Vogl, Christian

[["dc.bibliographiccitation.firstpage","3633"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","FEBS Letters"],["dc.bibliographiccitation.lastpage","3650"],["dc.bibliographiccitation.volume","592"],["dc.contributor.author","Pangrsic, Tina"],["dc.contributor.author","Vogl, Christian"],["dc.date.accessioned","2020-12-10T14:05:57Z"],["dc.date.available","2020-12-10T14:05:57Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1002/1873-3468.13258"],["dc.identifier.issn","0014-5793"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69717"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.issn","0014-5793"],["dc.title","Balancing presynaptic release and endocytic membrane retrieval at hair cell ribbon synapses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Molecular Neuroscience"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Rankovic, Vladan"],["dc.contributor.author","Vogl, Christian"],["dc.contributor.author","Dörje, Nele M."],["dc.contributor.author","Bahader, Iman"],["dc.contributor.author","Duque-Afonso, Carlos J."],["dc.contributor.author","Thirumalai, Anupriya"],["dc.contributor.author","Weber, Thomas"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2021-04-14T08:29:50Z"],["dc.date.available","2021-04-14T08:29:50Z"],["dc.date.issued","2021"],["dc.description.abstract","Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants. However, in some forms of genetic hearing impairment, the organ of Corti is structurally intact and therapeutic replacement of the mutated gene could potentially restore near natural hearing. In the case of defects of the otoferlin gene (OTOF), such gene therapy is hindered by the size of the coding sequence (~6 kb) exceeding the cargo capacity (\\u0026lt;5 kb) of the preferred viral vector, adeno-associated virus (AAV). Recently, a dual-AAV approach was used to partially restore hearing in deaf otoferlin knock-out (Otof-KO) mice. Here, we employed in vitro and in vivo approaches to assess the gene-therapeutic potential of naturally-occurring and newly-developed synthetic AAVs overloaded with the full-length Otof coding sequence. Upon early postnatal injection into the cochlea of Otof-KO mice, overloaded AAVs drove specific expression of otoferlin in ~30% of all IHCs, as demonstrated by immunofluorescence labeling and polymerase chain reaction. Recordings of auditory brainstem responses and a behavioral assay demonstrated partial restoration of hearing. Together, our results suggest that viral gene therapy of DFNB9—using a single overloaded AAV vector—is indeed feasible, reducing the complexity of gene transfer compared to dual-AAV approaches."],["dc.identifier.doi","10.3389/fnmol.2020.600051"],["dc.identifier.pmid","33488357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83002"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/123"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Frontiers Media S.A."],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1662-5099"],["dc.relation.workinggroup","RG Moser (Molecular Anatomy, Physiology and Pathology of Sound Encoding)"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","8758"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","21"],["dc.contributor.affiliation","Voorn, Roos Anouk; \t\t \r\n\t\t Presynaptogenesis and Intracellular Transport in Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37075 Goettingen, Germany, roosanouk.voorn@med.uni-goettingen.de\t\t \r\n\t\t Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences, 37075 Goettingen, Germany, roosanouk.voorn@med.uni-goettingen.de\t\t \r\n\t\t Collaborative Research Center 889 “Cellular Mechanisms of Sensory Processing”, 37075 Goettingen, Germany, roosanouk.voorn@med.uni-goettingen.de"],["dc.contributor.affiliation","Vogl, Christian; \t\t \r\n\t\t Presynaptogenesis and Intracellular Transport in Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37075 Goettingen, Germany, christian.vogl@med.uni-goettingen.de\t\t \r\n\t\t Collaborative Research Center 889 “Cellular Mechanisms of Sensory Processing”, 37075 Goettingen, Germany, christian.vogl@med.uni-goettingen.de"],["dc.contributor.author","Voorn, Roos Anouk"],["dc.contributor.author","Vogl, Christian"],["dc.date.accessioned","2021-04-14T08:31:05Z"],["dc.date.available","2021-04-14T08:31:05Z"],["dc.date.issued","2020"],["dc.date.updated","2022-09-06T17:44:57Z"],["dc.identifier.doi","10.3390/ijms21228758"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83482"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Molecular Assembly and Structural Plasticity of Sensory Ribbon Synapses—A Presynaptic Perspective"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","398"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","409"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Vogl, Christian"],["dc.contributor.author","Tanifuji, Shota"],["dc.contributor.author","Danis, Benedicte"],["dc.contributor.author","Daniels, Veronique"],["dc.contributor.author","Foerch, Patrik"],["dc.contributor.author","Wolff, Christian"],["dc.contributor.author","Whalley, Benjamin J."],["dc.contributor.author","Mochida, Sumiko"],["dc.contributor.author","Stephens, Gary J."],["dc.date.accessioned","2021-12-08T12:27:45Z"],["dc.date.available","2021-12-08T12:27:45Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1111/ejn.12799"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95440"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.issn","0953-816X"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Synaptic vesicle glycoprotein 2A modulates vesicular release and calcium channel function at peripheral sympathetic synapses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiation and Environmental Biophysics"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Krille, L."],["dc.contributor.author","Dreger, S."],["dc.contributor.author","Schindel, R."],["dc.contributor.author","Albrecht, T."],["dc.contributor.author","Asmussen, M."],["dc.contributor.author","Barkhausen, Joerg"],["dc.contributor.author","Berthold, J. D."],["dc.contributor.author","Chavan, A."],["dc.contributor.author","Claussen, Claus D."],["dc.contributor.author","Forsting, Michael"],["dc.contributor.author","Gianicolo, E. A. L."],["dc.contributor.author","Jablonka, K."],["dc.contributor.author","Jahnen, A."],["dc.contributor.author","Langer, M."],["dc.contributor.author","Laniado, Michael"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Mentzel, Hans Joachim"],["dc.contributor.author","Queisser-Wahrendorf, A."],["dc.contributor.author","Rompel, O."],["dc.contributor.author","Schlick, I."],["dc.contributor.author","Schneider, K."],["dc.contributor.author","Schumacher, M."],["dc.contributor.author","Seidenbusch, M."],["dc.contributor.author","Spix, C."],["dc.contributor.author","Spors, B."],["dc.contributor.author","Staatz, Gundula"],["dc.contributor.author","Vogl, T."],["dc.contributor.author","Wagner, J."],["dc.contributor.author","Weisser, G."],["dc.contributor.author","Zeeb, Hajo"],["dc.contributor.author","Blettner, M."],["dc.date.accessioned","2018-11-07T10:00:33Z"],["dc.date.available","2018-11-07T10:00:33Z"],["dc.date.issued","2015"],["dc.description.abstract","The aim of this cohort study was to assess the risk of developing cancer, specifically leukaemia, tumours of the central nervous system and lymphoma, before the age of 15 years in children previously exposed to computed tomography (CT) in Germany. Data for children with at least one CT between 1980 and 2010 were abstracted from 20 hospitals. Cancer cases occurring between 1980 and 2010 were identified by stochastic linkage with the German Childhood Cancer Registry (GCCR). For all cases and a sample of non-cases, radiology reports were reviewed to assess the underlying medical conditions at time of the CT. Cases were only included if diagnosis occurred at least 2 years after the first CT and no signs of cancer were recorded in the radiology reports. Standardised incidence ratios (SIR) using incidence rates from the general population were estimated. The cohort included information on 71,073 CT examinations in 44,584 children contributing 161,407 person-years at risk with 46 cases initially identified through linkage with the GCCR. Seven cases had to be excluded due to signs possibly suggestive of cancer at the time of first CT. Overall, more cancer cases were observed (O) than expected (E), but this was mainly driven by unexpected and possibly biased results for lymphomas. For leukaemia, the SIR (SIR = O/E) was 1.72 (95 % CI 0.89-3.01, O = 12), and for CNS tumours, the SIR was 1.35 (95 % CI 0.54-2.78, O = 7). Despite careful examination of the medical information, confounding by indication or reverse causation cannot be ruled out completely and may explain parts of the excess. Furthermore, the CT exposure may have been underestimated as only data from the participating clinics were available. This should be taken into account when interpreting risk estimates."],["dc.identifier.doi","10.1007/s00411-014-0580-3"],["dc.identifier.isi","000350215000001"],["dc.identifier.pmid","25567615"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37832"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.haserratum","/handle/2/70796"],["dc.relation.issn","1432-2099"],["dc.relation.issn","0301-634X"],["dc.title","Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","293"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Radiation and Environmental Biophysics"],["dc.bibliographiccitation.lastpage","297"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Krille, L."],["dc.contributor.author","Dreger, S."],["dc.contributor.author","Schindel, R."],["dc.contributor.author","Albrecht, T."],["dc.contributor.author","Asmussen, M."],["dc.contributor.author","Barkhausen, J."],["dc.contributor.author","Berthold, J. D."],["dc.contributor.author","Chavan, A."],["dc.contributor.author","Claussen, C."],["dc.contributor.author","Forsting, M."],["dc.contributor.author","Gianicolo, E. A. L."],["dc.contributor.author","Jablonka, K."],["dc.contributor.author","Jahnen, A."],["dc.contributor.author","Langer, M."],["dc.contributor.author","Laniado, M."],["dc.contributor.author","Lotz, J."],["dc.contributor.author","Mentzel, H. J."],["dc.contributor.author","Queißer-Wahrendorf, A."],["dc.contributor.author","Rompel, O."],["dc.contributor.author","Schlick, J."],["dc.contributor.author","Schneider, K."],["dc.contributor.author","Schumacher, M."],["dc.contributor.author","Seidenbusch, M."],["dc.contributor.author","Spix, C."],["dc.contributor.author","Spors, B."],["dc.contributor.author","Staatz, G."],["dc.contributor.author","Vogl, T."],["dc.contributor.author","Wagner, J."],["dc.contributor.author","Weisser, G."],["dc.contributor.author","Zeeb, H."],["dc.contributor.author","Blettner, M."],["dc.date.accessioned","2020-12-10T14:10:33Z"],["dc.date.available","2020-12-10T14:10:33Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00411-017-0694-5"],["dc.identifier.eissn","1432-2099"],["dc.identifier.issn","0301-634X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70796"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.iserratumof","/handle/2/37832"],["dc.title","Erratum to: Risk of cancer incidence before the age of 15 years after exposure to ionising radiation from computed tomography: results from a German cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","2081"],["dc.bibliographiccitation.journal","F1000Research"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Moser, Tobias"],["dc.contributor.author","Vogl, Christian"],["dc.date.accessioned","2017-09-07T11:53:14Z"],["dc.date.available","2017-09-07T11:53:14Z"],["dc.date.issued","2016"],["dc.description.abstract","The inner ear uses specialized synapses to indefatigably transmit sound information from hair cells to spiral ganglion neurons at high rates with submillisecond precision. The emerging view is that hair cell synapses achieve their demanding function by employing an unconventional presynaptic molecular composition. Hair cell active zones hold the synaptic ribbon, an electron-dense projection made primarily of RIBEYE, which tethers a halo of synaptic vesicles and is thought to enable a large readily releasable pool of vesicles and to contribute to its rapid replenishment. Another important presynaptic player is otoferlin, coded by a deafness gene, which assumes a multi-faceted role in vesicular exocytosis and, when disrupted, causes auditory synaptopathy. A functional peculiarity of hair cell synapses is the massive heterogeneity in the sizes and shapes of excitatory postsynaptic currents. Currently, there is controversy as to whether this reflects multiquantal release with a variable extent of synchronization or uniquantal release through a dynamic fusion pore. Another important question in the field has been the precise mechanisms of coupling presynaptic Ca2+ channels and vesicular Ca2+ sensors. This commentary provides an update on the current understanding of sound encoding in the cochlea with a focus on presynaptic mechanisms."],["dc.format.extent","1"],["dc.identifier.doi","10.12688/f1000research.8924.1"],["dc.identifier.gro","3145052"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2745"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","2046-1402"],["dc.title","New insights into cochlear sound encoding"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Physiological Reviews"],["dc.contributor.author","Kleinlogel, Sonja"],["dc.contributor.author","Vogl, Christian"],["dc.contributor.author","Jeschke, Marcus"],["dc.contributor.author","Neef, Jakob"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2021-04-14T08:32:51Z"],["dc.date.available","2021-04-14T08:32:51Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1152/physrev.00035.2019"],["dc.identifier.pmid","32191560"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84036"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/37"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1522-1210"],["dc.relation.issn","0031-9333"],["dc.relation.workinggroup","RG Moser (Molecular Anatomy, Physiology and Pathology of Sound Encoding)"],["dc.title","Emerging approaches for restoration of hearing and vision"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2536"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","EMBO Journal"],["dc.bibliographiccitation.lastpage","2552"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Vogl, Christian"],["dc.contributor.author","Panou, Iliana"],["dc.contributor.author","Yamanbaeva, Gulnara"],["dc.contributor.author","Wichmann, Carolin"],["dc.contributor.author","Mangosing, Sara J."],["dc.contributor.author","Vilardi, Fabio"],["dc.contributor.author","Indzhykulian, Artur A."],["dc.contributor.author","Pangršič, Tina"],["dc.contributor.author","Santarelli, Rosamaria"],["dc.contributor.author","Rodriguez‐Ballesteros, Montserrat"],["dc.contributor.author","Weber, Thomas"],["dc.contributor.author","Jung, Sangyong"],["dc.contributor.author","Cardenas, Elena"],["dc.contributor.author","Wu, Xudong"],["dc.contributor.author","Wojcik, Sonja M."],["dc.contributor.author","Kwan, Kelvin Y."],["dc.contributor.author","Castillo, Ignacio del"],["dc.contributor.author","Schwappach, Blanche"],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Corey, David P"],["dc.contributor.author","Lin, Shuh‐Yow"],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2017-09-07T11:54:19Z"],["dc.date.available","2017-09-07T11:54:19Z"],["dc.date.issued","2016"],["dc.description.abstract","The transmembrane recognition complex (TRC40) pathway mediates the insertion of tail‐anchored (TA) proteins into membranes. Here, we demonstrate that otoferlin, a TA protein essential for hair cell exocytosis, is inserted into the endoplasmic reticulum (ER) via the TRC40 pathway. We mutated the TRC40 receptor tryptophan‐rich basic protein (Wrb) in hair cells of zebrafish and mice and studied the impact of defective TA protein insertion. Wrb disruption reduced otoferlin levels in hair cells and impaired hearing, which could be restored in zebrafish by transgenic Wrb rescue and otoferlin overexpression. Wrb‐deficient mouse inner hair cells (IHCs) displayed normal numbers of afferent synapses, Ca2+ channels, and membrane‐proximal vesicles, but contained fewer ribbon‐associated vesicles. Patch‐clamp of IHCs revealed impaired synaptic vesicle replenishment. In vivo recordings from postsynaptic spiral ganglion neurons showed a use‐dependent reduction in sound‐evoked spiking, corroborating the notion of impaired IHC vesicle replenishment. A human mutation affecting the transmembrane domain of otoferlin impaired its ER targeting and caused an auditory synaptopathy. We conclude that the TRC40 pathway is critical for hearing and propose that otoferlin is an essential substrate of this pathway in hair cells."],["dc.identifier.doi","10.15252/embj.201593565"],["dc.identifier.fs","626014"],["dc.identifier.gro","3145137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2840"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","0261-4189"],["dc.title","Tryptophan‐rich basic protein (WRB) mediates insertion of the tail‐anchored protein otoferlin and is required for hair cell exocytosis and hearing"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3993"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","The Journal of Cell Biology"],["dc.bibliographiccitation.lastpage","4006"],["dc.bibliographiccitation.volume","217"],["dc.contributor.author","Hagiwara, Akari"],["dc.contributor.author","Kitahara, Yosuke"],["dc.contributor.author","Grabner, Chad Paul"],["dc.contributor.author","Vogl, Christian"],["dc.contributor.author","Abe, Manabu"],["dc.contributor.author","Kitta, Ryo"],["dc.contributor.author","Ohta, Keisuke"],["dc.contributor.author","Nakamura, Keiichiro"],["dc.contributor.author","Sakimura, Kenji"],["dc.contributor.author","Moser, Tobias"],["dc.contributor.author","Nishi, Akinori"],["dc.contributor.author","Ohtsuka, Toshihisa"],["dc.date.accessioned","2020-12-10T18:15:36Z"],["dc.date.available","2020-12-10T18:15:36Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1083/jcb.201704076"],["dc.identifier.eissn","1540-8140"],["dc.identifier.issn","0021-9525"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74896"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]