Brenig, Bertram B.

[["dc.bibliographiccitation.firstpage","161"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Bacteria"],["dc.bibliographiccitation.lastpage","182"],["dc.bibliographiccitation.volume","1"],["dc.contributor.affiliation","Valdez-Baez, Juan; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","da Costa, Francielly Morais Rodrigues; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","Pinto Gomide, Anne Cybelle; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","Profeta, Rodrigo; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","da Silva, Alessandra Lima; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","Sousa, Thiago de Jesus; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","Viana, Marcus Vinícius Canário; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","Bentes Kato, Rodrigo; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","Americo, Monique Ferrary; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","dos Santos Freitas, Andria; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","Carvalho, Rodrigo Dias de Oliveira; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.affiliation","Brenig, Bertram; 3Institute of Veterinary Medicine, University of Göttingen, Burckhardtweg 2, 37077 Göttingen, Germany; bbrenig@gwdg.de"],["dc.contributor.affiliation","Martins, Flaviano Santos; 4Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; flaviano@icb.ufmg.br"],["dc.contributor.affiliation","Aburjaile, Flavia; 5Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"],["dc.contributor.affiliation","Azevedo, Vasco; 1Laboratory of Cellular and Molecular Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil; juanlvaldezb@gmail.com (J.V.-B.); franrodriguesdacosta@gmail.com (F.M.R.d.C.); acybelle@gmail.com (A.C.P.G.); profeta.biotec@gmail.com (R.P.); alessandralima92@gmail.com (A.L.d.S.); thiagojsousa@gmail.com (T.d.J.S.); canarioviana@gmail.com (M.V.C.V.); rbkato@gmail.com (R.B.K.); moniquefamerico@gmail.com (M.F.A.); andria.sfreitas@gmail.com (A.d.S.F.); rodrigodoc2@gmail.com (R.D.d.O.C.)"],["dc.contributor.author","Valdez-Baez, Juan"],["dc.contributor.author","da Costa, Francielly Morais Rodrigues"],["dc.contributor.author","Pinto Gomide, Anne Cybelle"],["dc.contributor.author","Profeta, Rodrigo"],["dc.contributor.author","da Silva, Alessandra Lima"],["dc.contributor.author","Sousa, Thiago de Jesus"],["dc.contributor.author","Viana, Marcus Vinícius Canário"],["dc.contributor.author","Bentes Kato, Rodrigo"],["dc.contributor.author","Americo, Monique Ferrary"],["dc.contributor.author","dos Santos Freitas, Andria"],["dc.contributor.author","Carvalho, Rodrigo Dias de Oliveira"],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Martins, Flaviano Santos"],["dc.contributor.author","Aburjaile, Flavia"],["dc.contributor.author","Azevedo, Vasco"],["dc.date.accessioned","2022-09-05T08:55:09Z"],["dc.date.available","2022-09-05T08:55:09Z"],["dc.date.issued","2022-07-13"],["dc.date.updated","2022-09-04T02:42:38Z"],["dc.description.abstract","Bifidobacterium breve is among the first microorganisms colonizing the intestinal tract in humans and is a predominant species in the gut microbiota of newborns and children. This bacterium is widely used in the probiotic industry due to its capacity to improve host health. The search for new targets with probiotic properties is an increasing trend with the help of next-generation sequencing as they facilitate the characterization of the bacterial features. B. breve 1101A was isolated from the faeces of healthy children in Brazil and therefore could play a protective role in the gut. To investigate the beneficial properties of this strain, the present study performed a comprehensive characterization of the genetic features involved in the bacterium resistance and adaptation to gastrointestinal conditions, production of nutrients, and immunomodulatory compounds. Furthermore, this study carried out the prediction of genomic elements (plasmids, prophages, CRISPR-Cas systems, insertion sequences, genomic islands, antibiotic resistance genes) to evaluate the safety of B. breve 1101A. A comparative genomics approach using 45 B. breve complete genomes based on pangenome and phylogenomic analysis was also performed to identify specific genes in B. breve 1101A. The prediction of genetic elements, possibly safety-related, did not detect plasmids, but only one incomplete prophage, two non-functional CRISPR systems, and seven genomic islands. Additionally, three antibiotic resistance genes were identified: ileS (resistance to mupirocin), rpoB, and erm(X). In the comparative genomic analysis, the pangenome was revealed to be open, and B. breve 1101A presented 63 unique genes associated with several processes, such as transmembrane transport, membrane components, DNA processes, and carbohydrate metabolism. In conclusion, B. breve 1101A is potentially safe and well-adapted for intestinal disorder therapeutics, although the role of its unique genetic repertoire needs further investigation."],["dc.identifier.doi","10.3390/bacteria1030013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114070"],["dc.language.iso","en"],["dc.relation.eissn","2674-1334"],["dc.rights","CC BY 4.0"],["dc.title","Comparative Genomics and In Silico Evaluation of Genes Related to the Probiotic Potential of Bifidobacterium breve 1101A"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","139A"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Cytogenetic and Genome Research"],["dc.bibliographiccitation.lastpage","U2"],["dc.bibliographiccitation.volume","107"],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Beck, J."],["dc.contributor.author","Hall, A. J."],["dc.contributor.author","Broad, T. E."],["dc.contributor.author","Chowdhary, B. P."],["dc.contributor.author","Piumi, F."],["dc.date.accessioned","2018-11-07T10:52:18Z"],["dc.date.available","2018-11-07T10:52:18Z"],["dc.date.issued","2004"],["dc.identifier.doi","10.1159/000079585"],["dc.identifier.isi","000224244100024"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49083"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1424-8581"],["dc.title","Assignment of the equine solute carrier 26A2 gene (SLC26A2) to equine chromosome 14q15 -> q21 (ECA14q15 -> q21) by in situ hybridization and radiation hybrid panel mapping"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0154602"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Schuetz, Ekkehard"],["dc.contributor.author","Wehrhahn, Christin"],["dc.contributor.author","Wanjek, Marius"],["dc.contributor.author","Bortfeld, Ralf"],["dc.contributor.author","Wemheuer, Wilhelm E."],["dc.contributor.author","Beck, Julia"],["dc.contributor.author","Brenig, Bertram"],["dc.date.accessioned","2018-11-07T10:15:21Z"],["dc.date.available","2018-11-07T10:15:21Z"],["dc.date.issued","2016"],["dc.description.abstract","Background With the availability of massive SNP data for several economically important cattle breeds, haplotype tests have been performed to identify unknown recessive disorders. A number of so-called lethal haplotypes, have been uncovered in Holstein Friesian cattle and, for at least seven of these, the causative mutations have been identified in candidate genes. However, several lethal haplotypes still remain elusive. Here we report the molecular genetic causes of lethal haplotype 5 (HH5) and cholesterol deficiency (CDH). A targeted enrichment for the known genomic regions, followed by massive parallel sequencing was used to interrogate for causative mutations in a case/control approach. Methods Targeted enrichment for the known genomic regions, followed by massive parallel sequencing was used in a case/control approach. PCRs for the causing mutations were developed and compared to routine imputing in 2,100 (HH5) and 3,100 (CDH) cattle. Results HH5 is caused by a deletion of 138kbp, spanning position 93,233kb to 93,371kb on chromosome 9 (BTA9), harboring only dimethyl-adenosine transferase 1 (TFB1M). The deletion breakpoints are flanked by bovine long interspersed nuclear elements Bov-B (upstream) and L1ME3 (downstream), suggesting a homologous recombination/deletion event. TFB1M di-methylates adenine residues in the hairpin loop at the 3'-end of mitochondrial 12S rRNA, being essential for synthesis and function of the small ribosomal subunit of mitochondria. Homozygous TFB1M(-/-) mice reportedly exhibit embryonal lethality with developmental defects. A 2.8% allelic frequency was determined for the German HF population. CDH results from a 1.3kbp insertion of an endogenous retrovirus (ERV2-1-LTR_BT) into exon 5 of the APOB gene at BTA11: 77,959kb. The insertion is flanked by 6bp target site duplications as described for insertions mediated by retroviral integrases. A premature stop codon in the open reading frame of APOB is generated, resulting in a truncation of the protein to a length of only < 140 amino acids. Such early truncations have been shown to cause an inability of chylomicron excretion from intestinal cells, resulting in malabsorption of cholesterol. The allelic frequency of this mutation in the German HF population was 6.7%, which is substantially higher than reported so far. Compared to PCR assays inferring the genetic variants directly, the routine imputing used so far showed a diagnostic sensitivity of as low as 91% (HH5) and 88% (CDH), with a high specificity for both (>= 99.7%). Conclusion With the availability of direct genetic tests it will now be possible to more effectively reduce the carrier frequency and ultimately eliminate the disorders from the HF populations. Beside this, the fact that repetitive genomic elements (RE) are involved in both diseases, underline the evolutionary importance of RE, which can be detrimental as here, but also advantageous over generations."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2016"],["dc.identifier.doi","10.1371/journal.pone.0154602"],["dc.identifier.isi","000375212600046"],["dc.identifier.pmid","27128314"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13249"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40795"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights.access","openAccess"],["dc.title","The Holstein Friesian Lethal Haplotype 5 (HH5) Results from a Complete Deletion of TBF1M and Cholesterol Deficiency (CDH) from an ERV-(LTR) Insertion into the Coding Region of APOB"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Prion"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Wemheuer, Wiebke M."],["dc.contributor.author","Benestad, Sylvie L."],["dc.contributor.author","Wrede, Arne"],["dc.contributor.author","Wemheuer, Wilhelm E."],["dc.contributor.author","Pfander, Tatjana"],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.date.accessioned","2018-11-07T08:41:59Z"],["dc.date.available","2018-11-07T08:41:59Z"],["dc.date.issued","2010"],["dc.format.extent","126"],["dc.identifier.isi","000285872300045"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19596"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.publisher.place","Austin"],["dc.relation.issn","1933-6896"],["dc.title","Types or Strains: What Classifies Prion Diseases?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1569"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Animal Science"],["dc.bibliographiccitation.lastpage","1575"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Guo, Y. M."],["dc.contributor.author","Ai, H. S."],["dc.contributor.author","Ren, Jun"],["dc.contributor.author","Wang, G. J."],["dc.contributor.author","Wen, Y."],["dc.contributor.author","Mao, Huirong"],["dc.contributor.author","Lan, Luetao"],["dc.contributor.author","Ma, J. W."],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Rothschild, M. F."],["dc.contributor.author","Haley, Chris S."],["dc.contributor.author","Huang, L. S."],["dc.date.accessioned","2018-11-07T08:30:20Z"],["dc.date.available","2018-11-07T08:30:20Z"],["dc.date.issued","2009"],["dc.description.abstract","To detect QTL for leg weakness and its related traits in pigs, a total of 1,484 F-2 pigs were recorded for leg (at 76 and 213 d) and gait scores (at 153 and 223 d) in a White Duroc x Erhualian intercross. The length and weight of the biceps brachii muscle were measured after slaughter at 240 d. A genome scan was performed with 183 microsatellite markers in the population. A total of 42 QTL were detected, including 16 at the 1% genome-wide significant level and 6 at the 5% genome-wide significant level. Thirty-eight of the 42 QTL showed significant additive effects, and 14 had significant dominance effects. At least 2 QTL were detected for each trait except for leg score at 76 d, for which no QTL was identified. Some of the QTL for leg and gait scores confirmed previous findings. Eighteen QTL were detected for weight and length of the biceps brachii muscle. To our knowledge, this was the first report about QTL for weight and length of the biceps brachii muscle in pigs. Two chromosome regions each on SSC4 and SSC7 showed significant and multiple associations with both leg weakness and growth of the biceps brachii muscle, which are worthwhile for further investigation."],["dc.description.sponsorship","National 973 Program of China [2006CB708213]; Nanchang City Key Project"],["dc.identifier.doi","10.2527/jas.2008-1191"],["dc.identifier.isi","000265253600001"],["dc.identifier.pmid","19151150"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16874"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Animal Science"],["dc.relation.issn","0021-8812"],["dc.title","A whole genome scan for quantitative trait loci for leg weakness and its related traits in a large F-2 intercross population between White Duroc and Erhualian"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","66"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Animal Genetics"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Wen, G."],["dc.contributor.author","Baumgartner, B. G."],["dc.contributor.author","Leeb, T."],["dc.contributor.author","Hui, D."],["dc.contributor.author","Brenig, B."],["dc.date.accessioned","2021-12-08T12:27:31Z"],["dc.date.available","2021-12-08T12:27:31Z"],["dc.date.issued","2001"],["dc.identifier.doi","10.1046/j.1365-2052.1999.00323.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95378"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.issn","0268-9146"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","Characterisation of an Msp I transversion polymorphism in exon 8 of the porcine secretory carrier membrane protein 1 ( SCAMP1 ) gene"],["dc.title.alternative","Molecular Genetics Markers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","298"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Animal Genetics"],["dc.bibliographiccitation.lastpage","302"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","von Teichman, A."],["dc.contributor.author","Joerg, H."],["dc.contributor.author","Werner, P."],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Stranzinger, G."],["dc.date.accessioned","2018-11-07T08:33:27Z"],["dc.date.available","2018-11-07T08:33:27Z"],["dc.date.issued","2001"],["dc.description.abstract","The 3 beta -hydroxvsteroid dehydrogenase/Delta5-Delta4-isomerase (3 beta -HSD) enzymes are essential for the biosynthesis of steroid hormones. The 3 beta -HSD gene family has been reported to encode for different isoenzymes which function either as dehydrogenase/isomerase or as reductase. The 3 beta -HSD enzymes are involved in the formation of the pheromone androstenone (5 alpha -androst-16-ene-3-one) which contributes to the unpleasant odour present in the meat of uncastrated boars. An reverse-transcription-polymerase chain reaction (RT-PCR) probe from porcine testicular tissue of a 3 beta -HSD enzyme was used to screen a porcine adipose tissue cDNA library. Both strands of the positive clones were sequenced and the putative coding sequence of 1122 nucleotides encodes 374 amino acids. Comparison of the putative open reading frame with the bovine and the human type I homologues revealed 85.6 and 79.3% identity, respectively. Fluorescence in situ hybridization (FISH) was performed with a labelled PAC clone containing the gene of interest. The 3 beta -HSD gene was mapped to the porcine chromosome 4q16-4q21 which is in accordance with the comparative gene map."],["dc.identifier.doi","10.1046/j.1365-2052.2001.00775.x"],["dc.identifier.isi","000171848400010"],["dc.identifier.pmid","11683717"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17578"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0268-9146"],["dc.title","CDNA cloning and physical mapping of porcine 3 beta-hydroxysteroid dehydrogenase/Delta 5-Delta 4 isomerase"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","550"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","556"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Gordon, Paul M. K."],["dc.contributor.author","Schuetz, Ekkehard"],["dc.contributor.author","Beck, Julia"],["dc.contributor.author","Urnovitz, Howard B."],["dc.contributor.author","Graham, Catherine"],["dc.contributor.author","Clark, Renee"],["dc.contributor.author","Dudas, Sandor"],["dc.contributor.author","Czub, Stefanie"],["dc.contributor.author","Sensen, Maria"],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Groschup, Martin H."],["dc.contributor.author","Church, Robert B."],["dc.contributor.author","Sensen, Christoph W."],["dc.date.accessioned","2018-11-07T08:33:15Z"],["dc.date.available","2018-11-07T08:33:15Z"],["dc.date.issued","2009"],["dc.description.abstract","To gain insight into the disease progression of transmissible spongiform encephalopathies (TSE), we searched for disease-specific patterns in circulating nucleic acids (CNA) in elk and cattle. In a 25-month time-course experiment, CNAs were isolated from blood samples of 24 elk (Cervus elaphus) orally challenged with chronic wasting disease (CWD) infectious material. In a separate experiment, blood-sample CNAs from 29 experimental cattle (Bos taurus) 40 months post-inoculation with clinical bovine spongiform encephalopathy (BSE) were analyzed according to the same protocol. Next-generation sequencing provided broad elucidation of sample CNAs: we detected infection-specific sequences as early as 11 months in elk (i.e. at least 3 months before the appearance of the first clinical signs) and we established CNA patterns related to BSE in cattle at least 4 months prior to clinical signs. In elk, a progression of CNA sequence patterns was found to precede and correlate with macro-observable disease progression, including delayed CWD progression in elk with PrP genotype LM. Some of the patterns identified contain transcription-factor-binding sites linked to endogenous retroviral integration. These patterns suggest that retroviruses may be connected to the manifestation of TSEs. Our results may become useful for the early diagnosis of TSE in live elk and cattle."],["dc.identifier.doi","10.1093/nar/gkn963"],["dc.identifier.isi","000262963400031"],["dc.identifier.pmid","19059996"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17531"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0305-1048"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Disease-specific motifs can be identified in circulating nucleic acids from live elk and cattle infected with transmissible spongiform encephalopathies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e75485"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Beck, Julia"],["dc.contributor.author","Hennecke, Silvia"],["dc.contributor.author","Bornemann-Kolatzki, Kirsten"],["dc.contributor.author","Urnovitz, Howard B."],["dc.contributor.author","Neumann, Stephan"],["dc.contributor.author","Stroebel, Philipp"],["dc.contributor.author","Kaup, Franz-Josef"],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Schuetz, Ekkehard"],["dc.date.accessioned","2018-11-07T09:19:45Z"],["dc.date.available","2018-11-07T09:19:45Z"],["dc.date.issued","2013"],["dc.description.abstract","Mammary tumors are the most frequent cancers in female dogs exhibiting a variety of histopathological differences. There is lack of knowledge about the genomes of these common dog tumors. Five tumors of three different histological subtypes were evaluated. Massive parallel sequencing (MPS) was performed in comparison to the respective somatic genome of each animal. Copy number and structural aberrations were validated using droplet digital PCR (ddPCR). Using mate-pair sequencing chromosomal aneuploidies were found in two tumors, frequent smaller deletions were found in one, inter-chromosomal fusions in one other, whereas one tumor was almost normal. These aberrations affect several known cancer associated genes such as cMYC, and KIT. One common deletion of the proximal end of CFA27, harboring the tumor suppressor gene PFDN5 was detected in four tumors. Using ddPCR, this deletion was validated and detected in 50% of tumors (N = 20). Breakpoint specific dPCRs were established for four tumors and tumor specific cell-free DNA (cfDNA) was detected in the plasma. In one animal tumor-specific cfDNA was found >1 year after surgery, attributable to a lung metastasis. Paired-end sequencing proved that copy-number imbalances of the tumor are reflected by the cfDNA. This report on chromosomal instability of canine mammary cancers reveals similarities to human breast cancers as well as special canine alterations. This animal model provides a framework for using MPS for screening for individual cancer biomarkers with cost effective confirmation and monitoring using ddPCR. The possibility exists that ddPCR can be expanded to screening for common cancer related variants."],["dc.identifier.doi","10.1371/journal.pone.0075485"],["dc.identifier.isi","000325423500069"],["dc.identifier.pmid","24098698"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9419"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28716"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Genome Aberrations in Canine Mammary Carcinomas and Their Detection in Cell-Free Plasma DNA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Sousa, Thiago de Jesus"],["dc.contributor.author","Parise, Doglas"],["dc.contributor.author","Profeta, Rodrigo"],["dc.contributor.author","Parise, Mariana Teixeira Dornelles"],["dc.contributor.author","Gomide, Anne Cybelle Pinto"],["dc.contributor.author","Kato, Rodrigo Bentos"],["dc.contributor.author","Pereira, Felipe Luiz"],["dc.contributor.author","Figueiredo, Henrique Cesar Pereira"],["dc.contributor.author","Ramos, Rommel"],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Costa da Silva, Artur Luiz da"],["dc.contributor.author","Ghosh, Preetam"],["dc.contributor.author","Barh, Debmalya"],["dc.contributor.author","Góes-Neto, Aristóteles"],["dc.contributor.author","Azevedo, Vasco"],["dc.date.accessioned","2020-12-10T18:11:08Z"],["dc.date.available","2020-12-10T18:11:08Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1038/s41598-019-52695-4"],["dc.identifier.eissn","2045-2322"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16899"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73904"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Re-sequencing and optical mapping reveals misassemblies and real inversions on Corynebacterium pseudotuberculosis genomes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]