Posnien, Nico

[["dc.bibliographiccitation.artnumber","e1002416"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Koniszewski, Nikolaus Dieter Bernhard"],["dc.contributor.author","Hein, Hendrikje Jeannette"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:49:04Z"],["dc.date.available","2018-11-07T08:49:04Z"],["dc.date.issued","2011"],["dc.description.abstract","Several highly conserved genes play a role in anterior neural plate patterning of vertebrates and in head and brain patterning of insects. However, head involution in Drosophila has impeded a systematic identification of genes required for insect head formation. Therefore, we use the red flour beetle Tribolium castaneum in order to comprehensively test the function of orthologs of vertebrate neural plate patterning genes for a function in insect head development. RNAi analysis reveals that most of these genes are indeed required for insect head capsule patterning, and we also identified several genes that had not been implicated in this process before. Furthermore, we show that Tc-six3/optix acts upstream of Tc-wingless, Tc-orthodenticle1, and Tc-eyeless to control anterior median development. Finally, we demonstrate that Tc-six3/optix is the first gene known to be required for the embryonic formation of the central complex, a midline-spanning brain part connected to the neuroendocrine pars intercerebralis. These functions are very likely conserved among bilaterians since vertebrate six3 is required for neuroendocrine and median brain development with certain mutations leading to holoprosencephaly."],["dc.identifier.doi","10.1371/journal.pgen.1002416"],["dc.identifier.isi","000299167900033"],["dc.identifier.pmid","22216011"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21366"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7390"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Candidate Gene Screen in the Red Flour Beetle Tribolium Reveals Six3 as Ancient Regulator of Anterior Median Head and Central Complex Development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","62"],["dc.bibliographiccitation.journal","BMC Biology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Sharma, Prashant P."],["dc.contributor.author","Clark, Thomas"],["dc.contributor.author","Leite, Daniel J."],["dc.contributor.author","Wierschin, Torsten"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Akiyama-Oda, Yasuko"],["dc.contributor.author","Esposito, Lauren"],["dc.contributor.author","Bechsgaard, Jesper"],["dc.contributor.author","Bilde, Trine"],["dc.contributor.author","Buffry, Alexandra D."],["dc.contributor.author","Chao, Hsu"],["dc.contributor.author","Huyen, Dinh"],["dc.contributor.author","Doddapaneni, Harshavardhan"],["dc.contributor.author","Dugan, Shannon"],["dc.contributor.author","Eibner, Cornelius"],["dc.contributor.author","Extavour, Cassandra G."],["dc.contributor.author","Funch, Peter"],["dc.contributor.author","Garb, Jessica"],["dc.contributor.author","Gonzalez, Luis B."],["dc.contributor.author","Gonzalez, Vanessa L."],["dc.contributor.author","Griffiths-Jones, Sam"],["dc.contributor.author","Han, Yi"],["dc.contributor.author","Hayashi, Cheryl"],["dc.contributor.author","Hilbrant, Maarten"],["dc.contributor.author","Hughes, Daniel S. T."],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Lee, Sandra L."],["dc.contributor.author","Maeso, Ignacio"],["dc.contributor.author","Murali, Shwetha C."],["dc.contributor.author","Muzny, Donna M."],["dc.contributor.author","Nunes da Fonseca, Rodrigo"],["dc.contributor.author","Paese, Christian L. B."],["dc.contributor.author","Qu, Jiaxin"],["dc.contributor.author","Ronshaugen, Matthew"],["dc.contributor.author","Schomburg, Christoph"],["dc.contributor.author","Schönauer, Anna"],["dc.contributor.author","Stollewerk, Angelika"],["dc.contributor.author","Torres-Oliva, Montserrat"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Vanthournout, Bram"],["dc.contributor.author","Werren, John H."],["dc.contributor.author","Wolff, Carsten"],["dc.contributor.author","Worley, Kim C."],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Gibbs, Richard A."],["dc.contributor.author","Coddington, Jonathan"],["dc.contributor.author","Oda, Hiroki"],["dc.contributor.author","Stanke, Mario"],["dc.contributor.author","Ayoub, Nadia A."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Flot, Jean-Francois"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Richards, Stephen"],["dc.contributor.author","McGregor, Alistair P."],["dc.date.accessioned","2019-07-09T11:44:25Z"],["dc.date.available","2019-07-09T11:44:25Z"],["dc.date.issued","2017"],["dc.description.abstract","The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication. Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes."],["dc.identifier.doi","10.1186/s12915-017-0399-x"],["dc.identifier.pmid","28756775"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15127"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59010"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/14757 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The house spider genome reveals an ancient whole-genome duplication during arachnid evolution"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","399"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Arthropod Structure & Development"],["dc.bibliographiccitation.lastpage","410"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Schinko, Johannes B."],["dc.contributor.author","Kittelmann, Sebastian"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:37:17Z"],["dc.date.available","2018-11-07T08:37:17Z"],["dc.date.issued","2010"],["dc.description.abstract","Many questions regarding evolution and ontogeny of the insect head remain open. Likewise, the genetic basis of insect head development is poorly understood. Recently, the investigation of gene expression data and the analysis of patterning gene function have revived interest in insect head development. Here, we argue that the red flour beetle Tribolium castaneum is a well suited model organism to spearhead research with respect to the genetic control of insect head development. We review recent molecular data and discuss its bearing on early development and morphogenesis of the head. We present a novel hypothesis on the ontogenetic origin of insect head sutures and review recent insights into the question on the origin of the labrum. Further, we argue that the study of developmental genes may identify the elusive anterior non-segmental region and present some evidence in favor of its existence. With respect to the question of evolution of patterning we show that the head Anlagen of the fruit fly Drosophila melanogaster and Tribolium differ considerably and we review profound differences of their genetic regulation. Finally, we discuss which insect model species might help us to answer the open questions concerning the genetic regulation of head development and its evolution. (C) 2010 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.asd.2010.08.002"],["dc.identifier.isi","000285819100002"],["dc.identifier.pmid","20800703"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18495"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1467-8039"],["dc.title","Genetics, development and composition of the insect head - A beetle's view"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","107"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","338"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:46:09Z"],["dc.date.available","2018-11-07T08:46:09Z"],["dc.date.issued","2010"],["dc.description.abstract","The insect head is composed of several segments. During embryonic development, the segments fuse to form a rigid head capsule where obvious segmental boundaries are lacking. Hence, the assignment of regions of the insect head to specific segments is hampered, especially with respect to dorsal (vertex) and lateral (gena) parts. We show that upon Tribolium labial (Tc-lab) knock down, the intercalary segment is deleted but not transformed. Furthermore, we find that the intercalary segment contributes to lateral parts of the head cuticle in Tribolium. Based on several additional mutant and RNAi phenotypes that interfere with gnathal segment development, we show that these segments do not contribute to the dorsal head capsule apart from the dorsal ridge. Opposing the classical view but in line with findings in the vinegar fly Drosophila melanogaster and the milkweed bug Oncopeltus fasciatus, we propose a \"bend and zipper\" model for insect head capsule formation. (C) 2009 Elsevier Inc, All rights reserved."],["dc.description.sponsorship","DFG [BU-1443/2]; Marie-Curie Research Training Network \"Zoonet\""],["dc.identifier.doi","10.1016/j.ydbio.2009.11.010"],["dc.identifier.isi","000274173400010"],["dc.identifier.pmid","19913530"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20618"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1095-564X"],["dc.relation.issn","0012-1606"],["dc.title","Formation of the insect head involves lateral contribution of the intercalary segment, which depends on Tc-labial function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","600"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","613"],["dc.bibliographiccitation.volume","317"],["dc.contributor.author","Schinko, Johannes B."],["dc.contributor.author","Kreuzer, Nina"],["dc.contributor.author","Offen, Nils"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T11:15:05Z"],["dc.date.available","2018-11-07T11:15:05Z"],["dc.date.issued","2008"],["dc.description.abstract","The head gap genes orthodenticle (old), empty spiracles (ems) and buttonhead (btd) are required for metamerization and segment specification in Drosophila. We asked whether the function of their orthologs is conserved in the red flour beetle Tribolium castaneum which in contrast to Drosophila develops its larval head in a way typical for insects. We find that depending on dsRNA injection time, two functions of Tc-orthodenticle1 (Tc-otd1) can be identified. The early regionalization function affects all segments formed during the blastoderm stage while the later head patterning function is similar to Drosophila. In contrast, both expression and function of Tc-empty spiracles (Tc-ems) are restricted to the posterior part of the ocular and the anterior part of the antennal segment and Tc-buttonhead (Tc-btd) is not required for head cuticle formation at all. We conclude that the gap gene like roles of ems and btd are not conserved while at least the head patterning function of old appears to be similar in fly and beetle. Hence, the ancestral mode of insect head segmentation remains to be discovered. With this work, we establish Tribolium as a model system for arthropod head development that does not suffer from the Drosophila specific problems like head involution and Strongly reduced head structures. (C) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2008.03.005"],["dc.identifier.isi","000255898600020"],["dc.identifier.pmid","18407258"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54289"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Divergent functions of orthodenticle, empty spiracles and buttonhead in early head patterning of the beetle Tribolium castaneum (Coleoptera)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","215"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","227"],["dc.bibliographiccitation.volume","333"],["dc.contributor.author","Yang, Xiaoyun"],["dc.contributor.author","Weber, Markus"],["dc.contributor.author","ZarinKamar, Nazanin"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Friedrich, Frank"],["dc.contributor.author","Wigand, Barbara"],["dc.contributor.author","Beutel, Rolf"],["dc.contributor.author","Damen, Wim G. M."],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Klingler, Martin"],["dc.contributor.author","Friedrich, Markus"],["dc.date.accessioned","2018-11-07T11:24:39Z"],["dc.date.available","2018-11-07T11:24:39Z"],["dc.date.issued","2009"],["dc.description.abstract","The Pax6 genes eyeless (ey) and twin of eyeless (toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in Drosophila. Most animals possess a singleton Pax6 ortholog, but the dependence of eye development on Pax6 is widely conserved. A rare exception is given by the larval eyes of Drosophila, which develop independently of ey and toy. To obtain insight into the origin of differential larval and adult eye regulation, we studied the function of toy and ey in the red. our beetle Tribolium castaneum. We find that single and combinatorial knockdown of toy and ey affect larval eye development strongly but adult eye development only mildly in this primitive hemimetabolous species. Compound eye-loss, however, was provoked when ey and toy were RNAi-silenced in combination with the early retinal gene dachshund (dac). We propose that these data reflect a role of Pax6 during regional specification in the developing head and that the subsequent maintenance and growth of the adult eye primordium is regulated partly by redundant and partly by specific functions of toy, ey and dac in Tribolium. The results from embryonic knockdown and comparative protein sequence analysis lead us further to conclude that Tribolium represents an ancestral state of redundant control by ey and toy. Published by Elsevier Inc."],["dc.identifier.doi","10.1016/j.ydbio.2009.06.013"],["dc.identifier.isi","000272260100018"],["dc.identifier.pmid","19527703"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56454"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Probing the Drosophila retinal determination gene network in Tribolium (II): The Pax6 genes eyeless and twin of eyeless"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","480"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Evolution & Development"],["dc.bibliographiccitation.lastpage","488"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Bashasab, Fakrudin"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T11:24:52Z"],["dc.date.available","2018-11-07T11:24:52Z"],["dc.date.issued","2009"],["dc.description.abstract","The insect upper lip-the labrum-is a lobe-like structure anterior to the mouth opening. Whether the labrum represents a fused pair of segmental appendages or evolved independently is heavily debated. Here, we identify additional similarities of the regulatory gene network active in labrum and trunk appendages. However, we do not find a labral parasegment boundary and we show that labral Tc-Dll expression is independent of Tc-wg and Tc-hh signals. In contrast, Tc-Dll expression in all trunk appendages does require these signals. Finally, we identify crucial differences between the location of the labrum and trunk appendages: the labrum develops in median rather than lateral tissues and is part of an anterior nonsegmental tissue marked by and dependent on Tc-six3 activity. To reconcile these seeming contradictory results, we propose that the genetic network evolved in either labrum or trunk appendages and became redeployed at a novel location to form the other structure."],["dc.identifier.doi","10.1111/j.1525-142X.2009.00356.x"],["dc.identifier.isi","000269729200004"],["dc.identifier.pmid","19754705"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56505"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1520-541X"],["dc.title","The insect upper lip (labrum) is a nonsegmental appendage-like structure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7782"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","7786"],["dc.bibliographiccitation.volume","109"],["dc.contributor.author","Fu, Jinping"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Bolognesi, Renata"],["dc.contributor.author","Fischer, Tamara D."],["dc.contributor.author","Rayl, Parker"],["dc.contributor.author","Oberhofer, Georg"],["dc.contributor.author","Kitzmann, Peter"],["dc.contributor.author","Brown, Susan J."],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T09:10:25Z"],["dc.date.available","2018-11-07T09:10:25Z"],["dc.date.issued","2012"],["dc.description.abstract","Canonical Wnt signaling has been implicated in an AP axis polarizing mechanism in most animals, despite limited evidence from arthropods. In the long-germ insect, Drosophila, Wnt signaling is not required for global AP patterning, but in short-germ insects including Tribolium castaneum, loss of Wnt signaling affects development of segments in the growth zone but not those defined in the blastoderm. To determine the effects of ectopic Wnt signaling, we analyzed the expression and function of axin, which encodes a highly conserved negative regulator of the pathway. We found Tc-axin transcripts maternally localized to the anterior pole in freshly laid eggs. Expression spread toward the posterior pole during the early cleavage stages, becoming ubiquitous by the time the germ rudiment formed. Tc-axin RNAi produced progeny phenotypes that ranged from mildly affected embryos with cuticles displaying a graded loss of anterior structures, to defective embryos that condensed at the posterior pole in the absence of serosa. Altered expression domains of several blastodermal markers indicated anterior expansion of posterior fates. Analysis of other canonical Wnt pathway components and the expansion of Tc-caudal expression, a Wnt target, suggest that the effects of Tc-axin depletion are mediated through this pathway and that Wnt signaling must be inhibited for proper anterior development in Tribolium. These studies provide unique evidence that canonical Wnt signaling must be carefully regulated along the AP axis in an arthropod, and support an ancestral role for Wnt activity in defining AP polarity and patterning in metazoan development."],["dc.identifier.doi","10.1073/pnas.1116641109"],["dc.identifier.isi","000304369800049"],["dc.identifier.pmid","22552230"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26486"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Asymmetrically expressed axin required for anterior development in Tribolium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","174"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","184"],["dc.bibliographiccitation.volume","374"],["dc.contributor.author","Kittelmann, Sebastian"],["dc.contributor.author","Ulrich, Julia"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T09:28:46Z"],["dc.date.available","2018-11-07T09:28:46Z"],["dc.date.issued","2013"],["dc.description.abstract","Early embryonic stages differ significantly among related animal taxa while subsequent development converges at the conserved phylotypic stage before again diverging. Although this phenomenon has long been observed, its underlying genetic mechanisms remain enigmatic. The dipteran Drosophila melanogaster develops as a long germ embryo where the head anlagen form a cap at the anterior pole of the blastoderm. Consequently, the anterior and terminal maternal systems give crucial input for head patterning. However, in the short germ beetle Tribolium castaneum, as in most insects, the head anlagen is located at a ventral position distant from the anterior pole of the blastoderm. In line with these divergent embryonic anlagen, several differences in the axis formation between the insects have been discovered. We now ask to what extent patterning and morphogenesis of the anterior median region (AMR) of the head, including clypeolabral and stomodeal anlagen, differ among these insects. Unexpectedly, we find that Tc-huckebein is not a terminal gap gene and, unlike its Drosophila ortholog, is not involved in Tribolium head development. Instead, Tc-six3 acts upstream of Tc-crocodile and Tc-cap'n'collar to pattern posterior and anterior parts of the AMR, respectively. We further find that instead of huckebein, Tc-crocodile is required for stomodeum development by activating Tc-forkhead. Finally, a morphogenetic movement not found in Drosophila shapes the embryonic head of Tribolium. Apparently, with anterior displacement of the head anlagen during long germ evolution of Drosophila, the ancestral regulation by the bilaterian anterior control gene six3 was replaced by the anterior and terminal maternal systems, which were further elaborated by adding bicoid, tailless and huckebein as anterior regionalization genes. (c) 2012 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.ydbio.2012.11.026"],["dc.identifier.isi","000314145300016"],["dc.identifier.pmid","23201022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30856"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0012-1606"],["dc.title","Changes in anterior head patterning underlie the evolution of long germ embryogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","14"],["dc.bibliographiccitation.journal","EvoDevo"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Steinmetz, Patrick R. H."],["dc.contributor.author","Urbach, Rolf"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Eriksson, Joakim"],["dc.contributor.author","Kostyuchenko, Roman P."],["dc.contributor.author","Brena, Carlo"],["dc.contributor.author","Guy, Keren"],["dc.contributor.author","Akam, Michael"],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Arendt, Detlev"],["dc.date.accessioned","2018-11-07T08:47:38Z"],["dc.date.available","2018-11-07T08:47:38Z"],["dc.date.issued","2010"],["dc.description.abstract","Background: The heads of annelids (earthworms, polychaetes, and others) and arthropods (insects, myriapods, spiders, and others) and the arthropod-related onychophorans (velvet worms) show similar brain architecture and for this reason have long been considered homologous. However, this view is challenged by the 'new phylogeny' placing arthropods and annelids into distinct superphyla, Ecdysozoa and Lophotrochozoa, together with many other phyla lacking elaborate heads or brains. To compare the organisation of annelid and arthropod heads and brains at the molecular level, we investigated head regionalisation genes in various groups. Regionalisation genes subdivide developing animals into molecular regions and can be used to align head regions between remote animal phyla. Results: We find that in the marine annelid Platynereis dumerilii, expression of the homeobox gene six3 defines the apical region of the larval body, peripherally overlapping the equatorial otx+ expression. The six3+ and otx+ regions thus define the developing head in anterior-to-posterior sequence. In another annelid, the earthworm Pristina, as well as in the onychophoran Euperipatoides, the centipede Strigamia and the insects Tribolium and Drosophila, a six3/optix+ region likewise demarcates the tip of the developing animal, followed by a more posterior otx/otd+ region. Identification of six3+ head neuroectoderm in Drosophila reveals that this region gives rise to median neurosecretory brain parts, as is also the case in annelids. In insects, onychophorans and Platynereis, the otx + region instead harbours the eye anlagen, which thus occupy a more posterior position. Conclusions: These observations indicate that the annelid, onychophoran and arthropod head develops from a conserved anterior-posterior sequence of six3+ and otx+ regions. The six3+ anterior pole of the arthropod head and brain accordingly lies in an anterior-median embryonic region and, in consequence, the optic lobes do not represent the tip of the neuraxis. These results support the hypothesis that the last common ancestor of annelids and arthropods already possessed neurosecretory centres in the most anterior region of the brain. In light of its broad evolutionary conservation in protostomes and, as previously shown, in deuterostomes, the six3-otx head patterning system may be universal to bilaterian animals."],["dc.identifier.doi","10.1186/2041-9139-1-14"],["dc.identifier.isi","000208517600014"],["dc.identifier.pmid","21190549"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21003"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","2041-9139"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Six3 demarcates the anterior-most developing brain region in bilaterian animals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]