Schulz, Christian

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","367"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Asgari, S."],["dc.contributor.author","Schulz, T."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T10:40:45Z"],["dc.date.available","2018-11-07T10:40:45Z"],["dc.date.issued","2003"],["dc.format.extent","R135"],["dc.identifier.isi","000182435500535"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46377"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","44th Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie/20th Gesellschaft-fur-Umwelt-Mutationsforschung"],["dc.relation.eventlocation","MAINZ, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Thimerosal induces micronuclei in primary human lymphocytes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.volume","103"],["dc.contributor.author","Neuber, C."],["dc.contributor.author","Uebeler, June"],["dc.contributor.author","Schulze, T."],["dc.contributor.author","Sotoud, Hannieh"],["dc.contributor.author","El-Armouche, Ali"],["dc.contributor.author","Eschenhagen, Thomas"],["dc.date.accessioned","2018-11-07T09:37:38Z"],["dc.date.available","2018-11-07T09:37:38Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1093/cvr/cvu091.52"],["dc.identifier.isi","000343730100283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32884"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.conference","3rd Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","1755-3245"],["dc.relation.issn","0008-6363"],["dc.title","Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","4349"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Schulz, Christian"],["dc.contributor.author","Rehling, Peter"],["dc.date.accessioned","2017-09-07T11:46:11Z"],["dc.date.available","2017-09-07T11:46:11Z"],["dc.date.issued","2014"],["dc.description.abstract","Proteins with N-terminal targeting signals are transported across the inner mitochondrial membrane by the presequence translocase. To drive precursor translocation, the Hsp70-import motor associates with the protein-conducting channel of the TIM23 complex. It is unknown how the ATPase cycle of Hsp70 is regulated in the context of a translocating polypeptide chain. Here we establish an assay to monitor protein dynamics in the precursor-occupied presequence translocase and find that regulatory subunits of the import motor, such as the ATPase-stimulating J-protein Pam18, are recruited into the translocation intermediate. The presence of all Hsp70 co-chaperones at the import channel is not sufficient to promote matrix protein import, instead a recharging of the active translocase with Pam18 is required for motor activity. Thus, a replenishment cycle of co-chaperones at the TIM23 complex is an integral part of Hsp70's ATPase cycle at the channel exit site and essential to maintain motor-driven mitochondrial protein import."],["dc.format.extent","1"],["dc.identifier.doi","10.1038/ncomms5349"],["dc.identifier.gro","3142095"],["dc.identifier.isi","000340615500040"],["dc.identifier.pmid","25008211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4489"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","2041-1723"],["dc.title","Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3473"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Molecular and Cellular Biology"],["dc.bibliographiccitation.lastpage","3485"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Melin, Jonathan"],["dc.contributor.author","Schulz, Christian"],["dc.contributor.author","Wrobel, Lidia"],["dc.contributor.author","Bernhard, Olaf"],["dc.contributor.author","Chacinska, Agnieszka"],["dc.contributor.author","Jahn, Olaf"],["dc.contributor.author","Schmidt, Bernhard"],["dc.contributor.author","Rehling, Peter"],["dc.date.accessioned","2017-09-07T11:45:36Z"],["dc.date.available","2017-09-07T11:45:36Z"],["dc.date.issued","2014"],["dc.description.abstract","More than 70% of mitochondrial proteins utilize N-terminal presequences as targeting signals. Presequence interactions with redundant cytosolic receptor domains of the translocase of the outer mitochondrial membrane (TOM) are well established. However, after the presequence enters the protein-conducting Tom40 channel, the recognition events that occur at the trans side leading up to the engagement of the presequence with inner membrane-bound receptors are less well defined. Using a photoaffinity-labeling approach with modified presequence peptides, we identified Tom40 as a presequence interactor of the TOM complex. Utilizing mass spectrometry, we mapped Tom40's presequence-interacting regions to both sides of the beta-barrel. Analysis of a phosphorylation site within one of the presequence-interacting regions revealed altered translocation kinetics along the presequence pathway. Our analyses assess the relation between the identified presequence-binding region of Tom40 and the intermembrane space domain of Tom22. The identified presequence-interacting region of Tom40 is capable of functioning independently of the established trans-acting TOM presequence-binding domain during matrix import."],["dc.identifier.doi","10.1128/MCB.00433-14"],["dc.identifier.gro","3142065"],["dc.identifier.isi","000341024900010"],["dc.identifier.pmid","25002531"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4156"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1098-5549"],["dc.relation.issn","0270-7306"],["dc.title","Presequence Recognition by the Tom40 Channel Contributes to Precursor Translocation into the Mitochondrial Matrix"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Schanz, J."],["dc.contributor.author","Gassmann, W."],["dc.contributor.author","Yilmaz, A."],["dc.contributor.author","Vehmeyer, K."],["dc.contributor.author","Ludwig, W. D."],["dc.contributor.author","Wuchter, C."],["dc.contributor.author","Soeling, Ulrike"],["dc.contributor.author","Pies, A."],["dc.contributor.author","Schulz, T."],["dc.contributor.author","Verbeek, W."],["dc.contributor.author","Bartels, H."],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Griesinger, Frank"],["dc.contributor.author","Cliche, K. O."],["dc.contributor.author","Woermann, Bernhard"],["dc.date.accessioned","2018-11-07T09:48:12Z"],["dc.date.available","2018-11-07T09:48:12Z"],["dc.date.issued","2000"],["dc.format.extent","261B"],["dc.identifier.isi","000165256201199"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35257"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.publisher.place","Washington"],["dc.relation.issn","0006-4971"],["dc.title","Amifostin long-term application vs. supportive care - A multicentric phase III trial in patients with low-risk MDS (IPSS < 1.5)."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","363"],["dc.contributor.author","Westphal, Goetz Alexander"],["dc.contributor.author","Schulz, T."],["dc.contributor.author","Hallier, Ernst"],["dc.date.accessioned","2018-11-07T09:14:38Z"],["dc.date.available","2018-11-07T09:14:38Z"],["dc.date.issued","2001"],["dc.format.extent","R155"],["dc.identifier.isi","000167682100617"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27462"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0028-1298"],["dc.title","N-nitrosodiethylamine is Ames test positive using beta-naphtoflavone/phenobarbital induced S9 and gas-tight preincubation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Meteoritics and Planetary Science"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Wannek, D. L. M."],["dc.contributor.author","Reimold, W. U."],["dc.contributor.author","Thirlwall, M."],["dc.contributor.author","Hansen, Bent T."],["dc.contributor.author","Schulz, T."],["dc.contributor.author","Hoffmann, M."],["dc.contributor.author","Zaag, P. T."],["dc.contributor.author","Hauser, Natalie"],["dc.contributor.author","Siegert, S."],["dc.date.accessioned","2018-11-07T09:53:56Z"],["dc.date.available","2018-11-07T09:53:56Z"],["dc.date.issued","2015"],["dc.identifier.isi","000358591900350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36432"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","78th Annual Meeting of the Meteoritical-Society"],["dc.relation.eventlocation","Berkeley, CA"],["dc.title","ARE THERE TWO TYPES OF VREDEFORT GRANOPHYRE?"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","288"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","BIOMEDIZINISCHE TECHNIK"],["dc.bibliographiccitation.lastpage","292"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Rathgeber, J."],["dc.contributor.author","Kahle, G."],["dc.contributor.author","Schulze, T."],["dc.contributor.author","Zuchner, K."],["dc.date.accessioned","2018-11-07T09:22:48Z"],["dc.date.available","2018-11-07T09:22:48Z"],["dc.date.issued","2000"],["dc.description.abstract","A new hybrid humidity sensor comprising a conventional capacitance humidity sensor and a planar heating element is described. Owing to its short response time of only a few milliseconds, its great measuring accuracy, large measuring range, and simplicity in handling, the sensor is suitable for measuring water vapour partial pressure in gases with rapidly changing flow and direction, e.g. in ventilated patients in the fields of anaesthesia and intensive care medicine. The small dimensions permit measurements at almost any location within the ventilation system."],["dc.identifier.doi","10.1515/bmte.2000.45.10.288"],["dc.identifier.isi","000165101200006"],["dc.identifier.pmid","11085011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29431"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Fachverlag Schiele Schon"],["dc.relation.issn","0013-5585"],["dc.title","Rapid measurement of water vapour pressure at the saturation point using a new hybrid humidity sensor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5009"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Molecular and Cellular Biology"],["dc.bibliographiccitation.lastpage","5021"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Reinhold, Robert"],["dc.contributor.author","Krüger, Vivien"],["dc.contributor.author","Meinecke, Michael"],["dc.contributor.author","Schulz, Christian"],["dc.contributor.author","Schmidt, Bernhard"],["dc.contributor.author","Grunau, Silke D."],["dc.contributor.author","Guiard, Bernard"],["dc.contributor.author","Wiedemann, Nils"],["dc.contributor.author","van der Laan, Martin"],["dc.contributor.author","Wagner, Richard"],["dc.contributor.author","Rehling, Peter"],["dc.contributor.author","Dudek, Jan"],["dc.date.accessioned","2017-09-07T11:48:21Z"],["dc.date.available","2017-09-07T11:48:21Z"],["dc.date.issued","2012"],["dc.description.abstract","The majority of multispanning inner mitochondrial membrane proteins utilize internal targeting signals, which direct them to the carrier translocase (TIM22 complex), for their import. MPV17 and its Saccharomyces cerevisiae orthologue Sym1 are multispanning inner membrane proteins of unknown function with an amino-terminal presequence that suggests they may be targeted to the mitochondria. Mutations affecting MPV17 are associated with mitochondrial DNA depletion syndrome (MDDS). Reconstitution of purified Sym1 into planar lipid bilayers and electrophysiological measurements have demonstrated that Sym1 forms a membrane pore. To address the biogenesis of Sym1, which oligomerizes in the inner mitochondrial membrane, we studied its import and assembly pathway. Sym1 forms a transport intermediate at the translocase of the outer membrane (TOM) complex. Surprisingly, Sym1 was not transported into mitochondria by an amino-terminal signal, and in contrast to what has been observed in carrier proteins, Sym1 transport and assembly into the inner membrane were independent of small translocase of mitochondrial inner membrane (TIM) and TIM22 complexes. Instead, Sym1 required the presequence of translocase for its biogenesis. Our analyses have revealed a novel transport mechanism for a polytopic membrane protein in which internal signals direct the precursor into the inner membrane via the TIM23 complex, indicating a presequence-independent function of this translocase."],["dc.identifier.doi","10.1128/MCB.00843-12"],["dc.identifier.gro","3142435"],["dc.identifier.isi","000311492200011"],["dc.identifier.pmid","23045398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8252"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0270-7306"],["dc.title","The Channel-Forming Sym1 Protein Is Transported by the TIM23 Complex in a Presequence-Independent Manner"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","6213"],["dc.bibliographiccitation.firstpage","1059"],["dc.bibliographiccitation.issue","6213"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","1060"],["dc.bibliographiccitation.volume","346"],["dc.contributor.author","Schulz, Christian"],["dc.contributor.author","Rehling, Peter"],["dc.date.accessioned","2017-09-07T11:45:24Z"],["dc.date.available","2017-09-07T11:45:24Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1126/science.aaa2313"],["dc.identifier.gro","3142014"],["dc.identifier.isi","000345763400023"],["dc.identifier.pmid","25430757"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3590"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1095-9203"],["dc.relation.issn","0036-8075"],["dc.title","Cell Biology. Powering the cell cycle"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]