Krinsky, Valentin I.

[["dc.bibliographiccitation.firstpage","279"],["dc.bibliographiccitation.lastpage","294"],["dc.bibliographiccitation.seriesnr","20"],["dc.contributor.author","Krinsky, Valentin I."],["dc.contributor.author","Biktashev, Vadim N."],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.editor","Aranson, Igor S."],["dc.contributor.editor","Pikovsky, Arkady"],["dc.contributor.editor","Rulkov, Nikolai F."],["dc.contributor.editor","Tsimring, Lev S."],["dc.date.accessioned","2019-02-05T14:12:54Z"],["dc.date.available","2019-02-05T14:12:54Z"],["dc.date.issued","2017"],["dc.description.abstract","Methods for termination of three-dimensional electrical vortices in the heart are needed for development of patient-friendly cardiac defibrillation techniques (Nature 475, 235, 2011). The defibrillation technique used today is the delivery of a high-energy electric shock (360 J, 1 kV, 30 A, 12 ms, when applied externally) often associated with severe side effects. Developing low-energy defibrillation methods are hampered by two problems: the unknown locations of the cores of the vortices, and the unpredictable phases of the vortex waves rotating around these cores. The first problem has been resolved through the use of electric field pulses to excite the cores of all pinned vortices simultaneously. Approaches to solve the second problem are being developed. One of them is based on the phase scanning of all pinned vortices in parallel to hit the critical time window (“Vulnerable Window”, VW) of every pinned vortex. We investigate the related physical mechanisms and describe problems created by scanning. We describe also a mechanism by which a 3-dim scroll vortex may be terminated with a VW of the full 2π radians. It makes knowledge of the wave phase no longer required. We describe a mechanism terminating also a free (not pinned) vortex, when the vortex’s core passes not very far from a defect. About 500 experiments with termination of vortices during ventricular fibrillation in pig isolated hearts confirm that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for creation of new effective methods for termination vortices underlying fibrillation."],["dc.identifier.doi","10.1007/978-3-319-53673-6_17"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57522"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/166"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.publisher","Springer"],["dc.publisher.place","Cham, Switzerland"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A02: Bedeutung des Phosphatase-Inhibitors-1 für die SR-spezifische Modulation der Beta- adrenozeptor-Signalkaskade"],["dc.relation","SFB 1002 | A03: Bedeutung CaMKII-abhängiger Mechanismen für die Arrhythmogenese bei Herzinsuffizienz"],["dc.relation.crisseries","Nonlinear Systems and Complexity"],["dc.relation.doi","10.1007/978-3-319-53673-6"],["dc.relation.isbn","978-3-319-53672-9"],["dc.relation.isbn","978-3-319-53673-6"],["dc.relation.ispartof","Advances in Dynamics, Patterns, Cognition. Challenges in Complexity"],["dc.relation.ispartofseries","Nonlinear Systems and Complexity; 20"],["dc.relation.issn","2195-9994"],["dc.relation.issn","2196-0003"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Vortices Termination in the Cardiac Muscle"],["dc.type","book_chapter"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2221"],["dc.bibliographiccitation.issue","1918"],["dc.bibliographiccitation.journal","Philosophical Transactions of the Royal Society of London. A, Mathematical, Physical and Engineering Sciences"],["dc.bibliographiccitation.lastpage","2236"],["dc.bibliographiccitation.volume","368"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Squires, Amgad"],["dc.contributor.author","Luther, Gisa"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T08:43:15Z"],["dc.date.available","2018-11-07T08:43:15Z"],["dc.date.issued","2010"],["dc.description.abstract","Life-threatening cardiac arrhythmias are associated with the existence of stable and unstable spiral waves. Termination of such complex spatio-temporal patterns by local control is substantially limited by anchoring of spiral waves at natural heterogeneities. Far-field pacing (FFP) is a new local control strategy that has been shown to be capable of unpinning waves from obstacles. In this article, we investigate in detail the FFP unpinning mechanism for a single rotating wave pinned to a heterogeneity. We identify qualitatively different phase regimes of the rotating wave showing that the concept of vulnerability is important but not sufficient to explain the failure of unpinning in all cases. Specifically, we find that a reduced excitation threshold can lead to the failure of unpinning, even inside the vulnerable window. The critical value of the excitation threshold (below which no unpinning is possible) decreases for higher electric field strengths and larger obstacles. In contrast, for a high excitation threshold, the success of unpinning is determined solely by vulnerability, allowing for a convenient estimation of the unpinning success rate. In some cases, we also observe phase resetting in discontinuous phase intervals of the spiral wave. This effect is important for the application of multiple stimuli in experiments."],["dc.identifier.doi","10.1098/rsta.2010.0038"],["dc.identifier.isi","000276266400007"],["dc.identifier.pmid","20368243"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19914"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc"],["dc.relation.issn","1364-503X"],["dc.title","Phase-resolved analysis of the susceptibility of pinned spiral waves to far-field pacing in a two-dimensional model of excitable media"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","467"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","476"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Fenton, Flavio H."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Cherry, Elizabeth M."],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Pumir, Alain"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Gilmour, Robert F."],["dc.date.accessioned","2022-03-01T11:43:52Z"],["dc.date.available","2022-03-01T11:43:52Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1161/CIRCULATIONAHA.108.825091"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/102862"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Termination of Atrial Fibrillation Using Pulsed Low-Energy Far-Field Stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","170024"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Royal Society Open Science"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Biktashev, V. N."],["dc.contributor.author","Otani, N. F."],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Baig, T."],["dc.contributor.author","Berg, S."],["dc.contributor.author","Han, Sang Who"],["dc.contributor.author","Krinsky, V. I."],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T10:26:28Z"],["dc.date.available","2018-11-07T10:26:28Z"],["dc.date.issued","2017"],["dc.description.abstract","We propose a solution to a long-standing problem: how to terminate multiple vortices in the heart, when the locations of their cores and their critical time windows are unknown. We scan the phases of all pinned vortices in parallel with electric field pulses (E-pulses). We specify a condition on pacing parameters that guarantees termination of one vortex. For more than one vortex with significantly different frequencies, the success of scanning depends on chance, and all vortices are terminated with a success rate of less than one. We found that a similar mechanism terminates also a free (not pinned) vortex. A series of about 500 experiments with termination of ventricular fibrillation by E-pulses in pig isolated hearts is evidence that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for the creation of new effective low energy defibrillation methods based on the termination of vortices underlying fibrillation."],["dc.identifier.doi","10.1098/rsos.170024"],["dc.identifier.isi","000398107700049"],["dc.identifier.pmid","28405398"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14953"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43052"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/167"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/241526/EU//EUTRIGTREAT"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","2054-5703"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 4.0"],["dc.title","Mechanisms of vortices termination in the cardiac muscle"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","103012"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Bittihn, Philip;"],["dc.contributor.affiliation","Luther, Gisela;"],["dc.contributor.affiliation","Bodenschatz, Eberhard;"],["dc.contributor.affiliation","Krinsky, Valentin;"],["dc.contributor.affiliation","Parlitz, Ulrich;"],["dc.contributor.affiliation","Luther, Stefan;"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Luther, Gisela"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T11:10:06Z"],["dc.date.available","2018-11-07T11:10:06Z"],["dc.date.issued","2008"],["dc.date.updated","2022-02-09T13:17:44Z"],["dc.description.abstract","Removing anchored spirals from obstacles is an important step in terminating cardiac arrhythmia. Conventional anti-tachycardia pacing (ATP) has this ability, but only under very restrictive conditions. In a generic model of excitable media, we demonstrate that for unpinning spiral waves from obstacles this profound limitation of ATP can be overcome by far field pacing (FFP). More specifically, an argument is presented for why FFP includes and thus can only extend the capabilities of ATP in the configurations considered. By numerical simulations, we show that in the model there exists a parameter region in which unpinning is possible by FFP but not by ATP. The relevance of this result regarding clinical applications is discussed."],["dc.identifier.doi","10.1088/1367-2630/10/10/103012"],["dc.identifier.eissn","1367-2630"],["dc.identifier.fs","441448"],["dc.identifier.isi","000259958200001"],["dc.identifier.ppn","583657737"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53145"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.issn","1367-2630"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","Goescholar"],["dc.rights.uri","https://goedoc.uni-goettingen.de/licenses"],["dc.title","Far field pacing supersedes anti-tachycardia pacing in a generic model of excitable media"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1077"],["dc.bibliographiccitation.journal","Computing in Cardiology 2016"],["dc.bibliographiccitation.lastpage","1080"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Han, Shuyue"],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Krinski, Valentin"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-05T11:01:00Z"],["dc.date.available","2019-02-05T11:01:00Z"],["dc.date.issued","2016"],["dc.description.abstract","Introduction. Recently, there has been a major effort to develop new, low-energy defibrillation methods that would be less damaging and less traumatic for the patient, and would save battery energy. However, these methods have not been entirely successful, due in part to an incomplete understanding of all the mechanisms present that may help or hinder the process of terminating the rotating waves present during fibrillation. Here we describe new mechanisms whereby a far-field electric field pulse terminates unpinned waves that are rotating in the vicinity of a blood vessel, plaque deposit or other heterogeneity in the gap junction conductivity. Methods. We ran a series of two-dimensional computer simulations of a spiral wave rotating in the vicinity of a non-conducting obstacle. Application of a low-energy electric field pulse caused a semicircular action potential wave to be launched from the heterogeneity which then interacted with the rotating wave. Results and Conclusions: We found, that, when this interaction is combined with, importantly, the presence of nearby non-conductive boundaries, termination of the rotating waves can occur via a number of new mechanisms, overa wide range of timings of the electric field pulse, and for a number of different initial locations of the rotating wave. The mechanisms only require the rotating wave to be nearby, but not necessarily pinned to the heterogeneity, and thus extends the effectiveness of the electric field pulses used in low-energy defibrillation. Consideration of these mechanisms together with those already discovered could result in the development of improved, low-energy defibrillation protocols."],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57521"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/258"],["dc.language.iso","en"],["dc.notes.status","fcwi"],["dc.publisher","Computing in Cardiology"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.conference","Computing in Cardiology 2016"],["dc.relation.eventend","2016-09-14"],["dc.relation.eventlocation","Vancouver, Canada"],["dc.relation.eventstart","2016-09-11"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","A New Defibrillation Mechanism: Termination of Reentrant Waves by Propagating Action Potentials Induced by Nearby Heterogeneities"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","010901"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Physical Review E"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Pumir, Alain"],["dc.contributor.author","Sinha, Sitabhra"],["dc.contributor.author","Sridhar, S."],["dc.contributor.author","Argentina, Médéric"],["dc.contributor.author","Hörning, Marcel"],["dc.contributor.author","Filippi, Simonetta"],["dc.contributor.author","Cherubini, Christian"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Krinsky, Valentin"],["dc.date.accessioned","2022-03-01T11:46:57Z"],["dc.date.available","2022-03-01T11:46:57Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1103/PhysRevE.81.010901"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103857"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1550-2376"],["dc.relation.issn","1539-3755"],["dc.title","Wave-train-induced termination of weakly anchored vortices in excitable media"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","068102"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Wheeler, Kayleigh"],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2022-03-01T11:47:01Z"],["dc.date.available","2022-03-01T11:47:01Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1103/PhysRevLett.123.068102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103882"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.rights.uri","https://link.aps.org/licenses/aps-default-license"],["dc.title","Termination of Scroll Waves by Surface Impacts"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","043012"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Krinski, Valentin"],["dc.contributor.author","Bittihn, Philip"],["dc.date.accessioned","2019-02-27T14:16:19Z"],["dc.date.available","2019-02-27T14:16:19Z"],["dc.date.issued","2016"],["dc.description.abstract","Spiral waves in cardiac tissue can pin to tissue heterogeneities and form stable pinned waves. These waves can be unpinned by electric stimuli applied close to the pinning center during the vulnerable window of the spiral. Using a phase transition curve (PTC), we quantify the response of a pinned wave in a cardiac monolayer to secondary excitations generated electric field pulses. The PTC can be used to construct a one-dimensional map that faithfully predicts the pinned wave’s response to periodic field stimuli. Based on this 1D map, we predict that pacing at a frequency greater than the spiral frequency, over drive pacing, leads to phase locking of the spiral to the stimulus, which hinders unpinning. In contrast, under drive pacing can lead to scanning of the phase window of the spiral, which facilitates unpinning. The predicted mechanisms of phase scanning and phase locking are experimentally tested and confirmed in the same monolayers that were used to obtain the PTC. Our results have the potential to help choose optimal parameters for low energy antifibrillation pacing schemes."],["dc.identifier.doi","10.1088/1367-2630/18/4/043012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57648"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/168"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","1367-2630"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 3.0"],["dc.title","Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Pumir, A."],["dc.contributor.author","Nikolski, V."],["dc.contributor.author","Hörning, M."],["dc.contributor.author","Isomura, A."],["dc.contributor.author","Agladze, K."],["dc.contributor.author","Yoshikawa, K."],["dc.contributor.author","Gilmour, R."],["dc.contributor.author","Bodenschatz, E."],["dc.contributor.author","Krinsky, V."],["dc.date.accessioned","2022-06-08T08:00:18Z"],["dc.date.available","2022-06-08T08:00:18Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1103/PhysRevLett.99.208101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/111032"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.title","Wave Emission from Heterogeneities Opens a Way to Controlling Chaos in the Heart"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]