Kunz, Nikolaus

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurobiology of Aging"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Esselmann, Herrmann"],["dc.contributor.author","Kunz, N."],["dc.contributor.author","Smirnov, Alexey"],["dc.contributor.author","Paul, S."],["dc.contributor.author","Dombek, M."],["dc.contributor.author","Ruether, Eckhart"],["dc.contributor.author","Wiltfang, J."],["dc.contributor.author","Maler, M."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Hampel, Harald"],["dc.contributor.author","Buerger, Katharina"],["dc.date.accessioned","2018-11-07T10:23:03Z"],["dc.date.available","2018-11-07T10:23:03Z"],["dc.date.issued","2002"],["dc.format.extent","S17"],["dc.identifier.isi","000177465300067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42384"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.issn","0197-4580"],["dc.title","Primary cell culture of chicken telencephalon: A model to study the catabolic processing of endogenous amyloid precursor protein and abeta peptides"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","224"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Microscopy"],["dc.bibliographiccitation.lastpage","232"],["dc.bibliographiccitation.volume","230"],["dc.contributor.author","Kunze, S."],["dc.contributor.author","Lemke, K."],["dc.contributor.author","Metze, J."],["dc.contributor.author","Bloukas, G."],["dc.contributor.author","Kotta, K."],["dc.contributor.author","Panagiotidis, C. H."],["dc.contributor.author","Sklaviadis, T."],["dc.contributor.author","Bodemer, W."],["dc.date.accessioned","2022-10-06T13:25:05Z"],["dc.date.available","2022-10-06T13:25:05Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1111/j.1365-2818.2008.01979.x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114744"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0022-2720"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Atomic force microscopy to characterize the molecular size of prion protein"],["dc.title.alternative","AFM IMAGES OF SINGLE PRION PROTEIN MOLECULES"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","156"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain Research"],["dc.bibliographiccitation.lastpage","162"],["dc.bibliographiccitation.volume","1052"],["dc.contributor.author","Maler, Juan Manuel"],["dc.contributor.author","Esselmann, Herrmann"],["dc.contributor.author","Wiltfang, J."],["dc.contributor.author","Kunz, N."],["dc.contributor.author","Lewczuk, Piotr"],["dc.contributor.author","Reulbach, Udo"],["dc.contributor.author","Bleich, Stefan"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Kornhuber, Johannes"],["dc.date.accessioned","2018-11-07T10:56:49Z"],["dc.date.available","2018-11-07T10:56:49Z"],["dc.date.issued","2005"],["dc.description.abstract","The present study examined the effect of memantine, an uncompetitive NMDA receptor antagonist, on ethanol-induced NMDA receptor up-regulation. Primary glutamatergic rat hippocampal neurons were exposed to ethanol and memantine for 5 days. The ethanol-sensitive NMDA receptor subunits NR1, NR2A and NR213 were quantified by Western immunoblot analysis. Fxposure to ethanol (50 mM) caused an increase in the levels of NRI (137 +/- 11 % of untreated control, P = 0.009), NR2A (128 +/- 14 %. P 0.022) and N213 (136 +/- 119 %, P = 0.012). Coincubation with memantine (10 mu M) completely blocked the ethanol-induced up-regulation of NR1 (102, 4 %) NR2A (95 +/- 7 %) and NR2B (105 +/- 13 %). No effect of memantine on NR subunit expression was observable, except for NR2A, where a decrease (79 +/- 6 %, P = 0.034) was noted. Neither ethanol nor memantine alone or in combination were toxic in the concentrations tested. These results may provide a molecular explanation for beneficial effects of memantine on ethanol-induced glutamatergic hyperexcitability reflected in the ethanol withdrawal syndrome and on the development of ethanol dependence. (c) 2005 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.brainres.2005.06.017"],["dc.identifier.isi","000231493000005"],["dc.identifier.pmid","16009352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50105"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0006-8993"],["dc.title","Mernantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","236"],["dc.bibliographiccitation.issue","4-5"],["dc.bibliographiccitation.journal","Neurodegenerative Diseases"],["dc.bibliographiccitation.lastpage","241"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Esselmann, Hermann"],["dc.contributor.author","Maler, J. M."],["dc.contributor.author","Kunz, N."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Paul, S."],["dc.contributor.author","Lewczuk, Piotr"],["dc.contributor.author","Rüther, Eckart"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Wiltfang, Jens"],["dc.date.accessioned","2017-09-07T11:44:27Z"],["dc.date.available","2017-09-07T11:44:27Z"],["dc.date.issued","2004"],["dc.description.abstract","We studied endogenous amyloid precursor protein (APP) processing and amyloid beta (Aβ) peptide formation in primary chicken telencephalic neurons, because their Aβ peptide sequence is identical to humans. As detected by quantitative Aβ-SDS-PAGE/immunoblot, Aβ peptides 1–40/42 and three additional C-truncated species, namely Aβ1–37/38/39 were regularly released into the supernatant. The highly conserved Aβ quintet strongly resembles the pattern of Aβ peptides found in human cerebrospinal fluid. Furthermore, the C-terminally shorter Aβ peptides 1–33/34 could be readily detected. Recent evidence indicates that lithium specifically inhibits secretion of the amyloidogenic Aβ1–42 peptide in cultured permanent cells transfected with human APP. We therefore investigated the effect of lithium on Aβ peptide secretion as well as intracellular Aβ peptides in our untransfected primary cell culture system. Our data shows that lithium leads to a dose-dependent reduction of Aβ1–37/38/39/40/42 secretion. Surprisingly, intracellular analysis revealed that lithium specifically increases a band comigrating with synthetic Aβ1–38 while Aβ1–40 and Aβ1–42 remained almost unaffected. These results demonstrate for the first time that lithium treatment decreases Aβ peptide secretion in primary chicken neuronal cells but specifically elevates intracellular Aβ1–38. Therefore, we conclude that there are two independent mechanisms of lithium in intra- and extracellular Aβ peptide production."],["dc.identifier.doi","10.1159/000080992"],["dc.identifier.gro","3151670"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8488"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","chake"],["dc.relation.issn","1660-2854"],["dc.title","Lithium Decreases Secretion of Aβ1–42 and C-Truncated Species Aβ1–37/38/39/40 in Chicken Telencephalic Cultures but Specifically Increases Intracellular Aβ1–38"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]