Institut für Diagnostische und Interventionelle Radiologie

[["dc.bibliographiccitation.firstpage","653"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Der Radiologe"],["dc.bibliographiccitation.lastpage","659"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Vosshenrich, R."],["dc.contributor.author","Fischer, U."],["dc.contributor.author","Grabbe, E."],["dc.contributor.author","Raab, R.-W."],["dc.contributor.author","Funke, M."],["dc.date.accessioned","2021-06-01T10:49:05Z"],["dc.date.available","2021-06-01T10:49:05Z"],["dc.date.issued","2001"],["dc.identifier.doi","10.1007/s001170170114"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86163"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1432-2102"],["dc.relation.issn","0033-832X"],["dc.title","Intramurale Hämatome der Aorta"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neuroradiology"],["dc.bibliographiccitation.lastpage","109"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Ernstberger, Thorsten"],["dc.contributor.author","Heidrich, Gabert"],["dc.contributor.author","Schultz, Wolfgang"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.date.accessioned","2018-11-07T11:05:31Z"],["dc.date.available","2018-11-07T11:05:31Z"],["dc.date.issued","2007"],["dc.description.abstract","Introduction Intervertebral spacers for anterior spine fusion are made of different materials, such as titanium and cobalt chromium alloys and carbon fiber-reinforced polymers. Implant-related susceptibility artifacts can decrease the quality of MRI scans. The aim of this cadaveric study was to demonstrate the extent that implant-related MRI artifacting affects the postfusion differentiation of determined regions of interest (ROIs). Methods In six cadaveric porcine spines, we evaluated the postimplantation MRI scans of a titanium, cobalt-chromium and carbon spacer that differed in shape and surface qualities. A spacer made of human cortical bone was used as a control. A defined evaluation unit was divided into ROIs to characterize the spinal canal as well as the intervertebral disc space. Considering 15 different MRI sequences read independently by an interobserver-validated team of specialists the artifact-affected image quality of the median MRI slice was rated on a score of 0-3. A maximum score of 18 points (100%) for the determined ROIs was possible. Results Turbo spin echo sequences produced the best scores for all spacers and the control. Only the control achieved a score of 100%. For the determined ROI maximum scores for the cobalt-chromium, titanium and carbon spacers were 24%, 32% and 84%, respectively. Conclusion By using favored T1 TSE sequences the carbon spacer showed a clear advantage in postfusion spinal imaging. Independent of artifact dimensions, the scoring system used allowed us to create an implant-related ranking of MRI scan quality in reference to the bone control."],["dc.identifier.doi","10.1007/s00234-006-0161-5"],["dc.identifier.isi","000243926000002"],["dc.identifier.pmid","17086407"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52084"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0028-3940"],["dc.title","Implant detectibility of intervertebral disc spacers in post fusion MRI: evaluation of the MRI scan quality by using a scoring system - an in vitro study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","New England Journal of Medicine"],["dc.bibliographiccitation.volume","357"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.date.accessioned","2018-11-07T11:00:36Z"],["dc.date.available","2018-11-07T11:00:36Z"],["dc.date.issued","2007"],["dc.format.extent","391"],["dc.identifier.doi","10.1056/NEJMicm060694"],["dc.identifier.isi","000248283500011"],["dc.identifier.pmid","17652654"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50957"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Massachusetts Medical Soc"],["dc.relation.issn","0028-4793"],["dc.title","Metastatic germ-cell cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e118"],["dc.bibliographiccitation.firstpage","1232"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.lastpage","1243"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Missbach-Guentner, Jeannine"],["dc.contributor.author","Vogel, Wolfgang F."],["dc.contributor.author","Grabbe, Eckhardt"],["dc.contributor.author","Alves, Frauke"],["dc.date.accessioned","2018-11-07T11:01:18Z"],["dc.date.available","2018-11-07T11:01:18Z"],["dc.date.issued","2007"],["dc.description.abstract","Rapid progress in exploring the human and mouse genome has resulted in the generation of a multitude of mouse models to study gene functions in their biological context. However, effective screening methods that allow rapid noninvasive phenotyping of transgenic and knockout mice are still lacking. To identify murine models with bone alterations in vivo, we used flat-panel volume computed tomography (fpVCT) for high-resolution 3-D imaging and developed an algorithm with a computational intelligence system. First, we tested the accuracy and reliability of this approach by imaging discoidin domain receptor 2-(DDR2-) deficient mice, which display distinct skull abnormalities as shown by comparative landmark-based analysis. High-contrast fpVCT data of the skull with 200 mu m isotropic resolution and 8-s scan time allowed segmentation and computation of significant shape features as well as visualization of morphological differences. The application of a trained artificial neuronal network to these datasets permitted a semiautomatic and highly accurate phenotype classification of DDR2-deficient compared to C57BL/6 wild-type mice. Even heterozygous DDR2 mice with only subtle phenotypic alterations were correctly determined by fpVCT imaging and identified as a new class. In addition, we successfully applied the algorithm to classify knockout mice lacking the DDR1 gene with no apparent skull deformities. Thus, this new method seems to be a potential tool to identify novel mouse phenotypes with skull changes from transgenic and knockout mice on the basis of random mutagenesis as well as from genetic models. However for this purpose, new neuronal networks have to be created and trained. In summary, the combination of fpVCT images with artificial neuronal networks provides a reliable, novel method for rapid, cost-effective, and noninvasive primary screening tool to detect skeletal phenotypes in mice."],["dc.identifier.doi","10.1371/journal.pgen.0030118"],["dc.identifier.isi","000248350000010"],["dc.identifier.pmid","17658952"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8443"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51120"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7390"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Semi-automatic classification of skeletal morphology in genetically altered mice using flat-panel volume computed tomography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Radiology"],["dc.bibliographiccitation.lastpage","49"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Rodenwaldt, Jens"],["dc.contributor.author","Kopka, Lars"],["dc.contributor.author","Vosshenrich, Rolf"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.date.accessioned","2021-06-01T10:50:17Z"],["dc.date.available","2021-06-01T10:50:17Z"],["dc.date.issued","2000"],["dc.description.abstract","Objective: Evaluation of different contrast-enhanced MR angiography imaging protocols for visualization of the entire aorta in breath-hold technique. Methods ann patients: Three different CE (0.15 mmol/kg) MRA protocols were evaluated by phantom and patient studies: (1) two separate MRA with conventional application of the body-phased array coil; (2) a single-shot MRA with modified application of the body-phased array coil; (3) a single-shot MRA with the body coil. Duplex sonography, CTA and DSA were used as standard of reference. Results: In all examinations the entire aorta could be visualized. The best SNR was acquired with protocol (1). The SNR of protocol (2) was reduced if the sagittal body diameter of the patient was greater than 20 cm and decreased significantly with diameters over 30 cm. By the use of protocol (3) the SNR was notably poor. The quality scored for the visualization of the entire aorta was 97.5% (protocol 1), 92.5% (protocol 2); and 80.0% (protocol 3). Conclusion: In most cases the modified application of the body-phased array coil allows the imaging of the entire aorta as a single-shot 3D CE MRA in diagnostic quality. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0720-048X(99)00073-X"],["dc.identifier.isi","000084995900008"],["dc.identifier.pmid","10674789"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86599"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.relation.issn","0720-048X"],["dc.title","3D MR angiography of the entire aorta: modified application of the body-phased array coil for a single-shot technique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","668"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Human Pathology"],["dc.bibliographiccitation.lastpage","672"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Sander, Bjoern"],["dc.contributor.author","Middel, Peter"],["dc.contributor.author","Gunawan, Bastian"],["dc.contributor.author","Schulten, Hans-Juergen"],["dc.contributor.author","Baum, Friedeman"],["dc.contributor.author","Golas, Mariola Monika"],["dc.contributor.author","Schulze, Frank"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.contributor.author","Parwaresch, Reza"],["dc.contributor.author","Fuezesi, Laszlo"],["dc.date.accessioned","2018-11-07T11:03:31Z"],["dc.date.available","2018-11-07T11:03:31Z"],["dc.date.issued","2007"],["dc.description.abstract","Diagnosis of primary spindle cell tumors of the spleen is challenging because of the limited immunologic and cytogenetic characterization of this rare entity. We report a case of primary follicular dendritic cell (FDC) sarcoma of the spleen in a 44-year-old woman. Indications for FDC included positive staining for CD21, Ki-M4P, CD 14, and fascin. Expression of both standard FDC markers CD23 and CD35 was detected immunohistochemically using tyramide signal amplification. Cytogenetic analysis revealed multiple clonal chromosomal aberrations involving unbalanced translocations of chromosomes X, 3, 5, 7, 8, 9, and 10, leading to net gains at 3q, 7p, 8q, and 9q and net losses at Xp, 8p, 9p, and 10p. Loss at Xp has been described previously in another tumor with FDC features, suggesting that this aberration might play a common role in this malignancy. (c) 2007 Published by Elsevier Inc."],["dc.identifier.doi","10.1016/j.humpath.2006.08.030"],["dc.identifier.isi","000245319800020"],["dc.identifier.pmid","17367608"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51639"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","0046-8177"],["dc.title","Follicular dendritic cell sarcoma of the spleen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","228"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Photochemistry and Photobiology"],["dc.bibliographiccitation.lastpage","235"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Wessels, Johannes Theodor"],["dc.contributor.author","Busse, Ann-Christin"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Zaenker, Stephan"],["dc.contributor.author","Hermann, Robert"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.contributor.author","Mueller, Gerhard-Anton"],["dc.date.accessioned","2018-11-07T11:20:35Z"],["dc.date.available","2018-11-07T11:20:35Z"],["dc.date.issued","2008"],["dc.description.abstract","The renal cell carcinoma (RCC) is extremely resistant to chemotherapy and radiotherapy. The prognosis of patients with metastatic RCC still remains poor, the median survival is less than 12 months. Therefore, new therapeutic options are desirable. The aim of this study was to investigate the photosensitizing and radiosensitizing effects of hypericin on human RCC cells in vitro. First the RCC-derived cell lines A498 and ACHN were incubated with different concentrations of hypericin. In vitro uptake and intracellular distribution of hypericin were confirmed by fluorescence microscopy. Subsequently cells were illuminated and irradiated with a dose of 2-8 Gy, respectively. Finally, metabolic activity, apoptosis and clonogenic survival were investigated. Uptake of hypericin was observed for almost all cells. Hypericin treatment combined with illumination led to a 94-97% decrease in metabolic activity and caused apoptosis in nearly 100% of RCC cells. Hypericin enhanced the radiosensitivity of A498 cells in vitro. The clonogenic survival after irradiation was significantly reduced by hypericin treatment. Taken together, the photosensitizing and radiosensitizing effects of hypericin on human RCC cells we found in this investigation could be of clinical relevance, e.g. for radiotherapy and intraoperative photodynamic therapy, respectively."],["dc.identifier.doi","10.1111/j.1751-1097.2007.00225.x"],["dc.identifier.isi","000252506900032"],["dc.identifier.pmid","18173725"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55568"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Photobiology"],["dc.relation.issn","0031-8655"],["dc.title","Photosensitizing and radiosensitizing effects of hypericin on human renal carcinoma cells in Vitro"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","663"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Neoplasia"],["dc.bibliographiccitation.lastpage","673"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Missbach-Guentner, Jeannine"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Kimmina, Sarah"],["dc.contributor.author","Zientkowska, Marta"],["dc.contributor.author","Domeyer-Missbach, Melanie"],["dc.contributor.author","Malz, Cordula"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.contributor.author","Stühmer, Walter"],["dc.contributor.author","Alves, Frauke"],["dc.date.accessioned","2019-07-10T08:11:50Z"],["dc.date.available","2019-07-10T08:11:50Z"],["dc.date.issued","2008"],["dc.description.abstract","Noninvasive methods are strongly needed to detect and quantify not only tumor growth in murine tumor models but also the development of vascularization and necrosis within tumors. This study investigates the use of a new imaging technique, flat-panel detector volume computed tomography (fpVCT), to monitor in vivo tumor progression and structural changes within tumors of two murine carcinoma models. After tumor cell inoculation, single fpVCT scans of the entire mice were performed at different time points. The acquired isotropic, high-resolution volume data sets enable an accurate real-time assessment and precise measurements of tumor volumes. Spreading of contrast agent-containing blood vessels around and within the tumors was clearly visible over time. Furthermore, fpVCT permits the identification of differences in the uptake of contrast media within tumors, thus delineating necrosis, tumor tissues, and blood vessels. Classification of tumor tissues based on the decomposition of the underlying mixture distribution of tissue-related Hounsfield units allowed the quantitative acquisition of necrotic tissues at each time point. Morphologic alterations of the tumor depicted by fpVCT were confirmed by histopathologic examination. Concluding, our data show that fpVCT may be highly suitable for the noninvasive evaluation of tumor responses to anticancer therapies during the course of the disease."],["dc.identifier.doi","10.1593/neo.08270"],["dc.identifier.pii","S1476558608800048"],["dc.identifier.pmid","18592006"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11245"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60806"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/102991"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1476-5586"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.title","Morphologic changes of mammary carcinomas in mice over time as monitored by flat-panel detector volume computed tomography."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","988"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","European Journal of Gastroenterology & Hepatology"],["dc.bibliographiccitation.lastpage","994"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Armbrust, Thomas"],["dc.contributor.author","Sobotta, Michael"],["dc.contributor.author","Fuzesi, Laszlo"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.contributor.author","Ramadori, Giuliano"],["dc.date.accessioned","2018-11-07T10:56:09Z"],["dc.date.available","2018-11-07T10:56:09Z"],["dc.date.issued","2007"],["dc.description.abstract","Background Although modern chemotherapy of stage IV advanced colorectal cancer (CRC) has impressively improved overall survival, the response of the primary tumor has not been studied because surgical resection of the primary continues to be the standard procedure in stage IV CRC. Aim Long-term follow-up of the primary in patients with stage IV CRC under chemotherapy. Methods and results Here we report on the histological changes in the primary tumor in four patients suffering from stage IV CRC. Systemic chemotherapy was started immediately after endoscopic tumor debulking in three cases. In one case no endoscopic intervention was performed before chemotherapy. Neither macroscopic nor histological evidence for malignant tumor growth was found at the former site of the primary after 6, 23, 26 or 48 months, respectively. Two patients had a complete suppression of the primary, two patients had an adenoma at the former site of the primary. To date, three patients have died because of progression of liver metastases and one patient is still alive with no signs of tumor growth. Conclusion The four cases illustrate that today's chemotherapy may effectively induces suppression of the primary in CRC. The development of CRC may follow different pathways."],["dc.identifier.isi","000254356700013"],["dc.identifier.pmid","18049169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49947"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0954-691X"],["dc.title","Chemotherapy-induced suppression to adenoma or complete suppression of the primary in patients with stage IV colorectal cancer: report of four cases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","360"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Spine Journal"],["dc.bibliographiccitation.lastpage","367"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Ernstberger, Thorsten"],["dc.contributor.author","Heidrich, Gabert"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Buchhorn, Gottfried"],["dc.contributor.author","Grabbe, Eckhardt"],["dc.date.accessioned","2018-11-07T11:03:02Z"],["dc.date.available","2018-11-07T11:03:02Z"],["dc.date.issued","2007"],["dc.description.abstract","BACKGROUND CONTEXT: Image quality and implant detectability by conventional imaging methods are suboptimal for perioperative spinal diagnostics, primarily limited by implant-related artifacts. PURPOSE: To evaluate the imaging quality of various intervertebral spacers examined by flat-panel detector-based volumetric computed tomography (FD-VCT) versus magnetic resonance imaging (MRI). STUDY DESIGN/SETTING: A preclinical comparative study on an experimental porcine model. The study was performed at a university research facility. METHODS: Three different intervertebral spacer types (titanium, carbon fiber-reinforced polymer, cobalt-chrome-molybdenum) were implanted in a cadaveric porcine spine and then examined by MRI using T1-weighted spin echo (T1w-SE) and turbo spin echo (T1w-TSE) sequences. Comparative imaging was performed with an experimentally approved FD-VCT prototype featuring two-dimensional and three-dimensional imaging and high isotropic spatial resolution. Data analysis focused on spacer shape, implant positioning, and implant-bone interface. RESULTS: Compared with MRI, and despite the use of T1w-SE and T1w-TSE sequences, the image quality and delectability of all target characteristics were better with FD-VCT absent the usual artifacts. Using its option for implant-specific imaging, the experimental FD-VCT imager allowed reliable determination of additional variables such as dimension and volume. CONCLUSIONS: This experimental study provides initial evidence that FD-VCT produces excellently sharp, high-accuracy, artifact-free imaging quality that is superior to MRI in distinguishing key characteristics of intervertebral implants in a preclinical setting. (c) 2007 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.spinee.2006.03.017"],["dc.identifier.isi","000251490100017"],["dc.identifier.pmid","17482122"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51527"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1529-9430"],["dc.title","Preclinical evaluation by flat-panel detector-based volumetric CT versus MRI of intervertebral spacers implanted in a porcine model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]