Kauffels-Sprenger, Anne

[["dc.bibliographiccitation.firstpage","2039"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","2045"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Schmalz, Gerhard"],["dc.contributor.author","Meisel, Anja"],["dc.contributor.author","Kollmar, Otto"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Slotta, Jan E."],["dc.contributor.author","Kottmann, Tanja"],["dc.contributor.author","Haak, Rainer"],["dc.contributor.author","Ziebolz, Dirk"],["dc.date.accessioned","2021-06-01T10:49:16Z"],["dc.date.available","2021-06-01T10:49:16Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00784-017-2298-5"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86222"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1436-3771"],["dc.relation.issn","1432-6981"],["dc.title","Oral health-related quality of life depending on dental and periodontal health in different patients before and after liver transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical & Experimental Metastasis"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Kitzmüller, Marie"],["dc.contributor.author","Gruber, Andrea"],["dc.contributor.author","Nowack, Hannah"],["dc.contributor.author","Bohnenberger, Hanibal"],["dc.contributor.author","Spitzner, Melanie"],["dc.contributor.author","Kuthning, Anja"],["dc.contributor.author","Sprenger, Thilo"],["dc.contributor.author","Czejka, Martin"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Sperling, Jens"],["dc.date.accessioned","2020-12-10T14:11:27Z"],["dc.date.available","2020-12-10T14:11:27Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s10585-019-09954-5"],["dc.identifier.eissn","1573-7276"],["dc.identifier.issn","0262-0898"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71079"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Hepatic arterial infusion of irinotecan and EmboCept® S results in high tumor concentration of SN-38 in a rat model of colorectal liver metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","614"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie"],["dc.bibliographiccitation.lastpage","615"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Kauffels-Sprenger, Anne"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Ghadimi, Michael"],["dc.date.accessioned","2020-04-02T15:00:37Z"],["dc.date.available","2020-04-02T15:00:37Z"],["dc.date.issued","2019-12"],["dc.description.abstract","Offering a full-day program including practical courses and the possibility of direct exchange between medical students and university teachers, the \"Göttinger Aufschneidertag\" was launched to generate enthusiasm for surgery. Workshops comprising four surgical disciplines enable participants to gain insight into the craft of surgery. The program aims to create interest in surgery among medical students at an early point of their studies and to make them enjoy their profession."],["dc.identifier.doi","10.1055/a-1007-2062"],["dc.identifier.pmid","31639854"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63569"],["dc.language.iso","other"],["dc.relation.eissn","1438-9592"],["dc.relation.issn","0044-409X"],["dc.relation.issn","1438-9592"],["dc.title","The Joy of Being a Surgeon - How to Generate Enthusiasm in Undergraduate Medical Education - A Local Example: The \"Göttinger Aufschneidertag\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","532-535"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie"],["dc.bibliographiccitation.lastpage","535"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Adili, Farzin"],["dc.contributor.author","Dahmen, Uta"],["dc.contributor.author","Heinemann, Markus K"],["dc.contributor.author","Kadmon, Martina"],["dc.contributor.author","Kauffels-Sprenger, Anne"],["dc.contributor.author","König, Sarah"],["dc.contributor.author","Meder, Adrian"],["dc.contributor.author","Obertacke, Udo"],["dc.contributor.author","Schwanitz von Keitz, Paul"],["dc.contributor.author","Stefanescu, Christina"],["dc.contributor.author","Sterz, Jasmina"],["dc.contributor.author","Rüsseler, Miriam"],["dc.date.accessioned","2020-04-02T14:59:09Z"],["dc.date.available","2020-04-02T14:59:09Z"],["dc.date.issued","2019-12"],["dc.description.abstract","The \"Masterplan Medizinstudium 2020\" from the German Federal Government should not be underestimated as only one among many announcement. Thus, the Surgical Working Group on Medical Education (CAL) of the German Association of Surgeons (DGCH) comments on the intended measures of the \"Masterplan Medizinstudium 2020\" and discusses the challenges, consequences and duties arising from the \"Masterplan Medizinstudium 2020\" for the representatives of the surgical societies and those engaged in surgical undergraduate training."],["dc.identifier.doi","10.1055/a-0869-8081"],["dc.identifier.pmid","31067573"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63568"],["dc.language.iso","other"],["dc.relation.eissn","1438-9592"],["dc.relation.issn","0044-409X"],["dc.relation.issn","1438-9592"],["dc.title","Position Paper of the Surgical Working Group for Teaching of the German Society of Surgery Regarding the \"Master Plan 2020\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1015"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Chirurg"],["dc.bibliographiccitation.lastpage","1024"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Sperling, Jens"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Grade, Marian"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Kuehn, P."],["dc.contributor.author","Ghadimi, B. Michael"],["dc.date.accessioned","2018-11-07T10:05:08Z"],["dc.date.available","2018-11-07T10:05:08Z"],["dc.date.issued","2016"],["dc.description.abstract","Modern intraoperative techniques of visualization are increasingly being applied in general and visceral surgery. The combination of diverse techniques provides the possibility of multidimensional intraoperative visualization of specific anatomical structures. Thus, it is possible to differentiate between normal tissue and tumor tissue and therefore exactly define tumor margins. The aim of intraoperative visualization of tissue that is to be resected and tissue that should be spared is to lead to a rational balance between oncological and functional results. Moreover, these techniques help to analyze the physiology and integrity of tissues. Using these methods surgeons are able to analyze tissue perfusion and oxygenation. However, to date it is not clear to what extent these imaging techniques are relevant in the clinical routine. The present manuscript reviews the relevant modern visualization techniques focusing on intraoperative computed tomography and magnetic resonance imaging as well as augmented reality, fluorescence imaging and optoacoustic imaging."],["dc.identifier.doi","10.1007/s00104-016-0314-y"],["dc.identifier.isi","000389902200004"],["dc.identifier.pmid","27796416"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38840"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1433-0385"],["dc.relation.issn","0009-4722"],["dc.title","Intraoperative multidimensional visualization"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie"],["dc.contributor.author","König, Sarah"],["dc.contributor.author","Datta, Rabi Raj"],["dc.contributor.author","Flemming, Sven"],["dc.contributor.author","Kauffels-Sprenger, Anne"],["dc.contributor.author","Rüsseler, Miriam"],["dc.contributor.author","Sterz, Jasmina"],["dc.date.accessioned","2021-06-01T09:41:48Z"],["dc.date.available","2021-06-01T09:41:48Z"],["dc.date.issued","2021"],["dc.description.abstract","Zusammenfassung Die Gestaltung und Umsetzung von Online-Lehre werden schon seit Langem in der chirurgischen Ausbildung für das Medizinstudium diskutiert. Sie gewinnt im Zuge der fortschreitenden Digitalisierung und nicht zuletzt aufgrund des aktuellen Pandemiegeschehens eine besondere Bedeutung. Immer drängender stellen sich Fragen zu den Möglichkeiten und Grenzen der Online-Lehre, was sich aktuell unter dem Entwicklungsdruck bereits bewährt hat, und wie zukunftsträchtige Konzepte gestaltbar sind. Dieser Artikel adressiert die Rahmenbedingungen und die verschiedenen Online-Lehrformate in der Chirurgie und zeigt das Spannungsfeld zwischen technischer Machbarkeit, Umsetzungserfahrungen und didaktischer Zielerreichung auf."],["dc.identifier.doi","10.1055/a-1398-5737"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85044"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1438-9592"],["dc.relation.issn","0044-409X"],["dc.title","Online-Lehre in der Chirurgie"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Transplantation Journal"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Slotta, Jan Erik"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Gruenhage, Frank"],["dc.contributor.author","Lammert, Frank"],["dc.contributor.author","Kollmar, Otto"],["dc.date.accessioned","2018-11-07T09:54:49Z"],["dc.date.available","2018-11-07T09:54:49Z"],["dc.date.issued","2015"],["dc.format.extent","302"],["dc.identifier.isi","000368626500745"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36614"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","21st Annual International Congress of the International-Liver-Transplant-Society (ILTS)"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","1534-6080"],["dc.relation.issn","0041-1337"],["dc.title","Outcome After Marginal Donor Liver Transplantation at a Low-Volume Center"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","745"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","752"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Ziebolz, Dirk"],["dc.contributor.author","Schmalz, Gerhard"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Widmer, Florian"],["dc.contributor.author","Widmer, Katja"],["dc.contributor.author","Slotta, Jan Erik"],["dc.contributor.author","Mausberg, Rainer F."],["dc.contributor.author","Kollmar, Otto"],["dc.date.accessioned","2018-11-07T10:25:33Z"],["dc.date.available","2018-11-07T10:25:33Z"],["dc.date.issued","2017"],["dc.description.abstract","The aim of this single-center cross-sectional study was to detect the prevalence of selected periodontal pathogenic bacteria and active matrix metalloproteinase-8 (aMMP-8) level in patients before (preLTx) and after liver transplantation (postLTx). Periodontal pocket depth (PPD) and clinical attachment loss (CAL) were assessed. Subgingival biofilm samples were analyzed using polymerase chain reaction (PCR) to detect 11 common periodontal pathogens. Gingival crevicular fluid (GCF) samples were analyzed with enzyme-linked immunosorbent assay (ELISA) to determine aMMP-8 level and assigned to a scoring system: score 0: 0-8 ng/ml, score 1: 8-20 ng/ml, and score 2: > 20 ng/ml. The following were used for the statistical analysis: t test, Mann-Whitney U test, Fishers test (alpha = 5 %). In total, 110 patients (preLTx: n = 35, postLTx: n = 75) could be included in the study. Periodontal findings were not significantly different between groups. In microbiological analysis, a significantly higher prevalence of Campylobacter rectus in preLTx group was detected (p = 0.03). Significantly more patients with score 0 in postLTx group (p = 0.024) and significantly more patients with score 1 in preLTx group were found (p = 0.004). Furthermore, aMMP-8 concentrations for patients with moderate periodontitis were significantly lower in postLTx group compared to preLTx group (p = 0.045). Additionally, in postLTx group, aMMP-8 concentration was significantly higher in patients with severe periodontitis compared to those with no/mild periodontitis (p = 0.016). LTx appears to affect aMMP-8 level, but not bacterial findings in patients after LTx. Determination of aMMP-8 level in patients after LTx with immunosuppressive medication might lead to wrong interpretation of the results."],["dc.identifier.doi","10.1007/s00784-016-1821-4"],["dc.identifier.isi","000398710700003"],["dc.identifier.pmid","27074844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42876"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1436-3771"],["dc.relation.issn","1432-6981"],["dc.title","Periodontal pathogenic bacteria and aMMP-8 findings depending on periodontal conditions of patients before and after liver transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3053"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","The Journal of Clinical Investigation"],["dc.bibliographiccitation.lastpage","3070"],["dc.bibliographiccitation.volume","128"],["dc.contributor.author","Tampe, Björn"],["dc.contributor.author","Tampe, Désirée"],["dc.contributor.author","Nyamsuren, Gunsmaa"],["dc.contributor.author","Klöpper, Friederike"],["dc.contributor.author","Rapp, Gregor"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Lorf, Thomas"],["dc.contributor.author","Zeisberg, Elisabeth M."],["dc.contributor.author","Müller, Gerhard A."],["dc.contributor.author","Kalluri, Raghu"],["dc.contributor.author","Hakroush, Samy"],["dc.contributor.author","Zeisberg, Michael"],["dc.date.accessioned","2020-12-10T18:38:19Z"],["dc.date.available","2020-12-10T18:38:19Z"],["dc.date.issued","2018"],["dc.description.abstract","Progression of chronic kidney disease associated with progressive fibrosis and impaired tubular epithelial regeneration is still an unmet biomedical challenge because, once chronic lesions have manifested, no effective therapies are available as of yet for clinical use. Prompted by various studies across multiple organs demonstrating that preconditioning regimens to induce endogenous regenerative mechanisms protect various organs from later incurring acute injuries, we here aimed to gain insights into the molecular mechanisms underlying successful protection and to explore whether such pathways could be utilized to inhibit progression of chronic organ injury. We identified a protective mechanism controlled by the transcription factor ARNT that effectively inhibits progression of chronic kidney injury by transcriptional induction of ALK3, the principal mediator of antifibrotic and proregenerative bone morphogenetic protein-signaling (BMP-signaling) responses. We further report that ARNT expression itself is controlled by the FKBP12/YY1 transcriptional repressor complex and that disruption of such FKBP12/YY1 complexes by picomolar FK506 at subimmunosuppressive doses increases ARNT expression, subsequently leading to homodimeric ARNT-induced ALK3 transcription. Direct targeting of FKBP12/YY1 with in vivo morpholino approaches or small molecule inhibitors, including GPI-1046, was equally effective for inducing ARNT expression, with subsequent activation of ALK3-dependent canonical BMP-signaling responses and attenuated chronic organ failure in models of chronic kidney disease, and also cardiac and liver injuries. In summary, we report an organ-protective mechanism that can be pharmacologically modulated by immunophilin ligands FK506 and GPI-1046 or therapeutically targeted by in vivo morpholino approaches."],["dc.identifier.doi","10.1172/JCI89632"],["dc.identifier.pmid","29664738"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77269"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/308"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C01: Epigenetische Kontrolle der Herzfibrose"],["dc.relation","SFB 1002 | D03: ENPP3-vermittelter Phosphat-Metabolismus bei der Herzfibrose"],["dc.relation.eissn","1558-8238"],["dc.relation.issn","0021-9738"],["dc.relation.workinggroup","RG E. Zeisberg (Kardiales Stroma)"],["dc.relation.workinggroup","RG M. Zeisberg (Renale Fibrogenese)"],["dc.title","Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","72"],["dc.bibliographiccitation.journal","BMC Oral Health"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Schmalz, Gerhard"],["dc.contributor.author","Kauffels, Anne"],["dc.contributor.author","Kollmar, Otto"],["dc.contributor.author","Slotta, Jan Erik"],["dc.contributor.author","Vasko, Radovan"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Haak, Rainer"],["dc.contributor.author","Ziebolz, Dirk"],["dc.date.accessioned","2018-11-07T10:10:08Z"],["dc.date.available","2018-11-07T10:10:08Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Aim of this single center cross-sectional study was to investigate oral behavior, dental, periodontal and microbiological findings in patients undergoing hemodialysis (HD) and after kidney transplantation (KT). Methods: Patients undergoing HD for end-stage renal failure and after KT were investigated. Oral health behavior was recorded using a standardized questionnaire, e.g. dental behavior, tooth brushing, oral hygiene aids. Oral investigation included screening of oral mucosa, dental findings (DMF-T) and periodontal situation (Papilla bleeding index [PBI] periodontal probing depth [PPD] and clinical attachment loss [CAL]). Additionally, microbiological analysis of subgingival biofilm samples (PCR) was performed. Statistical analysis: Student's t-test or Mann-Whitney-U-test, Fisher's exact test (a = 5 %). Results: A total of 70 patients (HD: n = 35, KT: n = 35) with a mean age of 56.4 +/- 11.1 (HD) and 55.8 +/- 10.9 (KT) years were included. Lack in use of additional oral hygiene (dental floss, inter-dental brush) was found. KT group presented significantly more gingivial overgrowth (p = 0.01). DMF-T was 19.47 +/- 5.84 (HD) and 17.61 +/- 5.81 (KT; p = 0. 21). Majority of patients had clinically moderate and severe periodontitis; showing a need for periodontal treatment of 57 % (HD) and 71 % (KT; p = 0.30). Significantly higher prevalence of Parvimonas micra and Capnocytophaga species in the HD group were found (p < 0.01). Conclusion: Periodontal treatment need and lack in oral behavior for both groups indicate the necessity of an improved early treatment and prevention of dental and periodontal disease, e.g. in form of special care programs. Regarding microbiological findings, no major differences between KT and HD patients were found."],["dc.identifier.doi","10.1186/s12903-016-0274-0"],["dc.identifier.isi","000381734000003"],["dc.identifier.pmid","27531498"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13871"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39797"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1472-6831"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Oral behavior, dental, periodontal and microbiological findings in patients undergoing hemodialysis and after kidney transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]