Hahn, Liljan E.

[["dc.bibliographiccitation.firstpage","275"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Restorative Neurology and Neuroscience"],["dc.bibliographiccitation.lastpage","285"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Turi, Zsolt"],["dc.contributor.author","Ambrus, Geza Gergely"],["dc.contributor.author","Janacsek, Karolina"],["dc.contributor.author","Emmert, K."],["dc.contributor.author","Hahn, L."],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.date.accessioned","2018-11-07T09:30:04Z"],["dc.date.available","2018-11-07T09:30:04Z"],["dc.date.issued","2013"],["dc.description.abstract","Purpose: Transcranial alternating current stimulation (tACS) is a non-invasive stimulation technique for shaping neuroplastic processes and possibly entraining ongoing neural oscillations in humans. Despite the growing number of studies using tACS, we know little about the procedural sensations caused by stimulation. In order to fill this gap, we explored the cutaneous sensation and phosphene perception during tACS. Methods: Twenty healthy participants took part in a randomized, single-blinded, sham-controlled study, where volunteers received short duration stimulation at 1.0 mA intensity between 2 to 250 Hz using the standard left motor cortex - contralateral supraorbital montage. We recorded the perception onset latency and the strength of the sensations assessed by visual rating scale as dependent variables. Results: We found that tACS evoked both cutaneous sensation and phosphene perception in a frequency-dependent manner. Our results show that the most perceptible procedural sensations were induced in the beta and gamma frequency range, especially at 20 Hz, whereas minimal procedural sensations were indicated in the ripple range (140 and 250 Hz). Conclusions: We believe that our results provide a relevant insight into the procedural sensations caused by oscillatory currents, and will offer a basis for developing more sophisticated stimulation protocols and study designs for future investigations."],["dc.identifier.doi","10.3233/RNN-120297"],["dc.identifier.isi","000318266400006"],["dc.identifier.pmid","23478342"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31214"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ios Press"],["dc.relation.issn","0922-6028"],["dc.title","Both the cutaneous sensation and phosphene perception are modulated in a frequency-specific manner during transcranial alternating current stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S61"],["dc.bibliographiccitation.journal","Leukemia Research"],["dc.bibliographiccitation.lastpage","S62"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Schemenau, J."],["dc.contributor.author","Strupp, C."],["dc.contributor.author","Wulfert, M."],["dc.contributor.author","Schroeder, T."],["dc.contributor.author","Xicoy, B."],["dc.contributor.author","Nusch, A."],["dc.contributor.author","Langer, W."],["dc.contributor.author","Kalhori, N."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Bruemmendorf, Tim Hendrik"],["dc.contributor.author","Schuette, J."],["dc.contributor.author","Ganser, Arnold"],["dc.contributor.author","Parmentier, S."],["dc.contributor.author","Schulte, K."],["dc.contributor.author","Plewe, D."],["dc.contributor.author","Losem, C."],["dc.contributor.author","Biekmann, E."],["dc.contributor.author","Hoffmann, W."],["dc.contributor.author","Hahn, L."],["dc.contributor.author","Neise, M."],["dc.contributor.author","Lollert, A."],["dc.contributor.author","Maintz, C."],["dc.contributor.author","Hinske, C."],["dc.contributor.author","Weissinger, F."],["dc.contributor.author","Heudobler, D."],["dc.contributor.author","Rodermann, E."],["dc.contributor.author","Culmann, H."],["dc.contributor.author","Kretschmar, T."],["dc.contributor.author","Steinmetz, T."],["dc.contributor.author","Giagounidis, Aristoteles A. N."],["dc.contributor.author","Meckenstock, G."],["dc.contributor.author","Rune, Gabriele M."],["dc.contributor.author","Haas, Rainer"],["dc.contributor.author","Germing, U."],["dc.contributor.author","Hofmann, Wolf-Karsten"],["dc.contributor.author","Gattermann, Norbert"],["dc.date.accessioned","2018-11-07T09:59:22Z"],["dc.date.available","2018-11-07T09:59:22Z"],["dc.date.issued","2015"],["dc.identifier.isi","000373183500120"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37571"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.conference","13th International Symposium on Myelodysplastic Syndromes (MDS)"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","1873-5835"],["dc.relation.issn","0145-2126"],["dc.title","UPDATE ON THE MULTICENTER MDS BIOREGISTRY PROJECT OF THE \"KREBSHILFE-VERBUNDFORSCHUNGSPROJEKT MDS\" OF THE GERMAN MDS STUDY GROUP"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","249"],["dc.bibliographiccitation.journal","Oncology Research and Treatment"],["dc.bibliographiccitation.lastpage","250"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Schemenau, J."],["dc.contributor.author","Strupp, C."],["dc.contributor.author","Wulfert, M."],["dc.contributor.author","Schroeder, T."],["dc.contributor.author","Nusch, A."],["dc.contributor.author","Langer, W."],["dc.contributor.author","Kalhori, N."],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Bruemmendorf, Tim Hendrik"],["dc.contributor.author","Schuette, J."],["dc.contributor.author","Ganser, Arnold"],["dc.contributor.author","Parmentier, S."],["dc.contributor.author","Schulte, K."],["dc.contributor.author","Plewe, D."],["dc.contributor.author","Losem, C."],["dc.contributor.author","Biekmann, E."],["dc.contributor.author","Hoffmann, W."],["dc.contributor.author","Hahn, L."],["dc.contributor.author","Neise, M."],["dc.contributor.author","Lollert, A."],["dc.contributor.author","Maintz, C."],["dc.contributor.author","Hinske, C."],["dc.contributor.author","Weissinger, F."],["dc.contributor.author","Heudobler, D."],["dc.contributor.author","Rodermann, E."],["dc.contributor.author","Culmann, H."],["dc.contributor.author","Kretschmar, T."],["dc.contributor.author","Steinmetz, T."],["dc.contributor.author","Severin, K."],["dc.contributor.author","Schmitz, S."],["dc.contributor.author","Haas, Rainer"],["dc.contributor.author","Germing, U."],["dc.contributor.author","Hofmann, W-K"],["dc.contributor.author","Gattermann, Norbert"],["dc.date.accessioned","2018-11-07T09:34:17Z"],["dc.date.available","2018-11-07T09:34:17Z"],["dc.date.issued","2014"],["dc.identifier.isi","000343816900608"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32141"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","2296-5262"],["dc.relation.issn","2296-5270"],["dc.title","First report on the MDS Bioregistry project of the \"Krebshilfe-Verbundforschungsprojekt MDS\" of the German MDS study group"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","939"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","ACS Chemical Biology"],["dc.bibliographiccitation.lastpage","944"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Wilkins, Bryan J."],["dc.contributor.author","Hahn, Liljan E."],["dc.contributor.author","Heitmüller, Svenja"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Valerius, Oliver"],["dc.contributor.author","Braus, Gerhard H."],["dc.contributor.author","Neumann, Heinz"],["dc.date.accessioned","2018-09-28T07:57:34Z"],["dc.date.available","2018-09-28T07:57:34Z"],["dc.date.issued","2015"],["dc.description.abstract","Post-translational modifications of proteins are important modulators of protein function. In order to identify the specific consequences of individual modifications, general methods are required for homogeneous production of modified proteins. The direct installation of modified amino acids by genetic code expansion facilitates the production of such proteins independent of the knowledge and availability of the enzymes naturally responsible for the modification. The production of recombinant histone H4 with genetically encoded modifications has proven notoriously difficult in the past. Here, we present a general strategy to produce histone H4 with acetylation, propionylation, butyrylation, and crotonylation on lysine residues. We produce homogeneous histone H4 containing up to four simultaneous acetylations to analyze the impact of the modifications on chromatin array compaction. Furthermore, we explore the ability of antibodies to discriminate between alternative lysine acylations by incorporating these modifications in recombinant histone H4."],["dc.identifier.doi","10.1021/cb501011v"],["dc.identifier.pmid","25590375"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15833"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1554-8937"],["dc.title","Genetically encoding lysine modifications on histone H4"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1800"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","ChemBioChem"],["dc.bibliographiccitation.lastpage","1804"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Lammers, Christoph R."],["dc.contributor.author","Hahn, Liljan E."],["dc.contributor.author","Neumann, Heinz"],["dc.date.accessioned","2018-11-07T09:36:32Z"],["dc.date.available","2018-11-07T09:36:32Z"],["dc.date.issued","2014"],["dc.description.abstract","Incorporation of multiple different unnatural amino acids into the same polypeptide remains a significant challenge. Orthogonal ribosomes, which are evolvable as they direct the translation of a single dedicated orthogonal mRNA, can provide an avenue to produce such polypeptides routinely. Recent advances in engineering orthogonal ribosomes have created a prototype system to enable genetically encoded introduction of two different functional groups, albeit with limited efficiency. Here, we systematically investigated the limiting factors of this system by using assays to measure the levels and activities of individual components; we identified Methanosarcina barkeri PylRS as a limiting factor for protein yield. Balancing the expression levels of individual components significantly improved growth rate and protein yield. This optimization of the system is likely to increase the scope of evolved orthogonal ribosome-mediated incorporation of multiple different unnatural amino acids."],["dc.identifier.doi","10.1002/cbic.201402033"],["dc.identifier.isi","000340506200018"],["dc.identifier.pmid","24890611"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32638"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1439-7633"],["dc.relation.issn","1439-4227"],["dc.title","Optimized Plasmid Systems for the Incorporation of Multiple Different Unnatural Amino Acids by Evolved Orthogonal Ribosomes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]