Stoykova, Anastassia S.

[["dc.bibliographiccitation.firstpage","256"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","269"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Tuoc, Tran Cong"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Sansom, Stephen N."],["dc.contributor.author","Pitulescu, Mara-Elena"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Livesey, Frederick J."],["dc.contributor.author","Stoykova, Anastassia"],["dc.date.accessioned","2017-09-07T11:44:52Z"],["dc.date.available","2017-09-07T11:44:52Z"],["dc.date.issued","2013"],["dc.description.abstract","Increased cortical size is essential to the enhanced intellectual capacity of primates during mammalian evolution. The mechanisms that control cortical size are largely unknown. Here, we show that mammalian BAF170, a subunit of the chromatin remodeling complex mSWI/SNF, is an intrinsic factor that controls cortical size. We find that conditional deletion of BAF170 promotes indirect neurogenesis by increasing the pool of intermediate progenitors (IPs) and results in an enlarged cortex, whereas cortex-specific BAF170 overexpression results in the opposite phenotype. Mechanistically, BAF170 competes with BAF155 subunit in the BAF complex, affecting euchromatin structure and thereby modulating the binding efficiency of the Pax6/REST-corepressor complex to Pax6 target genes that regulate the generation of IPs and late cortical progenitors. Our findings reveal a molecular mechanism mediated by the mSWI/SNF chromatin-remodeling complex that controls cortical architecture."],["dc.identifier.doi","10.1016/j.devcel.2013.04.005"],["dc.identifier.gro","3150356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7111"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1534-5807"],["dc.title","Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1011109"],["dc.bibliographiccitation.journal","Frontiers in Cell and Developmental Biology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Nguyen, Huong; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Sokpor, Godwin; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Parichha, Arpan; \r\n5\r\nTata Institute of Fundamental Research, Mumbai, India"],["dc.contributor.affiliation","Pham, Linh; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Saikhedkar, Nidhi; \r\n5\r\nTata Institute of Fundamental Research, Mumbai, India"],["dc.contributor.affiliation","Xie, Yuanbin; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Ulmke, Pauline Antonie; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Rosenbusch, Joachim; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Pirouz, Mehdi; \r\n6\r\nMax Planck Institute for Multidisciplinary Sciences, Goettingen, Germany"],["dc.contributor.affiliation","Behr, Rüdiger; \r\n8\r\nGerman Primate Center-Leibniz Institute for Primate Research, Goettingen, Germany"],["dc.contributor.affiliation","Stoykova, Anastassia; \r\n6\r\nMax Planck Institute for Multidisciplinary Sciences, Goettingen, Germany"],["dc.contributor.affiliation","Brand-Saberi, Beate; \r\n4\r\nDepartment of Anatomy and Molecular Embryology, Ruhr University Bochum, Bochum, Germany"],["dc.contributor.affiliation","Nguyen, Huu Phuc; \r\n3\r\nDepartment of Human Genetics, Ruhr University Bochum, Bochum, Germany"],["dc.contributor.affiliation","Staiger, Jochen F.; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.affiliation","Tole, Shubha; \r\n5\r\nTata Institute of Fundamental Research, Mumbai, India"],["dc.contributor.affiliation","Tuoc, Tran; \r\n1\r\nInstitute for Neuroanatomy, University Medical Center, Georg-August-University Goettingen, Goettingen, Germany"],["dc.contributor.author","Nguyen, Huong"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Parichha, Arpan"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Saikhedkar, Nidhi"],["dc.contributor.author","Xie, Yuanbin"],["dc.contributor.author","Ulmke, Pauline Antonie"],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Pirouz, Mehdi"],["dc.contributor.author","Behr, Rüdiger"],["dc.contributor.author","Tuoc, Tran"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Brand-Saberi, Beate"],["dc.contributor.author","Nguyen, Huu Phuc"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Tole, Shubha"],["dc.date.accessioned","2022-11-01T10:17:17Z"],["dc.date.available","2022-11-01T10:17:17Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:12:49Z"],["dc.description.abstract","Early forebrain patterning entails the correct regional designation of the neuroepithelium, and appropriate specification, generation, and distribution of neural cells during brain development. Specific signaling and transcription factors are known to tightly regulate patterning of the dorsal telencephalon to afford proper structural/functional cortical arealization and morphogenesis. Nevertheless, whether and how changes of the chromatin structure link to the transcriptional program(s) that control cortical patterning remains elusive. Here, we report that the BAF chromatin remodeling complex regulates the spatiotemporal patterning of the mouse dorsal telencephalon. To determine whether and how the BAF complex regulates cortical patterning, we conditionally deleted the BAF complex scaffolding subunits BAF155 and BAF170 in the mouse dorsal telencephalic neuroepithelium. Morphological and cellular changes in the BAF mutant forebrain were examined using immunohistochemistry and\r\n in situ\r\n hybridization. RNA sequencing, Co-immunoprecipitation, and mass spectrometry were used to investigate the molecular basis of BAF complex involvement in forebrain patterning. We found that conditional ablation of BAF complex in the dorsal telencephalon neuroepithelium caused expansion of the cortical hem and medial cortex beyond their developmental boundaries. Consequently, the hippocampal primordium is not specified, the mediolateral cortical patterning is compromised, and the cortical identity is disturbed in the absence of BAF complex. The BAF complex was found to interact with the cortical hem suppressor LHX2. The BAF complex suppresses cortical hem fate to permit proper forebrain patterning. We provide evidence that BAF complex modulates mediolateral cortical patterning possibly by interacting with the transcription factor LHX2 to drive the LHX2-dependent transcriptional program essential for dorsal telencephalon patterning. Our data suggest a putative mechanistic synergy between BAF chromatin remodeling complex and LHX2 in regulating forebrain patterning and ontogeny."],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship"," National Institute of Diabetes and Digestive and Kidney Diseases http://dx.doi.org/10.13039/100000062"],["dc.identifier.doi","10.3389/fcell.2022.1011109"],["dc.identifier.pmid","36263009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/116773"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-605"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-634X"],["dc.relation.issn","2296-634X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2144"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Hippocampus"],["dc.bibliographiccitation.lastpage","2156"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Rosenthal, Eva H."],["dc.contributor.author","Tonchev, Anton B."],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Chowdhury, Kamal"],["dc.date.accessioned","2021-06-01T10:50:36Z"],["dc.date.available","2021-06-01T10:50:36Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1002/hipo.22035"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86721"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","1050-9631"],["dc.title","Regulation of archicortical arealization by the transcription factor Zbtb20"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","567"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.bibliographiccitation.lastpage","582"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Doeppner, Thorsten R."],["dc.contributor.author","Herz, Josephine"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Tonchev, Anton B."],["dc.contributor.author","Stoykova, Anastassia"],["dc.date.accessioned","2020-12-10T14:14:28Z"],["dc.date.available","2020-12-10T14:14:28Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s12035-018-1104-y"],["dc.identifier.eissn","1559-1182"],["dc.identifier.issn","0893-7648"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71350"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4618"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.bibliographiccitation.lastpage","4635"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Tuoc, Tran"],["dc.contributor.author","Dere, Ekrem"],["dc.contributor.author","Radyushkin, Konstantin"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Nguyen, Huong"],["dc.contributor.author","Tonchev, Anton B."],["dc.contributor.author","Sun, Guoqiang"],["dc.contributor.author","Ronnenberg, Anja"],["dc.contributor.author","Shi, Yanhong"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Stoykova, Anastassia"],["dc.date.accessioned","2017-09-07T11:46:21Z"],["dc.date.available","2017-09-07T11:46:21Z"],["dc.date.issued","2016"],["dc.description.abstract","The BAF chromatin remodeling complex plays an essential role in brain development. However its function in postnatal neurogenesis in hippocampus is still unknown. Here, we show that in postnatal dentate gyrus (DG), the BAF170 subunit of the complex is expressed in radial glial-like (RGL) progenitors and in cell types involved in subsequent steps of adult neurogenesis including mature astrocytes. Conditional deletion of BAF170 during cortical late neurogenesis as well as during adult brain neurogenesis depletes the pool of RGL cells in DG, and promotes terminal astrocyte differentiation. These derangements are accompanied by distinct behavioral deficits, as reflected by an impaired accuracy of place responding in the Morris water maze test, during both hidden platform as well as reversal learning. Inducible deletion of BAF170 in DG during adult brain neurogenesis resulted in mild spatial learning deficits, having a more pronounced effect on spatial learning during the reversal test. These findings demonstrate involvement of BAF170-dependent chromatin remodeling in hippocampal neurogenesis and cognition and suggest a specific role of adult neurogenesis in DG in adaptive behavior."],["dc.identifier.doi","10.1007/s12035-016-9948-5"],["dc.identifier.gro","3150498"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14191"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7269"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","0893-7648"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Ablation of BAF170 in developing and postnatal dentate gyrus affects neural stem cell proliferation, differentiation, and learning"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1795"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Cellular and Molecular Life Sciences"],["dc.bibliographiccitation.lastpage","1809"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Tylkowski, Marco Andreas"],["dc.contributor.author","Yang, Kefei"],["dc.contributor.author","Hoyer-Fender, Sigrid"],["dc.contributor.author","Stoykova, Anastassia"],["dc.date.accessioned","2018-11-07T09:58:04Z"],["dc.date.available","2018-11-07T09:58:04Z"],["dc.date.issued","2015"],["dc.description.abstract","Cortical glutamatergic neurons are generated by radial glial cells (RGCs), specified by the expression of transcription factor (TF) Pax6, in the germinative zones of the dorsal telencephalon. Here, we demonstrate that Pax6 regulates the structural assembly of the interphase centrosomes. In the cortex of the Pax6-deficient Small eye (Sey/Sey) mutant, we find a defect of the appendages of the mother centrioles, indicating incomplete centrosome maturation. Consequently, RGCs fail to generate primary cilia, and instead of staying in the germinative zone for renewal, RGCs detach from the ventricular surface thus affecting the interkinetic nuclear migration and they exit prematurely from mitosis. Mechanistically, we show that TF Pax6 directly regulates the activity of the Odf2 gene encoding for the appendage-specific protein Odf2 with a role for the assembly of mother centriole. Our findings demonstrate a molecular mechanism that explains important characteristics of the centrosome disassembly and malfunctioning in developing cortex lacking Pax6."],["dc.identifier.doi","10.1007/s00018-014-1766-1"],["dc.identifier.isi","000352791200011"],["dc.identifier.pmid","25352170"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37296"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Basel"],["dc.relation.issn","1420-9071"],["dc.relation.issn","1420-682X"],["dc.title","Pax6 controls centriole maturation in cortical progenitors through Odf2"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","109"],["dc.bibliographiccitation.journal","iScience"],["dc.bibliographiccitation.lastpage","126"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Narayanan, Ramanathan"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Kerimoglu, Cemil"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Castro Hernandez, Ricardo"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Ulmke, Pauline Antonie"],["dc.contributor.author","Kiszka, Kamila A."],["dc.contributor.author","Tonchev, Anton B."],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Seong, Rho H."],["dc.contributor.author","Teichmann, Ulrike"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Fischer, Andre"],["dc.contributor.author","Bonn, Stefan"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Tuoc, Tran"],["dc.date.accessioned","2020-12-10T14:24:42Z"],["dc.date.available","2020-12-10T14:24:42Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.isci.2018.05.014"],["dc.identifier.issn","2589-0042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72326"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","319"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","328"],["dc.bibliographiccitation.volume","233"],["dc.contributor.author","Pires-daSilva, A."],["dc.contributor.author","Nayernia, K."],["dc.contributor.author","Engel, Wolfgang"],["dc.contributor.author","Torres, M."],["dc.contributor.author","Stoykova, A."],["dc.contributor.author","Chowdhury, K."],["dc.contributor.author","Gruss, P."],["dc.date.accessioned","2018-11-07T09:03:50Z"],["dc.date.available","2018-11-07T09:03:50Z"],["dc.date.issued","2001"],["dc.description.abstract","Spermatid perinuclear RNA-binding protein (SPNR) is a microtubule-associated RNA-binding protein that localizes to the manchette in developing spermatids. The Spur mRNA is expressed at high levels in testis, ovary, and brain and is present in these tissues in multiple forms. We have generated a gene trap allele of the murine Spur, named Spnr(+/GT). Spnr(GT/GT) mutants show a high rate of mortality, reduced weight, and an abnormal clutching reflex. In addition to minor anatomical abnormalities in the brain males exhibit defects in spermatogenesis that include a thin seminiferous epithelium and disorganization of spermatogenesis. Most of the sperm from mutant males display defects in the flagellum and consequently show decreased motility and transport within the oviducts. furthermore, sperm from mutant males achieve in vitro fertilization less frequently. Our findings suggest that SPNR plays an important role in normal spermatogenesis and sperm function. Thus, the Spnr(GT/GT) mutant male mouse provides a unique model for some human male infertility cases. (C) 2001 Academic Press."],["dc.identifier.doi","10.1006/dbio.2001.0169"],["dc.identifier.isi","000168931800006"],["dc.identifier.pmid","11336498"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24978"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc"],["dc.relation.issn","0012-1606"],["dc.title","Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1579"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Oncology Reports"],["dc.bibliographiccitation.lastpage","1592"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Pavlakis, Evangelos"],["dc.contributor.author","Tonchev, Anton B."],["dc.contributor.author","Kaprelyan, Ara"],["dc.contributor.author","Enchev, Yavor"],["dc.contributor.author","Stoykova, Anastassia"],["dc.date.accessioned","2018-11-07T10:26:47Z"],["dc.date.available","2018-11-07T10:26:47Z"],["dc.date.issued","2017"],["dc.description.abstract","A misbalance between proliferation and differentiation of neural stem cells in niches for adult brain neurogenesis is a key mechanism in glioma pathogenesis. In the adult brain, the expression of Pax6 marks stem cells in the forebrain neurogenic niche. We analyzed the expression profile of the two active in vertebrates Pax6 isoforms, Pax6 and Pax6-5a, along with the expression of microRNA cluster miR-183-96-182 in a large set of glioma patient specimens and glioma cell lines which showed opposite expression level, low and high, respectively, with the progression of tumor malignancy. Our results from biochemical and in vitro studies in glioma cell lines disclosed a specific regulation of the PAX6-5a isoform by miR-183. Mechanistically, we show that the downregulation of the lipid kinase SPHK1 by both PAX6 isoforms and the simultaneous induction of CTNDD2 expression, specifically by PAX6-5a, results in reduced glioma cell survival, decreased migration and invasion and increased cell death, in glioma cell lines. Taken together, our findings point towards the important role of PAX6 and define PAX6-5a as a new essential player in glioma development. Finally, we propose that the expression level of TFs PAX6/PAX6-5a and miR-183-96-182 may potentially serve as prognostic markers for the progression of glioma tumors from low- to high-grade with a potential to identify new therapeutic approaches."],["dc.identifier.doi","10.3892/or.2017.5411"],["dc.identifier.isi","000396186600033"],["dc.identifier.pmid","28184912"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43118"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Spandidos Publ Ltd"],["dc.relation.issn","1791-2431"],["dc.relation.issn","1021-335X"],["dc.title","Interaction between transcription factors PAX6/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1006274"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Bachmann, Christina"],["dc.contributor.author","Nguyen, Huong"],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Pham, Linh"],["dc.contributor.author","Rabe, Tamara I."],["dc.contributor.author","Patwa, Megha"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Seong, Rho H."],["dc.contributor.author","Ashery-Padan, Ruth"],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Staiger, Jochen F."],["dc.contributor.author","Tuoc, Tran"],["dc.date.accessioned","2018-11-07T10:09:05Z"],["dc.date.available","2018-11-07T10:09:05Z"],["dc.date.issued","2016"],["dc.description.abstract","Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been reported to play essential roles in the neurogenesis of the central nervous system. However, whether BAF complexes are required for neuron generation in the olfactory system is unknown. Here, we identified onscBAF and ornBAF complexes, which are specifically present in olfactory neural stem cells (oNSCs) and olfactory receptor neurons (ORNs), respectively. We demonstrated that BAF155 subunit is highly expressed in both oNSCs and ORNs, whereas high expression of BAF170 subunit is observed only in ORNs. We report that conditional deletion of BAF155, a core subunit in both onscBAF and ornBAF complexes, causes impaired proliferation of oNSCs as well as defective maturation and axonogenesis of ORNs in the developing olfactory epithelium (OE), while the high expression of BAF170 is important for maturation of ORNs. Interestingly, in the absence of BAF complexes in BAF155/BAF170 double-conditional knockout mice (dcKO), OE is not specified. Mechanistically, BAF complex is required for normal activation of Pax6-dependent transcriptional activity in stem cells/progenitors of the OE. Our findings unveil a novel mechanism mediated by the mSWI/SNF complex in OE neurogenesis and development."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2016"],["dc.identifier.doi","10.1371/journal.pgen.1006274"],["dc.identifier.isi","000386069000012"],["dc.identifier.pmid","27611684"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13696"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39592"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1553-7404"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]