Barrantes-Freer, Alonso

[["dc.bibliographiccitation.firstpage","181"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Physiology"],["dc.bibliographiccitation.lastpage","196"],["dc.bibliographiccitation.volume","593"],["dc.contributor.author","Mortensen, Lena Sünke"],["dc.contributor.author","Schmidt, Hartmut"],["dc.contributor.author","Farsi, Zohreh"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Rubio, María E."],["dc.contributor.author","Ufartes, Roser"],["dc.contributor.author","Eilers, Jens"],["dc.contributor.author","Sakaba, Takeshi"],["dc.contributor.author","Stühmer, Walter"],["dc.contributor.author","Pardo, Luis A."],["dc.date.accessioned","2019-07-09T11:42:47Z"],["dc.date.available","2019-07-09T11:42:47Z"],["dc.date.issued","2014"],["dc.description.abstract","The voltage-gated potassium channel KV10.1 (Eag1) is widely expressed in the mammalian brain, but its physiological function is not yet understood. Previous studies revealed highest expression levels in hippocampus and cerebellumand suggested a synaptic localization of the channel. The distinct activation kinetics of KV10.1 indicate a role during repetitive activity of the cell.Here, we confirmthe synaptic localization of KV10.1 both biochemically and functionally and that the channel is sufficiently fast at physiological temperature to take part in repolarization of the action potential (AP).We studied the role of the channel in cerebellar physiology using patch clamp and two-photon Ca2+ imaging in KV10.1-deficient and wild-type mice. The excitability and action potential waveformrecorded at granule cell somata was unchanged, while Ca2+ influx into axonal boutons was enhanced in mutants in response to stimulation with three APs, but not after a single AP. Furthermore, mutants exhibited a frequency-dependent increase in facilitation at the parallel fibre–Purkinje cell synapse at high firing rates. We propose that KV10.1 acts as a modulator of local AP shape specifically during high-frequency burst firing when other potassium channels suffer cumulative inactivation."],["dc.identifier.doi","10.1113/jphysiol.2014.281600"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13714"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58742"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0022-3751"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","KV 10.1 opposes activity-dependent increase in Ca2+ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","112958"],["dc.bibliographiccitation.journal","Experimental Neurology"],["dc.bibliographiccitation.volume","320"],["dc.contributor.author","Huppke, Peter"],["dc.contributor.author","Wegener, Eike"],["dc.contributor.author","Gilley, Jonathan"],["dc.contributor.author","Angeletti, Carlo"],["dc.contributor.author","Kurth, Ingo"],["dc.contributor.author","Drenth, Joost P.H."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Nürnberg, Peter"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Orsomando, Giuseppe"],["dc.contributor.author","Coleman, Michael P."],["dc.date.accessioned","2020-12-10T14:24:01Z"],["dc.date.available","2020-12-10T14:24:01Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.expneurol.2019.112958"],["dc.identifier.issn","0014-4886"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72107"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4359"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Cancer Research"],["dc.bibliographiccitation.lastpage","4371"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Schwartz, H."],["dc.contributor.author","Blacher, E."],["dc.contributor.author","Amer, M."],["dc.contributor.author","Livneh, N."],["dc.contributor.author","Abramovitz, L."],["dc.contributor.author","Klein, A."],["dc.contributor.author","Ben-Shushan, D."],["dc.contributor.author","Soffer, S."],["dc.contributor.author","Blazquez, R."],["dc.contributor.author","Barrantes-Freer, A."],["dc.contributor.author","Mu ller, M."],["dc.contributor.author","Mu ller-Decker, K."],["dc.contributor.author","Stein, R."],["dc.contributor.author","Tsarfaty, G."],["dc.contributor.author","Satchi-Fainaro, R."],["dc.contributor.author","Umansky, V."],["dc.contributor.author","Pukrop, T."],["dc.contributor.author","Erez, N."],["dc.date.accessioned","2020-12-10T18:37:43Z"],["dc.date.available","2020-12-10T18:37:43Z"],["dc.date.issued","2016"],["dc.description.abstract","Malignant melanoma is the deadliest of skin cancers. Melanoma frequently metastasizes to the brain, resulting in dismal survival. Nevertheless, mechanisms that govern early metastatic growth and the interactions of disseminated metastatic cells with the brain microenvironment are largely unknown. To study the hallmarks of brain metastatic niche formation, we established a transplantable model of spontaneous melanoma brain metastasis in immunocompetent mice and developed molecular tools for quantitative detection of brain micrometastases. Here we demonstrate that micrometastases are associated with instigation of astrogliosis, neuroinflammation, and hyperpermeability of the blood-brain barrier. Furthermore, we show a functional role for astrocytes in facilitating initial growth of melanoma cells. Our findings suggest that astrogliosis, physiologically instigated as a brain tissue damage response, is hijacked by tumor cells to support metastatic growth. Studying spontaneous melanoma brain metastasis in a clinically relevant setting is the key to developing therapeutic approaches that may prevent brain metastatic relapse. (C) 2016 AACR."],["dc.identifier.doi","10.1158/0008-5472.CAN-16-0485"],["dc.identifier.eissn","1538-7445"],["dc.identifier.isi","000382295300008"],["dc.identifier.issn","0008-5472"],["dc.identifier.pmid","27261506"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77077"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Cancer Research"],["dc.relation.issn","1538-7445"],["dc.relation.issn","0008-5472"],["dc.title","Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","6"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2022-06-01T09:39:47Z"],["dc.date.available","2022-06-01T09:39:47Z"],["dc.date.issued","2022"],["dc.description.abstract","OBJECTIVE Fluorescence-guided resection of cerebral metastases has been proposed as an approach to visualize residual tumor tissue and maximize the extent of resection. Critics have argued that tumor cells at the resection margins might be overlooked under microscopic visualization because of technical limitations. Therefore, an endoscope, which is capable of inducing fluorescence, has been applied with the aim of improving exposure of fluorescent tumor tissue. In this retrospective analysis, authors assessed the utility of endoscope assistance in 5-aminolevulinic acid (5-ALA) fluorescence–guided resection of brain metastases. METHODS Between June 2013 and December 2016, a standard 20-mg/kg dose of 5-ALA was administered 4 hours prior to surgery in 26 patients with suspected single brain metastases. After standard neuronavigated microsurgical tumor resection, a microscope capable of inducing fluorescence was used to examine tumor margins. The authors classified the remaining fluorescence into 3 grades (0 = none, 1 = weak, and 2 = strong). Endoscopic assistance was employed if no or only weak fluorescence was visualized at the resection margins under the microscope. Endoscopically identified fluorescent tissue at the margins was resected and evaluated separately via histological examination to prove or disprove tumor infiltration. RESULTS Under the microscope, weakly fluorescent tissue was seen at the margins of the resection cavity in 15/26 (57.7%) patients. In contrast, endoscopic inspection revealed strongly fluorescent tissue in 22/26 (84.6%) metastases. In 11/26 (42.3%) metastases no fluorescence at the tumor margins was detected by the microscope; however, strong fluorescence was visualized under the endoscope in 7 (63.6%) of these 11 metastases. In the 15 metastases with microscopically weak fluorescence, strong fluorescence was seen when using the endoscope. Neither microscopic nor endoscopic fluorescence was found in 4/26 (15.4%) cases. In the 26 patients, 96 histological specimens were obtained from the margins of the resection cavity. Findings from these specimens were in conjunction with the histopathological findings, allowing identification of metastatic infiltration with a sensitivity of 95.5% and a specificity of 75% using endoscope assistance. CONCLUSIONS Fluorescence-guided endoscope assistance may overcome the technical limitations of the conventional microscopic exposure of 5-ALA–fluorescent metastases and thereby increase visualization of fluorescent tumor tissue at the margins of the resection cavity with high sensitivity and acceptable specificity."],["dc.identifier.doi","10.3171/2022.3.JNS212301"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108564"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","Endoscope-assisted visualization of 5-aminolevulinic acid fluorescence in surgery for brain metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1321"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","1324"],["dc.bibliographiccitation.volume","159"],["dc.contributor.author","Hernandez-Duran, S."],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von der Brelie, Christian"],["dc.date.accessioned","2018-11-07T10:22:12Z"],["dc.date.available","2018-11-07T10:22:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Posterior reversible encephalopathy syndrome (PRES) is thought to result from endothelial dysfunction and breakdown of the blood-brain barrier with subsequent vasogenic edema. Abrupt hypertension has been identified as one of its risk factors. We present a rare case of PRES in the anterior circulation with sudden onset of left hemiparesis and rapid neurological deterioration on the basis of hypertensive crisis. Due to refractory intracranial hypertension, the patient required emergent right decompressive craniectomy. Further investigations, including a biopsy, revealed an atypical form of PRES. This case illustrates the importance of aggressive medical and early surgical management to prevent permanent neurological deficits."],["dc.identifier.doi","10.1007/s00701-017-3197-x"],["dc.identifier.isi","000403508400022"],["dc.identifier.pmid","28516363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42234"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Posterior reversible encephalopathy syndrome presenting in the anterior circulation with malignant intracranial hypertension requiring surgical decompression: a case report and literature review"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","848"],["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.lastpage","849"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Bahn, Erik"],["dc.contributor.author","Paap, Franziska"],["dc.contributor.author","Mueller, F."],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Nessler, S."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:08:50Z"],["dc.date.available","2018-11-07T10:08:50Z"],["dc.date.issued","2016"],["dc.identifier.isi","000383267203281"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39546"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.eventlocation","London, ENGLAND"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","Histopathological characteristics of cavitary multiple sclerosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1381"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Physiological Reviews"],["dc.bibliographiccitation.lastpage","1431"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Timmler, Sebastian"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Simons, Mikael"],["dc.date.accessioned","2020-12-10T18:37:40Z"],["dc.date.available","2020-12-10T18:37:40Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1152/physrev.00031.2018"],["dc.identifier.eissn","1522-1210"],["dc.identifier.issn","0031-9333"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16423"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77059"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Myelin in the Central Nervous System: Structure, Function, and Pathology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.journal","Neuroscience & Biobehavioral Reviews"],["dc.bibliographiccitation.lastpage","98"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Parmar, Katrin"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Rocca, Maria A."],["dc.contributor.author","Langdon, Dawn"],["dc.contributor.author","D'Angelo, Egidio"],["dc.contributor.author","D’Souza, Marcus"],["dc.contributor.author","Burggraaff, Jessica"],["dc.contributor.author","Wegner, Christiane"],["dc.contributor.author","Sastre-Garriga, Jaume"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Dorn, Jonas"],["dc.contributor.author","Uitdehaag, Bernard M.J."],["dc.contributor.author","Montalban, Xavier"],["dc.contributor.author","Wuerfel, Jens"],["dc.contributor.author","Enzinger, Christian"],["dc.contributor.author","Rovira, Alex"],["dc.contributor.author","Tintore, Mar"],["dc.contributor.author","Filippi, Massimo"],["dc.contributor.author","Kappos, Ludwig"],["dc.contributor.author","Sprenger, Till"],["dc.date.accessioned","2020-12-10T15:20:25Z"],["dc.date.available","2020-12-10T15:20:25Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.neubiorev.2018.02.012"],["dc.identifier.issn","0149-7634"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72663"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The role of the cerebellum in multiple sclerosis—150 years after Charcot"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1037"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","1045"],["dc.bibliographiccitation.volume","161"],["dc.contributor.author","Fiss, Ingo"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Hernandez-Duran, Silvia"],["dc.contributor.author","Wolfert, Christina"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Ninkovic, Milena"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.date.accessioned","2020-12-10T14:10:53Z"],["dc.date.available","2020-12-10T14:10:53Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00701-019-03842-3"],["dc.identifier.eissn","0942-0940"],["dc.identifier.issn","0001-6268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70910"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Cerebral metastases: do size, peritumoral edema, or multiplicity predict infiltration into brain parenchyma?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","737"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.lastpage","747"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Albert, Monika"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Lohrberg, Melanie"],["dc.contributor.author","Antel, Jack P."],["dc.contributor.author","Prineas, John W."],["dc.contributor.author","Palkovits, Miklós"],["dc.contributor.author","Wolff, Joachim R."],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2022-03-01T11:47:07Z"],["dc.date.available","2022-03-01T11:47:07Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/bpa.12450"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103917"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","1015-6305"],["dc.title","Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis"],["dc.title.alternative","Synaptic pathology in the cerebellar dentate nucleus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]