Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie

[["dc.bibliographiccitation.artnumber","216"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Orphanet Journal of Rare Diseases"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Waltereit, Robert"],["dc.contributor.author","Beaure d’Augères, Guillaume"],["dc.contributor.author","Jancic, Jasna"],["dc.contributor.author","Kingswood, John C."],["dc.contributor.author","Koleva, Maya"],["dc.contributor.author","Marques, Ruben"],["dc.contributor.author","Villanueva, Vicente"],["dc.contributor.author","Auvin, Stéphane"],["dc.date.accessioned","2021-11-25T11:07:06Z"],["dc.date.accessioned","2022-08-18T12:37:40Z"],["dc.date.available","2021-11-25T11:07:06Z"],["dc.date.available","2022-08-18T12:37:40Z"],["dc.date.issued","2021-05-12"],["dc.date.updated","2022-07-29T12:17:43Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Tuberous sclerosis complex (TSC) is a rare, genetic, multisystem disorder characterized by the growth of hamartomas in several organs, including the brain, kidneys, heart, eyes, and lungs. Even though over 90% of patients will have some form of TSC-associated neuropsychiatric disorder (TAND), there is an apparent lack of involvement of mental health professionals (MHPs) in the care of patients with TSC. The aim of this study was to determine the current level of TAND awareness in the TSC community and to identify possible barriers to effective multidisciplinary collaboration between MHPs and other healthcare providers (HCPs) in TAND management.\r\n\r\n \r\n \r\n Methods\r\n An electronic survey on current TSC and TAND management was conducted, targeting TSC caregivers/families, psychiatrists, neurologists, TSC specialists, and primary care physicians.\r\n\r\n \r\n \r\n Results\r\n The invitation to participate in the survey was emailed to 659 HCPs and was disseminated through social media channels of patient advocacy groups. The survey was open for 4 months, with 359 responses collected. The majority of participants were TSC caregivers/families (73.3% of all responses). Of the 96 HCPs who participated, most were neurologists (61.5%) or TSC specialists (28.1%). Only 6 psychiatrists and 4 primary care physicians participated. Approximately half of patients have never had a neuropsychiatric assessment, and it was their caregivers/families who initiated the discussion of TAND with their providers. Almost 70% of TSC caregivers/families believed that psychiatric treatment could improve their quality of life. However, 54% of patients had difficulty obtaining psychiatric assessment. In turn, only 21% of HCPs believed that psychiatric therapy would help and 74% were concerned that their patients would be stigmatized by psychiatric referral.\r\n \r\n \r\n Conclusions\r\n This study focused on European healthcare systems suggests that current care for mental health issues in patients with TSC is inadequate, despite guideline recommendations for regular neuropsychiatric assessments. This appears to be due to a combination of gaps in diagnosis and surveillance, low frequency of psychiatric referrals, insufficient resources, and stigmatization of mental healthcare. There is a pressing need for further initiatives to study and address the mechanisms underlying the mental health treatment gap. The importance of MHP support must be recognized to optimize TSC management."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","Orphanet Journal of Rare Diseases. 2021 May 12;16(1):216"],["dc.identifier.doi","10.1186/s13023-021-01800-w"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93529"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112962"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1750-1172"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","TAND"],["dc.subject","TAND checklist"],["dc.subject","TSC-associated neuropsychiatric disorders"],["dc.subject","Tuberous sclerosis complex"],["dc.title","Involvement of mental health professionals in the treatment of tuberous sclerosis complex–associated neuropsychiatric disorders (TAND): results of a multinational European electronic survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e036093"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","BMJ Open"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Greimel, Ellen"],["dc.contributor.author","Feldmann, Lisa"],["dc.contributor.author","Piechaczek, Charlotte"],["dc.contributor.author","Oort, Frans"],["dc.contributor.author","Bartling, Jürgen"],["dc.contributor.author","Schulte-Rüther, Martin"],["dc.contributor.author","Schulte-Körne, Gerd"],["dc.date.accessioned","2021-04-14T08:27:26Z"],["dc.date.available","2021-04-14T08:27:26Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1136/bmjopen-2019-036093"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82290"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2044-6055"],["dc.relation.issn","2044-6055"],["dc.title","Study protocol for a randomised-controlled study on emotion regulation training for adolescents with major depression: the KONNI study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","jcpp.13650"],["dc.bibliographiccitation.journal","Journal of Child Psychology and Psychiatry"],["dc.contributor.author","Schulte‐Rüther, Martin"],["dc.contributor.author","Kulvicius, Tomas"],["dc.contributor.author","Stroth, Sanna"],["dc.contributor.author","Wolff, Nicole"],["dc.contributor.author","Roessner, Veit"],["dc.contributor.author","Marschik, Peter B."],["dc.contributor.author","Kamp‐Becker, Inge"],["dc.contributor.author","Poustka, Luise"],["dc.date.accessioned","2022-09-01T09:50:42Z"],["dc.date.available","2022-09-01T09:50:42Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1111/jcpp.13650"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113781"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1469-7610"],["dc.relation.issn","0021-9630"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Using machine learning to improve diagnostic assessment of\n ASD\n in the light of specific differential and co‐occurring diagnoses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of child psychology and psychiatry, and allied disciplines"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Freitag, Christine M."],["dc.contributor.author","Jensen, Katrin"],["dc.contributor.author","Elsuni, Leyla"],["dc.contributor.author","Sachse, Michael"],["dc.contributor.author","Herpertz-Dahlmann, Beate"],["dc.contributor.author","Schulte-Ruther, Martin"],["dc.contributor.author","Hanig, Susann"],["dc.contributor.author","von Gontard, Alexander"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Schad-Hansjosten, Tanja"],["dc.contributor.author","Wenzl, Christina"],["dc.contributor.author","Sinzig, Judith"],["dc.contributor.author","Taurines, Regina"],["dc.contributor.author","GeiSSler, Julia"],["dc.contributor.author","Kieser, Meinhard"],["dc.contributor.author","Cholemkery, Hannah"],["dc.date.accessioned","2017-09-07T11:46:30Z"],["dc.date.available","2017-09-07T11:46:30Z"],["dc.date.issued","2016"],["dc.description.abstract","BACKGROUND: Group-based psychotherapy in Autism Spectrum Disorder (ASD) has predominantly been studied in the United States by small studies in school-aged children without long-term follow-up. We report results of a large, confirmatory, multicentre randomized-controlled phase-III trial in children and adolescents studying the ASD specific, manualized group-based cognitive behavioural SOSTA-FRA approach.; METHODS: High-functioning ASD individuals aged 8-19years old were randomized to 12 sessions SOSTA-FRA or treatment as usual. Primary outcomes were change in total raw score of the parent-rated Social Responsiveness Scale (pSRS) between baseline (T2) and end of intervention (T4), and between T2 and 3 months after end of intervention (T5).; TRIAL REGISTRATION: ISRCTN94863788.; RESULTS: Between 20/5/2010 and 14/2/2013, n=320 ASD patients were screened, n=228 patients were randomized, and N=209 analysed. Mean pSRS difference between groups at T4 was -6.5 (95% CI -11.6 to - 1.4; p=.013), and at T5 -6.4 (-11.5 to -1.3, p=.015). Pre-treatment SRS and IQ were positively associated with stronger improvement at T4 and T5.; CONCLUSIONS: Short-term ASD-specific add-on group-based psychotherapy has shown postintervention efficacy with regard to parent-rated social responsiveness predominantly in male high-functioning children and adolescents with ASD. Future studies should implement blinded standardized observational measures of peer-related social interaction. 2015 Association for Child and Adolescent Mental Health."],["dc.identifier.doi","10.1111/jcpp.12509"],["dc.identifier.gro","3151924"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8759"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1469-7610"],["dc.title","Group-based cognitive behavioural psychotherapy for children and adolescents with ASD: the randomized, multicentre, controlled SOSTA-net trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neuroscience"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Weiss, Eileen Oberwelland"],["dc.contributor.author","Kruppa, Jana A."],["dc.contributor.author","Fink, Gereon R."],["dc.contributor.author","Herpertz-Dahlmann, Beate"],["dc.contributor.author","Konrad, Kerstin"],["dc.contributor.author","Schulte-Rüther, Martin"],["dc.date.accessioned","2021-04-14T08:29:50Z"],["dc.date.available","2021-04-14T08:29:50Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3389/fnins.2020.536596"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83004"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1662-453X"],["dc.title","Developmental Differences in Probabilistic Reversal Learning: A Computational Modeling Approach"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","14"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurodevelopmental Disorders"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Petrasek, Tomas"],["dc.contributor.author","Vojtechova, Iveta"],["dc.contributor.author","Klovrza, Ondrej"],["dc.contributor.author","Tuckova, Klara"],["dc.contributor.author","Vejmola, Cestmir"],["dc.contributor.author","Rak, Jakub"],["dc.contributor.author","Sulakova, Anna"],["dc.contributor.author","Kaping, Daniel"],["dc.contributor.author","Bernhardt, Nadine"],["dc.contributor.author","de Vries, Petrus J."],["dc.contributor.author","Otahal, Jakub"],["dc.contributor.author","Waltereit, Robert"],["dc.date.accessioned","2021-06-01T09:42:14Z"],["dc.date.accessioned","2022-08-18T12:30:09Z"],["dc.date.available","2021-06-01T09:42:14Z"],["dc.date.available","2022-08-18T12:30:09Z"],["dc.date.issued","2021-04-17"],["dc.date.updated","2022-07-29T11:24:34Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Tuberous sclerosis complex (TSC), a multi-system genetic disorder often associated with autism spectrum disorder (ASD), is caused by mutations of TSC1 or TSC2, which lead to constitutive overactivation of mammalian target of rapamycin (mTOR). In several Tsc1+/- and Tsc2+/- animal models, cognitive and social behavior deficits were reversed by mTOR inhibitors. However, phase II studies have not shown amelioration of ASD and cognitive deficits in individuals with TSC during mTOR inhibitor therapy. We asked here if developmental epilepsy, common in the majority of individuals with TSC but absent in most animal models, could explain the discrepancy.\r\n \r\n \r\n Methods\r\n At postnatal day P12, developmental status epilepticus (DSE) was induced in male Tsc2+/- (Eker) and wild-type rats, establishing four experimental groups including controls. In adult animals (n = 36), the behavior was assessed in the paradigms of social interaction test, elevated plus-maze, light-dark test, Y-maze, and novel object recognition. The testing was carried out before medication (T1), during a 2-week treatment with the mTOR inhibitor everolimus (T2) and after an 8-week washing-out (T3). Electroencephalographic (EEG) activity was recorded in a separate set of animals (n = 18).\r\n \r\n \r\n Results\r\n Both Tsc2+/- mutation and DSE caused social behavior deficits and epileptiform EEG abnormalities (T1). Everolimus led to a persistent improvement of the social deficit induced by Tsc2+/-, while deficits related to DSE did not respond to everolimus (T2, T3).\r\n \r\n \r\n Conclusions\r\n These findings may contribute to an explanation why ASD symptoms in individuals with TSC, where comorbid early-onset epilepsy is common, were not reliably ameliorated by mTOR inhibitors in clinical studies."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","Journal of Neurodevelopmental Disorders. 2021 Apr 17;13(1):14"],["dc.identifier.doi","10.1186/s11689-021-09357-2"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17759"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85185"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112887"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1866-1955"],["dc.relation.issn","1866-1947"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Tuberous sclerosis complex"],["dc.subject","TSC"],["dc.subject","Autism spectrum disorders"],["dc.subject","Developmental status epilepticus"],["dc.subject","mTOR"],["dc.subject","Everolimus"],["dc.title","mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Psychology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hartz, Arne"],["dc.contributor.author","Guth, Björn"],["dc.contributor.author","Jording, Mathis"],["dc.contributor.author","Vogeley, Kai"],["dc.contributor.author","Schulte-Rüther, Martin"],["dc.date.accessioned","2021-09-01T06:43:09Z"],["dc.date.available","2021-09-01T06:43:09Z"],["dc.date.issued","2021"],["dc.description.abstract","To navigate the social world, humans heavily rely on gaze for non-verbal communication as it conveys information in a highly dynamic and complex, yet concise manner: For instance, humans utilize gaze effortlessly to direct and infer the attention of a possible interaction partner. Many traditional paradigms in social gaze research though rely on static ways of assessing gaze interaction, e.g., by using images or prerecorded videos as stimulus material. Emerging gaze contingent paradigms, in which algorithmically controlled virtual characters can respond flexibly to the gaze behavior of humans, provide high ecological validity. Ideally, these are based on models of human behavior which allow for precise, parameterized characterization of behavior, and should include variable interactive settings and different communicative states of the interacting agents. The present study provides a complete definition and empirical description of a behavioral parameter space of human gaze behavior in extended gaze encounters. To this end, we (i) modeled a shared 2D virtual environment on a computer screen in which a human could interact via gaze with an agent and simultaneously presented objects to create instances of joint attention and (ii) determined quantitatively the free model parameters (temporal and probabilistic) of behavior within this environment to provide a first complete, detailed description of the behavioral parameter space governing joint attention. This knowledge is essential to enable the modeling of interacting agents with a high degree of ecological validity, be it for cognitive studies or applications in human-robot interaction."],["dc.description.abstract","To navigate the social world, humans heavily rely on gaze for non-verbal communication as it conveys information in a highly dynamic and complex, yet concise manner: For instance, humans utilize gaze effortlessly to direct and infer the attention of a possible interaction partner. Many traditional paradigms in social gaze research though rely on static ways of assessing gaze interaction, e.g., by using images or prerecorded videos as stimulus material. Emerging gaze contingent paradigms, in which algorithmically controlled virtual characters can respond flexibly to the gaze behavior of humans, provide high ecological validity. Ideally, these are based on models of human behavior which allow for precise, parameterized characterization of behavior, and should include variable interactive settings and different communicative states of the interacting agents. The present study provides a complete definition and empirical description of a behavioral parameter space of human gaze behavior in extended gaze encounters. To this end, we (i) modeled a shared 2D virtual environment on a computer screen in which a human could interact via gaze with an agent and simultaneously presented objects to create instances of joint attention and (ii) determined quantitatively the free model parameters (temporal and probabilistic) of behavior within this environment to provide a first complete, detailed description of the behavioral parameter space governing joint attention. This knowledge is essential to enable the modeling of interacting agents with a high degree of ecological validity, be it for cognitive studies or applications in human-robot interaction."],["dc.identifier.doi","10.3389/fpsyg.2021.673982"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89228"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1664-1078"],["dc.title","Temporal Behavioral Parameters of On-Going Gaze Encounters in a Virtual Environment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","erv.2911"],["dc.bibliographiccitation.journal","European Eating Disorders Review"],["dc.contributor.author","Ruan, Vanessa Ande"],["dc.contributor.author","Hartz, Arne"],["dc.contributor.author","Hueck, Manuel"],["dc.contributor.author","Dahmen, Brigitte"],["dc.contributor.author","von Polier, Georg"],["dc.contributor.author","Herpertz‐Dahlmann, Beate"],["dc.contributor.author","Konrad, Kerstin"],["dc.contributor.author","Schulte‐Rüther, Martin"],["dc.contributor.author","Seitz, Jochen"],["dc.date.accessioned","2022-07-01T07:34:51Z"],["dc.date.available","2022-07-01T07:34:51Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1002/erv.2911"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112029"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.eissn","1099-0968"],["dc.relation.issn","1072-4133"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc/4.0/"],["dc.title","Neural mechanisms underlying social recognition and theory of mind in adolescent patients with bulimia nervosa and transdiagnostic comparison with anorexia nervosa"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Social Cognitive and Affective Neuroscience"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Kruppa, Jana A"],["dc.contributor.author","Reindl, Vanessa"],["dc.contributor.author","Gerloff, Christian"],["dc.contributor.author","Oberwelland Weiss, Eileen"],["dc.contributor.author","Prinz, Julia"],["dc.contributor.author","Herpertz-Dahlmann, Beate"],["dc.contributor.author","Konrad, Kerstin"],["dc.contributor.author","Schulte-Rüther, Martin"],["dc.date.accessioned","2021-06-01T09:41:56Z"],["dc.date.available","2021-06-01T09:41:56Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract Brain-to-brain synchrony has been proposed as an important mechanism underlying social interaction. While first findings indicate that it may be modulated in children with autism spectrum disorder (ASD), no study to date has investigated the influence of different interaction partners and task characteristics. Using functional near-infrared spectroscopy hyperscanning, we assessed brain-to-brain synchrony in 41 male typically developing (TD) children (8–18 years; control sample), as well as 18 children with ASD and age-matched TD children (matched sample), while performing cooperative and competitive tasks with their parents and an adult stranger. Dyads were instructed either to respond jointly in response to a target (cooperation) or to respond faster than the other player (competition). Wavelet coherence was calculated for oxy- and deoxyhemoglobin brain signals. In the control sample, a widespread enhanced coherence was observed for parent–child competition, and a more localized coherence for parent–child cooperation in the frontopolar cortex. While behaviorally, children with ASD showed a lower motor synchrony than children in the TD group, no significant group differences were observed on the neural level. In order to identify biomarkers for typical and atypical social interactions in the long run, more research is needed to investigate the neurobiological underpinnings of reduced synchrony in ASD."],["dc.identifier.doi","10.1093/scan/nsaa092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85083"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1749-5024"],["dc.relation.issn","1749-5016"],["dc.title","Brain and motor synchrony in children and adolescents with ASD—a fNIRS hyperscanning study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]