Institut für Medizinische Informatik

[["dc.contributor.author","Bauer, Christian R."],["dc.contributor.author","Knopp, Cornelius"],["dc.contributor.author","Bender, Theresa"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Sax, Ulrich"],["dc.creator.author","Ulrich Sax"],["dc.creator.author","Christian R. Bauer"],["dc.creator.author","Theresa Bender"],["dc.creator.author","Harald Kusch"],["dc.creator.author","Cornelius Knopp"],["dc.date.accessioned","2019-10-16T07:41:00Z"],["dc.date.available","2019-10-16T07:41:00Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3205/18gmds093"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62502"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/227"],["dc.language.iso","en"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | INF: Unterstützung der SFB 1002 Forschungsdatenintegration, -visualisierung und -nachnutzung"],["dc.relation.conference","63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS)"],["dc.relation.eventlocation","Osnabrück"],["dc.relation.eventstart","2018"],["dc.relation.workinggroup","RG Nußbeck"],["dc.title","Application of basic research data management with FAIRDOM/SEEK from a medical informatics perspective"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","394"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Translational Medicine"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Bahls, Thomas"],["dc.contributor.author","Pung, Johannes"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Hauswaldt, Johannes"],["dc.contributor.author","Demmer, Iris"],["dc.contributor.author","Blumentritt, Arne"],["dc.contributor.author","Rau, Henriette"],["dc.contributor.author","Drepper, Johannes"],["dc.contributor.author","Wieder, Philipp"],["dc.contributor.author","Groh, Roland"],["dc.contributor.author","Hummers, Eva"],["dc.contributor.author","Schlegelmilch, Falk"],["dc.date.accessioned","2020-10-29T15:25:39Z"],["dc.date.available","2020-10-29T15:25:39Z"],["dc.date.issued","2020"],["dc.description.abstract","Medical data from family doctors are of great importance to health care researchers but seem to be locked in German practices and, thus, are underused in research. The RADAR project (Routine Anonymized Data for Advanced Health Services Research) aims at designing, implementing and piloting a generic research architecture, technical software solutions as well as procedures and workflows to unlock data from family doctor's practices. A long-term medical data repository for research taking legal requirements into account is established. Thereby, RADAR helps closing the gap between the European countries and to contribute data from primary care in Germany."],["dc.identifier.doi","10.1186/s12967-020-02547-x"],["dc.identifier.pmid","33076938"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17623"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68099"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","RADARplus - Anonymisierte Routinedaten aus der ambulanten Versorgung für die Versorgungsforschung"],["dc.relation.issn","1479-5876"],["dc.relation.orgunit","Institut für Medizinische Informatik"],["dc.relation.orgunit","Institut für Allgemeinmedizin"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Designing and piloting a generic research architecture and workflows to unlock German primary care data for secondary use"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","663"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz"],["dc.bibliographiccitation.lastpage","668"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Rienhoff, O."],["dc.contributor.author","Verhey, J."],["dc.date.accessioned","2021-06-01T10:49:03Z"],["dc.date.available","2021-06-01T10:49:03Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1007/s00103-005-1064-z"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86150"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1437-1588"],["dc.relation.issn","1436-9990"],["dc.title","Europäische Perspektive der Gesundheitstelematik"],["dc.title.translated","European perspectives of health telematics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","178301"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Krefting, Dagmar"],["dc.contributor.author","Kaira, Prabha"],["dc.contributor.author","Rotermund, Harm Hinrich"],["dc.date.accessioned","2021-09-17T10:19:54Z"],["dc.date.available","2021-09-17T10:19:54Z"],["dc.date.issued","2009-05-01"],["dc.description.abstract","Periodic forcing of chemical turbulence in the catalytic CO oxidation on Pt(110) can induce a period doubling cascade to chaos. Using a forcing frequency near the second harmonic of the system's natural frequency, and carefully increasing the forcing amplitude, the system successively exhibits spiral wave turbulence, resonant pattern formation, and chaotic oscillations. In the latter case, global coupling induces strong spatial correlation. Experimental results are presented as well as numerical simulations using a realistic model. Good agreement is found between experiment and theory. The results give further insight into the complex nature of reaction-diffusion systems and are of high importance regarding control strategies on such systems. The presented setup enhances the range of achievable dynamical states and allows for new experimental investigations on the dynamics of extended oscillatory systems."],["dc.identifier.doi","10.1103/PhysRevLett.102.178301"],["dc.identifier.pmid","19518840"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89667"],["dc.language.iso","en"],["dc.relation.issn","0031-9007"],["dc.title","Period doubling and spatiotemporal chaos in periodically forced CO oxidation on Pt(110)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e30"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","e30"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Löchel, Hannah F"],["dc.contributor.author","Welzel, Marius"],["dc.contributor.author","Hattab, Georges"],["dc.contributor.author","Hauschild, Anne-Christin"],["dc.contributor.author","Heider, Dominik"],["dc.date.accessioned","2022-06-08T07:59:10Z"],["dc.date.available","2022-06-08T07:59:10Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract The use of complex biological molecules to solve computational problems is an emerging field at the interface between biology and computer science. There are two main categories in which biological molecules, especially DNA, are investigated as alternatives to silicon-based computer technologies. One is to use DNA as a storage medium, and the other is to use DNA for computing. Both strategies come with certain constraints. In the current study, we present a novel approach derived from chaos game representation for DNA to generate DNA code words that fulfill user-defined constraints, namely GC content, homopolymers, and undesired motifs, and thus, can be used to build codes for reliable DNA storage systems."],["dc.identifier.doi","10.1093/nar/gkab1209"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110655"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.title","Fractal construction of constrained code words for DNA storage systems"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","105534"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","iScience"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Hauschild, Anne-Christin"],["dc.contributor.author","Martin, Roman"],["dc.contributor.author","Holst, Sabrina Celine"],["dc.contributor.author","Wienbeck, Joachim"],["dc.contributor.author","Heider, Dominik"],["dc.date.accessioned","2022-12-01T08:30:38Z"],["dc.date.available","2022-12-01T08:30:38Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1016/j.isci.2022.105534"],["dc.identifier.pii","S2589004222018065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117938"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","2589-0042"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Guideline for software life cycle in health informatics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e29888"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Streitberger, Kaspar-Josche"],["dc.contributor.author","Sack, Ingolf"],["dc.contributor.author","Krefting, Dagmar"],["dc.contributor.author","Pfüller, Caspar"],["dc.contributor.author","Braun, Jürgen"],["dc.contributor.author","Paul, Friedemann"],["dc.contributor.author","Wuerfel, Jens"],["dc.date.accessioned","2021-09-17T10:19:34Z"],["dc.date.available","2021-09-17T10:19:34Z"],["dc.date.issued","2012"],["dc.description.abstract","Viscoelastic properties indicate structural alterations in biological tissues at multiple scales with high sensitivity. Magnetic Resonance Elastography (MRE) is a novel technique that directly visualizes and quantitatively measures biomechanical tissue properties in vivo. MRE recently revealed that early relapsing-remitting multiple sclerosis (MS) is associated with a global decrease of the cerebral mechanical integrity. This study addresses MRE and MR volumetry in chronic-progressive disease courses of MS."],["dc.identifier.doi","10.1371/journal.pone.0029888"],["dc.identifier.pmid","22276134"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89663"],["dc.language.iso","en"],["dc.relation.eissn","1932-6203"],["dc.title","Brain viscoelasticity alteration in chronic-progressive multiple sclerosis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","919"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Magnetic Resonance in Medicine"],["dc.bibliographiccitation.lastpage","924"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Elgeti, Thomas"],["dc.contributor.author","Tzschätzsch, Heiko"],["dc.contributor.author","Hirsch, Sebastian"],["dc.contributor.author","Krefting, Dagmar"],["dc.contributor.author","Klatt, Dieter"],["dc.contributor.author","Niendorf, Thoralf"],["dc.contributor.author","Braun, Jürgen"],["dc.contributor.author","Sack, Ingolf"],["dc.date.accessioned","2021-09-17T10:19:31Z"],["dc.date.available","2021-09-17T10:19:31Z"],["dc.date.issued","2012-04"],["dc.description.abstract","Vibration synchronized magnetic resonance imaging of harmonically oscillating tissue interfaces is proposed for cardiac magnetic resonance elastography. The new approach exploits cardiac triggered cine imaging synchronized with extrinsic harmonic stimulation (f = 22.83 Hz) to display oscillatory tissue deformations in magnitude images. Oscillations are analyzed by intensity threshold-based image processing to track wave amplitude variations over the cardiac cycle. In agreement to literature data, results in 10 volunteers showed that endocardial wave amplitudes during systole (0.13 ± 0.07 mm) were significantly lower than during diastole (0.34 ± 0.14 mm, P < 0.001). Wave amplitudes were found to decrease 117 ± 40 ms before myocardial contraction and to increase 75 ± 31 ms before myocardial relaxation. Vibration synchronized magnetic resonance imaging improves the temporal resolution of magnetic resonance elastography as it overcomes the use of extra motion encoding gradients, is less sensitive to susceptibility artifacts, and does not suffer from dynamic range constraints frequently encountered in phase-based magnetic resonance elastography."],["dc.identifier.doi","10.1002/mrm.24185"],["dc.identifier.pmid","22294295"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89662"],["dc.language.iso","en"],["dc.relation.eissn","1522-2594"],["dc.relation.issn","0740-3194"],["dc.title","Vibration-synchronized magnetic resonance imaging for the detection of myocardial elasticity changes"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Psychiatry"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Corthals, Kristina"],["dc.contributor.author","Heukamp, Alina Sophia"],["dc.contributor.author","Kossen, Robert"],["dc.contributor.author","Großhennig, Isabel"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Gras, Heribert"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Heinrich, Ralf"],["dc.contributor.author","Geurten, Bart R. H."],["dc.date.accessioned","2019-07-09T11:43:34Z"],["dc.date.available","2019-07-09T11:43:34Z"],["dc.date.issued","2017"],["dc.description.abstract","The genome of Drosophila melanogaster includes homologs to approximately one-third of the currently known human disease genes. Flies and humans share many biological processes, including the principles of information processing by excitable neurons, synaptic transmission, and the chemical signals involved in intercellular communication. Studies on the molecular and behavioral impact of genetic risk factors of human neuro- developmental disorders [autism spectrum disorders (ASDs), schizophrenia, attention deficit hyperactivity disorders, and Tourette syndrome] increasingly use the well-studied social behavior of D. melanogaster, an organism that is amenable to a large variety of genetic manipulations. Neuroligins (Nlgs) are a family of phylogenetically conserved postsynaptic adhesion molecules present (among others) in nematodes, insects, and mammals. Impaired function of Nlgs (particularly of Nlg 3 and 4) has been associated with ASDs in humans and impaired social and communication behavior in mice. Making use of a set of behavioral and social assays, we, here, analyzed the impact of two Drosophila Nlgs, Dnlg2 and Dnlg4, which are differentially expressed at excitatory and inhibitory central nervous synapses, respectively. Both Nlgs seem to be associated with diurnal activity and social behavior. Even though deficiencies in Dnlg2 and Dnlg4 appeared to have no effects on sensory or motor systems, they differentially impacted on social interactions, suggesting that social behavior is distinctly regulated by these Nlgs."],["dc.identifier.doi","10.3389/fpsyt.2017.00113"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58919"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-0640"],["dc.relation.issn","1664-0640"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Neuroligins Nlg2 and Nlg4 Affect Social Behavior in Drosophila melanogaster"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Integrative Bioinformatics"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Barbosa, Eudes"],["dc.contributor.author","Röttger, Richard"],["dc.contributor.author","Hauschild, Anne-Christin"],["dc.contributor.author","de Castro Soares, Siomar"],["dc.contributor.author","Böcker, Sebastian"],["dc.contributor.author","Azevedo, Vasco"],["dc.contributor.author","Baumbach, Jan"],["dc.date.accessioned","2021-09-17T08:41:11Z"],["dc.date.available","2021-09-17T08:41:11Z"],["dc.date.issued","2017-07-05"],["dc.description.abstract","Distinct bacteria are able to cope with highly diverse lifestyles; for instance, they can be free living or host-associated. Thus, these organisms must possess a large and varied genomic arsenal to withstand different environmental conditions. To facilitate the identification of genomic features that might influence bacterial adaptation to a specific niche, we introduce LifeStyle-Specific-Islands (LiSSI). LiSSI combines evolutionary sequence analysis with statistical learning (Random Forest with feature selection, model tuning and robustness analysis). In summary, our strategy aims to identify conserved consecutive homology sequences (islands) in genomes and to identify the most discriminant islands for each lifestyle."],["dc.identifier.doi","10.1515/jib-2017-0010"],["dc.identifier.pmid","28678736"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89610"],["dc.language.iso","en"],["dc.relation.issn","1613-4516"],["dc.title","LifeStyle-Specific-Islands (LiSSI): Integrated Bioinformatics Platform for Genomic Island Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]