Stahl-Hennig, Christiane

[["dc.bibliographiccitation.firstpage","473"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Virology"],["dc.bibliographiccitation.lastpage","485"],["dc.bibliographiccitation.volume","305"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Gundlach, Björn R."],["dc.contributor.author","Dittmer, Ulf"],["dc.contributor.author","ten Haaft, Peter"],["dc.contributor.author","Heeney, Jonathan"],["dc.contributor.author","Zou, Weiping"],["dc.contributor.author","Emilie, Dominique"],["dc.contributor.author","Sopper, Sieghart"],["dc.contributor.author","Überla, Klaus"],["dc.date.accessioned","2022-10-06T13:26:59Z"],["dc.date.available","2022-10-06T13:26:59Z"],["dc.date.issued","2003"],["dc.identifier.doi","10.1006/viro.2002.1763"],["dc.identifier.pii","S0042682202917630"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115219"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0042-6822"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Replication, Immunogenicity, and Protective Properties of Live-Attenuated Simian Immunodeficiency Viruses Expressing Interleukin-4 or Interferon-γ"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","787"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","AIDS"],["dc.bibliographiccitation.lastpage","796"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Voss, Gerald"],["dc.contributor.author","Dittmer, Ulf"],["dc.contributor.author","Coulibaly, Cheick"],["dc.contributor.author","Petry, Harald"],["dc.contributor.author","Makoschey, Birgit"],["dc.contributor.author","Cranage, Martin P."],["dc.contributor.author","Aubertin, Anne Marie"],["dc.contributor.author","Lüke, Wolfgang"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.date.accessioned","2022-10-06T13:35:28Z"],["dc.date.available","2022-10-06T13:35:28Z"],["dc.date.issued","1993"],["dc.identifier.doi","10.1097/00002030-199306000-00005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116105"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0269-9370"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Protection of monkeys by a split vaccine against SIVmac depends upon biological properties of the challenge virus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","101"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Immunology and Immunopathology"],["dc.bibliographiccitation.lastpage","105"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Spring, Michael"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Nißlein, Thomas"],["dc.contributor.author","Locher, Christopher"],["dc.contributor.author","Fuchs, Dietmar"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Dittmer, Ulf"],["dc.date.accessioned","2022-10-06T13:26:22Z"],["dc.date.available","2022-10-06T13:26:22Z"],["dc.date.issued","1998"],["dc.identifier.doi","10.1006/clin.1997.4511"],["dc.identifier.pii","S0090122997945116"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115067"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0090-1229"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Suppression of Viral Replication in a Long-Term Nonprogressing Rhesus Macaque Experimentally Infected with Pathogenic Simian Immunodeficiency Virus (SIV)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","300"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Virology"],["dc.bibliographiccitation.lastpage","309"],["dc.bibliographiccitation.volume","383"],["dc.contributor.author","Schulte, Reiner"],["dc.contributor.author","Suh, You-Suk"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Ochieng, Washingtone"],["dc.contributor.author","Sopper, Sieghart"],["dc.contributor.author","Kim, Kwang S."],["dc.contributor.author","Ahn, So-Shin"],["dc.contributor.author","Park, Ki S."],["dc.contributor.author","Stolte-Leeb, Nicole"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.date.accessioned","2021-06-01T10:49:57Z"],["dc.date.available","2021-06-01T10:49:57Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1016/j.virol.2008.10.012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86471"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0042-6822"],["dc.title","Mucosal prior to systemic application of recombinant adenovirus boosting is more immunogenic than systemic application twice but confers similar protection against SIV-challenge in DNA vaccine-primed macaques"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","816"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Nature Medicine"],["dc.bibliographiccitation.lastpage","816"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Dittmer, Ulf"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.date.accessioned","2022-10-06T13:34:12Z"],["dc.date.available","2022-10-06T13:34:12Z"],["dc.date.issued","1997"],["dc.identifier.doi","10.1038/nm0897-816b"],["dc.identifier.pii","BFnm0897816b"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115853"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1546-170X"],["dc.relation.issn","1078-8956"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Live HIV vaccines — How safe?"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3400"],["dc.bibliographiccitation.journal","Journal of General Virology"],["dc.bibliographiccitation.lastpage","3412"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Javed, Aneela"],["dc.contributor.author","Leuchte, Nicole"],["dc.contributor.author","Salinas, Gabriela"],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Sopper, Sieghart"],["dc.contributor.author","Sauermann, Ulrike"],["dc.date.accessioned","2018-11-07T10:05:02Z"],["dc.date.available","2018-11-07T10:05:02Z"],["dc.date.issued","2016"],["dc.description.abstract","CD8(+) cells from simian immunodeficiency virus (SIV)-infected long-term non-progressors and some uninfected macaques can suppress viral replication in vitro without killing the infected cells. The aim of this study was to identify factors responsible for non-cytolytic viral suppression by transcriptional profiling and to investigate their potential impact on SIV replication. Results of microarray experiments and further validation with cells from infected and uninfected macaques revealed that FAM26F RNA levels distinguished CD8(+) cells of controllers and non-controllers (P=0.001). However, FAM26F was also expressed in CD4(+) T-cells and B-cells. FAM26F expression increased in lymphocytes after in vitro IFN-gamma treatment on average 40-fold, and ex vivo FAM26F RNA levels in peripheral blood mononuclear cells correlated with plasma IFN-gamma but not with IFN-alpha. Baseline FAM26F expression appeared to be stable for months, albeit the individual expression levels varied up to tenfold. Investigating its role in SIV-infection revealed that FAM26F was upregulated after infection (P<0.0008), but did not directly correlate with viral load in contrast to MX1 and CXCL10. However, pre-infection levels of FAM26F correlated inversely with overall plasma viral load (AUC) during the acute and post-acute phases of infection (e.g. AUC weeks post infection 0-8; no AIDS vaccine: P<0.0001, Spearman rank correlation coefficient (rs)=-0.89, n=16; immunized with an AIDS vaccine: P=0.033, rs=-0.43; n=25). FAM26F transcript levels prior to infection can provide information about the pace and strength of the antiviral immune response during the early stage of infection. FAM26F expression represented, in our experiments, one of the earliest prognostic markers, and could supplement major histocompatibility complex (MHC)-typing to predict disease progression before SIV-infection."],["dc.identifier.doi","10.1099/jgv.0.000632"],["dc.identifier.isi","000390684000030"],["dc.identifier.pmid","27902344"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38817"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Microbiology Soc"],["dc.relation.issn","1465-2099"],["dc.relation.issn","0022-1317"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pre-infection transcript levels of FAM26F in peripheral blood mononuclear cells inform about overall plasma viral load in acute and post-acute phase after simian immunodeficiency virus infection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","316"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Immunology and Cell Biology"],["dc.bibliographiccitation.lastpage","320"],["dc.bibliographiccitation.volume","95"],["dc.contributor.author","Kotb, Ahmad"],["dc.contributor.author","Klippert, Antonina"],["dc.contributor.author","Daskalaki, Maria"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Stahl‐Hennig, Christiane"],["dc.contributor.author","Neumann, Berit"],["dc.date.accessioned","2021-06-01T10:50:33Z"],["dc.date.available","2021-06-01T10:50:33Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1038/icb.2016.96"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86700"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1440-1711"],["dc.relation.issn","0818-9641"],["dc.title","Elevated granzyme B + B‐cell level in SIV‐infection correlate with viral load and low CD4 T‐cell count"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","353"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","AIDS Research and Human Retroviruses"],["dc.bibliographiccitation.lastpage","357"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Dietrich, Ursula"],["dc.contributor.author","Landersz, Margot"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Geiger, Christina"],["dc.contributor.author","Foley, Brian T."],["dc.date.accessioned","2022-10-06T13:34:48Z"],["dc.date.available","2022-10-06T13:34:48Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1089/aid.2014.0244"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115982"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1931-8405"],["dc.relation.issn","0889-2229"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Genetic Characterization of Near Full Length SIVdrl Genomes from Four Captive Drills\n (Mandrillus leucophaeus)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","19"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Leukocyte Biology"],["dc.bibliographiccitation.lastpage","30"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Neumann, Berit"],["dc.contributor.author","Klippert, Antonina"],["dc.contributor.author","Raue, Katharina"],["dc.contributor.author","Sopper, Sieghart"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.date.accessioned","2021-06-01T10:48:08Z"],["dc.date.available","2021-06-01T10:48:08Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1189/jlb.1HI0514-243R"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85838"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0741-5400"],["dc.title","Characterization of B and plasma cells in blood, bone marrow, and secondary lymphoid organs of rhesus macaques by multicolor flow cytometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","902"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","912"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Lang, S M"],["dc.contributor.author","Weeger, M"],["dc.contributor.author","Stahl-Hennig, C"],["dc.contributor.author","Coulibaly, C"],["dc.contributor.author","Hunsmann, G"],["dc.contributor.author","Müller, J"],["dc.contributor.author","Müller-Hermelink, H"],["dc.contributor.author","Fuchs, D"],["dc.contributor.author","Wachter, H"],["dc.contributor.author","Daniel, M M"],["dc.date.accessioned","2022-10-06T13:25:39Z"],["dc.date.available","2022-10-06T13:25:39Z"],["dc.date.issued","1993"],["dc.description.abstract","The importance of the vpr gene for simian immunodeficiency virus (SIV) replication, persistence, and disease progression was examined by using the infectious pathogenic molecular clone called SIVmac239. The ATG start codon of the vpr gene was converted to TTG by site-specific mutagenesis. The constructed Vpr- mutant virus is identical with the parental SIVmac239/nef-stop virus with the exception of this one nucleotide. These viruses replicated with similar kinetics and to similar extents in rhesus monkey lymphocyte cultures and in the human CEMX174 cell line. Five rhesus monkeys were inoculated with the Vpr- variant of SIVmac239/nef-stop, and two monkeys received SIVmac239/nef-stop as controls. Both controls showed reversion of the TAA stop signal in nef by 2 weeks postinfection, as has been observed previously. Reversion of the TAA stop codon in nef also occurred in the five monkeys that received the Vpr- variant, but reversion was delayed on average to about 4 weeks. Thus, the mutation in vpr appeared to delay the rapidity with which reversion occurred in the nef gene. Reversion of the TTG sequence in vpr to ATG was observed in three of the five test animals. Reversion in vpr was first observed in these three animals 4 to 8 weeks postinfection. No vpr revertants were found over the entire 66 weeks of observation in the other two test animals that received the vpr mutant. Antibodies to vpr developed in those three animals in which reversion of vpr was documented, but antibodies to vpr were not observed in the two animals in which reversion of vpr was not detected. Antibody responses to gag and to whole virus antigens were of similar strength in all seven animals. Both control animals and two of the test animals in which vpr reverted maintained high virus loads and developed progressive disease. Low virus burden and no disease have been observed in the two animals in which vpr did not revert and in the one animal in which vpr reversion was first detected only at 8 weeks. The reversion of vpr in three of the five test animals indicates that there is significant selective pressure for functional forms of vpr in vivo. Furthermore, the results suggest that both vpr and nef are important for maximal SIV replication and persistence in vivo and for disease progression."],["dc.identifier.doi","10.1128/jvi.67.2.902-912.1993"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114885"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]