Posnien, Nico

[["dc.bibliographiccitation.artnumber","e27590"],["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Benton, Matthew A"],["dc.contributor.author","Kenny, Nathan J"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Roth, Siegfried"],["dc.date.accessioned","2020-09-04T13:25:46Z"],["dc.date.available","2020-09-04T13:25:46Z"],["dc.date.issued","2017"],["dc.description.abstract","Organizers play important roles during the embryonic development of many animals. The most famous example is the Spemann organizer that sets up embryonic axes in amphibian embryos. In spiders, a group of BMP secreting mesenchymal cells (the cumulus) functions as an organizer of the dorsoventral axis. Similar to experiments performed with the Spemann organizer, transplantation of the cumulus is able to induce a secondary axis in spiders. Despite the importance of this structure, it is unknown which factors are needed to activate cumulus specific gene expression. To address this question, we performed a transcriptomic analysis of early embryonic development in the spider Parasteatoda tepidariorum. Through this work, we found that the transcription factor Pt-Ets4 is needed for cumulus integrity, dorsoventral patterning and for the activation of Pt-hunchback and Pt-twist expression. Furthermore, ectopic expression of Pt-Ets4 is sufficient to induce cell delamination and migration by inducing a mesoderm-like cell fate."],["dc.identifier.doi","10.7554/eLife.27590"],["dc.identifier.eissn","2050-084X"],["dc.identifier.pmid","28849761"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67645"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2050-084X"],["dc.relation.issn","2050-084X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A novel role for Ets4 in axis specification and cell migration in the spider Parasteatoda tepidariorum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1155"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Biology Open"],["dc.bibliographiccitation.lastpage","1164"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Al Khatib, Amer"],["dc.contributor.author","Siomava, Natalia"],["dc.contributor.author","Iannini, Antonella"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Casares, Fernando"],["dc.date.accessioned","2020-09-04T13:25:40Z"],["dc.date.available","2020-09-04T13:25:40Z"],["dc.date.issued","2017-08-15"],["dc.description.abstract","Organ size and pattern results from the integration of two positional information systems. One global information system, encoded by the Hox genes, links organ type with position along the main body axis. Within specific organs, local information is conveyed by signaling molecules that regulate organ growth and pattern. The mesothoracic (T2) wing and the metathoracic (T3) haltere of Drosophila represent a paradigmatic example of this coordination. The Hox gene Ultrabithorax (Ubx), expressed in the developing T3, selects haltere identity by, among other processes, modulating the production and signaling efficiency of Dpp, a BMP2-like molecule that acts as a major regulator of size and pattern. However, the mechanisms of the Hox-signal integration in this well-studied system are incomplete. Here, we have investigated this issue by studying the expression and function of the Six3 transcription factor optix during Drosophila wing and haltere development. We find that in both organs, Dpp defines the expression domain of optix through repression, and that the specific position of this domain in wing and haltere seems to reflect the differential signaling profile among these organs. We show that optix expression in wing and haltere primordia is conserved beyond Drosophila in other higher diptera. In Drosophila, optix is necessary for the growth of wing and haltere. In the wing, optix is required for the growth of the most anterior/proximal region (the 'marginal cell') and for the correct formation of sensory structures along the proximal anterior wing margin; the halteres of optix mutants are also significantly reduced. In addition, in the haltere, optix is necessary for the suppression of sensory bristles."],["dc.identifier.doi","10.1242/bio.023606"],["dc.identifier.pmid","28642242"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67644"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2046-6390"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Specific expression and function of the Six3 optix in Drosophila serially homologous organs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3152"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Genome Biology and Evolution"],["dc.bibliographiccitation.lastpage","3166"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Reis, Micael"],["dc.contributor.author","Vieira, Cristina P."],["dc.contributor.author","Lata, Rodrigo"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Vieira, Jorge"],["dc.date.accessioned","2019-08-09T07:10:34Z"],["dc.date.accessioned","2020-06-25T10:16:52Z"],["dc.date.available","2019-08-09T07:10:34Z"],["dc.date.available","2020-06-25T10:16:52Z"],["dc.date.issued","2018"],["dc.description.abstract","In Drosophila, large variations in rearrangement rate have been reported among different lineages and among Muller's elements. Nevertheless, the mechanisms that are involved in the generation of inversions, their increase in frequency, as well as their impact on the genome are not completely understood. This is in part due to the lack of comparative studies on species distantly related to Drosophila melanogaster. Therefore, we sequenced and assembled the genomes of two species of the virilis phylad (Drosophila novamexicana [15010-1031.00] and Drosophila americana [SF12]), which are diverging from D. melanogaster for more than 40 Myr. Based on these data, we identified the precise location of six novel inversion breakpoints. A molecular characterization provided clear evidence that DAIBAM (a miniature inverted-repeat transposable element) was involved in the generation of eight out of the nine inversions identified. In contrast to what has been previously reported for D. melanogaster and close relatives, ectopic recombination is thus the prevalent mechanism of generating inversions in species of the virilis phylad. Using pool-sequencing data for three populations of D. americana, we also show that common polymorphic inversions create a high degree of genetic differentiation between populations for chromosomes X, 4, and 5 over large physical distances. We did not find statistically significant differences in expression levels between D. americana (SF12) and D. novamexicana (15010-1031.00) strains for the three genes surveyed (CG9588, Fig 4, and fab1) flanking three inversion breakpoints."],["dc.identifier.doi","10.1093/gbe/evy239"],["dc.identifier.pmid","30376068"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16345"],["dc.identifier.scopus","2-s2.0-85060237162"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62355"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66745"],["dc.identifier.url","http://www.scopus.com/inward/record.url?eid=2-s2.0-85060237162&partnerID=MN8TOARS"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1759-6653"],["dc.relation.issn","1759-6653"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Origin and Consequences of Chromosomal Inversions in the virilis Group of Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Siomava, Natalia"],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Posnien, Nico"],["dc.date.accessioned","2020-09-04T13:26:54Z"],["dc.date.available","2020-09-04T13:26:54Z"],["dc.date.issued","2017"],["dc.description.abstract","The ability to powered flight facilitated a great evolutionary success of insects and allowed them to occupy various ecological niches. In addition to primary tasks, wings are often involved in various premating behaviors, such as courtship songs and initiation of mating in flight. These specific implications require certain wing morphology, size, and shape. Although wing properties have been extensively studied in Drosophila, a comprehensive understanding of sexual shape dimorphisms and developmental plasticity in wing morphology is missing for other Diptera. To acquire this knowledge, we applied geometric morphometrics and analyzed wing shape in three dipteran species (Drosophila, Ceratitis, and Musca) raised in different environmental conditions. We extensively studied sexual dimorphism and impact of sex and environment on the adult wing morphology. We present allometric and non-allometric shape differences between males and females and show that wing shape is influenced by rearing conditions in a sex dependent manner. We determine common trends in shape alterations and show that the anterior and posterior crossveins are likely to be plastic regions changing substantially at different environmental conditions. We discuss our data in the light of vein development and hypothesize that the observed shape differences might recapitulate different mating behaviors and flight capabilities."],["dc.format.extent","32"],["dc.identifier.doi","10.1101/135749"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67649"],["dc.language.iso","en"],["dc.title","Extensive sexual wing shape dimorphism in Drosophila melanogaster, Ceratitis capitata, and Musca domestica"],["dc.type","preprint"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","155"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.lastpage","172"],["dc.bibliographiccitation.volume","230"],["dc.contributor.author","Cordellier, Mathilde"],["dc.contributor.author","Schneider, Jutta M"],["dc.contributor.author","Uhl, Gabriele"],["dc.contributor.author","Posnien, Nico"],["dc.date.accessioned","2020-09-04T13:25:59Z"],["dc.date.available","2020-09-04T13:25:59Z"],["dc.date.issued","2020-03"],["dc.description.abstract","Sexual reproduction is pervasive in animals and has led to the evolution of sexual dimorphism. In most animals, males and females show marked differences in primary and secondary sexual traits. The formation of sex-specific organs and eventually sex-specific behaviors is defined during the development of an organism. Sex determination processes have been extensively studied in a few well-established model organisms. While some key molecular regulators are conserved across animals, the initiation of sex determination is highly diverse. To reveal the mechanisms underlying the development of sexual dimorphism and to identify the evolutionary forces driving the evolution of different sexes, sex determination mechanisms must thus be studied in detail in many different animal species beyond the typical model systems. In this perspective article, we argue that spiders represent an excellent group of animals in which to study sex determination mechanisms. We show that spiders are sexually dimorphic in various morphological, behavioral, and life history traits. The availability of an increasing number of genomic and transcriptomic resources and functional tools provides a great starting point to scrutinize the extensive sexual dimorphism present in spiders on a mechanistic level. We provide an overview of the current knowledge of sex determination in spiders and propose approaches to reveal the molecular and genetic underpinnings of sexual dimorphism in these exciting animals."],["dc.identifier.doi","10.1007/s00427-020-00657-6"],["dc.identifier.pmid","32052129"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67647"],["dc.language.iso","en"],["dc.relation.eissn","1432-041X"],["dc.relation.issn","0949-944X"],["dc.relation.issn","1432-041X"],["dc.title","Sex differences in spiders: from phenotype to genomics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1002416"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Koniszewski, Nikolaus Dieter Bernhard"],["dc.contributor.author","Hein, Hendrikje Jeannette"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:49:04Z"],["dc.date.available","2018-11-07T08:49:04Z"],["dc.date.issued","2011"],["dc.description.abstract","Several highly conserved genes play a role in anterior neural plate patterning of vertebrates and in head and brain patterning of insects. However, head involution in Drosophila has impeded a systematic identification of genes required for insect head formation. Therefore, we use the red flour beetle Tribolium castaneum in order to comprehensively test the function of orthologs of vertebrate neural plate patterning genes for a function in insect head development. RNAi analysis reveals that most of these genes are indeed required for insect head capsule patterning, and we also identified several genes that had not been implicated in this process before. Furthermore, we show that Tc-six3/optix acts upstream of Tc-wingless, Tc-orthodenticle1, and Tc-eyeless to control anterior median development. Finally, we demonstrate that Tc-six3/optix is the first gene known to be required for the embryonic formation of the central complex, a midline-spanning brain part connected to the neuroendocrine pars intercerebralis. These functions are very likely conserved among bilaterians since vertebrate six3 is required for neuroendocrine and median brain development with certain mutations leading to holoprosencephaly."],["dc.identifier.doi","10.1371/journal.pgen.1002416"],["dc.identifier.isi","000299167900033"],["dc.identifier.pmid","22216011"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21366"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1553-7390"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Candidate Gene Screen in the Red Flour Beetle Tribolium Reveals Six3 as Ancient Regulator of Anterior Median Head and Central Complex Development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","47"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Herndon, Nicolae"],["dc.contributor.author","Shelton, Jennifer"],["dc.contributor.author","Gerischer, Lizzy"],["dc.contributor.author","Ioannidis, Panos"],["dc.contributor.author","Ninova, Maria"],["dc.contributor.author","Dönitz, Jürgen"],["dc.contributor.author","Waterhouse, Robert M"],["dc.contributor.author","Liang, Chun"],["dc.contributor.author","Damm, Carsten"],["dc.contributor.author","Siemanowski, Janna"],["dc.contributor.author","Kitzmann, Peter"],["dc.contributor.author","Ulrich, Julia"],["dc.contributor.author","Dippel, Stefan"],["dc.contributor.author","Oberhofer, Georg"],["dc.contributor.author","Hu, Yonggang"],["dc.contributor.author","Schwirz, Jonas"],["dc.contributor.author","Schacht, Magdalena"],["dc.contributor.author","Lehmann, Sabrina"],["dc.contributor.author","Montino, Alice"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Gurska, Daniela"],["dc.contributor.author","Horn, Thorsten"],["dc.contributor.author","Seibert, Jan"],["dc.contributor.author","Vargas Jentzsch, Iris M"],["dc.contributor.author","Panfilio, Kristen A"],["dc.contributor.author","Li, Jianwei"],["dc.contributor.author","Wimmer, Ernst A"],["dc.contributor.author","Stappert, Dominik"],["dc.contributor.author","Roth, Siegfried"],["dc.contributor.author","Schröder, Reinhard"],["dc.contributor.author","Park, Yoonseong"],["dc.contributor.author","Schoppmeier, Michael"],["dc.contributor.author","Chung, Ho-Ryun"],["dc.contributor.author","Klingler, Martin"],["dc.contributor.author","Kittelmann, Sebastian"],["dc.contributor.author","Friedrich, Markus"],["dc.contributor.author","Chen, Rui"],["dc.contributor.author","Altincicek, Boran"],["dc.contributor.author","Vilcinskas, Andreas"],["dc.contributor.author","Zdobnov, Evgeny"],["dc.contributor.author","Griffiths-Jones, Sam"],["dc.contributor.author","Ronshaugen, Matthew"],["dc.contributor.author","Stanke, Mario"],["dc.contributor.author","Brown, Sue J"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2020-09-04T13:25:52Z"],["dc.date.available","2020-09-04T13:25:52Z"],["dc.date.issued","2020-01-14"],["dc.description.abstract","The red flour beetle Tribolium castaneum has emerged as an important model organism for the study of gene function in development and physiology, for ecological and evolutionary genomics, for pest control and a plethora of other topics. RNA interference (RNAi), transgenesis and genome editing are well established and the resources for genome-wide RNAi screening have become available in this model. All these techniques depend on a high quality genome assembly and precise gene models. However, the first version of the genome assembly was generated by Sanger sequencing, and with a small set of RNA sequence data limiting annotation quality."],["dc.identifier.doi","10.1186/s12864-019-6394-6"],["dc.identifier.pmid","31937263"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17122"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/67646"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1471-2164"],["dc.relation.issn","1471-2164"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Enhanced genome assembly and a new official gene set for Tribolium castaneum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","62"],["dc.bibliographiccitation.journal","BMC Biology"],["dc.bibliographiccitation.lastpage","27"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schwager, Evelyn E."],["dc.contributor.author","Sharma, Prashant P."],["dc.contributor.author","Clark, Thomas"],["dc.contributor.author","Leite, Daniel J."],["dc.contributor.author","Wierschin, Torsten"],["dc.contributor.author","Pechmann, Matthias"],["dc.contributor.author","Akiyama-Oda, Yasuko"],["dc.contributor.author","Esposito, Lauren"],["dc.contributor.author","Bechsgaard, Jesper"],["dc.contributor.author","Bilde, Trine"],["dc.contributor.author","Buffry, Alexandra D."],["dc.contributor.author","Chao, Hsu"],["dc.contributor.author","Huyen, Dinh"],["dc.contributor.author","Doddapaneni, Harshavardhan"],["dc.contributor.author","Dugan, Shannon"],["dc.contributor.author","Eibner, Cornelius"],["dc.contributor.author","Extavour, Cassandra G."],["dc.contributor.author","Funch, Peter"],["dc.contributor.author","Garb, Jessica"],["dc.contributor.author","Gonzalez, Luis B."],["dc.contributor.author","Gonzalez, Vanessa L."],["dc.contributor.author","Griffiths-Jones, Sam"],["dc.contributor.author","Han, Yi"],["dc.contributor.author","Hayashi, Cheryl"],["dc.contributor.author","Hilbrant, Maarten"],["dc.contributor.author","Hughes, Daniel S. T."],["dc.contributor.author","Janssen, Ralf"],["dc.contributor.author","Lee, Sandra L."],["dc.contributor.author","Maeso, Ignacio"],["dc.contributor.author","Murali, Shwetha C."],["dc.contributor.author","Muzny, Donna M."],["dc.contributor.author","Nunes da Fonseca, Rodrigo"],["dc.contributor.author","Paese, Christian L. B."],["dc.contributor.author","Qu, Jiaxin"],["dc.contributor.author","Ronshaugen, Matthew"],["dc.contributor.author","Schomburg, Christoph"],["dc.contributor.author","Schönauer, Anna"],["dc.contributor.author","Stollewerk, Angelika"],["dc.contributor.author","Torres-Oliva, Montserrat"],["dc.contributor.author","Turetzek, Natascha"],["dc.contributor.author","Vanthournout, Bram"],["dc.contributor.author","Werren, John H."],["dc.contributor.author","Wolff, Carsten"],["dc.contributor.author","Worley, Kim C."],["dc.contributor.author","Bucher, Gregor"],["dc.contributor.author","Gibbs, Richard A."],["dc.contributor.author","Coddington, Jonathan"],["dc.contributor.author","Oda, Hiroki"],["dc.contributor.author","Stanke, Mario"],["dc.contributor.author","Ayoub, Nadia A."],["dc.contributor.author","Prpic, Nikola-Michael"],["dc.contributor.author","Flot, Jean-Francois"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Richards, Stephen"],["dc.contributor.author","McGregor, Alistair P."],["dc.date.accessioned","2019-07-09T11:44:25Z"],["dc.date.available","2019-07-09T11:44:25Z"],["dc.date.issued","2017"],["dc.description.abstract","The duplication of genes can occur through various mechanisms and is thought to make a major contribution to the evolutionary diversification of organisms. There is increasing evidence for a large-scale duplication of genes in some chelicerate lineages including two rounds of whole genome duplication (WGD) in horseshoe crabs. To investigate this further, we sequenced and analyzed the genome of the common house spider Parasteatoda tepidariorum. We found pervasive duplication of both coding and non-coding genes in this spider, including two clusters of Hox genes. Analysis of synteny conservation across the P. tepidariorum genome suggests that there has been an ancient WGD in spiders. Comparison with the genomes of other chelicerates, including that of the newly sequenced bark scorpion Centruroides sculpturatus, suggests that this event occurred in the common ancestor of spiders and scorpions, and is probably independent of the WGDs in horseshoe crabs. Furthermore, characterization of the sequence and expression of the Hox paralogs in P. tepidariorum suggests that many have been subject to neo-functionalization and/or sub-functionalization since their duplication. Our results reveal that spiders and scorpions are likely the descendants of a polyploid ancestor that lived more than 450 MYA. Given the extensive morphological diversity and ecological adaptations found among these animals, rivaling those of vertebrates, our study of the ancient WGD event in Arachnopulmonata provides a new comparative platform to explore common and divergent evolutionary outcomes of polyploidization events across eukaryotes."],["dc.identifier.doi","10.1186/s12915-017-0399-x"],["dc.identifier.pmid","28756775"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15127"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59010"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/14757 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The house spider genome reveals an ancient whole-genome duplication during arachnid evolution"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","399"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Arthropod Structure & Development"],["dc.bibliographiccitation.lastpage","410"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Posnien, Nico"],["dc.contributor.author","Schinko, Johannes B."],["dc.contributor.author","Kittelmann, Sebastian"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-11-07T08:37:17Z"],["dc.date.available","2018-11-07T08:37:17Z"],["dc.date.issued","2010"],["dc.description.abstract","Many questions regarding evolution and ontogeny of the insect head remain open. Likewise, the genetic basis of insect head development is poorly understood. Recently, the investigation of gene expression data and the analysis of patterning gene function have revived interest in insect head development. Here, we argue that the red flour beetle Tribolium castaneum is a well suited model organism to spearhead research with respect to the genetic control of insect head development. We review recent molecular data and discuss its bearing on early development and morphogenesis of the head. We present a novel hypothesis on the ontogenetic origin of insect head sutures and review recent insights into the question on the origin of the labrum. Further, we argue that the study of developmental genes may identify the elusive anterior non-segmental region and present some evidence in favor of its existence. With respect to the question of evolution of patterning we show that the head Anlagen of the fruit fly Drosophila melanogaster and Tribolium differ considerably and we review profound differences of their genetic regulation. Finally, we discuss which insect model species might help us to answer the open questions concerning the genetic regulation of head development and its evolution. (C) 2010 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.asd.2010.08.002"],["dc.identifier.isi","000285819100002"],["dc.identifier.pmid","20800703"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18495"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1467-8039"],["dc.title","Genetics, development and composition of the insect head - A beetle's view"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","257"],["dc.bibliographiccitation.journal","Development Genes and Evolution"],["dc.bibliographiccitation.volume","226"],["dc.contributor.author","Siomava, Natalia"],["dc.contributor.author","Wimmer, Ernst A."],["dc.contributor.author","Posnien, Nico"],["dc.date.accessioned","2018-11-07T10:13:30Z"],["dc.date.available","2018-11-07T10:13:30Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1007/s00427-016-0553-4"],["dc.identifier.isi","000377362100012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40445"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.iserratumof","/handle/2/40444"],["dc.relation.issn","1432-041X"],["dc.relation.issn","0949-944X"],["dc.title","Erratum to: Size relationships of different body parts in the three dipteran species Drosophila melanogaster, Ceratitis capitata and Musca domestica"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]