Groeneveld, Linn Fenna

[["dc.bibliographiccitation.artnumber","e39064"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Groeneveld, Linn Fenna"],["dc.contributor.author","Atencia, Rebeca"],["dc.contributor.author","Garriga, Rosa M."],["dc.contributor.author","Vigilant, Linda"],["dc.date.accessioned","2018-11-07T09:08:17Z"],["dc.date.available","2018-11-07T09:08:17Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: The PRDM9 locus in mammals has increasingly attracted research attention due to its role in mediating chromosomal recombination and possible involvement in hybrid sterility and hence speciation processes. The aim of this study was to characterize sequence variation at the PRDM9 locus in a sample of our closest living relatives, the chimpanzees and bonobos. Methodology/Principal Findings: PRDM9 contains a highly variable and repetitive zinc finger array. We amplified this domain using long-range PCR and determined the DNA sequences using conventional Sanger sequencing. From 17 chimpanzees representing three subspecies and five bonobos we obtained a total of 12 alleles differing at the nucleotide level. Based on a data set consisting of our data and recently published Pan PRDM9 sequences, we found that at the subspecies level, diversity levels did not differ among chimpanzee subspecies or between chimpanzee subspecies and bonobos. In contrast, the sample of chimpanzees harbors significantly more diversity at PRDM9 than samples of humans. Pan PRDM9 shows signs of rapid evolution including no alleles or ZnFs in common with humans as well as signals of positive selection in the residues responsible for DNA binding. Conclusions and Significance: The high number of alleles specific to the genus Pan, signs of positive selection in the DNA binding residues, and reported lack of conservation of recombination hotspots between chimpanzees and humans suggest that PRDM9 could be active in hotspot recruitment in the genus Pan. Chimpanzees and bonobos are considered separate species and do not have overlapping ranges in the wild, making the presence of shared alleles at the amino acid level between the chimpanzee and bonobo species interesting in view of the hypothesis that PRDM9 plays a universal role in interspecific hybrid sterility."],["dc.description.sponsorship","Max Planck Society; Ministry of Forest of the Republic of Congo"],["dc.identifier.doi","10.1371/journal.pone.0039064"],["dc.identifier.isi","000305966500007"],["dc.identifier.pmid","22768294"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25993"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.title","High Diversity at PRDM9 in Chimpanzees and Bonobos"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","83"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Evolutionary Biology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Zinner, Dietmar"],["dc.contributor.author","Groeneveld, Linn F."],["dc.contributor.author","Keller, Christina"],["dc.contributor.author","Roos, Christian"],["dc.date.accessioned","2022-08-09T12:22:51Z"],["dc.date.available","2022-08-09T12:22:51Z"],["dc.date.issued","2009-04-23"],["dc.description.abstract","Baboons of the genus Papio are distributed over wide ranges of Africa and even colonized parts of the Arabian Peninsula. Traditionally, five phenotypically distinct species are recognized, but recent molecular studies were not able to resolve their phylogenetic relationships. Moreover, these studies revealed para- and polyphyletic (hereafter paraphyletic) mitochondrial clades for baboons from eastern Africa, and it was hypothesized that introgressive hybridization might have contributed substantially to their evolutionary history. To further elucidate the phylogenetic relationships among baboons, we extended earlier studies by analysing the complete mitochondrial cytochrome b gene and the 'Brown region' from 67 specimens collected at 53 sites, which represent all species and which cover most of the baboons' range."],["dc.identifier.doi","10.1186/1471-2148-9-83"],["dc.identifier.pmid","19389236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112706"],["dc.language.iso","en"],["dc.relation.eissn","1471-2148"],["dc.relation.haserratum","/handle/2/91752"],["dc.relation.issn","1471-2148"],["dc.rights","CC BY 2.0"],["dc.title","Mitochondrial phylogeography of baboons (Papio spp.): indication for introgressive hybridization?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","229"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Zoological Journal of the Linnean Society"],["dc.bibliographiccitation.lastpage","244"],["dc.bibliographiccitation.volume","161"],["dc.contributor.author","Groeneveld, Linn Fenna"],["dc.contributor.author","Rasoloarison, Rodin M."],["dc.contributor.author","Kappeler, Peter"],["dc.date.accessioned","2017-09-07T11:48:21Z"],["dc.date.available","2017-09-07T11:48:21Z"],["dc.date.issued","2010"],["dc.description.abstract","Detailed knowledge of the identity and distributions of extant species is essential for unravelling patterns and mechanisms of biodiversity, and it provides indispensable baseline data for conservation efforts. The taxonomy of the primates of Madagascar (Lemuriformes) has experienced drastic revisions in the last decades, with species numbers skyrocketing, especially in the genera Microcebus, Avahi, and Lepilemur. The dwarf lemurs (genus Cheirogaleus) have received less attention in terms of their taxonomy, even though they are closely related and syntopic with these diverse genera. The last revision of the genus was based on morphological data from museum specimens, and accepted seven species: Cheirogaleus medius, Cheirogaleus major, Cheirogaleus crossleyi, Cheirogaleus adipicaudatus, Cheirogaleus sibreei, Cheirogaleus ravus, and Cheirogaleus minusculus, whereas a more recent multilocus molecular study only detected three lineages: C. medius, C. major, and C. crossleyi. The goal of this study was to reassess the currently accepted taxonomy of the genus by examining six external and 32 craniodental characters of 120 museum specimens and 36 new specimens from the field. This study, in conjunction with a complementary molecular study, revealed lower diversity and a lower number of distinct morphs of dwarf lemurs than previously postulated. We conclude that in our sample there are three distinct morphs in the genus Cheirogaleus that correspond to C. medius, C. major, and C. crossleyi. We formally recognize C. adipicaudatus and C. ravus as synonyms of C. medius and C. major, respectively, and consider C. minusculus and C. sibreei to be potential synonyms of C. medius."],["dc.identifier.doi","10.1111/j.1096-3642.2010.00634.x"],["dc.identifier.gro","3150779"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7569"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0024-4082"],["dc.title","Morphometrics confirm taxonomic deflation in dwarf lemurs (Primates: Cheirogaleidae), as suggested by genetics"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","198"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Evolutionary Biology"],["dc.bibliographiccitation.lastpage","15"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Zinner, Dietmar"],["dc.contributor.author","Groeneveld, Linn F"],["dc.contributor.author","Keller, Christina"],["dc.contributor.author","Roos, Christian"],["dc.date.accessioned","2019-11-10T04:17:11Z"],["dc.date.accessioned","2021-10-27T13:13:07Z"],["dc.date.available","2019-11-10T04:17:11Z"],["dc.date.available","2021-10-27T13:13:07Z"],["dc.date.issued","2019"],["dc.date.updated","2019-11-10T04:17:12Z"],["dc.description.abstract","Following publication of the original article [1], we have been notified that some of the NCB accession numbers were incorrectly associated to their corresponding taxon in the Additional file 1."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2019"],["dc.identifier.doi","10.1186/s12862-019-1537-6"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91752"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.iserratumof","/handle/2/112706"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights","CC BY 2.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Correction to: Mitochondrial phylogeography of baboons (Papio spp.) – Indication for introgressive hybridization?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","133"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","American Journal of Physical Anthropology"],["dc.bibliographiccitation.lastpage","140"],["dc.bibliographiccitation.volume","150"],["dc.contributor.author","Zinner, Dietmar"],["dc.contributor.author","Wertheimer, Jenny"],["dc.contributor.author","Liedigk, Rasmus"],["dc.contributor.author","Groeneveld, Linn F."],["dc.contributor.author","Roos, Christian"],["dc.date.accessioned","2018-11-07T09:30:16Z"],["dc.date.available","2018-11-07T09:30:16Z"],["dc.date.issued","2013"],["dc.description.abstract","Baboons (genus Papio) are an interesting phylogeographical primate model for the evolution of savanna species during the Pleistocene. Earlier studies, based on partial mitochondrial sequence information, revealed seven major haplogroups indicating multiple para-and polyphylies among the six baboon species. The most basal splits among baboon lineages remained unresolved and the credibility intervals for divergence time estimates were rather large. Assuming that genetic variation within the two studied mitochondrial loci so far was insufficient to infer the apparently rapid early radiation of baboons we used complete mitochondrial sequence information of ten specimens, representing all major baboon lineages, to reconstruct a baboon phylogeny and to re-estimate divergence times. Our data confirmed the earlier tree topology including the para-and polyphyletic relationships of most baboon species; divergence time estimates are slightly younger and credibility intervals narrowed substantially, thus making the estimates more precise. However, the most basal relationships could not be resolved and it remains open whether (1) the most southern population of baboons diverged first or (2) a major split occurred between southern and northern clades. Our study shows that complete mitochondrial genome sequences are more effective to reconstruct robust phylogenies and to narrow down estimated divergence time intervals than only short portions of the mitochondrial genome, although there are also limitations in resolving phylogenetic relationships. Am J Phys Anthropol 150:133-140, 2013. (C)2012 Wiley Periodicals, Inc."],["dc.description.sponsorship","German Primate Center"],["dc.identifier.doi","10.1002/ajpa.22185"],["dc.identifier.isi","000313705200015"],["dc.identifier.pmid","23180628"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10975"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31266"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0002-9483"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Baboon Phylogeny as Inferred From Complete Mitochondrial Genomes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","154"],["dc.bibliographiccitation.journal","Journal of human evolution"],["dc.bibliographiccitation.lastpage","164"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Kopp, Gisela H."],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Butynski, Thomas M."],["dc.contributor.author","Wildman, Derek E."],["dc.contributor.author","Alagaili, Abdulaziz N."],["dc.contributor.author","Groeneveld, Linn F."],["dc.contributor.author","Zinner, Dietmar"],["dc.date.accessioned","2019-07-09T11:40:49Z"],["dc.date.available","2019-07-09T11:40:49Z"],["dc.date.issued","2014-11-01"],["dc.description.abstract","Many species of Arabian mammals are considered to be of Afrotropical origin and for most of them the Red Sea has constituted an obstacle for dispersal since the Miocene-Pliocene transition. There are two possible routes, the 'northern' and the 'southern', for terrestrial mammals (including humans) to move between Africa and Arabia. The 'northern route', crossing the Sinai Peninsula, is confirmed for several taxa by an extensive fossil record, especially from northern Egypt and the Levant, whereas the 'southern route', across the Bab-el-Mandab Strait, which links the Red Sea with the Gulf of Aden, is more controversial, although post-Pliocene terrestrial crossings of the Red Sea might have been possible during glacial maxima when sea levels were low. Hamadryas baboons (Papio hamadryas) are the only baboon taxon to disperse out of Africa and still inhabit Arabia. In this study, we investigate the origin of Arabian hamadryas baboons using mitochondrial sequence data from 294 samples collected in Arabia and Northeast Africa. Through the analysis of the geographic distribution of genetic diversity, the timing of population expansions, and divergence time estimates combined with palaeoecological data, we test: (i) if Arabian and African hamadryas baboons are genetically distinct; (ii) if Arabian baboons exhibit population substructure; and (iii) when, and via which route, baboons colonized Arabia. Our results suggest that hamadryas baboons colonized Arabia during the Late Pleistocene (130-12 kya [thousands of years ago]) and also moved back to Africa. We reject the hypothesis that hamadryas baboons were introduced to Arabia by humans, because the initial colonization considerably predates the earliest records of human seafaring in this region. Our results strongly suggest that the 'southern route' from Africa to Arabia could have been used by hamadryas baboons during the same time period as proposed for modern humans."],["dc.identifier.doi","10.1016/j.jhevol.2014.08.003"],["dc.identifier.fs","606482"],["dc.identifier.pmid","25257698"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11382"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58262"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1095-8606"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Out of Africa, but how and when? The case of hamadryas baboons (Papio hamadryas)."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","483"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Animal Genetics"],["dc.bibliographiccitation.lastpage","502"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Lenstra, J. A."],["dc.contributor.author","Groeneveld, Linn Fenna"],["dc.contributor.author","Eding, H."],["dc.contributor.author","Kantanen, J."],["dc.contributor.author","Williams, J. L."],["dc.contributor.author","Taberlet, Pierre"],["dc.contributor.author","Nicolazzi, E. L."],["dc.contributor.author","Soelkner, J."],["dc.contributor.author","Simianer, Henner"],["dc.contributor.author","Ciani, E."],["dc.contributor.author","Garcia, J. F."],["dc.contributor.author","Bruford, M. W."],["dc.contributor.author","Ajmone-Marsan, P."],["dc.contributor.author","Weigend, Steffen"],["dc.date.accessioned","2018-11-07T09:05:38Z"],["dc.date.available","2018-11-07T09:05:38Z"],["dc.date.issued","2012"],["dc.description.abstract","Genetic studies of livestock populations focus on questions of domestication, within- and among-breed diversity, breed history and adaptive variation. In this review, we describe the use of different molecular markers and methods for data analysis used to address these questions. There is a clear trend towards the use of single nucleotide polymorphisms and whole-genome sequence information, the application of Bayesian or Approximate Bayesian analysis and the use of adaptive next to neutral diversity to support decisions on conservation."],["dc.description.sponsorship","European Commission [ResGen 09-118, GlobalDiv Agri Gen Res 067]"],["dc.identifier.doi","10.1111/j.1365-2052.2011.02309.x"],["dc.identifier.isi","000308330200001"],["dc.identifier.pmid","22497351"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25369"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0268-9146"],["dc.title","Molecular tools and analytical approaches for the characterization of farm animal genetic diversity"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","833"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Molecular Phylogenetics and Evolution"],["dc.bibliographiccitation.lastpage","845"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Groeneveld, Linn Fenna"],["dc.contributor.author","Blanco, Marina B."],["dc.contributor.author","Raharison, Jean-Luc"],["dc.contributor.author","Rahalinarivo, Vololonirina"],["dc.contributor.author","Rasoloarison, Rodin M."],["dc.contributor.author","Kappeler, Peter"],["dc.contributor.author","Godfrey, Laurie"],["dc.contributor.author","Irwin, Mitchell T."],["dc.date.accessioned","2017-09-07T11:48:21Z"],["dc.date.available","2017-09-07T11:48:21Z"],["dc.date.issued","2010"],["dc.description.abstract","Madagascar is a biodiversity hotspot, well known for its endemic primates, the lemurs. Numbers of recognized lemur species have increased drastically in some genera (e.g. Microcebus), while field-based studies revealed low species diversity in the dwarf lemurs (genus Cheirogaleus). Only three (C. medius, C. major, C. crossleyi) of seven described species have to date been identified in field-based studies. Blanco et al. (2009) reported two sympatric Cheirogaleus species at Tsinjoarivo based on morphological data, one of which they attributed to C. crossleyi and the other of which they described as C. sibreei-like, or possibly a new species. Based on comparative analyses of mtDNA (cytb) and nDNA (vWF, fiba, adora3), we confirm the presence of C. crossleyi and show that the C. sibreei-like individuals form a well-defined fourth clade, basal to the three recognized species. Whereas these molecular analyses demonstrate that a non-holotype museum specimen considered by Groves (2000) to belong to C. sibreei does not cluster with the C. sibreei-like individuals from Tsinjoarivo, morphometric analysis of one Tsinjoarivo individual, the C. sibreei holotype from Ankeramadinika, and samples of C. medius, C. major, and C. crossleyi strongly suggests that the fourth (and basal) clade is indeed C. sibreei. Tsinjoarivo therefore becomes the only known field site harboring C. sibreei today. Given ongoing forest loss and fragmentation at Tsinjoarivo we can surmise that this population, critical to our understanding of the evolution of the genus Cheirogaleus, is also critically endangered."],["dc.identifier.doi","10.1016/j.ympev.2010.03.004"],["dc.identifier.gro","3150776"],["dc.identifier.pmid","20211744"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7566"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1055-7903"],["dc.title","MtDNA and nDNA corroborate existence of sympatric dwarf lemur species at Tsinjoarivo, eastern Madagascar"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","30"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Evolutionary Biology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Groeneveld, Linn Fenna"],["dc.contributor.author","Weisrock, David"],["dc.contributor.author","Rasoloarison, Rodin M."],["dc.contributor.author","Yoder, Anne D."],["dc.contributor.author","Kappeler, Peter"],["dc.date.accessioned","2017-09-07T11:48:28Z"],["dc.date.available","2017-09-07T11:48:28Z"],["dc.date.issued","2009"],["dc.description.abstract","BACKGROUND:Species are viewed as the fundamental unit in most subdisciplines of biology. To conservationists this unit represents the currency for global biodiversity assessments. Even though Madagascar belongs to one of the top eight biodiversity hotspots of the world, the taxonomy of its charismatic lemuriform primates is not stable. Within the last 25 years, the number of described lemur species has more than doubled, with many newly described species identified among the nocturnal and small-bodied cheirogaleids. Here, we characterize the diversity of the dwarf lemurs (genus Cheirogaleus) and assess the status of the seven described species, based on phylogenetic and population genetic analysis of mtDNA (cytb + cox2) and three nuclear markers (adora3, fiba and vWF).RESULTS:This study identified three distinct evolutionary lineages within the genus Cheirogaleus. Population genetic cluster analyses revealed a further layer of population divergence with six distinct genotypic clusters.CONCLUSION:Based on the general metapopulation lineage concept and multiple concordant data sets, we identify three exclusive groups of dwarf lemur populations that correspond to three of the seven named species: C. major, C. medius and C. crossleyi. These three species were found to be genealogically exclusive in both mtDNA and nDNA loci and are morphologically distinguishable. The molecular and morphometric data indicate that C. adipicaudatus and C. ravus are synonymous with C. medius and C. major, respectively. Cheirogaleus sibreei falls into the C. medius mtDNA clade, but in morphological analyses the membership is not clearly resolved. We do not have sufficient data to assess the status of C. minusculus. Although additional patterns of population differentiation are evident, there are no clear subdivisions that would warrant additional specific status. We propose that ecological and more geographic data should be collected to confirm these results."],["dc.identifier.doi","10.1186/1471-2148-9-30"],["dc.identifier.gro","3150837"],["dc.identifier.pmid","19193227"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5768"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7631"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","1471-2148"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Species delimitation in lemurs: multiple genetic loci reveal low levels of species diversity in the genus Cheirogaleus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","425"],["dc.bibliographiccitation.journal","BMC Bioinformatics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Truong, Cong V. C."],["dc.contributor.author","Groeneveld, Linn F."],["dc.contributor.author","Morgenstern, Burkhard"],["dc.contributor.author","Groeneveld, Eildert"],["dc.date.accessioned","2018-11-07T08:50:35Z"],["dc.date.available","2018-11-07T08:50:35Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Long-term sample storage, tracing of data flow and data export for subsequent analyses are of great importance in genetics studies. Therefore, molecular labs do need a proper information system to handle an increasing amount of data from different projects. Results: We have developed a molecular labs information management system (MolabIS). It was implemented as a web-based system allowing the users to capture original data at each step of their workflow. MolabIS provides essential functionality for managing information on individuals, tracking samples and storage locations, capturing raw files, importing final data from external files, searching results, accessing and modifying data. Further important features are options to generate ready-to-print reports and convert sequence and microsatellite data into various data formats, which can be used as input files in subsequent analyses. Moreover, MolabIS also provides a tool for data migration. Conclusions: MolabIS is designed for small-to-medium sized labs conducting Sanger sequencing and microsatellite genotyping to store and efficiently handle a relative large amount of data. MolabIS not only helps to avoid time consuming tasks but also ensures the availability of data for further analyses. The software is packaged as a virtual appliance which can run on different platforms (e. g. Linux, Windows). MolabIS can be distributed to a wide range of molecular genetics labs since it was developed according to a general data model. Released under GPL, MolabIS is freely available at http://www.molabis.org."],["dc.description.sponsorship","German Federal Ministry of Research and Education (BMBF) [VNB 03/B14]"],["dc.identifier.doi","10.1186/1471-2105-12-425"],["dc.identifier.isi","000299822500001"],["dc.identifier.pmid","22040322"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21728"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2105"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","MolabIS - An integrated information system for storing and managing molecular genetics data"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]