Treatment of Levodopa-Induced Dyskinesias: Results of 2 Randomized Controlled Trials"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S97"],["dc.bibliographiccitation.journal","AKTUELLE NEUROLOGIE"],["dc.bibliographiccitation.lastpage","S101"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Schulz, Joerg B."],["dc.contributor.author","Benecke, R."],["dc.contributor.author","Dodel, R."],["dc.contributor.author","Eggert, K."],["dc.contributor.author","Fogel, W."],["dc.contributor.author","Gerlach, M."],["dc.contributor.author","Reichmann, Heinz"],["dc.contributor.author","Riederer, Peter"],["dc.contributor.author","Schwartz, A."],["dc.contributor.author","Winkler, J."],["dc.date.accessioned","2018-11-07T10:55:52Z"],["dc.date.available","2018-11-07T10:55:52Z"],["dc.date.issued","2005"],["dc.description.abstract","In order to make a diagnosis of idiopathic Parkinson's disease, it is necessary to rule out the possibility of symptomatic or atypical Parkinsonian syndromes. Atypical Parkinsonian syndromes include multiple system atrophy, progressive supranuclear palsy, dementia with Lewy bodies and corticobasal degeneration. The most common symptomatic Parkinsonian syndromes are caused by vascular disease or induced by neuroleptics. Red flags that point to a diagnosis different from idiopathic Parkinson's disease include missing or unsatisfactory response to L-dopa and additional symptoms such as cerebella ataxia, ocular motor symptoms, dysfunction of the autonomic nervous system, positive pyramidal signs, apraxia and early postural instability. Fluctuations of consciousness and the development of a dementia in early stages of the disease also point against idiopathic Parkins, disease. In addition to clinical symptoms, structural and functional imaging techniques, tests for L-dopa responsiveness and the evaluation of autonomic dysfunction help to increase the diagnostic accuracy. In this review we recommend a step-by-step rational procedure for the accurate diagnosis of Parkinsonian syndromes."],["dc.identifier.doi","10.1055/s-2005-866880"],["dc.identifier.isi","000232124700004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49885"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0302-4350"],["dc.title","Stepwise diagnostics for Parkinsonian syndromes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]