Trautmann, Sandra

[["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Arthritis & Rheumatism"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Blaschke, Sabine"],["dc.contributor.author","Trautmann, Sandra"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Mai, Burkhard"],["dc.contributor.author","Koelling, Sebastian"],["dc.contributor.author","Breysach, Caroline"],["dc.contributor.author","Wolf, Gabriele"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-11-07T09:04:58Z"],["dc.date.available","2018-11-07T09:04:58Z"],["dc.date.issued","2012"],["dc.format.extent","S517"],["dc.identifier.isi","000309748302284"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25220"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP)"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","0004-3591"],["dc.title","Functional Role of Chondrogenic Progenitor Cells in Rheumatoid Arthritis."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Zeitschrift für Rheumatologie"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Trautmann, Sandra"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Mai, Burkhard"],["dc.contributor.author","Breysach, Caroline"],["dc.contributor.author","Wolf, G."],["dc.contributor.author","Mueller, G."],["dc.contributor.author","Blaschke, S."],["dc.date.accessioned","2018-11-07T09:20:02Z"],["dc.date.available","2018-11-07T09:20:02Z"],["dc.date.issued","2013"],["dc.format.extent","47"],["dc.identifier.isi","000331709100073"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28783"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1435-1250"],["dc.relation.issn","0340-1855"],["dc.title","Regulation of osteoclast bone resorptive activity in rheumatoid arthritis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","440"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Immunology"],["dc.bibliographiccitation.lastpage","445"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Trautmann, Sandra"],["dc.contributor.author","Mai, Burkhard"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Blaschke, Sabine"],["dc.date.accessioned","2018-08-20T12:24:05Z"],["dc.date.available","2018-08-20T12:24:05Z"],["dc.date.issued","2016"],["dc.description.abstract","Mesenchymal stem cells are known to exert immunomodulatory effects in inflammatory diseases. Immuneregulatory cells lead to progressive joint destruction in rheumatoid arthritis (RA). Proinflammatory cytokines, such as tumour necrosis factor α (TNF-α) and interleukins (ILs) are the main players. Here, we studied progenitor cells from RA cartilage (RA-CPCs) that are positive for IL-17 receptors to determinate the effects of inflammation on their chondrogenic potenial. IL-17A/F reduced the chondrogenic potential of these cells via the upregulation of RUNX2 protein and enhanced IL-6 protein and MMP3 mRNA levels. Blocking antibodies against IL-17 positively influenced their repair potential. Furthermore, treating the RA-CPCs with the anti-human IL-17 antibody secukinumab or the anti-TNF-α antibody adalimumab reduced the proinflammatory IL-6 protein level and positively influenced the secretion of anti-inflammatory IL-10 protein. Additionally, adalimumab and secukinumab in particular reduced RUNX2 protein to promote chondrogenesis. The amelioration of inflammation, particularly via IL-17 antagonism, might be a new therapeutic approach for enhancing intrinsic cartilage repair mechanisms in RA patients."],["dc.identifier.doi","10.1002/eji.201545910"],["dc.identifier.pmid","26558442"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15432"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1521-4141"],["dc.relation.eissn","0014-2980"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","102266"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","iScience"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Imre, Gergely"],["dc.contributor.author","Krähling, Verena"],["dc.contributor.author","Eichler, Madeleine"],["dc.contributor.author","Trautmann, Sandra"],["dc.contributor.author","Ferreirós, Nerea"],["dc.contributor.author","Aman, M. Javad"],["dc.contributor.author","Kashanchi, Fatah"],["dc.contributor.author","Rajalingam, Krishnaraj"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Pfeilschifter, Josef"],["dc.date.accessioned","2021-06-01T09:41:21Z"],["dc.date.available","2021-06-01T09:41:21Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.isci.2021.102266"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84890"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","2589-0042"],["dc.title","The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]