Bothe, Ulrich

[["dc.bibliographiccitation.firstpage","1296"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Chemistry - A European Journal"],["dc.bibliographiccitation.lastpage","1302"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Griesbach, U."],["dc.contributor.author","Schuberth, I."],["dc.contributor.author","Bothe, U."],["dc.contributor.author","Marra, A."],["dc.contributor.author","Dondoni, A."],["dc.date.accessioned","2018-11-07T10:39:58Z"],["dc.date.available","2018-11-07T10:39:58Z"],["dc.date.issued","2003"],["dc.description.abstract","The synthesis of the novel unprotected carboranyl C-glycosides 2 and 20 24 starting from ethynyl C-glycosides 1, 5-8, 10, and 13 is described. The new compounds are highly water-soluble and display only a very low cytotoxicity, which makes them promising candidates for use in boron neutron capture therapy for the treatment of cancer."],["dc.identifier.doi","10.1002/chem.200390148"],["dc.identifier.isi","000181817400005"],["dc.identifier.pmid","12645018"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46188"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","0947-6539"],["dc.title","Novel carboranyl C-glycosides for the treatment of cancer by boron neutron capture therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1747"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Bioorganic & Medicinal Chemistry"],["dc.bibliographiccitation.lastpage","1752"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Bothe, U."],["dc.contributor.author","Griesbach, U."],["dc.contributor.author","Nakaichi, M."],["dc.contributor.author","Hasegawa, T."],["dc.contributor.author","Nakamura, H."],["dc.contributor.author","Yamamoto, Y."],["dc.date.accessioned","2018-11-07T08:53:51Z"],["dc.date.available","2018-11-07T08:53:51Z"],["dc.date.issued","2001"],["dc.description.abstract","Distinct biological properties of the ortho-carboranyl (1,2-dicarba-closo-dodecaboranyl) glycosides 1, 2 and 3 were evaluated to estimate the suitability of these compounds for cancer treatment by boron neutron capture therapy. The boron uptake into B16-Melanoma cells was significantly higher by incubating the cells with aqueous solutions of carboranyl glucoside 1 (11.2 ppm after 3 h), lactoside 2 (13.2 ppm after 12 h) and maltoside 3 (20.0 ppm after 24 h) compared with solutions of clinically used p-boronophenylalanine (BPA) 5 (3.1 ppm after 34 h), Carboranyl maltoside 3 was more effective than boron-10 enriched 5 in killing C-6 rat glioma cells by incubating the cells with the compound and subsequent treatment with thermal neutrons. 3 was also administrated iv, in concentrations of 25 mg boron/kg body weight to rats bearing brain tumors. After a period of 4 h after administration the concentration of boron in the tumor tissue was 3.0 ppm. (C) 2001 Elsevier Science Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0968-0896(01)00061-X"],["dc.identifier.isi","000169580500013"],["dc.identifier.pmid","11425576"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22525"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0968-0896"],["dc.title","ortho-Carboranyl glycosides for the treatment of cancer by boron neutron capture therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","326"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","ChemBioChem"],["dc.bibliographiccitation.lastpage","334"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Bothe, U."],["dc.contributor.author","Griesbach, U."],["dc.contributor.author","Nakaichi, M."],["dc.contributor.author","Hasegawa, T."],["dc.contributor.author","Nakamura, H."],["dc.contributor.author","Yamamoto, Y."],["dc.date.accessioned","2018-11-07T09:04:25Z"],["dc.date.available","2018-11-07T09:04:25Z"],["dc.date.issued","2001"],["dc.description.abstract","Boron neutron capture therapy is a special type of radiotherapy for the treatment of cancer by using boron compounds. Problems often arise from the: low water solubility of these compounds, their unselective uptake into the cancer cells, and their toxicity Here we describe the novel water-soluble ortho-carboranyl bisglycosides 7 and 10 containing either lactose or glucose and the mixed bisglycosides 1 and 28 containing glucose mannose, and galactose. The carboranyl bisglycosides show almost no toxicity toward bronchial carcinoma cells of line A549 up to a concentration of 0.50 mM As anticipated, these compounds exhibit nearly no uptake into C6 glioma cells; they can therefore be used for a selective delivery into malignant cells:by using conjugates of glycohydrolases and monoclonal antibodies which bind to tumor-associated antigens, since by enzymatic hydrolysis the bisglycosides are transformed into lipophilic compounds."],["dc.identifier.doi","10.1002/1439-7633(20010504)2:5<326::AID-CBIC326>3.3.CO;2-P"],["dc.identifier.isi","000168615400004"],["dc.identifier.pmid","11828461"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25114"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1439-4227"],["dc.title","Carboranyl bisglycosides for the treatment of cancer by boron neutron capture therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","219"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","ChemBioChem"],["dc.bibliographiccitation.lastpage","225"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Griesbach, U."],["dc.contributor.author","Bothe, U."],["dc.contributor.author","Nakamura, H."],["dc.contributor.author","Yamamoto, Y."],["dc.date.accessioned","2018-11-07T10:31:17Z"],["dc.date.available","2018-11-07T10:31:17Z"],["dc.date.issued","2002"],["dc.description.abstract","The synthesis and biological evaluation of two ortho-carborane derivatives which contain a 5,6,7-trimethoxyindole (TMI) unit for use in boron neutron capture therapy is described. The TMI moiety is known to be the DNA-binding part of the highly potent anticancer agent duocarmycin A. The ortho-carborane derivatives were prepared from amino alkynes which were bound to a protected TMI carboxylic acid. Addition of decaborane(14) to the alkyne triple bond with subsequent removal of the tert-butoxy-carbonyl (Boc) and benzyl protecting groups gave the desired product. Boron uptake from the ortho-carborane derivatives into B-16 melanoma cells was higher and faster than that observed with L-p-boronophenylalanine (BPA), which is in use in the clinic."],["dc.identifier.doi","10.1002/1439-7633(20020301)3:2/3<219::AID-CBIC219>3.0.CO;2-#"],["dc.identifier.isi","000174383700012"],["dc.identifier.pmid","11921401"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44071"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1439-7633"],["dc.relation.issn","1439-4227"],["dc.title","Novel carboranes with a DNA binding unit for the treatment of cancer by boron neutron capture therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]