Kutschka, Ingo

[["dc.bibliographiccitation.firstpage","107"],["dc.bibliographiccitation.issue","02"],["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.bibliographiccitation.lastpage","113"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Saha, Shekhar"],["dc.contributor.author","Varghese, Sam"],["dc.contributor.author","Ahmad, Ammar Al"],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Waezi, Narges"],["dc.contributor.author","Niehaus, Heidi"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Kutschka, Ingo"],["dc.date.accessioned","2020-12-10T18:12:17Z"],["dc.date.available","2020-12-10T18:12:17Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1055/s-0038-1670663"],["dc.identifier.eissn","1439-1902"],["dc.identifier.issn","0171-6425"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74313"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Complex Valve Surgery in Elderly Patients: Increasingly Necessary and Surprisingly Feasible"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","590"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Perfusion"],["dc.bibliographiccitation.lastpage","597"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Saha, Shekhar"],["dc.contributor.author","Varghese, Sam"],["dc.contributor.author","Herr, Mike"],["dc.contributor.author","Leistner, Marcus"],["dc.contributor.author","Ulrich, Christian"],["dc.contributor.author","Niehaus, Heidi"],["dc.contributor.author","Ahmad, Ammar Al"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Kutschka, Ingo"],["dc.date.accessioned","2020-12-10T18:38:24Z"],["dc.date.available","2020-12-10T18:38:24Z"],["dc.date.issued","2019"],["dc.description.abstract","Objectives: Minimally invasive extracorporeal circulation circuits provide several advantages compared to conventional extracorporeal circulation circuits. We compared the results of a minimally invasive extracorporeal circulation system with those of conventional extracorporeal circulation system, in patients undergoing isolated coronary artery bypass grafting. Methods: We identified 753 consecutive patients who underwent coronary artery bypass grafting at our centre between October 2014 and September 2016. These patients were divided into two groups: a minimally invasive extracorporeal circulation group (M, n = 229) and a conventional extracorporeal circulation group (C, n = 524). Baseline parameters, details of cardiac surgery as well as postoperative complications and outcomes were compared by means of a propensity-matched analysis of 180 matched pairs. Results: The median EuroSCORE II was 1.3%. Transfusion requirement of packed red blood cells (p = 0.002) was lower in Group M compared to conventional extracorporeal circulation systems. There were no differences in hospital mortality or in rates of adverse events between the matched groups. Total in-hospital mortality of the cohort was 1.7%. Conclusion: The use of minimally invasive extracorporeal circulation is associated with a significantly lower use of blood products after isolated coronary revascularisation. There were no differences concerning duration of surgery, complication rates and mortality between the groups. Therefore, the application of minimally invasive extracorporeal circulation systems should be considered as preferred technique in isolated coronary artery bypass grafting procedures."],["dc.identifier.doi","10.1177/0267659119842060"],["dc.identifier.eissn","1477-111X"],["dc.identifier.issn","0267-6591"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77306"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","SAGE Publications"],["dc.relation.eissn","1477-111X"],["dc.relation.issn","0267-6591"],["dc.title","Minimally invasive versus conventional extracorporeal circulation circuits in patients undergoing coronary artery bypass surgery: a propensity-matched analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.contributor.author","Saha, Shekhar"],["dc.contributor.author","Dudakova, Anna"],["dc.contributor.author","Danner, Bernhard C."],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Schulze, Marco H."],["dc.contributor.author","Niehaus, Heidi"],["dc.date.accessioned","2022-04-01T10:02:45Z"],["dc.date.available","2022-04-01T10:02:45Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Objective The rising incidence of infective endocarditis (IE) accompanied by the de-escalation of antibiotic prophylaxis and the complexity of surgical treatment makes IE a daunting foe. We reviewed all patients who underwent cardiac surgery for IE at our institution with a focus on causative organisms and infective foci. Methods A review of 3,952 consecutive patients who underwent cardiac surgery at our institution between January 2013 and December 2017 revealed 160 patients (4%) who were operated for IE. Results The predominantly affected valves were the aortic (30%) and mitral valve (26.9%) as well as a combination of both (8.8%). A total of 28.8% of patients suffered from prosthetic valve endocarditis (PVE). The most frequently identified causative organisms were Staphylococcus (45.7%), Streptococcus (27.5%), and Enterococcus species (16.7%), which was predominantly associated with PVE (p = 0.050). In 13.1% of patients, a causative organism has not been detected. The most frequent infective foci were dental (15%), soft-tissue infections (15%), spondylodiscitis (10%), and infected intravascular implants (8.8%). Relevant predisposing factors were immunosuppression (9.4%) and intravenous drug abuse (4.4%). Septic cerebral infarctions were diagnosed in 28.8% of patients. Postoperative mortality was 22.5%. Conclusions As the bacterial spectrum and the infective foci are still the “old acquaintances,” and with regard to the increasing incidence of IE, current risk–benefit evaluations concerning antibiotic prophylaxis may need to be revisited."],["dc.identifier.doi","10.1055/s-0041-1740540"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105997"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1439-1902"],["dc.relation.issn","0171-6425"],["dc.title","Bacterial Spectrum and Infective Foci in Patients Operated for Infective Endocarditis: Time to Rethink Strategies?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0192652"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Dahlmann, Julia"],["dc.contributor.author","Awad, George"],["dc.contributor.author","Dolny, Carsten"],["dc.contributor.author","Weinert, Sönke"],["dc.contributor.author","Richter, Karin"],["dc.contributor.author","Fischer, Klaus-Dieter"],["dc.contributor.author","Munsch, Thomas"],["dc.contributor.author","Leßmann, Volkmar"],["dc.contributor.author","Volleth, Marianne"],["dc.contributor.author","Zenker, Martin"],["dc.contributor.author","Chen, Yaoyao"],["dc.contributor.author","Merkl, Claudia"],["dc.contributor.author","Schnieke, Angelika"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Kensah, George"],["dc.date.accessioned","2019-07-09T11:45:08Z"],["dc.date.available","2019-07-09T11:45:08Z"],["dc.date.issued","2018"],["dc.description.abstract","The possibility to generate cardiomyocytes from pluripotent stem cells in vitro has enormous significance for basic research, disease modeling, drug development and heart repair. The concept of heart muscle reconstruction has been studied and optimized in the rat model using rat primary cardiovascular cells or xenogeneic pluripotent stem cell derived-cardiomyocytes for years. However, the lack of rat pluripotent stem cells (rPSCs) and their cardiovascular derivatives prevented the establishment of an authentic clinically relevant syngeneic or allogeneic rat heart regeneration model. In this study, we comparatively explored the potential of recently available rat embryonic stem cells (rESCs) and induced pluripotent stem cells (riPSCs) as a source for cardiomyocytes (CMs). We developed feeder cell-free culture conditions facilitating the expansion of undifferentiated rPSCs and initiated cardiac differentiation by embryoid body (EB)-formation in agarose microwell arrays, which substituted the robust but labor-intensive hanging drop (HD) method. Ascorbic acid was identified as an efficient enhancer of cardiac differentiation in both rPSC types by significantly increasing the number of beating EBs (3.6 ± 1.6-fold for rESCs and 17.6 ± 3.2-fold for riPSCs). These optimizations resulted in a differentiation efficiency of up to 20% cTnTpos rPSC-derived CMs. CMs showed spontaneous contractions, expressed cardiac markers and had typical morphological features. Electrophysiology of riPSC-CMs revealed different cardiac subtypes and physiological responses to cardio-active drugs. In conclusion, we describe rPSCs as a robust source of CMs, which is a prerequisite for detailed preclinical studies of myocardial reconstruction in a physiologically and immunologically relevant small animal model."],["dc.identifier.doi","10.1371/journal.pone.0192652"],["dc.identifier.pmid","29513687"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59166"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/241504/EU//EURATRANS"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","614"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie"],["dc.bibliographiccitation.lastpage","615"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Kauffels-Sprenger, Anne"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Ghadimi, Michael"],["dc.date.accessioned","2020-04-02T15:00:37Z"],["dc.date.available","2020-04-02T15:00:37Z"],["dc.date.issued","2019-12"],["dc.description.abstract","Offering a full-day program including practical courses and the possibility of direct exchange between medical students and university teachers, the \"Göttinger Aufschneidertag\" was launched to generate enthusiasm for surgery. Workshops comprising four surgical disciplines enable participants to gain insight into the craft of surgery. The program aims to create interest in surgery among medical students at an early point of their studies and to make them enjoy their profession."],["dc.identifier.doi","10.1055/a-1007-2062"],["dc.identifier.pmid","31639854"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63569"],["dc.language.iso","other"],["dc.relation.eissn","1438-9592"],["dc.relation.issn","0044-409X"],["dc.relation.issn","1438-9592"],["dc.title","The Joy of Being a Surgeon - How to Generate Enthusiasm in Undergraduate Medical Education - A Local Example: The \"Göttinger Aufschneidertag\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4603"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Anticancer Research"],["dc.bibliographiccitation.lastpage","4612"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","BUENTZEL, JUDITH"],["dc.contributor.author","HEINZ, JUDITH"],["dc.contributor.author","BLECKMANN, ANNALEN"],["dc.contributor.author","BAUER, CHRISTOPH"],["dc.contributor.author","RÖVER, CHRISTIAN"],["dc.contributor.author","BOHNENBERGER, HANIBAL"],["dc.contributor.author","SAHA, SHEKHAR"],["dc.contributor.author","HINTERTHANER, MARC"],["dc.contributor.author","BARAKI, HASSINA"],["dc.contributor.author","KUTSCHKA, INGO"],["dc.contributor.author","EMMERT, ALEXANDER"],["dc.date.accessioned","2020-12-10T18:43:04Z"],["dc.date.available","2020-12-10T18:43:04Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.21873/anticanres.13640"],["dc.identifier.eissn","1791-7530"],["dc.identifier.issn","0250-7005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78183"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","154"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","ESC Heart Failure"],["dc.bibliographiccitation.lastpage","163"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Ahmad, Shakil"],["dc.contributor.author","Tirilomis, Petros"],["dc.contributor.author","Pabel, Steffen"],["dc.contributor.author","Dybkova, Nataliya"],["dc.contributor.author","Hartmann, Nico"],["dc.contributor.author","Molina, Cristina E."],["dc.contributor.author","Tirilomis, Theodoros"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Frey, Norbert"],["dc.contributor.author","Maier, Lars S."],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Streckfuss-Bömeke, Katrin"],["dc.contributor.author","Sossalla, Samuel"],["dc.date.accessioned","2019-02-26T11:03:53Z"],["dc.date.available","2019-02-26T11:03:53Z"],["dc.date.issued","2019"],["dc.description.abstract","Aims In hypertrophy and heart failure, the proarrhythmic persistent Na+ current (INaL) is enhanced. We aimed to investigate the electrophysiological role of neuronal sodium channel NaV1.8 in human hypertrophied myocardium. Methods and results Myocardial tissue of 24 patients suffering from symptomatic severe aortic stenosis and concomitant significant afterload-induced hypertrophy with preserved ejection fraction was used and compared with 12 healthy controls. We performed quantitative real-time PCR and western blot and detected a significant up-regulation of NaV1.8 mRNA (2.34fold) and protein expression (1.96-fold) in human hypertrophied myocardium compared with healthy hearts. Interestingly, NaV1.5 protein expression was significantly reduced in parallel (0.60-fold). Using whole-cell patch-clamp technique, we found that the prominent INaL was significantly reduced after addition of novel NaV1.8-specific blockers either A-803467 (30 nM) or PF-01247324 (1 μM) in human hypertrophic cardiomyocytes. This clearly demonstrates the relevant contribution of NaV1.8 to this proarrhythmic current. We observed a significant action potential duration shortening and performed confocal microscopy, demonstrating a 50% decrease in proarrhythmic diastolic sarcoplasmic reticulum (SR)-Ca2+ leak and SR-Ca2+ spark frequency after exposure to both NaV1.8 inhibitors."],["dc.identifier.doi","10.1002/ehf2.12378"],["dc.identifier.pmid","30378291"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57615"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/242"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | D01: Erholung aus der Herzinsuffizienz – Einfluss von Fibrose und Transkriptionssignatur"],["dc.relation.workinggroup","RG Hasenfuß (Transition zur Herzinsuffizienz)"],["dc.relation.workinggroup","RG L. Maier (Experimentelle Kardiologie)"],["dc.relation.workinggroup","RG Sossalla (Kardiovaskuläre experimentelle Elektrophysiologie und Bildgebung)"],["dc.rights","CC BY-NC 4.0"],["dc.title","The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","436"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie"],["dc.bibliographiccitation.lastpage","445"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Zardo, Patrick"],["dc.contributor.author","Busk, Henning"],["dc.contributor.author","Piatek, Stefan"],["dc.contributor.author","Zinne, Norman"],["dc.contributor.author","Kropivnitskaya, Irina"],["dc.contributor.author","Kutschka, Ingo"],["dc.date.accessioned","2018-11-07T10:23:06Z"],["dc.date.available","2018-11-07T10:23:06Z"],["dc.date.issued","2017"],["dc.identifier.isi","000403318500011"],["dc.identifier.pmid","28614864"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42394"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-1074"],["dc.relation.issn","0939-2661"],["dc.title","The Patient with Chest Trauma: surgical Care"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1434"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic and Vascular Anesthesia"],["dc.bibliographiccitation.lastpage","1438"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Saha, Shekhar"],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Leistner, Marcus"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Niehaus, Heidi"],["dc.date.accessioned","2020-12-10T18:11:59Z"],["dc.date.available","2020-12-10T18:11:59Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1053/j.jvca.2019.10.055"],["dc.identifier.issn","1053-0770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74207"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Turning Things Around: The Role of Prone Positioning in the Management of Acute Respiratory Failure After Cardiac Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Herz"],["dc.bibliographiccitation.lastpage","94"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Hadem, J."],["dc.contributor.author","Rossnick, R."],["dc.contributor.author","Hesse, B."],["dc.contributor.author","Herr, M."],["dc.contributor.author","Hansen, M."],["dc.contributor.author","Bergmann, A."],["dc.contributor.author","Kensah, G."],["dc.contributor.author","Maess, C."],["dc.contributor.author","Baraki, H."],["dc.contributor.author","Kümpers, P."],["dc.contributor.author","Lukasz, A."],["dc.contributor.author","Kutschka, I."],["dc.date.accessioned","2020-12-10T14:07:55Z"],["dc.date.available","2020-12-10T14:07:55Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00059-018-4708-0"],["dc.identifier.eissn","1615-6692"],["dc.identifier.issn","0340-9937"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70333"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Endotheliale Dysfunktion nach koronarer Bypass-Operation"],["dc.title.alternative","Endothelial dysfunction following coronary artery bypass grafting. Influence of patient and procedural factors"],["dc.title.subtitle","Einfluss von Patientenfaktoren und Operationstechnik"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]